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Hemoglobinopathies in Pregnancy

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Disorders of Thrombosis and Hemostasis in Pregnancy

Abstract

Pregnancies in women with both sickle and thalassemia disorders are seen increasingly worldwide, but outside a small number of specialist centers, most obstetricians and hematologists will see only a few affected pregnancies. Prospective trials addressing the challenges of managing these disorders in pregnancy remain limited so that current management often differs between centers. Both sickle and thalassemia disorders share increased thromboembolic and infection risks, but other complications differ. The UK and international data on maternal and fetal morbidity and mortality in pregnancies complicated by maternal sickle cell disease and thalassaemia disorders are described here in order to assist both obstetricians and haematologists in arriving at informed decisions.

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Authors and Affiliations

  1. St. Thomas’ Hospital, Westminster Bridge Road, London, SE1 7EH, UK

    Joanna Howard MA, MRCP, MRCPath

  2. Consultant in Obstetrics & Gynaecology, Royal Free Hospital, Pond Street, London, NW3 2QG, UK

    Susan Tuck MD, FRCOG, DCH, MRCGP

  3. Royal Free Hospital, Pond Street, London, NW3 2QG, UK

    Asma Eissa MRCOG

  4. University College London Hospitals NHS Foundation Trust, 250 Euston Road, London, NW1 2PJ, UK

    John Porter MA, MD, FRCP, FRCPath

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  1. Joanna Howard MA, MRCP, MRCPath
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  2. Susan Tuck MD, FRCOG, DCH, MRCGP
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  4. John Porter MA, MD, FRCP, FRCPath
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Correspondence to John Porter MA, MD, FRCP, FRCPath .

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    Hannah Cohen

  2. Dept. Obstetrics & Gynaecology, University College Hospital, Chenies Mews 86-96, London, WC1E 6HX, United Kingdom

    Patrick O'Brien

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Howard, J., Tuck, S., Eissa, A., Porter, J. (2012). Hemoglobinopathies in Pregnancy. In: Cohen, H., O'Brien, P. (eds) Disorders of Thrombosis and Hemostasis in Pregnancy. Springer, London. https://doi.org/10.1007/978-1-4471-4411-3_14

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  • DOI: https://doi.org/10.1007/978-1-4471-4411-3_14

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