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Ocular Inflammation

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Ophthalmic Histopathology

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Abstract

This chapter deals predominantly with inflammatory disease in the eye as it is seen in surgical enucleation specimens. The various operative procedures used for the treatment of glaucoma, cataract and retinal detachment are complicated by secondary exogenous infection in only a small percentage of total cases treated surgically, but the numbers are significant in terms of specimens received in the laboratory. Cases of nonsurgical trauma complicated by infection also add to the numbers in the files (Kunimoto et al. 1999a and b). If the inflammatory process is restricted to the tissues within the scleral envelope, the condition is referred to as endophthalmitis; if the episcleral tissues are involved, the term panophthalmitis is appropriate.

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References

  • Abi-Hanna D, McCluskey P, Wakefield D (1989) HLA antigens in iris and aqueous humour gamma interferon levels in anterior uveitis. Invest Ophthalmol Vis Sci 30:990–994

    PubMed  CAS  Google Scholar 

  • Affeldt JC, Flynn HW, Forster RK, Mandelbaum S, Clarkson JG, Jarus GD (1987) Microbial endophthalmitis resulting from ocular trauma. Ophthalmology 94:407–413

    PubMed  CAS  Google Scholar 

  • Al-Yousuf NH, Dhillon B, Ironside J (2000) Gancyclovir implant: clinicopathological study. Eye 14:110–113

    Article  PubMed  Google Scholar 

  • Anand R, Font RL, Fish RH, Nightingale SD (1993) Pathology of cytomegalovirus retinitis treated with sustained release intravitreal ganciclovir. Ophthalmology 100:1602–1603

    Google Scholar 

  • Ashton N (1960) Larval granulomatosis of the retina due to Toxocara. Br J Ophthalmol 44:129–148

    Article  PubMed  CAS  Google Scholar 

  • Banker AS, Gonzalez C, Wiley CA, Bergeron-Lynn G, Freeman WR. (1996) The Agar sandwich technique for retinal biopsy processing. Retina 16:530–534

    PubMed  CAS  Google Scholar 

  • Beck AD, Newman NJ, Grossniklaus HE, Galetta SL, Kramer TR (1994 Optic nerve enlargement and visual loss. Sury Ophthalmol 38:555–566

    Article  CAS  Google Scholar 

  • Benson WE (1988) Posterior scleritis. Sury Ophthalmol 32:297–316

    Article  CAS  Google Scholar 

  • Biswas J, Fogla R, Srinivasan P, Narayan S, Haranath K, Badrinath V (1996) Ocular malaria. A clinical and histopathologic study. Ophthalmology 103:1471–1475

    PubMed  CAS  Google Scholar 

  • Bodaghi B, Dauga C, Cassoux N, Wechsler B et al. (1998) Whipples’s syndrome (uveitis, B27-negative spondylarthropathy, meningitis and lymphadenopathy) associated with Arthrobacter sp. infection. Ophthalmology 105:1891–1896

    Article  PubMed  CAS  Google Scholar 

  • Bowyer JD, Gormley PD, Seth R, Downes RN, Lowe J (1999) Choroidal tuberculosis diagnosed by polymerase chain reaction: a clinicopathologic case report. Ophthalmology 106:290–294

    Article  PubMed  CAS  Google Scholar 

  • Buggage RR, Chan CC, Matteson DM, Reed GF, Whitcup SM (2000) Apoptosis in cytomegalovirus retinitis associated with AIDS. Curr Eye Res 21:721–729

    Article  PubMed  CAS  Google Scholar 

  • Chan CC, Palestine AG, Kuwabara T, Nussenblatt RB (1988) Immunopathologic study of Vogt-Koyanaga-Harada syndrome. Am J Ophthalmol 105:607–611

    PubMed  CAS  Google Scholar 

  • Charles NC, Boxrud CA, Small EA (1992) Cryptococcosis of the anterior segment in acquired immunodeficiency syndrome. Ophthalmology 99:813–816

    PubMed  CAS  Google Scholar 

  • Charteris DG, Lee WR (1990) Multifocal posterior uveitis: clinical and pathological findings. Br J Ophthalmol 74:688–693

    Article  PubMed  CAS  Google Scholar 

  • Charteris DG, Barton K, McCartney AC, Lightman SL (1992) CD4+ lymphocyte involvement in ocular Behçet’s disease. Autoimmunity 12:201–206

    Article  PubMed  CAS  Google Scholar 

  • Coskuncan NM, Jabs DA, Dunn JP, Haller JA et al.(1994) The eye in bone marrow transplantation. VI. Retinal complications. Arch Ophthalmol 112:372–379

    Article  CAS  Google Scholar 

  • Cunha De Souza E, Jaikh AE, Trempe CL (1988) Unusual central chorioretinitis as the first manifestation of early secondary syphilis. Am J Ophthalmol 105:271–276

    Google Scholar 

  • De la Maza MS, Foster S (1991) Necrotizing scleritis after ocular surgery. Ophthalmology 98:1720–1726

    Google Scholar 

  • Driebe WT, Mandelbaum S. Forster RK, Schwarz LK Culbertson WW (1986) Pseudophakic endophthalmitis: diagnosis and management. Ophthalmology 93:442–448

    PubMed  Google Scholar 

  • Duguid IM (1961) Chronic endophthalmitis due to Toxocara. Br J Ophthalmol 45:705–717

    Article  PubMed  CAS  Google Scholar 

  • Duker JS, Blumenkranz MS (1991) Diagnosis and management of the acute retinal necrosis syndrome. Sury Ophthalmol 35:327–343

    Article  CAS  Google Scholar 

  • Dunlop AAS, Cree IA, Hague S, Luthert PJ, Lightman S (1998) Multifocal choroiditis: clinicopathologic correlation. Arch Ophthalmol 116:801–803

    PubMed  CAS  Google Scholar 

  • Dutton JJ (1991) Coralline hydroxyapatite as an ocular implant. Ophthalmology 98:370–377

    PubMed  CAS  Google Scholar 

  • Elkins BS, Holland GN, Opremcak EM, Dunn JP et al. (1994) Ocular toxoplasmosis misdiagnosed as cytomegalovirus retinopathy in immunocompromised patients. Ophthalmology 101:499–507

    PubMed  CAS  Google Scholar 

  • Ferrone PJ, Dutton JJ (1992) Rate of vascularization of coralline hydroxyapatite implants. Ophthalmology 99:376–379

    PubMed  CAS  Google Scholar 

  • Fong LP, de la Maza MS, Rice BA, Kupferman AE et al. (1991) Immunopathology of scleritis. Ophthalmology 98:472–479

    PubMed  CAS  Google Scholar 

  • Forrester JV (1990) Endogenous posterior uveitis. Br J Ophthalmol 74:620–623

    Article  PubMed  CAS  Google Scholar 

  • Freeman WR, Stern WH, Gross JG, Taylor PB et al. (1990) Pathologic observations made by retinal biopsy. Retina 10:195–204

    PubMed  CAS  Google Scholar 

  • Fujikawa LS, Haugen J-P (1990) Immunopathology of vitreous and retinochoroid biopsy in posterior uveitis. Ophthalmology 97:1644–1653

    PubMed  CAS  Google Scholar 

  • George RK, Chan C-C, Whitcup SM, Nussenblatt RB (1997) Ocular immunopathology of Behçet’s disease. Sury Ophthalmol 42:157–162

    Article  CAS  Google Scholar 

  • Glasgow B (1997) Evidence for vascular breaches of the retinal vasculature in acquired immune deficiency syndrome angiopathy. Ophthalmology 104:753–760

    PubMed  CAS  Google Scholar 

  • Greenwald MJ, Wohl LG, Sell CH (1986) Metastatic bacterial endophthalmitis: a contemporary re-appraisal. Sury Ophthalmol 31:81–101

    Article  CAS  Google Scholar 

  • Greven CM, Teot LA (1994) Cytologic identification of Toxoplasma gondii from vitreous fluid. Arch Ophthalmol 112:1086–1088

    Article  PubMed  CAS  Google Scholar 

  • Grossniklaus HE, Frank KE, Tomsak PL (1987) Cytomegalovirus retinitis and optic neuritis in acquired immune deficiency syndrome. Ophthalmology 94:1601–1604

    PubMed  CAS  Google Scholar 

  • Grossniklaus HE, Specht CS, Allaire G, Leavitt JA(1990) Toxoplasma gondii, retinochoroiditis and optic neuritis in acquired immunodeficiency syndrome. Ophthalmology 97:1272–1346

    Google Scholar 

  • Haltia M, Tarkkanen A, Kivela T (1989) Rabies: Ocular pathology. Br J Ophthalmol 73:61–67

    Article  PubMed  CAS  Google Scholar 

  • Hay J, Graham DI, Lee WR, Dutton GN, Hutchison WM (1987) Congenital neuro-ophthalmic toxoplasmosis in the mouse. Annals Trop Med Parasitol 81:25–28.

    CAS  Google Scholar 

  • Helm CJ, Holland GN (1993) Ocular tuberculosis. Sury Ophthalmol 38:229–256

    Article  CAS  Google Scholar 

  • Hennis HL, Scott AA, Apple DJ (1989) Cytomegalovirus retinitis. Sury Ophthalmol 34:193–203

    Article  CAS  Google Scholar 

  • Hidayat AA, Nalbandian RM, Sammons DW, Fleischman JA, Johnson TE (1993) The diagnostic histopathologic features of ocular malaria. Ophthalmology 100:1183–1186

    PubMed  CAS  Google Scholar 

  • Hoang-Xuan T, Bodaghi B, Toublanc M, Delmer A, Schwartz L, D’Hermies F (1996) Scleritis and mucosal-associated lymphoid tissue lymphoma. A new masquerade syndrome. Ophthalmology 103:631–635

    PubMed  CAS  Google Scholar 

  • Holland GN (1992) Acquired immunodeficiency syndrome: the first decade. Am J Ophthalmol 114:86–95

    PubMed  CAS  Google Scholar 

  • Holz FG. Kim RY, Schwartz SD, Harper CA et al. (1994) Acute zonal occult outer retinopathy (AZOOR) associated with multifocal choroidopathy Eye 8:77–83

    Article  PubMed  Google Scholar 

  • Hunt KE, Glasgow BJ (1996) Aspergillus endophthalmitis. An unrecognised endemic disease in orthotopic liver transplantation. Ophthalmology 103:757–767

    PubMed  CAS  Google Scholar 

  • Jabs DA, Johns CJ (1986) Ocular involvement in chronic sarcoidosis. Am J Ophthalmol 102:297–301

    PubMed  CAS  Google Scholar 

  • Jabs DA, Green WR, Fox R, Polk BF, Bartlet JG (1989) Ocular manifestations of acquired immunodeficiency syndrome. Ophthalmology 96:1092–1099

    PubMed  CAS  Google Scholar 

  • Jones NP (1993) Fuchs’ heterochromic uveitis: an update. Sury Ophthalmol 37:253–272

    Article  CAS  Google Scholar 

  • Jordan DR, Brownstein S, Jolly SS (1996) Abscessed hydroxyapatite orbital implants. Ophthalmology 103:1784–1787

    PubMed  CAS  Google Scholar 

  • Kahn M, Pepose JS, Green WR, Miller J, Foos RY (1993) Immunocytologic findings in a case of Vogt-Koyanagi-Harada syndrome. Ophthalmology 100:1191–1198

    PubMed  CAS  Google Scholar 

  • Kalina PH, Campbell RJ (1991) Aspergillus terreus endophthalmitis in a patient with chronic lymphocytic leukemia. Arch Ophthalmol 109:102–103

    Article  PubMed  CAS  Google Scholar 

  • Kashiwase M, Sata T, Yamauchi Y, Minoda H et al. (2000) Progressive outer retinal necrosis caused by herpes simplex virus type 1 in a patient with acquired immunodeficiency syndrome. Ophthalmology 107:790–794

    Article  PubMed  CAS  Google Scholar 

  • Kilmartin DJ, Fletcher ZJ, Almeida JA, Liversedge J, Forrester J, Dick AD (2001) CD69 expression on peripheral CD4 T cells parallels disease activity and is reduced by mycophenolate mofetil therapy in uveitis. Invest Ophthalmol Vis Sci 42:1285–1292

    PubMed  CAS  Google Scholar 

  • Kunimoto DY, Das T, Sharma S, Jalil S et al. (1999a) Microbiologic spectrum and susceptibility of isolates: part I. Postoperative endophthalmitis. Endophthalmitis research Group. Am J Ophthalmol 128:240–242

    Article  PubMed  CAS  Google Scholar 

  • Kunimoto DY, Das T, Sharma S, Jalil S et al. (1999b) Microbiologic spectrum and susceptibility of isolates: part II. Posttraumatic endophthalmitis. Endophthalmitis research. Am J Ophthalmol 128:242–244

    Article  PubMed  CAS  Google Scholar 

  • Lardenoye CW, Van der Lelij A, de Loos WS, Treffers WF, Rothova A (1997) Peripheral multifocal chorioretinal choroiditis: a distinct clinical entity? Ophthalmology 104:1820–1826

    PubMed  CAS  Google Scholar 

  • Leavitt JA, Campbell RJ (1998) Cost effectiveness in the diagnosis of sarcoidosis: the conjunctival biopsy. Eye 12:959–962

    Article  PubMed  Google Scholar 

  • Li S, Perlman JL, Edward DP, Weiss R (1998) Unilateral blastomycosis dermatitidis endophthalmitis and orbital cellulitis. A case report and literature review. Ophthalmology 105:1466–1470

    Article  PubMed  CAS  Google Scholar 

  • Lightman S, Chan C-C (1990) Immune mechanisms in choroido-retinal inflammation in man. Eye 4:345–353

    Article  PubMed  Google Scholar 

  • Lyness RW, Early OE, Logan WC, Archer DB (1987) Ocular larva migrans: a case report. Br J Ophthalmol 71:396–401

    Article  PubMed  CAS  Google Scholar 

  • Maguire AM, Green WR, Michels RG, Erozan YS (1990) Recovery of intraocular toxocara canis by pars plana vitrectomy. Ophthalmology 97:675–680

    PubMed  CAS  Google Scholar 

  • Margo CE, Fitzgerald CR.(1990) Postoperative endophthalmitis caused by Wangiella dermatitidis. Am J Ophthalmol 110:322–323

    PubMed  CAS  Google Scholar 

  • Margo CE, Pavan PR, Groden LR (1988) Chronic vitritis with macrophagic inclusions: A sequela of treated endophthalmitis due to a coryneform bacterium. Ophthalmology 95:156–161

    PubMed  CAS  Google Scholar 

  • Margo CE, Mames RN, Guy JR (1994) Endogenous klebsiella endophthalmitis. Report of two cases and review of the literature. Ophthalmology 101:1298–12301

    PubMed  CAS  Google Scholar 

  • Mittra RA, Pulido JS, Hanson GA, Kajdacsy-Balla A, Brummitt CF. (1999) Primary ocular Epstein-Barr virus-associated non-Hodgkin’s lymphoma in a patient with AIDS: a clinicopathologic report. Retina 19:45–50

    Article  PubMed  CAS  Google Scholar 

  • Moorthy RS, Smith RE, Rao NA (1993) Progressive ocular toxoplasmosis in patients with acquired immunodeficiency syndrome. Am J Ophthalmol 115:742–747

    PubMed  CAS  Google Scholar 

  • O’Connor GR (1985) Heterochromic iridocyclitis. Trans Ophthalmol Soc UK 104:219–231

    PubMed  Google Scholar 

  • Oestreicher JH, Liu E, Berkowitz M (1997) Complications of hydroxyapatite orbital implants. Ophthalmology 104:324–329

    PubMed  CAS  Google Scholar 

  • Ormerod DL, Skolnick KA, Menosky MM, Pavan PP, Pon DM (1998) Retinal and choroidal manifestations of cat-scratch disease. Ophthalmology 105:1024–1031

    Article  PubMed  CAS  Google Scholar 

  • Park DW, Boldt HC Massicotte SJ, Akang EEU et al. (1997) Subacute sclerosing panencephalitis manifesting as viral retinitis: clinical and histopathologic findings. Am J Ophthalmol 123:533–542

    PubMed  CAS  Google Scholar 

  • Patel AS, Hemady RK, Rodrigues M, Rajagopalan S, Elman MJ (1994) Endogenous Fusarium endophthalmitis in a patient with acute lymphocytic leukemia. Am J Ophthalmol 117:363–368

    PubMed  CAS  Google Scholar 

  • Pavan PR, Margo CE (1996) Submacular neovascular membrane and focal granulomatous inflammation. Ophthalmology 103:586–589

    PubMed  CAS  Google Scholar 

  • Pavesio CE, Lightman S (1996) Toxoplasma gondii and ocular toxoplasmosis: pathogenesis. Br J Ophthalmol 80:1099–1107

    Article  PubMed  CAS  Google Scholar 

  • Pflugfelder SC, Flynn HW, Zwickey TA, Forster RK et al. (1988) Exogenous fungal endophthalmitis. Ophthalmology 95:19–30

    PubMed  CAS  Google Scholar 

  • Rahhal FM, Siegel LM, Russak V, Wiley CA et al. (1996) Clinicopathologic correlations in acute retinal necrosis caused by herpes simplex virus type 2. Arch Ophthalmol 114:1416–1419

    Article  PubMed  CAS  Google Scholar 

  • Rao NA, Zimmerman PL, Boyer D, Biswas J et al. (1989) A clinical, histopathologic and electron microscopic study of Pneumocystis carinii choroiditis. Am J Ophthalmol 107:218–228

    PubMed  CAS  Google Scholar 

  • Reed JB, Scales DK, Wong MT, Lattuada CP, Dolan MJ, Schwab IR (1998) Bartonella henselae neuroretinitis in cat scratch disease. Ophthalmology 105:459–466

    Article  PubMed  CAS  Google Scholar 

  • Riono WP, Hidayat AA, Rao NA (1999) Scleritis: a clinicopathologic study of 55 cases. Ophthalmology 106:1328–1333

    Article  PubMed  CAS  Google Scholar 

  • Robin JB, Schanzlin DJ, Verity SM, Barron BA et al. (1986) Peripheral corneal disorders. Sury Ophthalmol 31:1–36

    Article  CAS  Google Scholar 

  • Rubsamen PE, Gass DM (1991) Vogt-Koyanagi-Harada syndromes: clinical course, therapy and long-term outcome. Arch Ophthalmol 109:682–687

    Article  PubMed  CAS  Google Scholar 

  • Rummelt V, Rummelt C, Jahn G, Wenkel H et al. (1994) Triple retinal infection with human immunodeficiency virus type 1, cytomegalovirus and herpes simplex virus type 1. Ophthalmology 101:270–279

    PubMed  CAS  Google Scholar 

  • Salmon JF, Pan EL, Murray ADN (1991) Visual loss with dancing extremities and mental disturbances. Sury Ophthalmol 35:299–306

    Article  CAS  Google Scholar 

  • Schanzer CM, Font RL, O’Malley RE (1991) Primary ocular malignant lymphoma associated with the acquired immune deficiency syndrome. Ophthalmology 98:88–91

    PubMed  CAS  Google Scholar 

  • Schneiderman TE, Faber DW, Gross JG, Wiley CA, Freeman WR (1989) The agar-albumen sandwich technique for processing retinal biopsy specimens. Am J Ophthalmol 108:567–571

    PubMed  CAS  Google Scholar 

  • Scott JA, Clearkin LG (1994) Surgically induced diffuse scleritis following cataract surgery. Eye 8:292–297

    Article  PubMed  Google Scholar 

  • Sekundo W, Seifert P (1998) Hydroxyapatite orbital implant. Ophthalmology 105:539–543

    Article  PubMed  CAS  Google Scholar 

  • Sheu S-J, Chen Y-C, Kuo N-W, Wang JH, Chen C-J (1998) Endogenous cryptococcal endophthalmitis. Ophthalmology 105:377–381

    Article  PubMed  CAS  Google Scholar 

  • Shields JA (1984) Ocular toxocariasis. A review. Sury Ophthalmol 28:361–381

    Article  CAS  Google Scholar 

  • Suttorp-Schulten MS, Bollemeij er JG, Bos PJ, Rothova A (1997) Presumed ocular histoplasmosis in the Netherlands — an area without histoplasmosis. Br J Ophthalmol 81:7–11

    Article  PubMed  CAS  Google Scholar 

  • Tabbara KF, al Jabarti AL (1999) Hospital construction-associated outbreak of ocular aspergillosis after cataract surgery. Ophthalmology 105:522–526

    Article  Google Scholar 

  • Warhekar PT, Gupta SK, Mansefield DC, Seal DV, Lee WR (1998) Postoperative saccular endophthalmitis caused by macrophage-associated staphylococci. Eve 12:1019–1021

    Google Scholar 

  • Weishaar PD, Flynn HW, Murray TG, Davis JL et al. (1998) Endogenous aspergillus endophthalmitis. Ophthalmology 105:57–68

    Article  PubMed  CAS  Google Scholar 

  • Winreb RN, Tessler H (1984) Laboratory diagnosis of ophthalmic sarcoidosis. Sury Ophthalmol 28:633–664

    Google Scholar 

  • Young RD, Powell J, Watson PG (1988) Ultrastructural changes in scleral proteoglycans precede destruction of the collagen fibres in necrotising scleritis. Histopathology 12:75–84

    Article  PubMed  CAS  Google Scholar 

  • Yoser SL, Forster DJ, Rao NA (1993) Systemic viral infections and their retinal and choroidal manifestations. Sury Ophthalmol 37:313–352

    Article  CAS  Google Scholar 

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  1. Department of Pathology, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, UK

    William R. Lee (Honorary Senior Research Fellow)

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© 2002 Springer-Verlag London

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Lee, W.R. (2002). Ocular Inflammation. In: Ophthalmic Histopathology. Springer, London. https://doi.org/10.1007/978-1-4471-3910-2_6

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  • DOI: https://doi.org/10.1007/978-1-4471-3910-2_6

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