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Pluripotent Stem Cells of the Mammalian Early Embryo

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Human Fetal Tissue Transplantation

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Abstract

The early embryo harbors the most amazing cells, the embryonic stem (ES) cells, pluripotent cells capable of generating all the tissues and cell types of a mature animal. Discovery and establishment of culture techniques able to maintain in culture human embryonic stem cells revolutionized the scientific community about a decade ago. In addition to ES cells, other lesser-known stem cells have their niche in the early embryo, such as trophoblast stem cells, and at later stages, epiblast stem cells and embryonic germ cells. This chapter will discuss current knowledge of these cell types, the results of their use in preclinical studies using animal models, and current cell therapies for human disease treatment.

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Acknowledgement

This work was supported in part by grants (PI07119) from the “Fondo de Investigaciones Sanitarias”, Ministry of Health, and Agencia Laín Entralgo, Madrid, Spain; SAF2010-19230 and BFU2004-00467 from the Ministry of Science and Innovation, Spain; the BioMedical Foundation Mutua Madrileña, Spain; and PAMER grants, Aragon Health Sciences Institute, Spain. The authors wish to acknowledge Fatima Dominguez for technical assistance and Gareth William Osborne for linguistic assistance.

Conflict of Interest:The authors declare no potential conflicts of interest.

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  1. Cell Engineering Laboratory, IdiPAZ, La Paz Hospital Research Institute, Maternity Building, Paseo Castellana 261, Madrid, 28046, Spain

    Maria P. De Miguel & Ignacio Garcia-Tuñón

  2. ARAID Foundation, Regenerative Medicine Program, IACS/IISA,Department de Anatomía, Embriologíay Genética Animal, Facultad de Veterinaria, University of Zaragoza, Zaragoza, Spain

    Jon Schoorlemmer

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  1. Southend Park 55, Kolkata, 700029, India

    Niranjan Bhattacharya

  2. Dept. Obstetrics & Gynaecology, Boston University Medical Centre, E. Concord Street 85, Boston, 02118, Massachusetts, USA

    Phillip Stubblefield

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De Miguel, M.P., Schoorlemmer, J., Garcia-Tuñón, I. (2013). Pluripotent Stem Cells of the Mammalian Early Embryo. In: Bhattacharya, N., Stubblefield, P. (eds) Human Fetal Tissue Transplantation. Springer, London. https://doi.org/10.1007/978-1-4471-4171-6_8

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