Abstract
Ankylosing spondylitis is a chronic inflammatory disorder affecting predominantly the lumbar spine where 95 % of patients are HLA-B27 positive. Increased levels of antibodies to the gut microbe Klebsiella pneumoniae have been reported, suggesting an aetiological role for this microbe in the pathogenesis of this disease. Sera from patients with this condition have been investigated in cytotoxicity studies, and sera from patients with rheumatoid arthritis have been used as ‘disease controls’ together with sera obtained from healthy blood donor subjects.
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References
Ahmadi K, Wilson C, Tiwana H, Shanmuganathan S, Binder A, Ebringer A. Antibodies to Klebsiella pneumoniae nitrogenase reductase in patients with ankylosing spondylitis. Ann Rheum Dis. 1998;57:441.
Avakian H, Abuknesha R, Welsh J, Ebringer A. Uveitis, vitreous humour and Klebsiella. I. Binding studies with rabbit antisera. Br J Ophthalmol. 1981;65:315–22.
Cunningham MW, Antone SM, Gulizia JM, McManus BM, Fischetti VA, Gaunt CJ. Cytotoxic and viral neutralising antibodies cross-react with streptococcal M protein, enteroviruses and human cardiac myosin. Proc Natl Acad Sci USA. 1992;89:1320–4.
Eady R, Smith B, Cook K, Postgate J. Nitrogenase of Klebsiella pneumoniae. Biochem J. 1972;128:655–75.
Ebringer A. Ankylosing spondylitis is caused by Klebsiella. Rheumatic Dis Clin North Am. 1992;18:105–21.
Ewing C, Ebringer R, Tribbick G, Geysen HM. Antibody activity in ankylosing spondylitis sera to two sites on HLA-B27.1 at the MHC groove (within sequence 65–85) and to a Klebsiella pneumoniae nitrogenase reductase peptide (within sequence 181–199). J Exp Med. 1990;171:1635–47.
Fielder M, Pirt SJ, Tarpey I, Wilson C, Cunningham P, Ettelaie C, Binder A, Bansal S, Ebringer A. Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae. FEBS Lett. 1995;369:243–8.
Newkirk MM, Goldbach-Mansky R, Senior BW, Klippel J, Schumacher HR, El-Gabalawy HS. Elevated levels of IgA and IgM antibodies to Proteus mirabilis and IgM antibodies to Escherichia coli are associated with early rheumatoid factor (RF) positive rheumatoid arthritis. Rheumatology (Oxford). 2005;44:1433–41.
Schwimmbeck P, Yu DT, Oldstone M. Autoantibodies to HLA-B27 in the sera of HLA-B27 positive patients with ankylosing spondylitis and Reiter’s syndrome. J Exp Med. 1987;166:173–81.
Senior BW, McBride RDP, Morley KD, Kerr MA. The detection of raised levels of IgM to Proteus mirabilis in sera from patients with rheumatoid arthritis. J Med Microbiol. 1995;43:176–84.
Welsh J, Avakian H, Ebringer A. Uveitis, vitreous humour and Klebsiella: II. Cross-reactivity studies with radioimmunoassay. Br J Ophthalmol. 1981;65:323–8.
White L, McCoy R, Tait B, Ebringer R. A search for gram-negative enteric micro-organisms in acute anterior uveitis: association of Klebsiella with recent onset of disease, HLA-B27 and B7 CREG. Br J Ophthalmol. 1984;68:750–5.
Wilson C, Rashid T, Tiwana H, Beyan H, Hughes L, Bansal S, Ebringer A, Binder A. Cytotoxicity responses to peptide antigens in rheumatoid arthritis and ankylosing spondylitis. J Rheumatol. 2003;30:972–8.
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Ebringer, A., Ebringer, A. (2013). Ankylosing Spondylitis Sera Are Cytotoxic to Cells Bearing HLA-B27 Sequences. In: Ankylosing spondylitis and Klebsiella. Springer, London. https://doi.org/10.1007/978-1-4471-4300-0_18
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DOI: https://doi.org/10.1007/978-1-4471-4300-0_18
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