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Role of Matrix Metalloproteinases and Aortic Wall Degradation in Abdominal Aortic Aneurysms

  • George A. AntoniouEmail author
  • George S. Georgiadis
Chapter
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Abstract

AAA is the most common type of true aneurysm. Aneurysm is defined as local dilatation of at least 1.5 times the expected normal arterial diameter. In clinical practice, a practical definition for AAA of a transverse diameter of greater than 3 cm is used. It is present in 5–10 % of men aged between 65 and 79 years [1]. Its major complication is rupture, which presents as a surgical emergency. The mortality associated with rupture is high; approximately 80 % of those who reach the hospital and 50 % of those undergoing emergency surgery for ruptured AAA will die [2]. In the United States, ruptured AAA is the 15th leading cause of death overall [3]. Elective aneurysm repair is associated with a 30-day mortality of 2–6 % [4]. These mortality figures have not changed in the last decades, despite improvements in operative techniques and perioperative management. Furthermore, the incidence of AAA seems to be increasing, which cannot be explained only by improvements in detection [5].

Keywords

Aortic Aneurysm Abdominal Aortic Aneurysm Abdominal Aortic Aneurysm Aortic Wall Aneurysm Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of Vascular and Endovascular SurgeryManchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation TrustManchesterUK
  2. 2.Department of Vascular and Endovascular SurgeryUniversity Hospital of Alexandroupolis, Democritus University of ThraceAlexandroupolisGreece

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