Thromboembolism in Cyanotic Heart Disease: Mechanisms and Therapies

Chapter

Abstract

Thrombosis is formed in the presence of an abnormal vascular wall including endothelial damage and dysfunction, altered function of platelets and coagulation factors, and/or abnormal bloodstream. Once the endothelium has been injured and the blood exposed to the thrombogenic matrix, such as collagen, on the vascular wall, platelets adhere to the endothelium via platelet-glycoprotein (GP) interaction with von Willebrand factor on the vascular wall. After platelet adhesion, platelets are activated and bind to fibrinogen via GP 2b/3a receptors, and they release their granules into the bloodstream. Platelet activation and granule secretion result in further platelet aggregation and thrombin generation. Thrombin activates the coagulation cascade and platelets [1–4]. In addition to normal hemostasis, platelet activation may result in the pathologic process of thrombosis and inflammation.

Keywords

Aspirin Heparin Anemia Dehydration Warfarin 

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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of Pediatric CardiologyHeart Institute, Tokyo Women’s Medical UniversityShinjuku-ku, TokyoJapan

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