Arterial Wall Remodeling and Restenosis Following Vascular Reconstruction

  • Xue Ma
  • Randolph L. GearyEmail author


Restenosis, simply defined, is a new lumen narrowing at the site of a previous vascular reconstruction. Restenosis has been a major limitation of surgical and endovascular reconstructions since their inception, and while decades of research have yielded vastly improved results for percutaneous coronary interventions (PCI), strategies to eliminate restenosis remain elusive. Increased application of endovascular therapy to extra-coronary beds has been met with sobering rates of late failures. This persistence of the problem reflects our incomplete understanding of its complex pathogenesis, and further research and novel approaches to prevention are needed before the full potential of our interventions can be realized.


Percutaneous Coronary Intervention Arterial Wall Connective Tissue Growth Factor Intimal Hyperplasia Bare Metal Stent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of Vascular and Endovascular SurgeryWake Forest University School of MedicineWinston-SalemUSA
  2. 2.Department of Pathology, Section on Comparative MedicineWake Forest University School of MedicineWinston-SalemUSA

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