Modulation of Inflammatory Response in Cardiopulmonary Bypass

  • Shahzad G. RajaEmail author


Cardiac surgery and cardiopulmonary bypass initiate a systemic inflammatory response largely determined by blood contact with foreign surfaces and the activation of complement. It is generally accepted that cardiopulmonary bypass initiates a whole-body inflammatory reaction varies, but the persistence of any degree of inflammation may be considered potentially harmful to the cardiac patient. The development of strategies to control the inflammatory following cardiac surgery is currently the focus of considerable research efforts. Diverse techniques including maintenance of hemodynamic stability, minimization of exposure to cardiopulmonary bypass circuitry, and pharmacologic and immunomodulatory agents have been examined in clinical studies. This chapter provides a brief overview of the various therapeutic strategies being used to modulate the inflammatory response initiated by cardiopulmonary bypass.


Coronary Artery Bypass Graft Cardiopulmonary Bypass Systemic Inflammatory Response Syndrome Centrifugal Pump Cardiac Surgical Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of Cardiac SurgeryHarefield HospitalLondonUK

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