Changing Views of NREM Sleep Homeostatic Regulation
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The homeostatic sleep regulation idea underwent important development. Sleep homeostasis was first connected to the duration of the preceding awake time. Due to increasing innovative research in this field with convincing evidences on local sleep regulation, it seems that beyond the length of waking time, use-dependent afferent stimulation and synaptic upscaling (learning) are the main factors regulating the NREM sleep slow-wave activity (SWA). Further achievement of the same research line was to obtain evidences that plastic modulation of local slow-wave power during NREM sleep is closely related to the recreation of cognitive functions in the cortex, mainly in the frontal lobes. Slow-wave homeostasis and use-dependent plasticity are probably two sides of the same coin representing the biological function of slow-wave sleep.
KeywordsSleep homeostasis Use-dependent plasticity Local sleep Slow-wave activity Delta activity
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