Abstract
Bradyarrhythmias are a heterogeneous group of cardiac rhythm disturbances which are implicated in over 40 % of sudden cardiac deaths in the hospital. Broadly classified, they are manifestations of either a failure of cardiac impulse generation or impulse propagation. They may be physiologic and benign, as in sinus bradycardia and sinus arrhythmia in athletes, or pathologic and warranting intervention, as in compromising bradycardia from sinus node dysfunction or ventricular asystole from high-grade atrioventricular (AV) block after an anterior myocardial infarction (MI).
The purpose of this chapter is to review the pathophysiology of various bradyarrhythmias and to review treatment options available. In addition, a brief overview of pacemakers and cardiac resynchronization therapy (CRT) will be provided.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- ACC:
-
American College of Cardiology
- AF:
-
Atrial fibrillation
- AHA:
-
American Heart Association
- AV:
-
Atrioventricular
- BPEG:
-
British Pacing Electrophysiology Group
- bpm:
-
Beats per minute
- CHB:
-
Complete heart block
- CL:
-
Cycle length
- CRT:
-
Cardiac resynchronization therapy
- cSNRT:
-
Corrected sinoatrial node recovery time
- ECG:
-
Electrocardiogram
- EP:
-
Electrophysiologic
- FDA:
-
Food and Drug Administration
- HCM:
-
Hypertrophic cardiomyopathy
- HF:
-
Heart failure
- HR:
-
Heart rate
- HRS:
-
Heart Rhythm Society
- ICD:
-
Implantable cardioverter defibrillator
- LAFB:
-
Left anterior fascicular block
- LBBB:
-
Left bundle branch block
- LPFB:
-
Left posterior fascicular block
- LQT1:
-
Long QT syndrome type 1
- LV:
-
Left ventricular
- LVEF:
-
Left ventricular Ejection fraction
- MI:
-
Myocardial infarction
- NASPE:
-
North American Society for Pacing and ElectroÂphysiology
- NYHA:
-
New York Heart Association
- PPM:
-
Permanent pacemakers
- RA:
-
Right atrium
- RBBB:
-
Right bundle branch block
- RV:
-
Right ventricle
- SA:
-
Sinoatrial
- SACT:
-
Sinoatrial conduction time
- SND:
-
Sinus node dysfunction
- SNRT:
-
Sinoatrial node recovery time
- VT:
-
Ventricular tachycardia
References
Yasuma F, Hayano J. Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm? Chest. 2004;125(2):683–90. Epub 2004/02/11.
Peltola M, Tulppo MP, Kiviniemi A, Hautala AJ, Seppanen T, Barthel P, et al. Respiratory sinus arrhythmia as a predictor of sudden cardiac death after myocardial infarction. Ann Med. 2008;40(5):376–82. Epub 2008/05/27.
Deboor SS, Pelter MM, Adams MG. Nonrespiratory sinus arrhythmia. Am J Crit Care. 2005;14(2):161–2. Epub 2005/02/25.
Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA, Freedman RA, Gettes LS, et al. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008;51(21):62. Epub 2008/05/24.
Ferrer MI. The sick sinus syndrome in atrial disease. JAMA. 1968;206(3):645–6. Epub 1968/10/14.
Rosenqvist M, Obel IW. Atrial pacing and the risk for AV block: is there a time for change in attitude? Pacing Clin Electrophysiol. 1989;12(1 Pt 1):97–101. Epub 1989/01/01.
Dobrzynski H, Boyett MR, Anderson RH. New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation. 2007;115(14):1921–32. Epub 2007/04/11.
Zipes DP, DiMarco JP, Gillette PC, Jackman WM, Myerburg RJ, Rahimtoola SH, et al. Guidelines for clinical intracardiac electrophysiological and catheter ablation procedures. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Clinical Intracardiac Electrophysiologic and Catheter Ablation Procedures), developed in collaboration with the North American Society of Pacing and Electrophysiology. J Am Coll Cardiol. 1995;26(2):555–73. Epub 1995/08/01.
Shaw DB, Southall DP. Sinus node arrest and sino-atrial block. Eur Heart J. 1984;5(Suppl A):83–7. Epub 1984/03/01.
Hiss RG, Lamb LE. Electrocardiographic findings in 122,043 individuals. Circulation. 1962;25:947–61. Epub 1962/06/01.
Cheng S, Keyes MJ, Larson MG, McCabe EL, Newton-Cheh C, Levy D, et al. Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA. 2009;301(24):2571–7. Epub 2009/06/25.
Rosenbaum MB, Elizari MV, Lazzari J, Nau GJ, Levi RJ, Halpern MS. Intraventricular trifascicular blocks. Review of the literature and classification. Am Heart J. 1969;78(4):450–9. Epub 1969/10/01.
MacAlpin RN. In search of left septal fascicular block. Am Heart J. 2002;144(6):948–56. Epub 2002/12/18.
Fisch GR, Zipes DP, Fisch C. Bundle branch block and sudden death. Prog Cardiovasc Dis. 1980;23(3):187–224. Epub 1980/11/01.
Hindman MC, Wagner GS, JaRo M, Atkins JM, Scheinman MM, DeSanctis RW, et al. The clinical significance of bundle branch block complicating acute myocardial infarction. 1. Clinical characteristics, hospital mortality, and one-year follow-up. Circulation. 1978;58(4):679–88. Epub 1978/10/01.
Lamas GA, Muller JE, Turi ZG, Stone PH, Rutherford JD, Jaffe AS, et al. A simplified method to predict occurrence of complete heart block during acute myocardial infarction. Am J Cardiol. 1986;57(15):1213–9. Epub 1986/06/01.
Parsonnet V, Furman S, Smyth NP. Implantable cardiac pacemakers status report and resource guideline. Pacemaker Study Group. Circulation. 1974;50(4):21–35. Epub 1974/10/01.
Bernstein AD, Daubert JC, Fletcher RD, Hayes DL, Luderitz B, Reynolds DW, et al. The revised NASPE/BPEG generic code for antibradycardia, adaptive-rate, and multisite pacing. Pacing Clin Electrophysiol. 2002;25(2):260–4. Epub 2002/03/28.
Lamas GA, Lee KL, Sweeney MO, Silverman R, Leon A, Yee R, et al. Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. N Engl J Med. 2002;346(24):1854–62.
Sweeney MO, Hellkamp AS, Ellenbogen KA, Greenspon AJ, Freedman RA, Lee KL, et al. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2003;107(23):2932–7. Epub 2003/06/05.
Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352(15):1539–49. Epub 2005/03/09.
Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350(21):2140–50. Epub 2004/05/21.
Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346(24):1845–53. Epub 2002/06/14.
Young JB, Abraham WT, Smith AL, Leon AR, Lieberman R, Wilkoff B, et al. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial. JAMA. 2003;289(20):2685–94. Epub 2003/05/29.
Cazeau S, Leclercq C, Lavergne T, Walker S, Varma C, Linde C, et al. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med. 2001;344(12):873–80. Epub 2001/03/22.
Auricchio A, Stellbrink C, Sack S, Block M, Vogt J, Bakker P, et al. Long-term clinical effect of hemodynamically optimized cardiac resynchronization therapy in patients with heart failure and ventricular conduction delay. J Am Coll Cardiol. 2002;39(12):2026–33. Epub 2002/06/27.
Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, et al. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009;361(14):1329–38. Epub 2009/09/03.
Tang AS, Wells GA, Talajic M, Arnold MO, Sheldon R, Connolly S, et al. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med. 2010;363(25):2385–95. Epub 2010/11/16.
Podrid PJ, Kowey PR. Cardiac arrhythmia: mechanisms, diagnosis, and management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 973.
Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation. 2004;110(9):82–292. Epub 2004/09/02.
Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA 3rd, Freedman RA et al. 2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2013;61(3):e6–75.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag London
About this chapter
Cite this chapter
Upadhyay, G.A., Singh, J.P. (2014). Bradycardia and Pacemakers/CRT. In: Gaggin, H., Januzzi, Jr., J. (eds) MGH Cardiology Board Review. Springer, London. https://doi.org/10.1007/978-1-4471-4483-0_25
Download citation
DOI: https://doi.org/10.1007/978-1-4471-4483-0_25
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-4482-3
Online ISBN: 978-1-4471-4483-0
eBook Packages: MedicineMedicine (R0)