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Ulcerated Nodules in a Healthy Woman

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Abstract

A 55-year-old female presented with 19-month duration of asymptomatic ulcerated nodules in the upper thigh and groin (Fig. 42.1). She was otherwise healthy, with no fever, no fatigue and no systemic symptoms.

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Bibliography

  • Agnarsson BA, Vonderheid EC, Kadin ME. Cutaneous T-cell lymphoma with suppressor/cytotoxic (CD8) phenotype: identification of rapidly progressive and chronic subtypes. J Am Acad Dermatol. 1990;22:569–77.

    Article  PubMed  CAS  Google Scholar 

  • Arnulf B, Copie-Bergman C, Delfau-Larue MH, et al. Nonhepatosplenic gamma-delta T-cell lymphoma: a subset of cytotoxic lymphomas with mucosal or skin localization. Blood. 1998;91:1723–31.

    PubMed  CAS  Google Scholar 

  • Bekkenk MW, Vermeer MH, Jansen PM, et al. Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients. Blood. 2003;102:2213–9.

    Article  PubMed  CAS  Google Scholar 

  • Beljaards RC, Meijer CJLM, van der Putte SCJ, et al. Primary cutaneous T-cell lymphomas: clinicopathologic features and prognostic parameters of 35 cases other than mycosis fungoides and CD30-positive large cell lymphoma. J Pathol. 1994;172:53–60.

    Article  PubMed  CAS  Google Scholar 

  • Berti E, Cerri A, Cavicchini S, et al. Primary cutaneous gamma/delta lymphoma presenting as disseminated pagetoid reticulosis. J Invest Dermatol. 1991;96:718–23.

    Article  PubMed  CAS  Google Scholar 

  • Berti E, Tomasini D, Vermeer MH, Meijer CJLM, Alessi E, Willemze R. Primary cutaneous CD8-positive epidermotropic cytotoxic T-cell lymphoma: a distinct clinicopathologic entity with an aggressive clinical behaviour. Am J Pathol. 1999;155:483–92.

    Article  PubMed  CAS  Google Scholar 

  • Burg G, Dummer R, Wilhelm M, et al. A subcutaneous delta-positive T-cell lymphoma that produces interferon gamma. N Engl J Med. 1991;325:1078–81.

    Article  PubMed  CAS  Google Scholar 

  • Chan JK, Sin VC, Wong KF, et al. Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm. Blood. 1997;89:4501–13.

    PubMed  CAS  Google Scholar 

  • de Wolf-Peeters C, Achten R. Gamma-delta T-cell lymphomas: a homogeneous entity? Histopathology. 2000;36:294–305.

    Article  PubMed  Google Scholar 

  • DiGiuseppe JA, Louie DC, Williams JE, et al. Blastic natural killer cell leukemia/lymphoma: a clinicopathologic study. Am J Surg Pathol. 1997;21:1223–30.

    Article  PubMed  CAS  Google Scholar 

  • Fink-Puches R, Zenahlik P, Bäck B, Smolle J, Kerl H, Cerroni L. Primary cutaneous lymphomas: applicability of current classification schemes (EORTC, WHO) based on clinicopathologic features observed in a large group of patients. Blood. 2002;99:800–5.

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez CL, Medeiros LJ, Braziiel RM, Jaffe ES. T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome. Am J Surg Pathol. 1991;15:17–27.

    Article  PubMed  CAS  Google Scholar 

  • Grange F, Hedelin G, Joly P, et al. Prognostic factors in primary cutaneous lymphomas other than mycosis fungoides and the Sezary syndrome: the French study group on cutaneous lymphomas. Blood. 1999;93:3637–42.

    PubMed  CAS  Google Scholar 

  • Groves FD, Linet MS, Travis LB, Devesa SS. Cancer surveillance series: non-Hodgkin’s lymphoma incidence by histologic subtype in the United States from 1978 through 1995. J Natl Cancer Inst. 2000;92:1240–51.

    Article  PubMed  CAS  Google Scholar 

  • Hoque SR, Child FJ, Whittaker SJ, et al. Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol. 2003;148:516–25.

    Article  PubMed  CAS  Google Scholar 

  • Jacob MC, Chaperot C, Mossuz P, et al. CD4+ CD56+ lineage negative malignancies: a new entity developed from malignant early plasmacytoid dendritic cells. Haematologica. 2003;88:941–55.

    PubMed  Google Scholar 

  • Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. World Health Organization classification of tumors: pathology and genetics of tumours of hematopoietic and lymphoid tissues. Lyon: IARC Press; 2001.

    Google Scholar 

  • Jones D, Vega F, Sarris A, Medeiros LJ. CD4- CD8- “Double-negative” cutaneous T-cell lymphomas share common histologic features and an aggressive clinical course. Am J Surg Pathol. 2002;26:225–31.

    Article  PubMed  Google Scholar 

  • Massone C, Chott A, Metze D, et al. Subcutaneous, blastic natural killer (NK), NK/T-cell and other cytotoxic lymphomas of the skin: a morphologic, immunophenotypic and molecular study of 50 patients. Am J Surg Pathol. 2004;28:719–35.

    Article  PubMed  Google Scholar 

  • Mraz-Gernhard S, Natkunam Y, Hoppe RT, LeBoit P, Kohler S, Kim Y. Natural killer/natural killer-like T-cell lymphoma, CD56+, presenting in the skin: an increasingly recognized entity with an aggressive course. J Clin Oncol. 2001;19:2179–88.

    PubMed  CAS  Google Scholar 

  • Natkunam Y, Smoller BR, Zehnder JL, Dorfman RF, Warnke RA. Aggressive cutaneous NK and NK-like T-cell lymphomas: clinicopathologic, immunohistochemical, and molecular analyses of 12 cases. Am J Surg Pathol. 1999;23:571–81.

    Article  PubMed  CAS  Google Scholar 

  • Norton AJ. Classification of cutaneous lymphoma: a critical appraisal of recent proposals. Am J Dermatopathol. 1999;21:279–87.

    Article  PubMed  CAS  Google Scholar 

  • Petrella T, Dalac S, Maynadié M, et al. CD4+ CD56+ cutaneous neoplasms: a distinct hematological entity? Am J Surg Pathol. 1999;23:137–46.

    Article  PubMed  CAS  Google Scholar 

  • Petrella T, Comeau MR, Maynadié M, et al. “Agranular CD4+ CD56+ hematodermic neoplasm” (blastic NK-cell lymphoma) originates from a population of CD56+ precursor cells related to plasmacytoid monocytes. Am J Surg Pathol. 2002;26:852–62.

    Article  PubMed  Google Scholar 

  • Russell-Jones R. World Health Organization of hematopoietic and lymphoid tissues: implications for dermatology. J Am Acad Dermatol. 2003;48:93–102.

    Article  PubMed  Google Scholar 

  • Salhany KE, Macon WR, Choi JK, et al. Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes. Am J Surg Pathol. 1998;22:881–93.

    Article  PubMed  CAS  Google Scholar 

  • Sander CA, Flaig MJ, Jaffe ES. Cutaneous manifestations of lymphoma: a clinical guide based on the WHO classification. Clin Lymphoma. 2001;2:86–100.

    Article  PubMed  CAS  Google Scholar 

  • Santucci M, Pimpinelli N, Massi D, et al. Cytotoxic/natural killer cell cutaneous lymphomas: report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer. 2003;97:610–27.

    Article  PubMed  Google Scholar 

  • Toro JR, Liewehr DJ, Pabby N, et al. Gamma-delta-T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. Blood. 2003;101:3407–12.

    Article  PubMed  CAS  Google Scholar 

  • Weenig RH, Ng CS, Perniciaro C. Subcutaneous panniculitis-like T-cell lymphoma. Am J Dermatopathol. 2001;23:206–15.

    Article  PubMed  CAS  Google Scholar 

  • Willemze R, Meijer CJ. EORTC classification for primary cutaneous lymphomas: the best guide to good clinical management. European Organization for Research and Treatment of Cancer. Am J Dermatopathol. 1999;21:265–73.

    Article  PubMed  CAS  Google Scholar 

  • Willemze R, Meijer CJLM, Sentis HJ, et al. Primary cutaneous large cell lymphomas of follicular center cell origin. J Am Acad Dermatol. 1987;16:518–26.

    Article  PubMed  CAS  Google Scholar 

  • Willemze R, Kerl H, Sterry W, et al. EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer (EORTC). Blood. 1997;90:354–71.

    PubMed  CAS  Google Scholar 

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El-Darouti, M.A. (2013). Ulcerated Nodules in a Healthy Woman. In: Challenging Cases in Dermatology. Springer, London. https://doi.org/10.1007/978-1-4471-4249-2_42

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  • DOI: https://doi.org/10.1007/978-1-4471-4249-2_42

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4248-5

  • Online ISBN: 978-1-4471-4249-2

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