Abstract
The proportion of elderly patients with significant cardiac comorbidities undergoing noncardiac operations is likely to increase in the future. A perioperative myocardial infarction is associated with high in-hospital mortality and poor long-term outcomes. The majority of these events are clinically and electrocardiographically silent requiring active surveillance with cardiac biomarkers (preferably troponins).
Most myocardial infarctions in the perioperative period result from a mismatch between oxygen supply and demand in patients with stable coronary artery disease. Most of the research in the field has been focused on risk stratification and prevention prior to the noncardiac operation with little emphasis in best treatment strategies after the event has occurred. Clinical trials are needed to define the role of adjunct pharmacology and cardiac imaging, including angiography, in this special population.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Devereaux PJ, Goldman L, Cook DJ, et al. Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk. CMAJ. 2005;173(6):627–34.
Ford ES, Ajani UA, Croft JB, et al. Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. N Engl J Med. 2007;356(23):2388–98.
Leon MB, Smith CR, Mack M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010;363(17):1597–607.
Nowygrod R, Egorova N, Greco G, et al. Trends, complications and mortality in peripheral vascular surgery. J Vasc Surg. 2006;43:205–16.
Badner NH, Knil RL, Brown JE, et al. Myocardial infarction after noncardiac surgery. Anesthesiology. 1998;88:572–8.
Le Manach Y, Pereal A, Coriat P, et al. Early and delayed myocardial infarction after abdominal aortic surgery. Anesthesiology. 2005;102:885–91.
Mangano DT, Browner WS, Hollenberg M, et al. Association of perioperative myocardial ischemia with cardiac mortality in men undergoing noncardiac surgery: the study of perioperative ischemia research group. N Engl J Med. 1990;323:1781–8.
McFalls E, Ward H, Moritz T, et al. Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with documented coronary artery disease: results of the coronary artery revascularization prophylaxis (CARP) trial. Eur Heart J. 2008;29:394–401.
Lee T, Marcantonio E, Mangione C, et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation. 1999;100:1043–9.
Durazzo AE, Machado FS, Ikeoka DT, et al. Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial. J Vasc Surg. 2004;39(5):967–75; discussion 975–66.
McFalls E, Ward H, Moritz T, et al. Coronary-artery revascularization before elective major vascular surgery. N Engl J Med. 2004;351:2795–804.
Mangano DT, Layug EL, Wallace A, Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group. N Engl J Med. 1996;335(23):1713–20.
Landesberg G, Beattie S, Mosseri M, Jaffe AS, Alpert JS. Perioperative myocardial infarction. Circulation. 2009;119:2936–44.
Bottiger BW, Motsch J, Teschendorf P, et al. Postoperative 12-lead ECG predicts peri-operative myocardial ischaemia associated with myocardial cell damage. Anaesthesia. 2004;59:1083–90.
Landesberg G, Maseri M, Zahger D, et al. Myocardial infarction following vascular surgery: the role of prolonged, stress-induced. ST-depression-type ischemia. J Am Coll Cardiol. 2001;37:1839–45.
Sametz W, Metzler H, Gries M, et al. Perioperative catecholamine changes in cardiac risk patients. Eur J Clin Invest. 1999;29:582–7.
Parker SD, Breslow MJ, Frank SM, et al. Catecholamine and cortisol responses to lower extremity revascularization: correlation with outcome variables. Crit Care Med. 1995;23:1954–61.
Hertzer N, Beven E, Young J, et al. Coronary artery disease in peripheral vascular patients: a classification of 1000 coronary angiograms and results of surgical management. Ann Surg. 1984;199:223–33.
Ellis SG, Hertzer NR, Young JR, Brener S. Angiographic correlates of cardiac death and myocardial infarction complicating major nonthoracic vascular surgery. Am J Cardiol. 1996;77(12):1126–8.
Dawood MM, Gutpa DK, Southern J, et al. Pathology of fatal perioperative myocardial infarction: implications regarding pathophysiology and prevention. Int J Cardiol. 1996;57(1):37–44.
Cohen MC, Aretz TH. Histological analysis of coronary artery lesions in fatal postoperative myocardial infarction. Cardiovasc Pathol. 1999;8(3):133–9.
Thygesen K, Alpert J, Jaffe AS, et al. Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2551–67.
Devereaux PJ, Xavier D, Pogue J, et al. Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study. Ann Intern Med. 2011;154:523–8.
Garcia S, Marston N, Sandoval Y, et al. Prognostic value of 12-lead electrocardiogram and peak troponin I level after vascular surgery. J Vasc Surg. 2013;57(1):166–72.
Marston N, Brenes J, Garcia S, et al. Peak postoperative troponin levels outperform preoperative cardiac risk indices as predictors of long-term mortality after vascular surgery troponins and postoperative outcomes. J Crit Care. 2012;27:66–72.
Poldermans D, Boersma E, Bax JJ, et al. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. N Engl J Med. 1999;341(24):1789–94.
Yang H, Raymer K, Butler R, Parlow J, Roberts R. The effects of perioperative beta-blockade: results of the Metoprolol after Vascular Surgery (MaVS) study, a randomized controlled trial. Am Heart J. 2006;152:983–90.
POISE STUDY GROUP, Devereaux P, Yang H, Yusuf S, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet. 2008;371:1839–47.
Mastracci TM, Aarts MA, Cassivi SD, Garcia S, McLean RF, McFalls EO, Members of the Evidence Based Reviews in Surgery Group. CAGS and ACS evidence based reviews in surgery. 34: effects of ß-blockers in patients undergoing noncardiac surgery. Can J Surg. 2010;53(5):342–4.
Schouten O, Boersma E, Hoeks SE, et al. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group (DECREASE). Fluvastatin and perioperative events in patients undergoing vascular surgery. N Engl J Med. 2009;361:980–9.
Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89–118.
Garcia S, Moritz T, Goldman S, et al. Perioperative complications after vascular surgery are predicted by the revised cardiac risk index but are not reduced in high-risk subsets with preoperative revascularization. Circ Cardiovasc Qual Outcomes. 2009;2:73–7.
Poldermans D, Schouten O, Vidakovic R, et al. A clinical randomized trial to evaluate the safety of a noninvasive approach in high-risk patients undergoing major vascular surgery: the DECREASE-V Pilot Study. J Am Coll Cardiol. 2007;49(17):1763–9.
Martinez E, Kim L, Rosenfeld B, et al. Early detection and real-time intervention of postoperative myocardial ischemia: the STOPMI (Study for the Treatment of Perioperative Myocardial Ischemia) Study. Abstract presented at: Association of University Anesthesiologists; 16–18 May 2008; Durham.
Wu WC, Schifftner TL, Henderson WG, et al. Preoperative hematocrit levels and postoperative outcomes in older patients undergoing noncardiac surgery. JAMA. 2007;297(22):2481–8.
Deans KJ, Minneci PC, Suffredini AF, et al. Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols. Crit Care Med. 2007;35(6):1509–16.
Rao SV, Jollis JG, Harrington RA, et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA. 2004;292(13):1555–62.
McFalls EO, Larsen G, Johnson GR, et al. Outcomes of hospitalized patients with non-acute coronary syndrome and elevated cardiac troponin level. Am J Med. 2011;124(7):630–5.
Brilakis ES, Banerjee S, Berger PB. Perioperative management of patients with coronary stents. J Am Coll Cardiol. 2007;49(22):2145–50.
Holmes Jr DR, Kereiakes DJ, Garg S, et al. Stent thrombosis. J Am Coll Cardiol. 2010;56(17):1357–65.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag London
About this chapter
Cite this chapter
Garcia, S., McFalls, E.O. (2014). Perioperative Myocardial Infarction. In: Stergiopoulos, K., Brown, D. (eds) Evidence-Based Cardiology Consult. Springer, London. https://doi.org/10.1007/978-1-4471-4441-0_36
Download citation
DOI: https://doi.org/10.1007/978-1-4471-4441-0_36
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-4440-3
Online ISBN: 978-1-4471-4441-0
eBook Packages: MedicineMedicine (R0)