Human Heterotopic Fetal Cardiac Tissue Transplant in Patients with Varying Degrees of Cardiomyopathy with Ischemic Heart Disease and Diabetes Mellitus: A Report of 7 Cases
Cardiomyopathy is a difficult condition of the heart muscle when the cardiac cells lose their specialized function and behave like normal muscle. The causes could be extrinsic factors or secondary factors, for instance, drugs (alcohol and others), endocrine, inflammatory, metabolic, nutritional, neuromuscular, and autoimmune, acting either singly or in combination, affecting the myocardium. The other cause is intrinsic (primary), where the problem lies with the functioning of the cardiac muscles itself, with predisposition of genetic (a heritable 25-base pair [bp] deletion from the gene coding for cardiac myosin-binding protein-C (MYBPC3) is associated with various MYBPC3 mutations which predisposes cardiac diseases), acquired, or mixed etiology. From the functional point of view, it could be of a dilated variety, a restrictive variety, and an obstructive variety.
KeywordsVentricular Assisted Device Multipotent Mesenchymal Stromal Cell Restrictive Cardiomyopathy Endomyocardial Fibrosis Myocardial Blood Flow Reserve
The Department of Science and Technology, Government of West Bengal supported the investigator with a research grant during his tenure at Bijoygarh State Hospital from 1999 to 2006. The work started in Bijoygarh Government Hospital (1999–2006) and was followed up at Vidyasagore Government Hospital subsequently. The author gratefully acknowledges the support of the patients who volunteered for this research work. The guidance of Prof. K. L. Mukherjee of Biochemistry and Prof. M. K. Chhetri, former Director of Health Services, is gratefully acknowledged.
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