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Ophthalmic Histopathology pp 63–99Cite as

“Absolute Glaucoma”

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Abstract

Some 30% of the globes received in the laboratory will have been enucleated in treatment of the complications and the intractable pain which are the features of secondary end-stage or “absolute” glaucoma. The commonest cause of secondary absolute glaucoma in the elderly patient was previously thrombotic occlusion of the central retinal vein (see p. 108), but, like diabetic eye disease this is now less common due to effective suppression of intraocular neovascularisation by panretinal laser treatment (photoablation). Secondary “neovascular glaucoma” is brought about by proliferation of fibrovascular tissue in the chamber angle and this vasosoproliferation is a response to transport, via the ocular fluids, of vasoformative biochemical agents synthesised in the retina in conditions in which there is underperfusion and hypoxia in the neural tissues. Ischaemic disease is often present in several tissue components in the elderly eye, and this is often the final stage in a process that may have been initiated by the primary and secondary glaucomas which will be described in this chapter.

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  1. Department of Pathology, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, UK

    William R. Lee (Honorary Senior Research Fellow)

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© 2002 Springer-Verlag London

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Lee, W.R. (2002). “Absolute Glaucoma”. In: Ophthalmic Histopathology. Springer, London. https://doi.org/10.1007/978-1-4471-3910-2_3

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