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Carotid Endarterectomy: Inflammatory Aspects

  • Sthefano Atique GabrielEmail author
  • Edmo Atique Gabriel
Chapter
  • 1.2k Downloads

Abstract

Carotid artery stenosis is a common disease related to the occurrence of transient ischemic attacks and strokes. Carotid endarterectomy (CEA), first performed by De Bakey in 1953, is a widely applied method to prevent recurrent neurological symptoms and stroke in patients with severe carotid artery stenosis. However, 3–7 % of the CEA procedures are complicated by disabling or nondisabling strokes [1, 2].

Keywords

Carotid Endarterectomy Carotid Plaque Carotid Atherosclerosis Carotid Artery Stenosis Carotid Artery Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ferguson GG, Eliasziw M, Barr HW, Clagett GP, Barnes RW, Wallace MC, et al. The North American Symptomatic Carotid Endarterectomy Trial: surgical results in 1415 patients. Stroke. 1999;30:1751–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Hansson GK. Mechanisms of disease: inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–95.PubMedCrossRefGoogle Scholar
  3. 3.
    Halvorsen B, Otterdal K, Skjelland M, et al. Atherosclerotic plaque stability—what determines the fate of the plaque? Prog Cardiovasc Dis. 2008;51(3):183–94.PubMedCrossRefGoogle Scholar
  4. 4.
    Hermus L, Lefrandt JD, Tio RA, Breek JC, Zeebregts CJ. Carotid plaque formation and serum biomarkers. Atherosclerosis. 2010;213(1):21–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Zhou W, Chai H, Ding R, Lam HY. Distribution of inflammatory mediators in carotid and femoral plaques. J Am Coll Surg. 2010;211(1):92–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Schillinger M, Exner M, Mlekusch W, et al. Inflammation and Carotid Artery—risk for Atherosclerosis Study (ICARAS). Circulation. 2005;111(17):2203–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Brea D, Sobrino T, Blanco M, et al. Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation. Atherosclerosis. 2009;205(2):561–7.PubMedCrossRefGoogle Scholar
  8. 8.
    Blankenberg S, Luc G, Ducimetiere P, et al. PRIME Study Group Interleukin-18 and the risk of coronary heart disease in European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation. 2003;108(20):2453–9.PubMedCrossRefGoogle Scholar
  9. 9.
    Kerr R, Stirling D, Ludlam CA. Interleukin 6 and haemostasis. Br J Haematol. 2001;115(1):3–12.PubMedCrossRefGoogle Scholar
  10. 10.
    Schindhelm RK, van der Zwan LP, Teerlink T, Scheffer PG. Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification? Clin Chem. 2009;55(8):1462–70.PubMedCrossRefGoogle Scholar
  11. 11.
    Heider P, Pfäffle N, Pelisek J, et al. Is serum pregnancy-associated plasma protein a really a potential marker of atherosclerotic carotid plaque stability? Eur J Vasc Endovasc Surg. 2010;39(6):668–75.PubMedCrossRefGoogle Scholar
  12. 12.
    Profumo E, Siracusano A, Ortona E, et al. Cytokine expression in circulating T lymphocytes from patients undergoing carotid endarterectomy. J Cardiovasc Surg. 2003;44:237–42.Google Scholar
  13. 13.
    Profumo E, Esposito C, Buttari B, et al. Intracellular expression of cytokines in peripheral blood from patients with atherosclerosis before and after carotid endarterectomy. Atherosclerosis. 2007;191:340–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Profumo E, Buttari B, Tosti ME, et al. Association of intracellular pro- and anti-inflammatory cytokines in peripheral blood with the clinical or ultrasound indications for carotid endarterectomy in patients with carotid atherosclerosis. Clin Exp Immunol. 2008;152(1):120–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Rerkasem K, Gallagher PJ, Grimble RF, Calder PC, Shearman CP. Sex difference in composition of plaques of patients undergoing carotid endarterectomy. Vascular. 2010;18(2):77–81.PubMedCrossRefGoogle Scholar
  16. 16.
    Halvorsen DS, Johnsen SH, Mathiesen EB, et al. The association between inflammatory markers and carotid atherosclerosis is sex dependent: the Tromso Study. Cerebrovasc Dis. 2009;27:392–7.PubMedCrossRefGoogle Scholar
  17. 17.
    Hellings WE, Pasterkamp G, Verhoeven BA, et al. Gender- associated differences in plaque phenotype of patients undergoing carotid endarterectomy. J Vasc Surg. 2007;45:289–96.PubMedCrossRefGoogle Scholar
  18. 18.
    Loftus IM, Naylor AR, Goodall S, Crowther M, Jones L, Bell PR. Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption. Stroke. 2000;31:40–7.PubMedCrossRefGoogle Scholar
  19. 19.
    Molloy KJ, Thompson MM, Jones JL, Schwalbe EC, Bell PR, Naylor AR, et al. Unstable carotid plaques exhibit raised matrix metalloproteinase-8 activity. Circulation. 2004;110:337–43.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Sthefano Atique Gabriel
    • 1
    • 2
    Email author
  • Edmo Atique Gabriel
    • 3
  1. 1.Department of Vascular SurgeryPontifical Catholic University of CampinasSão PauloBrazil
  2. 2.Department of Vascular SurgeryCelso Pierro Hospital and MaternityCampinasBrazil
  3. 3.Department of Cardiovascular SurgeryUniversity Nove de JulhoSão PauloBrazil

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