Endovascular Treatment of Carotid Disease: Inflammatory Aspects

  • Sthefano Atique GabrielEmail author
  • Edmo Atique Gabriel


Recent studies have shown an important interest in the inflammatory aspects of carotid artery stenting; however, the pathophysiology of the vascular wall reaction after stent implantation is not yet entirely understood.


Stent Implantation Carotid Plaque Carotid Artery Stenting Arteriosclerosis Obliterans Inflammatory Aspect 
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  1. 1.
    Virmani R, Farb A. Pathology of in-stent re-stenosis. Curr Opin Lipidol. 1999;10:499–506.PubMedCrossRefGoogle Scholar
  2. 2.
    Kornowski R, Hong MK, Tio FO, et al. In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia. J Am Coll Cardiol. 1998;31:224–30.PubMedCrossRefGoogle Scholar
  3. 3.
    Yutani C, Ishibashi-Ueda H, Suzuki T, et al. Histologic evidence of foreign body granulation tissue and de novo lesions in patients with coronary stent stenosis. Cardiology. 1999;92:171–7.PubMedCrossRefGoogle Scholar
  4. 4.
    Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135–43.PubMedCrossRefGoogle Scholar
  5. 5.
    Koenig W, Khuseyinova N. Biomarkers of atherosclerotic plaque instability and rupture. Arterioscler Thromb Vasc Biol. 2007;27:15–26.PubMedCrossRefGoogle Scholar
  6. 6.
    Abe Y, Sakaguchi M, Furukado S, Okazaki S, Fujinaka T, Sakoda S, et al. Associations of local release of inflammatory biomarkers during carotid artery stenting with plaque echogenicity and calcification. Cerebrovasc Dis. 2010;30:402–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Uwatoko T, Toyoda K, Inoue T, Yasumori K, Hirai Y, Makihara N, et al. Carotid artery calcification on multislice detector-row computed tomography. Cerebrovasc Dis. 2007;24:20–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Wasser K, Schnaudigel S, Wohlfahrt J, Psychogios M-N, Knauth M, et al. Inflammation and in-stent restenosis: the role of serum markers and stent characteristics in carotid artery stenting. PLoS One. 2011;6(7):e22683. doi: 10.1371/journal.pone.0022683.PubMedCrossRefGoogle Scholar
  9. 9.
    Weintraub WS. The pathophysiology and burden of restenosis. Am J Cardiol. 2007;100(5A):3K–99.PubMedCrossRefGoogle Scholar
  10. 10.
    Kornowski R, Hong MK, Tio FO, Bramwell O, Wu H, et al. In-stent restenosis: contributions of inflammatory responses and arterial injury to neointimal hyperplasia. J Am Coll Cardiol. 1998;31(1):224–30.PubMedCrossRefGoogle Scholar
  11. 11.
    Clark DJ, Lessio S, O’Donoghue M, Tsalamandris C, Schainfeld R, et al. Mechanisms and predictors of carotid artery stent restenosis: a serial intravascular ultrasound study. J Am Coll Cardiol. 2006;47(12):2390–6.PubMedCrossRefGoogle Scholar
  12. 12.
    Schillinger M, Exner M, Mlekusch W, Rumpold H, Ahmadi R, et al. Acute-phase response after stent implantation in the carotid artery: association with 6-month in-stent restenosis. Radiology. 2003;227(2):516–21.PubMedCrossRefGoogle Scholar
  13. 13.
    Gröschel K, Ernemann U, Larsen J, Knauth M, Schmidt F, Artschwager J, et al. Preprocedural C-reactive protein levels predict stroke and death in patients undergoing carotid stenting. AJNR Am J Neuroradiol. 2007;28(9):1743–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Sthefano Atique Gabriel
    • 1
    • 2
    Email author
  • Edmo Atique Gabriel
    • 3
  1. 1.Department of Vascular SurgeryPontifical Catholic University of CampinasSão PauloBrazil
  2. 2.Department of Vascular SurgeryCelso Pierro Hospital and MaternityCampinasBrazil
  3. 3.Department of Cardiovascular SurgeryUniversity Nove de JulhoSão PauloBrazil

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