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Physiology of Stem Cells

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Heart Failure

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Abstract

Stem cells are rare cells that have the ability to choose between self-renewal and differentiation. They can be found in an organism during development, starting with the pluripotent zygote, and continue to be present in organisms throughout their lifespans. In tissues with high turnover like blood, stem cells are continuously needed to produce new cells. In view of their proliferative potential stem cell regulation has to be extensive and complex. Much of it occurs in specialized sites known as stem cell niches. In addition to the stem cells that are present in the body, it is now possible to transform cells without stem cell potential into pluripotent stem cells using gene transfer. Stem cells have enormous clinical potential due to their diverse functional capabilities. Currently, the field of hematopoiesis has been the most successful in harnessing stem cell potential, and hematopoietic stem cells have become part of routine clinical care. Applications to other organ systems, including heart, are under active investigation and are the subjects of ongoing clinical trials.

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Authors and Affiliations

  1. Section of Cardiac Surgery, Children’s Mercy Hospital and Clinics and University of Missouri, Room 3730-08, 2401 Gilham Road, Kansas City, MO, 64108, USA

    Jos Domen PhD

  2. Department of Biomedical and Health Informatics, University of Missouri, 4451 Francis Street, Kansas City, KS, 66103, USA

    Kimberly Gandy MD, PhD

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  1. Jos Domen PhD
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  2. Kimberly Gandy MD, PhD
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Correspondence to Jos Domen PhD .

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  1. Division of Cardiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Howard Eisen

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Domen, J., Gandy, K. (2017). Physiology of Stem Cells. In: Eisen, H. (eds) Heart Failure. Springer, London. https://doi.org/10.1007/978-1-4471-4219-5_30

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  • DOI: https://doi.org/10.1007/978-1-4471-4219-5_30

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