Platelets and Coronary Artery Disease
Platelets play a critical role in thrombosis and hemostasis [1, 2]. Beyond that, platelets have been recognized to act as an interface between thrombosis and inflammation . Previous research has shown that inflammation plays a key role in the development of coronary artery disease (CAD) and other manifestations of atherosclerosis . Recently, platelets have been recognized to trigger atherosclerotic lesion formation, to favor plaque instability, and to form thrombosis at areas of vulnerable plaques, resulting in myocardial infarction and tissue ischemia. During atherogenesis platelets interact with a variety of vascular and blood-borne cells (e.g., endothelial cells and leukocytes) and regulate chemotaxis, migration, and cytokine/chemokine release, which further propagate inflammation within vascular lesions [3, 5]. Understanding the role of platelets in atherogenesis will allow developing new strategies in the treatment of coronary artery disease.
KeywordsMigration Ischemia Foam Fibrinogen Mast
The authors were supported in part by the Deutsche Forschungsgemeinschaft and the Klinische Forschergruppe KFO-274 “Platelets-Molecular Mechanisms and Translational Implications”.
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