Abstract
In the early 1980s, the Immunology Unit of King’s College had shown that there were elevated levels of antibodies to the Gram-negative bowel microbe Klebsiella in patients suffering from ankylosing spondylitis. These patients were being investigated in the ‘Ankylosing Spondylitis Research Unit’ of the Middlesex Hospital which had been set up in 1976 to study why up to 96 % of ankylosing spondylitis with this disease possessed the HLA-B27 major histocompatibility group antigen, whilst the frequency of this antigen in the general population of England or of the United States was only 8 %.
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Ebringer, A., Ebringer, A. (2013). Antibodies to Klebsiella and HLA-B27 Peptides in Ankylosing Spondylitis Patients from Southern Japan. In: Ankylosing spondylitis and Klebsiella. Springer, London. https://doi.org/10.1007/978-1-4471-4300-0_17
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DOI: https://doi.org/10.1007/978-1-4471-4300-0_17
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