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A Study and Follow-Up (1999–2012) of Fetal Midbrain Tissue Transplant (Iatrogenic Chimera) at a Heterotopic Site in Axilla as a Treatment Support in Cases of Adult Idiopathic Parkinsonism Patients

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Abstract

The most advanced research on the use of human fetal tissue has been done in Parkinson’s disease, which affects about 1.5 million people in the USA only. Patients with Parkinson’s disease experience tremors, slurred speed, and slowness of movement that eventually progresses to total paralysis. In this progressive, debilitating illness, the cells in a small part of the brain called the substantia nigra are destroyed, depriving the striatum (the part of the brain that controls movement) of a critical molecule called dopamine. Despite devastating loss of motor control, mental faculties in Parkinson’s patients remain intact, and while the disease is in itself not fatal, patients often succumb to complications such as injuries from falls or pneumonia.

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References

  1. Curtis MA, Faull RLM, Eriksson PS. The effect of neurodegenerative diseases on the subventricular zone. Nat Rev Neurosci. 2007;8:712–23.

    Article  PubMed  CAS  Google Scholar 

  2. Vandenbosch R, Borgs L, Beukelaers P, Belachew S, Moonen G, Nguyen L, Malgrange B. Adult neurogenesis and the diseased brain. Curr Med Chem. 2009;16(6):652–66.

    Article  PubMed  CAS  Google Scholar 

  3. Kaneko N, Sawamoto K. Adult neurogenesis in physiological and pathological conditions. Brain Nerve. 2008;60(4):319–28.

    PubMed  CAS  Google Scholar 

  4. Linnarsson S, Willson CA, Ernfors P. Cell death in regenerating populations of neurons in BDNF mutant mice. Brain Res Mol Brain Res. 2000;75(1):61–9.

    Article  PubMed  CAS  Google Scholar 

  5. Bhattacharya N. A study and follow-up (1999–2009) of human fetal neurotransplants at a heterotopic site outside the brain in patients of advanced Idiopathic Parkinsonism. In: Bhattacharya N, Stubblefield P, ­editors. Regenerative medicine using pregnancy-specific biological substances. London: Springer-Verlag Limited; 2011. p. 407. doi:10.1007/978-1-84882-718-9_39.

    Chapter  Google Scholar 

  6. Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368–76.

    Article  PubMed  CAS  Google Scholar 

  7. Fahn S, Elton RL. Members of the UPDRS Development Committee. Unified Parkinson’s disease rating scale. In: Fahn S, Marden CD, Calne D, Goldstein M, editors. Recent developments in Parkinson’s disease, vol. 2. Macmillan Healthcare Information: Florham Park; 1987. p. 153–63.

    Google Scholar 

  8. Parashos SA, Johnson ML, Erickson-Davis C, Wielinski CL. Assessing cognition in Parkinson ­disease: use of the cognitive linguistic quick test. J Geriatr Psychiatry Neurol. 2009;22(4):228–34.

    Article  PubMed  Google Scholar 

  9. Zigmnond-AS S-RP. The hospital anxiety and depression-scale. Acta Psychiatr Scand. 1983;67:361–70.

    Article  Google Scholar 

  10. Snaith RP, Taylor CM. Rating scales for depression and anxiety: a current perspective. Br J Clin Pharmacol. 1985;19:17S–20.

    Article  PubMed  Google Scholar 

  11. Channer KS, James MA, Papouchado M, Res JR. Anxiety and depression in patients with chest pain referred for exercise testing. Lancet. 1985;2:820–2.

    Article  PubMed  CAS  Google Scholar 

  12. Snaith RP, Zigmond AS. The hospital anxiety and depression scale manual. Windsor: NFER-Nelson; 1994. p. 9.

    Google Scholar 

  13. Yrjö TK, Emilia K, Vasily S, Wagner HD, Jaakko L, Veli-Matti T, Zygmunt M. Extracellular matrix and tissue regeneration. In: Gustav S, editor. Regenerative medicine. Dordrecht: Springer; 2011. p. 21–80. doi:10.1007/978-90-481-9075-1_2. Part 1.

    Google Scholar 

  14. Yamazaki Y, Makino H, Hamaguchi-Hamada K, Hamada S, Sugino H, Kawase E, Miyata T, Ogawa M, Yanagimachi R, Yagi T. Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer. Proc Natl Acad Sci USA. 2001;98(24):14022–6.

    Article  PubMed  CAS  Google Scholar 

  15. Rinkevich B. Human natural chimerism: an acquired character or a vestige of evolution? Hum Immunol. 2001;62(6):651–7.

    Article  PubMed  CAS  Google Scholar 

  16. Samanta BK. A study of fetal neuronal tissue graft at a heterotopic transplantation site and its implications. PhD thesis (Jadavpur University, Kolkata). 2009.

    Google Scholar 

  17. Dunnett SB, Björklund A. Prospects for new restorative and neuroprotective treatments in Parkinson’s disease. Nature. 1999;399(6738 Suppl):A32–9.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

1.Investigator 1 is grateful to the Department of Science and Technology, Government of West Bengal, who supported the Sr. investigator with a research grant during his tenure at Bijoygarh State Hospital from 1999 to 2006. The work started at Bijoygarh Government Hospital (1999–2006), Calcutta, India, and was followed up at Vidyasagore Government Hospital subsequently. The author gratefully acknowledges the support of the patients who volunteered for this research work. The guidance of Prof. K. L. Mukherjee of Biochemistry and Prof. M. K. Chhetri, former Director of Health Services, is gratefully acknowledged.

2.Investigator 2 was associated from the concept state to its implementation phase including follow-up as technical guide and also actual periodic participation during his visit to Calcutta, India.

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Correspondence to Niranjan Bhattacharya D.Sc., M.D., M.S., FACS .

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Bhattacharya, N., Chaudhuri, A. (2013). A Study and Follow-Up (1999–2012) of Fetal Midbrain Tissue Transplant (Iatrogenic Chimera) at a Heterotopic Site in Axilla as a Treatment Support in Cases of Adult Idiopathic Parkinsonism Patients. In: Bhattacharya, N., Stubblefield, P. (eds) Human Fetal Tissue Transplantation. Springer, London. https://doi.org/10.1007/978-1-4471-4171-6_30

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  • DOI: https://doi.org/10.1007/978-1-4471-4171-6_30

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4170-9

  • Online ISBN: 978-1-4471-4171-6

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