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Trichorrhexis Nodosa

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Atlas of Trichoscopy

Abstract

The trichoscopic appearance of trichorrhexis nodosa depends on the magnification and the presence of immersion fluid. At low magnifications, trichoscopy reveals nodular thickenings along hair shafts, and these thickenings appear lighter in the dark hair shafts. At these sites, the hairs bend with a rounded edge and eventually break, leaving a slightly thickened, rounded hair shaft end. At higher magnifications, trichoscopy reveals numerous small fibers, producing a picture that resembles two brooms or brushes aligned in opposition. To better visualize trichorrhexis nodosa, the hairs should be evaluated with dry trichoscopy.

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References

  1. Bartels NG, Blume-Peytavi U. Hair loss in children. In: Blume-Peytavi U, Tosti A, Whiting D, Trüeb R, editors. Hair growth and disorders. Leipzig: Springer; 2008. p. 293–4.

    Google Scholar 

  2. Chernosky ME, Owens DW. Trichorrhexis nodosa. Clinical and investigative studies. Arch Dermatol. 1966;94(5):577–85.

    Article  PubMed  CAS  Google Scholar 

  3. Smith VV, Anderson G, Malone M, Sebire NJ. Light microscopic examination of scalp hair samples as an aid in the diagnosis of paediatric disorders: retrospective review of more than 300 cases from a single centre. J Clin Pathol. 2005;58(12):1294–8.

    Article  PubMed  CAS  Google Scholar 

  4. Martin AM, Sugathan P. Localised acquired trichorrhexis nodosa of the scalp hair induced by a specific comb and combing habit—a report of three cases. Int J Trichol. 2011;3(1):34–7.

    Article  Google Scholar 

  5. Mirmirani P. Ceramic flat irons: improper use leading to acquired trichorrhexis nodosa. J Am Acad Dermatol. 2010;62(1):145–7.

    Article  PubMed  Google Scholar 

  6. Burkhart CG, Burkhart CN. Trichorrhexis nodosa revisited. Skinmed. 2007;6(2):57–8.

    Article  PubMed  Google Scholar 

  7. Callender VD, McMichael AJ, Cohen GF. Medical and surgical therapies for alopecias in black women. Dermatol Ther. 2004;17(2):164–76.

    Article  PubMed  Google Scholar 

  8. Pollitt RJ, Jenner FA, Davies M. Sibs with mental and physical retardation and trichorrhexis nodosa with abnormal amino acid composition of the hair. Arch Dis Child. 1968;43(228):211–6.

    Article  PubMed  CAS  Google Scholar 

  9. Fabre A, Andre N, Breton A, Broue P, Badens C, Roquelaure B. Intractable diarrhea with “phenotypic anomalies” and tricho-hepato-enteric syndrome: two names for the same disorder. Am J Med Genet A. 2007;143(6):584–8.

    PubMed  Google Scholar 

  10. Erez A, Nagamani SC, Lee B. Argininosuccinate lyase deficiency-argininosuccinic aciduria and beyond. Am J Med Genet C Semin Med Genet. 2011;157(1):45–53.

    Article  PubMed  CAS  Google Scholar 

  11. Abdel-Salam GM, Afifi HH, Eid MM, El-Badry TH, Kholoussi N. Ectodermal abnormalities in patients with Kabuki syndrome. Pediatr Dermatol. 2011;28(5):507–11.

    Article  PubMed  Google Scholar 

  12. Wang XH, Lu JL, Zhang LP, Zou LP, Wu HS, Wang X, et al. Clinical and laboratory features of the Menkes disease [in Chinese]. Zhonghua Er Ke Za Zhi. 2009;47(8):604–7.

    PubMed  Google Scholar 

  13. Kelly SC, Ratajczak P, Keller M, Purcell SM, Griffin T, Richard G. A novel GJA 1 mutation in oculo-dento-digital dysplasia with curly hair and hyperkeratosis. Eur J Dermatol. 2006;16(3):241–5.

    PubMed  Google Scholar 

  14. Rouse C, Siegfried E, Breer W, Nahass G. Hair and sweat glands in families with hypohidrotic ectodermal dysplasia: further characterization. Arch Dermatol. 2004;140(7):850–5.

    Article  PubMed  Google Scholar 

  15. Zlotogorski A, Marek D, Horev L, Abu A, Ben-Amitai D, Gerad L, et al. An autosomal recessive form of monilethrix is caused by mutations in DSG4: clinical overlap with localized autosomal recessive hypotrichosis. J Invest Dermatol. 2006;126(6):1292–6.

    Article  PubMed  CAS  Google Scholar 

  16. Colomb D, Cretin J, Vibert J, Steiner HG. Trichorrhexis nodosa in a hypothrepsic child with hypovitaminosis A [in French]. Lyon Med. 1970;223(5):337–8.

    PubMed  CAS  Google Scholar 

  17. Botta E, Nardo T, Broughton BC, Marinoni S, Lehmann AR, Stefanini M. Analysis of mutations in the XPD gene in Italian patients with trichothiodystrophy: site of mutation correlates with repair deficiency, but gene dosage appears to determine clinical severity. Am J Hum Genet. 1998;63(4):1036–48.

    Article  PubMed  CAS  Google Scholar 

  18. Lurie R, Ben-Amitai D, Laron Z. Laron syndrome (primary growth hormone insensitivity): a unique model to explore the effect of insulin-like growth factor 1 deficiency on human hair. Dermatology. 2004;208(4):314–8.

    Article  PubMed  CAS  Google Scholar 

  19. Silengo M, Valenzise M, Pagliardini S, Spada M. Hair changes in congenital disorders of glycosylation (CDG type 1). Eur J Pediatr. 2003;162(2):114–5.

    PubMed  Google Scholar 

  20. Traupe H, Happle R, Grobe H, Bertram HP. Polarization microscopy of hair in acrodermatitis enteropathica. Pediatr Dermatol. 1986;3(4):300–3.

    Article  PubMed  CAS  Google Scholar 

  21. Slonim AE, Sadick N, Pugliese M, Meyers-Seifer CH. Clinical response of alopecia, trichorrhexis nodosa, and dry, scaly skin to zinc supplementation. J Pediatr. 1992;121(6):890–5.

    Article  PubMed  CAS  Google Scholar 

  22. Blume-Peytavi U, Fohles J, Schulz R, Wortmann G, Gollnick H, Orfanos CE. Hypotrichosis, hair structure defects, hypercysteine hair and glucosuria: a new genetic syndrome? Br J Dermatol. 1996;134(2):319–24.

    Article  PubMed  CAS  Google Scholar 

  23. Colomb D, Ducros B, Boussuge N. Bazex, Dupre and Christol ­syndrome. Apropos of a case with prolymphocytic leukemia [in French]. Ann Dermatol Venereol. 1989;116(5):381–7.

    PubMed  CAS  Google Scholar 

  24. Lurie R, Hodak E, Ginzburg A, David M. Trichorrhexis nodosa: a manifestation of hypothyroidism. Cutis. 1996;57(5):358–9.

    PubMed  CAS  Google Scholar 

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Correspondence to Lidia Rudnicka .

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© 2012 Springer-Verlag London

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Rudnicka, L., Olszewska, M., Rakowska, A., Pinheiro, A.M.C. (2012). Trichorrhexis Nodosa. In: Rudnicka, L., Olszewska, M., Rakowska, A. (eds) Atlas of Trichoscopy. Springer, London. https://doi.org/10.1007/978-1-4471-4486-1_10

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  • DOI: https://doi.org/10.1007/978-1-4471-4486-1_10

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  • Online ISBN: 978-1-4471-4486-1

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