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Disorders of Thrombosis and Hemostasis in Pregnancy pp 143–156Cite as

Inherited Bleeding Disorders in Pregnancy: Platelet Defects

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Abstract

Platelet function disorders (PFDs) include the severe bleeding disorders Glanzmann thrombasthenia (GT) and Bernard Soulier syndrome (BSS), and a heterogenous group of other non-severe phenotype platelet defects. GT and BSS confer significant risk of ante-partum and post-partum bleeding and may be complicated by alloimmunisation against platelet antigens, potentially causing maternal platelet refractoriness and fetal alloimmune thrombocytopenia. This chapter reviews the prevalence of bleeding in GT and BSS, and in non-severe PFDs. We describe the available therapies to prevent or treat obstetric bleeding in women with PFD and summarise current management strategies.

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Authors and Affiliations

  1. Bristol Heart Institute, University of Bristol, Level 7 Bristol Royal Infirmary, Bristol, BS2 8HW, UK

    Andrew D. Mumford PhD, FRCPath

  2. Bristol Haemophilia Centre, University Hospitals NHS Foundation Trust, Bristol, BS2 8ED, UK

    Amanda Clark FRCPath

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  1. Andrew D. Mumford PhD, FRCPath
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  2. Amanda Clark FRCPath
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Correspondence to Andrew D. Mumford PhD, FRCPath .

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  1. Aberdare Gardens 36, London, NW6 3QA, United Kingdom

    Hannah Cohen

  2. Dept. Obstetrics & Gynaecology, University College Hospital, Chenies Mews 86-96, London, WC1E 6HX, United Kingdom

    Patrick O'Brien

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Mumford, A.D., Clark, A. (2012). Inherited Bleeding Disorders in Pregnancy: Platelet Defects. In: Cohen, H., O'Brien, P. (eds) Disorders of Thrombosis and Hemostasis in Pregnancy. Springer, London. https://doi.org/10.1007/978-1-4471-4411-3_10

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