Skip to main content

Patient Selection

  • Chapter
  • First Online:
  • 4760 Accesses

Abstract

Left ventricular assist device therapy improves quality of life and increases survival in end-stage congestive heart failure. Patient selection remains the most important factor in determining a successful outcome. Evaluation of a patient for LVAD implantation should involve a thorough clinical evaluation, including an echocardiographic and invasive hemodynamic assessment. An assessment of the patients overall outcome should be made based on risk factors that have been identified in previous studies as associated with poor outcomes. In addition, an evaluation of the degree of right ventricular dysfunction and potential for right ventricular failure after device implantation must be made. Finally, the optimal timing for device therapy must be determined. Appropriate patient selection for LVAD therapy will result in prolonged survival and better quality of life.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   199.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Cowie M, Mosterd A, Wood D, Deckers J, Poole-Wilson P, Sutton G, et al. The epidemiology of heart failure. Eur Heart J. 1997;18(2):208–25.

    Article  CAS  PubMed  Google Scholar 

  2. Lund LH, Matthews J, Aaronson K. Patient selection for left ventricular assist devices. Eur J Heart Fail. 2010;12(5):434–43.

    Article  PubMed  Google Scholar 

  3. Deng MC. Orthotopic heart transplantation: highlights and limitations. Surg Clinics N Am. 2004;84(1):243–55.

    Article  Google Scholar 

  4. Lund LH, Mancini D. Heart failure in women. Med Clin N Am. 2004;88(5):1321.

    Article  PubMed  Google Scholar 

  5. Schocken DD, Arrieta MI, Leaverton PE, Ross EA. Prevalence and mortality rate of congestive heart failure in the United States. J Am Coll Cardiol. 1992;20(2):301–6.

    Article  CAS  PubMed  Google Scholar 

  6. Stevenson LW. Evolving role of mechanical circulatory support in advanced heart failure. In: Frazier OH, Kirklin JK, editors. Mechanical Circulatory Support. Philadelphia, PA: Elsevier, 2006:181–283.

    Google Scholar 

  7. Taylor DO, Edwards LB, Boucek MM, Trulock EP, Aurora P, Christie J, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult heart transplant report – 2007. J Heart Lung Transplant Rev. 2007;26(8):769–81.

    Article  Google Scholar 

  8. Deng MC, Edwards LB, Hertz MI, Rowe AW, Keck BM, Kormos R, et al. Mechanical circulatory support device database of the International Society for Heart and Lung Transplantation: third annual report – 2005. J Heart Lung Transplant 2005;24(9):1182–7.

    Google Scholar 

  9. Frazier O, Rose EA, McCarthy P, Burton NA, Tector A, Levin H, et al. Improved mortality and rehabilitation of transplant candidates treated with a long-term implantable left ventricular assist system. Ann Surg. 1995;222(3):327.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kirklin JK, Naftel DC, Kormos RL, Stevenson LW, Pagani FD, Miller MA, et al. Third INTERMACS annual report: the evolution of destination therapy in the United States. J Heart Lung Transplant. 2011;30(2):115–23.

    Article  PubMed  Google Scholar 

  11. Miller LW, Pagani FD, Russell SD, John R, Boyle AJ, Aaronson KD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357(9):885–96.

    Article  CAS  PubMed  Google Scholar 

  12. Pagani FD, Miller LW, Russell SD, Aaronson KD, John R, Boyle AJ, et al. Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol. 2009;54(4):312–21.

    Article  PubMed  Google Scholar 

  13. Rogers JG, Aaronson KD, Boyle AJ, Russell SD, Milano CA, Pagani FD, et al. Continuous flow left ventricular assist device improves functional capacity and quality of life of advanced heart failure patients. J Am Coll Cardiol Res Support Non-US Gov’t. 2010;55(17):1826–34.

    Article  Google Scholar 

  14. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, et al. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345(20):1435–43.

    Article  CAS  PubMed  Google Scholar 

  15. Boyle AJ, Russell SD, Teuteberg JJ, Slaughter MS, Moazami N, Pagani FD, et al. Low thromboembolism and pump thrombosis with the heartMate II left ventricular assist device: analysis of outpatient anti-coagulation. J Heart Lung Transplant. 2009;28(9):881–7.

    Article  PubMed  Google Scholar 

  16. John R, Kamdar F, Liao K, Colvin-Adams M, Boyle A, Joyce L. Improved survival and decreasing incidence of adverse events with the HeartMate II left ventricular assist device as bridge-to-transplant therapy. Ann Thorac Surg. [Comparative Study]. 2008;86(4):1227–34; discussion 34–5.

    Google Scholar 

  17. Ammar KA, Jacobsen SJ, Mahoney DW, Kors JA, Redfield MM, Burnett Jr JC, et al. Prevalence and prognostic significance of heart failure stages. Circulation. 2007;115(12):1563–70.

    Article  PubMed  Google Scholar 

  18. Baughman KL, Jarcho JA. Bridge to life – cardiac mechanical support. N Engl J Med 2007;357(9):846–9.

    Google Scholar 

  19. Gronda E, Bourge RC, Costanzo MR, Deng M, Mancini D, Martinelli L, et al. Heart rhythm considerations in heart transplant candidates and considerations for ventricular assist devices: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates – 2006. J Heart Lung Tranplant. 2006;25(9):1043–56.

    Article  Google Scholar 

  20. Slaughter MS, Meyer AL, Birks EJ. Destination therapy with left ventricular assist devices: patient selection and outcomes. Curr Op Cardiol. 2011;26(3):232.

    Article  Google Scholar 

  21. Slaughter MS, Pagani FD, Rogers JG, Miller LW, Sun B, Russell SD, et al. Clinical management of continuous-flow left ventricular assist devices in advanced heart failure. J Heart Lung Transplant. 2010;29(4):S1–S39.

    Article  PubMed  Google Scholar 

  22. Butler J, Geisberg C, Howser R, Portner PM, Rogers JG, Deng MC, et al. Relationship between renal function and left ventricular assist device use. Ann Thorac Surg. 2006;81(5):1745–51.

    Article  PubMed  Google Scholar 

  23. Sandner SE, Zimpfer D, Zrunek P, Rajek A, Schima H, Dunkler D, et al. Renal function and outcome after continuous flow left ventricular assist device implantation. Ann Thorac Surg. 2009;87(4):1072–8.

    Article  PubMed  Google Scholar 

  24. Radovancevic B, Vrtovec B, de Kort E, Radovancevic R, Gregoric ID, Frazier O. End-organ function in patients on long-term circulatory support with continuous-or pulsatile-flow assist devices. J Heart Lung Transplant. 2007;26(8):815–8.

    Article  PubMed  Google Scholar 

  25. Letsou GV, Myers TJ, Gregoric ID, Delgado R, Shah N, Robertson K, et al. Continuous axial-flow left ventricular assist device (Jarvik 2000) maintains kidney and liver perfusion for up to 6 months. Ann Thorac Surg. 2003;76(4):1167–70.

    Article  PubMed  Google Scholar 

  26. Reinhartz O, Farrar DJ, Hershon JH, Avery GJ, Haeusslein EA, Hill JD. Importance of preoperative liver function as a predictor of survival in patients supported with Thoratec ventricular assist devices as a bridge to transplantation. J Thorac Cardiovasc Surg. 1998;116(4):633–40.

    Article  CAS  PubMed  Google Scholar 

  27. Farrar DJ, Hill J. Recovery of major organ function in patients awaiting heart transplantation with Thoratec ventricular assist devices. Thoratec Ventricular Assist Device Principal Investigators. J Heart Lung Transplant. 1994;13(6):1125.

    CAS  PubMed  Google Scholar 

  28. Frazier O, Rose EA, Oz MC, Dembitsky W, McCarthy P, Radovancevic B, et al. Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation. J Thorac Cardiovasc Surg. 2001;122(6):1186.

    Article  CAS  PubMed  Google Scholar 

  29. Aaronson KD, Patel H, Pagani FD. Patient selection for left ventricular assist device therapy. Ann Thorac Surg. 2003;75(6):S29–35.

    Article  PubMed  Google Scholar 

  30. Miller LW. Patient selection for the use of ventricular assist devices as a bridge to transplantation. Ann Thorac Surg. 2003;75(6):S66–71.

    Article  PubMed  Google Scholar 

  31. Frazier O, Delgado RM. Mechanical circulatory support for advanced heart failure. Circulation. 2003;108(25):3064–8.

    Article  CAS  PubMed  Google Scholar 

  32. Williams MR, Oz MC. Indications and patient selection for mechanical ventricular assistance. Ann Thorac Surg. 2001;71(3):S86–91.

    Article  CAS  PubMed  Google Scholar 

  33. Deng MC, Edwards LB, Hertz MI, Rowe AW, Keck BM, Kormos R, et al. Mechanical circulatory support device database of the International Society for Heart and Lung Transplantation: second annual report – 2004. J Heart Lung Transplant. 2004;23(9):1027–34.

    Article  PubMed  Google Scholar 

  34. Lockard K, Degore L, Schwarm P, Winowich S, O’Shea G, Siegenthaler M, et al. 5: lack of improvement in prealbumin at two weeks predicts a poor outcome after mechanical circulatory support. J Heart Lung Transplant. 2009;28(2):S66.

    Article  Google Scholar 

  35. Butler J, Howser R, Portner PM, Pierson RN. Body mass index and outcomes after left ventricular assist device placement. Ann Thorac Surg. 2005;79(1):66–73.

    Article  PubMed  Google Scholar 

  36. Boyle AJ, Ascheim DD, Russo MJ, Kormos RL, John R, Naka Y, et al. Clinical outcomes for continuous-flow left ventricular assist device patients stratified by pre-operative INTERMACS classification. J Heart Lung Transplant. 2011;30(4):402–7.

    Article  PubMed  Google Scholar 

  37. Teuteberg JJ, Ewald GA, Adamson RM, Lietz K, Miller LW, Tatooles AJ, et al. Risk assessment for continuous flow left ventricular assist devices: does the destination therapy risk score work? An analysis of over 1,000 patients. J Am Coll Cardiol. 2012;60(1):44–51.

    Article  PubMed  Google Scholar 

  38. Stevenson LW, Pagani FD, Young JB, Jessup M, Miller L, Kormos RL, et al. INTERMACS profiles of advanced heart failure: the current picture. J Heart Lung Transplant. 2009;28(6):535–41.

    Article  PubMed  Google Scholar 

  39. Alba AC, Rao V, Ivanov J, Ross HJ, Delgado DH. Usefulness of the INTERMACS scale to predict outcomes after mechanical assist device implantation. J Heart Lung Transplant. 2009;28(8):827–33.

    Article  PubMed  Google Scholar 

  40. Oz MC, Goldstein DJ, Pepino P, Weinberg AD, Thompson SM, Catanese KA, et al. Screening scale predicts patients successfully receiving long-term implantable left ventricular assist devices. Circulation. 1995;92(9):169–73.

    Article  Google Scholar 

  41. Rao V, Oz MC, Flannery MA, Catanese KA, Argenziano M, Naka Y. Revised screening scale to predict survival after insertion of a left ventricular assist device. J Thorac Cardiovasc Surg. 2003;125(4):855–62.

    Article  PubMed  Google Scholar 

  42. Klotz S, Vahlhaus C, Riehl C, Reitz C, Sindermann JR, Scheld HH. Pre-operative prediction of post-VAD implant mortality using easily accessible clinical parameters. J Heart Lung Transplant. 2010;29(1):45–52.

    Article  PubMed  Google Scholar 

  43. Holman WL, Kormos RL, Naftel DC, Miller MA, Pagani FD, Blume E, et al. Predictors of death and transplant in patients with a mechanical circulatory support device: a multi-institutional study. J Heart Lung Transplant. 2009;28(1):44–50.

    Article  PubMed  Google Scholar 

  44. Feldman D, Menachemi DM, Abraham WT, Wexler RK. Management strategies for stage-D patients with acute heart failure. Clin Cardiol. 2008;31(7):297–301.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Lietz K, Miller LW. Patient selection for left-ventricular assist devices. Curr Opin Cardiol. 2009;24(3):246–51.

    Article  PubMed  Google Scholar 

  46. Farrar D. Ventricular interactions during mechanical circulatory support. Sem Thoracic Cardiovasc Surg. 1994;6(3):163–8.

    CAS  Google Scholar 

  47. Farrar DJ, Compton PG, Hershon JJ, Fonger JD, Hill JD. Right heart interaction with the mechanically assisted left heart. World J Surg. 1985;9(1):89–102.

    Article  CAS  PubMed  Google Scholar 

  48. Matthews JC, Koelling TM, Pagani FD, Aaronson KD. The right ventricular failure risk score: a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates. J Am Coll Cardiol. 2008;51(22):2163–72.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Dang NC, Topkara VK, Mercando M, Kay J, Kruger KH, Aboodi MS, et al. Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure. J Heart Lung Transplant. 2006;25(1):1.

    Article  PubMed  Google Scholar 

  50. Kavarana MN, Pessin-Minsley MS, Urtecho J, Catanese KA, Flannery M, Oz MC, et al. Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem. Ann Thorac Surg. 2002;73(3):745–50.

    Article  PubMed  Google Scholar 

  51. Ochiai Y, McCarthy PM, Smedira NG, Banbury MK, Navia JL, Feng J, et al. Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation. 2002;106(12 suppl 1):I-198–202.

    Google Scholar 

  52. Morgan JA, John R, Lee BJ, Oz MC, Naka Y. Is severe right ventricular failure in left ventricular assist device recipients a risk factor for unsuccessful bridging to transplant and post-transplant mortality. Ann Thorac Surg. 2004;77(3):859–63.

    Article  PubMed  Google Scholar 

  53. Kukucka M, Stepanenko A, Potapov E, Krabatsch T, Redlin M, Mladenow A, et al. Right-to-left ventricular end-diastolic diameter ratio and prediction of right ventricular failure with continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2011;30(1):64–9.

    Article  PubMed  Google Scholar 

  54. Fitzpatrick III JR, Frederick JR, Hsu VM, Kozin ED, O’Hara ML, Howell E, et al. A risk score derived from preoperative data analysis predicts the need for biventricular mechanical circulatory support. J Heart Lung Transplantation Off J Heart Lung Transplant. 2008;27(12):1286.

    Article  Google Scholar 

  55. Kormos RL, Teuteberg JJ, Pagani FD, Russell SD, John R, Miller LW, et al. Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes. J Thorac Cardiovasc Surg. 2010;139(5):1316.

    Article  PubMed  Google Scholar 

  56. Stevenson LW, Shekar P. Ventricular assist devices for durable support. Circulation. 2005;112(9):e111–e5.

    Article  PubMed  Google Scholar 

  57. Pal JD, Klodell CT, John R, Pagani FD, Rogers JG, Farrar DJ, et al. Low operative mortality with implantation of a continuous-flow left ventricular assist device and impact of concurrent cardiac procedures. Circulation. 2009;120(11 suppl 1):S215–S9.

    Article  PubMed  Google Scholar 

  58. Stevenson LW, Miller LW, Desvigne-Nickens P, Ascheim DD, Parides MK, Renlund DG, et al. Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy. Circulation. 2004;110(8):975–81.

    Article  PubMed  Google Scholar 

  59. Lietz K, Long JW, Kfoury AG, Slaughter MS, Silver MA, Milano CA, et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era. Circulation. 2007;116(5):497–505.

    Article  PubMed  Google Scholar 

  60. Lietz K, Miller LW. Improved survival of patients with end-stage heart failure listed for heart transplantation: analysis of organ procurement and transplantation network/US United Network of Organ Sharing data, 1990 to 2005. J Am Coll Cardiol. 2007;50(13):1282–90.

    Article  PubMed  Google Scholar 

  61. Mancini D, Eisen H, Kussmaul W, Mull R, Edmunds Jr L, Wilson J. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83(3):778–86.

    Article  CAS  PubMed  Google Scholar 

  62. Mehra MR, Kobashigawa J, Starling R, Russell S, Uber PA, Parameshwar J, et al. Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates – 2006. J Heart Lung Transplant. 2006;25(9):1024.

    Article  PubMed  Google Scholar 

  63. Aaronson KD, Schwartz JS, Chen TM, Wong KL, Goin JE, Mancini DM. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation. 1997;95(12):2660–7.

    Article  CAS  PubMed  Google Scholar 

  64. Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB, et al. The seattle heart failure model prediction of survival in heart failure. Circulation. 2006;113(11):1424–33.

    Article  PubMed  Google Scholar 

  65. Copeland JG, Smith RG, Arabia FA, Nolan PE, Sethi GK, Tsau PH, et al. Cardiac replacement with a total artificial heart as a bridge to transplantation. N Engl J Med. 2004;351(9):859–67.

    Article  CAS  PubMed  Google Scholar 

  66. Gray NA, Selzman CH. Current status of the total artificial heart. Am Heart J. 2006;152(1):4–10.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Abeel A. Mangi MD, FACC, FACS .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag London

About this chapter

Cite this chapter

Taghavi, S., Mangi, A.A. (2017). Patient Selection. In: Eisen, H. (eds) Heart Failure. Springer, London. https://doi.org/10.1007/978-1-4471-4219-5_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-4219-5_25

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4218-8

  • Online ISBN: 978-1-4471-4219-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics