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Bone Marrow Lymphoid Infiltrates pp 145–169Cite as

Singularities in Pediatric Bone Marrow Lymphoid Processes

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Abstract

There are several unique features of hematopoiesis and hematopoietic diseases in children relative to adults. For example, evaluation of lymphoid lesions in the pediatric population is impacted by the fact that lymphoid cells normally comprise a larger percentage of blood and bone marrow cells in children than in adults. The nature of bone marrow lymphoid infiltrates in children differs to some extent from those in adults. In this chapter on singularities in pediatric bone marrow lymphoid processes, the unique characteristics of lymphoid lesions and diseases specific to children will be emphasized. It is important to note that evaluation of lymphoid lesions should include examination of well prepared and stained specimens of the peripheral blood, bone marrow (BM) aspirate smears, touch imprints of the trephine biopsy, and sections of the trephine biopsy and particles/clot. It is often the combination of clues gleaned from the composite of preparations that allows for diagnosis.

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Authors and Affiliations

  1. Division of Hematopathology and Division of Molecular Genetics Pathology, Department of Laboratory Medicine and Pathology, University of Minnesota, Mayo Building D219-1 420 Delaware Street SE, Minneapolis, MN, 55455, USA

    Sophia L. Yohe

  2. Division of Hematopathology, Department of Laboratory Medicine and Pathology, University of Minnesota, Mayo Building D219-1 420 Delaware Street SE, Minneapolis, MN, 55455, USA

    Robert W. McKenna

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Correspondence to Sophia L. Yohe .

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  1. , Department of Hematopathology, Evangelismos Hospital, Ersis Street 9, Athens, 15452, Greece

    Dimitra Anagnostou

  2. Royal Marsden Hospital, Inst. Cancer Research, NHS Foundation Trust, Fulham Road, London, SW3 6JJ, United Kingdom

    Estella Matutes

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Yohe, S.L., McKenna, R.W. (2012). Singularities in Pediatric Bone Marrow Lymphoid Processes. In: Anagnostou, D., Matutes, E. (eds) Bone Marrow Lymphoid Infiltrates. Springer, London. https://doi.org/10.1007/978-1-4471-4174-7_9

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