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Inflammatory Response in Cardiovascular Surgery pp 231–243Cite as

Modulation of Inflammatory Response in Cardiopulmonary Bypass

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Abstract

Cardiac surgery and cardiopulmonary bypass initiate a systemic inflammatory response largely determined by blood contact with foreign surfaces and the activation of complement. It is generally accepted that cardiopulmonary bypass initiates a whole-body inflammatory reaction varies, but the persistence of any degree of inflammation may be considered potentially harmful to the cardiac patient. The development of strategies to control the inflammatory following cardiac surgery is currently the focus of considerable research efforts. Diverse techniques including maintenance of hemodynamic stability, minimization of exposure to cardiopulmonary bypass circuitry, and pharmacologic and immunomodulatory agents have been examined in clinical studies. This chapter provides a brief overview of the various therapeutic strategies being used to modulate the inflammatory response initiated by cardiopulmonary bypass.

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Authors and Affiliations

  1. Department of Cardiac Surgery, Harefield Hospital, London, UK

    Shahzad G. Raja BSc, MBBS, MRCS, FRCS(C-Th)

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  1. Shahzad G. Raja BSc, MBBS, MRCS, FRCS(C-Th)
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Correspondence to Shahzad G. Raja BSc, MBBS, MRCS, FRCS(C-Th) .

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  1. University Nove de Julho, Melo Alves 685, São Paulo, 01417-010, São Paulo, Brazil

    Edmo Atique Gabriel

  2. Pontifícia Universidade Católica de Camp, Rodovia D. Pedro I, km 136, São Paulo, 13086-900, São Paulo, Brazil

    Sthefano Atique Gabriel

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Raja, S.G. (2013). Modulation of Inflammatory Response in Cardiopulmonary Bypass. In: Gabriel, E., Gabriel, S. (eds) Inflammatory Response in Cardiovascular Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4429-8_27

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  • DOI: https://doi.org/10.1007/978-1-4471-4429-8_27

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