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Role of BNP in Pediatric Heart Transplantation

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Inflammatory Response in Cardiovascular Surgery

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Abstract

The role of hormonal changes and biomarkers has been studied after heart transplantation; they include B-type natriuretic peptide (BNP), atrial natriuretic peptide (ANP), adrenomedullin (ADM), cardiac troponin T (cTnT), C-reactive protein (CRP), endothelial growth factor, glycoprotein 130, and cytokines, such as tumor necrosis factor α (TNF), interleukin 1 beta (IL-1ß), and interleukin 6 (IL-6) [1].

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References

  1. Rejeição após transplante cardíaco pediátrico. Utilidade do Peptídeo Natriurético tipo B (BNP). Tese de Doutorado – Cardiologia – Faculdade de Medicina USP; 2005.

    Google Scholar 

  2. Kisch B. A significant electron microscopic difference between the atria and the ventricles of the mammarian heart. Exp Med Surg. 1963;21:193–221.

    PubMed  CAS  Google Scholar 

  3. Jamieson JD, Palade GE. Specific granules in atrial muscle cells. J Cell Biol. 1964;23:151–72.

    Article  PubMed  CAS  Google Scholar 

  4. de Bold AJ, Borenstein HB, Veress AT, Sonenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extracts in rats. Life Sci. 1981;28:89.

    Article  PubMed  Google Scholar 

  5. Wilkins MR, Redondo J, Brown LA. The natriuretic peptide family. Lancet. 1997;349:1307.

    Article  PubMed  CAS  Google Scholar 

  6. Endlich K, Forssmann WG, Steinhausen M. Effects of urodilatin in the rat kidney: comparison with ANF and interaction with vasoactive substances. Kidney Int. 1995;47:1558.

    Article  PubMed  CAS  Google Scholar 

  7. Daniels L, Maisel AS. Natriuretic peptides. J Am Coll Cardiol. 2007;50(25):2357–68.

    Article  PubMed  CAS  Google Scholar 

  8. Flynn TG, de Bold ML, de Bold AJ. The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties. Biochem Biophys Res Commun. 1983;117(3):859–65.

    Article  PubMed  CAS  Google Scholar 

  9. Maack T. The broad homeostatic role of natriuretic peptides. Arq Bras Endocrinol Metabol. 2006;50(2):198–207.

    Article  PubMed  Google Scholar 

  10. Davidson NC, Struthers AD. Brain natriuretic peptide. J Hypertens. 1994;12:329.

    Article  PubMed  CAS  Google Scholar 

  11. Rothemburger M, Stypmann J, Hoffmeier A, Berendes E, Etz C, Pioux A, et al. Aminoterminal pro type B natriuretic peptide as a predictive and prognostic marker in patients with chronic heart failure. J Heart Lung Transplant. 2004;23(10):1189–97.

    Article  Google Scholar 

  12. Soldin SJ, Soldin OP, Boyajian AJ, Madeleine ST. Pediatric brain natriuretic and N-terminal pro-brain natriuretic peptide reference intervals. Clin Chim Acta. 2006;366:304–8.

    Article  PubMed  CAS  Google Scholar 

  13. Troughton RW, Prior DL, Pereira JJ, Martin M, Fogarty A, Morehead A, et al. Plasma brain natriuretic peptide levels in systolic heart failure: importance of left ventricular diastolic function and right ventricular systolic function. J Am Coll Cardiol. 2004;43(3):416–22.

    Article  PubMed  CAS  Google Scholar 

  14. Bibbins-Domingo K, Ansari M, Schiller NB, Massie B, Whooley MA. B-natriuretic peptide and ischemia in patients with stable coronary disease. Circulation. 2003;108(24):2987–92.

    Article  PubMed  CAS  Google Scholar 

  15. Mayer SA, De Lemos JA, Murphy SA, Brooks S, Robert BJ, Grayburn PA. Comparison of B-natriuretic peptide levels in patients with heart failure versus without mitral regurgitation. Am J Cardiol. 2004;15(8):1002–6.

    Article  Google Scholar 

  16. Kruger S, Graf J, Kumz D, Stickel T, Hanrath P, Jansens U. Brain natriuretic peptide levels predict functional capacity in patients with chronic heart failure. J Am Coll Cardiol. 2002;21(4):718–22.

    Article  Google Scholar 

  17. Tang WH, Girod JP, Lee MJ, Starling RC, Ypung JB, Van Lente F, et al. Plasma brain natriuretic peptide levels in ambulatory patients with established chronic symtomatic systolic heart failure. Circulation. 2003;208(24):2964–6.

    Article  Google Scholar 

  18. Wang TJ, Larson MG, Levy D, Benjamin E, Leip EP, Omland T, et al. Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N Engl J Med. 2004;350(7):655–63.

    Article  PubMed  CAS  Google Scholar 

  19. Groenning B, Raymond I, Hildebrandt PR, Nilsson JC, Baumann M, Pedersen F. Diagnostic and prognostic evaluation of left ventricular systolic heart failure by plasma N terminal pro-brain natriuretic peptide concentration in a large sample of general population. Heart. 2004;90(3):297–303.

    Article  PubMed  CAS  Google Scholar 

  20. Villacorta H, Duarte NM, Carrano A, Mesquita ET, Dohmann HJ, Ferreira FE. The role of B-type natriuretic peptide in the diagnosis of congestive heart failure in patients presenting to an emergency department with dyspnea. Arq Bras Cardiol. 2002;79(6):564–8.

    Article  Google Scholar 

  21. Akioka K, Takeuchi K, Yanagi S, Hirota K, Sakamoto K, Yoshimura T, et al. Prognostic value of Doppler transmitral flow patterns and cardiac natriuretic peptides in patients with chronic congestive heart failure admitted for episodes of acute decompensation. Heart Vessels. 2000;15(2):53–60.

    Article  PubMed  CAS  Google Scholar 

  22. Westerling A, Wahlander H, Lindstedt G, Lundberg PA, Holmgren D. Clinical signs of heart failure are associated with increased levels of natriuretic peptide types B and A in children with congenital heart defects or cardiomyopathy. Acta Paediatr. 2004;93(3):340–5.

    Article  Google Scholar 

  23. Kunni O, Kamada M, Ohtsuki S, Araki T, Kataoka K, Kageyama M, et al. Plasma brain natriuretic peptide and the evaluation of volume overload in infants and children with congenital heart disease. Acta Med Okayama. 2003;57(4):191–7.

    Google Scholar 

  24. Redfield MM, Rodeheffer RJ, Jacobsen SJ, Mahoney DW, Bailey KR, Burnett Jr JC. Plasma brain natriuretic peptide concentration; impact of age and gender. J Am Coll Cardiol. 2002;40(5):976–82.

    Article  PubMed  CAS  Google Scholar 

  25. Cowley CG, Bradley JD, Shaddy RE. B-type natriuretic peptide levels in congenital heart disease. Pediatr Cardiol. 2004;25(4):336–40.

    Article  PubMed  CAS  Google Scholar 

  26. Koch A, Singer H. Normal values of B-type natriuretic peptide in infants, children and adolescents. Heart. 2003;89(8):874–8.

    Article  Google Scholar 

  27. Azeka E, Barbero-Marcial M, Jatene M, Auler JO, Ramires JA. Eight years experience of pediatric heart transplantation: clinical outcome using non-invasive methods for the evaluation of acute rejection. Pediatr Transplant. 2002;6(3):208–13.

    Article  PubMed  Google Scholar 

  28. Jatene MB, Miana LA, Pessoa AJ, Riso A, Azeka E, Tanamati C, et al. Pediatric heart transplantation in refractory cardiogenic shock: a critical analysis of feasibility, applicability and results. Arq Bras Cardiol. 2008;90(5):329–33.

    Article  PubMed  Google Scholar 

  29. Barnard CN. The operation. A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. S Afr Med J. 1967;41(48):1271–4.

    PubMed  CAS  Google Scholar 

  30. Kantrowitz A, Haller JD, Joos H, Cerruti MM, Carstensen HE. Transplantation of the heart in an infant and an adult. Am J Cardiol. 1968;22:782–90.

    Article  PubMed  CAS  Google Scholar 

  31. Modry DL, Oyer PE, Jamieson SW, Stinson EB, Baldwin JC, Reitz BA, et al. Cyclosporine in heart and heart-lung transplantation. Can J Surg. 1985;28(3):274–80, 282.

    PubMed  CAS  Google Scholar 

  32. Sylos C, Azeka E, Kajita L, Benvenutti L, Strunz CC, Branco KC, et al. B-type natriuretic peptide assessment in the diagnosis of rejection after pediatric heart transplant. Arq Bras Cardiol. 2009;92(3):215–26.

    Article  PubMed  Google Scholar 

  33. Hervas I, Almenar L, Perez-Pastor JL, Chirivella M, Osa A, Martinez-Doltz P, et al. Radioimmunometric assay of B-type natriuretic peptide (BNP) in heart transplantation: correlation between BNP determination and biopsy grading of rejection. Nucl Med Commun. 2003;24(8):925–31.

    PubMed  CAS  Google Scholar 

  34. Ationu A, Sorensen K, Whitehead B, Singer D, Burch M, Carter ND. Ventricular expression of brain natriuretic peptide gene following orthotopic cardiac transplantation in children – a three year follow up. Cardiovasc Res. 1993;27(12):2135–9.

    Article  PubMed  CAS  Google Scholar 

  35. Hammerer-Lercher A, Mair J, Antretter H, Ruttmann E, Poeltzl G, Laufer G, et al. B-type natriuretic peptide as a marker of allograft rejection after heart transplantation. J Heart Lung Transplant. 2005;24(9):1444–7.

    Article  PubMed  Google Scholar 

  36. Martinez-Doltz L, Almenara L, Hervas I, Moro J, Aguero J, Sanchez-Lazaro I, et al. Prognostic relationship between two serial determination of B-type natriuretic peptide and medium-long term events in heart transplantation. J Heart Lung Transplant. 2008;27(7):735–40.

    Article  Google Scholar 

  37. Lan YT, Chang RK, Alejos JC, Burch C, Wetzel GT. B-type natriuretic peptide in children after cardiac transplantation. J Heart Lung Transplant. 2004;23(5):558–63.

    Article  PubMed  Google Scholar 

  38. Iene Claudius MD, Yueh-Tze Lan MD, Chang RK, Wetzel GT, Alejos J. Usefulness of B-type natriuretic peptide as a noninvasive screening tool for cardiac allograft pathology in pediatric heart transplant recipients. Am J Cardiol. 2003;92(11):1368–70.

    Article  Google Scholar 

  39. Rossano JW, Denfield SW, Kim JJ, Price JF, Jefferies JJ, Decker JA, et al. B-type natriuretic peptide is a sensitive screening test for acute rejection in pediatric heart transplant patients. Pediatr Transplant. 2008;27(6):649–54.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Pediatric Cardiothoracic Surgery Unit, Heart Institute (InCor), University of Sao Paulo Medical School, Av. Eneas de Carvalho Aguiar, 44, 2nd Floor – Block 2, Room 5, 05403-000, Sao Paulo, Brazil

    Marcelo Biscegli Jatene MD

  2. Pediatric Cardiology and Adult Congenital Heart Disease Unit, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil

    Estela Azeka MD, PhD

Authors
  1. Marcelo Biscegli Jatene MD
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  2. Estela Azeka MD, PhD
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Correspondence to Marcelo Biscegli Jatene MD .

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Editors and Affiliations

  1. University Nove de Julho, Melo Alves 685, São Paulo, 01417-010, São Paulo, Brazil

    Edmo Atique Gabriel

  2. Pontifícia Universidade Católica de Camp, Rodovia D. Pedro I, km 136, São Paulo, 13086-900, São Paulo, Brazil

    Sthefano Atique Gabriel

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Jatene, M.B., Azeka, E. (2013). Role of BNP in Pediatric Heart Transplantation. In: Gabriel, E., Gabriel, S. (eds) Inflammatory Response in Cardiovascular Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4429-8_47

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  • DOI: https://doi.org/10.1007/978-1-4471-4429-8_47

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4428-1

  • Online ISBN: 978-1-4471-4429-8

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