Abstract
A 55-year-old female presented with 19-month duration of asymptomatic ulcerated nodules in the upper thigh and groin (Fig. 42.1). She was otherwise healthy, with no fever, no fatigue and no systemic symptoms.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
Agnarsson BA, Vonderheid EC, Kadin ME. Cutaneous T-cell lymphoma with suppressor/cytotoxic (CD8) phenotype: identification of rapidly progressive and chronic subtypes. J Am Acad Dermatol. 1990;22:569–77.
Arnulf B, Copie-Bergman C, Delfau-Larue MH, et al. Nonhepatosplenic gamma-delta T-cell lymphoma: a subset of cytotoxic lymphomas with mucosal or skin localization. Blood. 1998;91:1723–31.
Bekkenk MW, Vermeer MH, Jansen PM, et al. Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients. Blood. 2003;102:2213–9.
Beljaards RC, Meijer CJLM, van der Putte SCJ, et al. Primary cutaneous T-cell lymphomas: clinicopathologic features and prognostic parameters of 35 cases other than mycosis fungoides and CD30-positive large cell lymphoma. J Pathol. 1994;172:53–60.
Berti E, Cerri A, Cavicchini S, et al. Primary cutaneous gamma/delta lymphoma presenting as disseminated pagetoid reticulosis. J Invest Dermatol. 1991;96:718–23.
Berti E, Tomasini D, Vermeer MH, Meijer CJLM, Alessi E, Willemze R. Primary cutaneous CD8-positive epidermotropic cytotoxic T-cell lymphoma: a distinct clinicopathologic entity with an aggressive clinical behaviour. Am J Pathol. 1999;155:483–92.
Burg G, Dummer R, Wilhelm M, et al. A subcutaneous delta-positive T-cell lymphoma that produces interferon gamma. N Engl J Med. 1991;325:1078–81.
Chan JK, Sin VC, Wong KF, et al. Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm. Blood. 1997;89:4501–13.
de Wolf-Peeters C, Achten R. Gamma-delta T-cell lymphomas: a homogeneous entity? Histopathology. 2000;36:294–305.
DiGiuseppe JA, Louie DC, Williams JE, et al. Blastic natural killer cell leukemia/lymphoma: a clinicopathologic study. Am J Surg Pathol. 1997;21:1223–30.
Fink-Puches R, Zenahlik P, Bäck B, Smolle J, Kerl H, Cerroni L. Primary cutaneous lymphomas: applicability of current classification schemes (EORTC, WHO) based on clinicopathologic features observed in a large group of patients. Blood. 2002;99:800–5.
Gonzalez CL, Medeiros LJ, Braziiel RM, Jaffe ES. T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome. Am J Surg Pathol. 1991;15:17–27.
Grange F, Hedelin G, Joly P, et al. Prognostic factors in primary cutaneous lymphomas other than mycosis fungoides and the Sezary syndrome: the French study group on cutaneous lymphomas. Blood. 1999;93:3637–42.
Groves FD, Linet MS, Travis LB, Devesa SS. Cancer surveillance series: non-Hodgkin’s lymphoma incidence by histologic subtype in the United States from 1978 through 1995. J Natl Cancer Inst. 2000;92:1240–51.
Hoque SR, Child FJ, Whittaker SJ, et al. Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol. 2003;148:516–25.
Jacob MC, Chaperot C, Mossuz P, et al. CD4+ CD56+ lineage negative malignancies: a new entity developed from malignant early plasmacytoid dendritic cells. Haematologica. 2003;88:941–55.
Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. World Health Organization classification of tumors: pathology and genetics of tumours of hematopoietic and lymphoid tissues. Lyon: IARC Press; 2001.
Jones D, Vega F, Sarris A, Medeiros LJ. CD4- CD8- “Double-negative” cutaneous T-cell lymphomas share common histologic features and an aggressive clinical course. Am J Surg Pathol. 2002;26:225–31.
Massone C, Chott A, Metze D, et al. Subcutaneous, blastic natural killer (NK), NK/T-cell and other cytotoxic lymphomas of the skin: a morphologic, immunophenotypic and molecular study of 50 patients. Am J Surg Pathol. 2004;28:719–35.
Mraz-Gernhard S, Natkunam Y, Hoppe RT, LeBoit P, Kohler S, Kim Y. Natural killer/natural killer-like T-cell lymphoma, CD56+, presenting in the skin: an increasingly recognized entity with an aggressive course. J Clin Oncol. 2001;19:2179–88.
Natkunam Y, Smoller BR, Zehnder JL, Dorfman RF, Warnke RA. Aggressive cutaneous NK and NK-like T-cell lymphomas: clinicopathologic, immunohistochemical, and molecular analyses of 12 cases. Am J Surg Pathol. 1999;23:571–81.
Norton AJ. Classification of cutaneous lymphoma: a critical appraisal of recent proposals. Am J Dermatopathol. 1999;21:279–87.
Petrella T, Dalac S, Maynadié M, et al. CD4+ CD56+ cutaneous neoplasms: a distinct hematological entity? Am J Surg Pathol. 1999;23:137–46.
Petrella T, Comeau MR, Maynadié M, et al. “Agranular CD4+ CD56+ hematodermic neoplasm” (blastic NK-cell lymphoma) originates from a population of CD56+ precursor cells related to plasmacytoid monocytes. Am J Surg Pathol. 2002;26:852–62.
Russell-Jones R. World Health Organization of hematopoietic and lymphoid tissues: implications for dermatology. J Am Acad Dermatol. 2003;48:93–102.
Salhany KE, Macon WR, Choi JK, et al. Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes. Am J Surg Pathol. 1998;22:881–93.
Sander CA, Flaig MJ, Jaffe ES. Cutaneous manifestations of lymphoma: a clinical guide based on the WHO classification. Clin Lymphoma. 2001;2:86–100.
Santucci M, Pimpinelli N, Massi D, et al. Cytotoxic/natural killer cell cutaneous lymphomas: report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer. 2003;97:610–27.
Toro JR, Liewehr DJ, Pabby N, et al. Gamma-delta-T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. Blood. 2003;101:3407–12.
Weenig RH, Ng CS, Perniciaro C. Subcutaneous panniculitis-like T-cell lymphoma. Am J Dermatopathol. 2001;23:206–15.
Willemze R, Meijer CJ. EORTC classification for primary cutaneous lymphomas: the best guide to good clinical management. European Organization for Research and Treatment of Cancer. Am J Dermatopathol. 1999;21:265–73.
Willemze R, Meijer CJLM, Sentis HJ, et al. Primary cutaneous large cell lymphomas of follicular center cell origin. J Am Acad Dermatol. 1987;16:518–26.
Willemze R, Kerl H, Sterry W, et al. EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer (EORTC). Blood. 1997;90:354–71.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
El-Darouti, M.A. (2013). Ulcerated Nodules in a Healthy Woman. In: Challenging Cases in Dermatology. Springer, London. https://doi.org/10.1007/978-1-4471-4249-2_42
Download citation
DOI: https://doi.org/10.1007/978-1-4471-4249-2_42
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-4248-5
Online ISBN: 978-1-4471-4249-2
eBook Packages: MedicineMedicine (R0)