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The Orbit: Biopsy, Excision Biopsy and Exenteration Specimens

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Ophthalmic Histopathology

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Abstract

Orbital disease is encountered in three forms in surgical pathology — as a diagnostic biopsy, an excision biopsy and in an “exenteration” specimen. In general, the use of biopsy is restricted to tumours or orbital inflammatory processes (“pseudotumour”) which simulate neoplasia. An orbital exenteration is reserved for inflammatory and neoplastic diseases which involve the tissues extensively, usually when the eye is blind. For the uninitiated, the techniques required for dealing with an exenteration specimen are somewhat specialised and the topic is dealt with separately at the end of the chapter.

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References

  • Adkins JW, Shields JA, Shields CL, Eagle RC, Flanagan JC, Campanella PC (1996) plasmacytoma of the eye and orbit. Int Ophthalmol 20:339–343

    PubMed  Google Scholar 

  • Alford EC Jr, Lofton S (1988) Gliomas of the optic nerve or chiasm. Outcome by patients’ age, site and treatment. J Neurosurg 68:85–98

    Article  Google Scholar 

  • Auerbach DB, Bilyk JR (1999) Lung cancer and decreased vision. Sury Ophthalmol 43:405–412

    Article  CAS  Google Scholar 

  • Aylward GW, Sullivan TJ, Garner A, Mosely I, Wright JE (1995) Orbital involvement in multifocal fibrosclerosis. Br J Ophthalmol 79:246–249

    Article  PubMed  CAS  Google Scholar 

  • Badhe PB, Desai AP 1996 Large optic nerve glioma. J Postgrad Med 42:76–78

    PubMed  CAS  Google Scholar 

  • Bickler-Bluth ME, Custer PL, Smith ME (1988) Neurolemmoma as a presenting feature of neurofibromatosis. Arch Ophthalmol 106:665–667

    Article  PubMed  CAS  Google Scholar 

  • Bolt HC, Nerad JA (1988) Orbital metastases from prostatic carcinoma. Arch Ophthalmol 106:1403–1408

    Article  Google Scholar 

  • Boynton JR, Searl SS, Ferry AP, Kaltreider SA, Rodenhouse TG (1992) Primary nonkeratinized epithelial (“conjunctival”) orbital cysts. Arch Ophthalmol 110:1238–1242

    Article  PubMed  CAS  Google Scholar 

  • Bray WH, Giangiacomo J, Ide CH (1988) Orbital apex syndrome. Sury Ophthalmol 32:136–140

    Article  Google Scholar 

  • Brown HH, Kersten RC, Kulwin DR (1991) Lipomatous hamartoma of the orbit. Arch Ophthalmol 109:240–243

    Article  PubMed  CAS  Google Scholar 

  • Buggage RR, Spraul CW, Wojno TH, Grossniklaus HE (1999) Kimura disease of the orbit and ocular adnexa. Sury Ophthalmol 44:79–91

    Article  CAS  Google Scholar 

  • Bullen CL, Liesegang TJ, McDonald TH, DeRemee RA (1983) Ocular complications of Wegener’s granulomatosis. Ophthalmology 90: 279–290

    PubMed  CAS  Google Scholar 

  • Capps DH, Brodsky MC, Rice CD, Mrak RE, Glasier CM, Brown HH (1990) Orbital intramuscular schwannoma. Am J Ophthalmol 110: 535–539

    PubMed  CAS  Google Scholar 

  • Carrera M, Prat J, Quintana M (2001) Malignant solitary fibrous histiocytoma of the orbit: report of a case with 8 years follow-up. Eye 15:102–104

    Article  PubMed  CAS  Google Scholar 

  • Cascone P, Valentini V, Agrillo A (1998) Orbital hemangiopericytoma: case report of a long-term recurrency. J Craniofac Surg 9:55–59

    Article  PubMed  CAS  Google Scholar 

  • Char DH (1996) Thyroid eye disease. Br J Ophthalmol 80:922–926

    Article  PubMed  CAS  Google Scholar 

  • Chynn EW, Rubin PA (1997) Metastatic Ewing cell sarcoma of the sinus and osteoid osteoma of the orbit. Am J Ophthalmol 123:565–567

    PubMed  CAS  Google Scholar 

  • Cockerham KP, Cockerham GC, Stutzman R, Hidayat AA et al. (1999) The clinical spectrum of Schwannomas presenting with visual dysfunction: a clinicopathologic study of three cases. Sury Ophthalmol 44:226–234

    Article  CAS  Google Scholar 

  • Cole CH, Magee JF, Gianoulis M, Rogers PC (1993) Malignant fibrous histiocytoma in childhood. Cancer 71:4077–4083

    Article  PubMed  CAS  Google Scholar 

  • Collins MJ, Wojno TH, Grossniklaus H (1999) Metastatic esophageal carcinoma to the orbit. Am J Ophthalmol 127:228–229

    Article  PubMed  CAS  Google Scholar 

  • Collison JMT, Miller NR, Green WR (1986) Involvement of orbital tissues by sarcoid. Am J Ophthalmol 102:302–307

    PubMed  CAS  Google Scholar 

  • Cornblath WT, Elner V, Rolfe M (1993) Extraocular muscle involvement in sarcoidosis. Ophthalmology 100:501–505

    PubMed  CAS  Google Scholar 

  • Coupland SE, Krause L, Delecluse HJ, Anagnostopoulos I et al. (1998) Lymphoproliferative lesions of the ocular adnexa. Analysis of 112 cases. Ophthalmology 105:1430–1441

    Article  PubMed  CAS  Google Scholar 

  • Coupland SE, Heimann H, Hoffmeister B, Lee WR, Foerster MH, Gross U (1999) Immunohistochemical examination of an orbital alveolar soft part sarcoma. Graefes Arch Clin Exp Ophthalmol 237:266–272

    Article  PubMed  CAS  Google Scholar 

  • Coupland SE, Foss HD, Assaf C, Auw-Heydrich C et al. (2000) T cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: a clinicopathologic, immunohistochemical and molecular study of seven cases. Ophthalmology 106:2109–2120

    Article  Google Scholar 

  • Croxatto JO, Font RL (1982) Hemangiopericytoma of the orbit: a clinicopathologic study of 30 cases. Hum Pathol 13:210–218

    Article  PubMed  CAS  Google Scholar 

  • Cutarelli PE, Roessmann UR, Miller RH, Specht CS, Grossniklaus HE (1991) Immunohistochemical properties of human optic nerve glioma. Evidence of type 1 astrocyte origin. Invest Ophthalmol Vis Sci 32:2521–2524

    PubMed  CAS  Google Scholar 

  • Dario A, Iadini A, Cerati M, Marra A (1999) Malignant optic glioma of adulthood. Case report and review of the literature. Acta Neurol Scand 100:350–353

    Article  PubMed  CAS  Google Scholar 

  • De Backer CM, Bodker F, Putterman AM, Beckmann E (1996) Solitary fibrous tumour of the orbit. Am J Ophthalmol 121:447–448

    Google Scholar 

  • Del Tos A, Seregard S, Calonje E, Chan JKC, Fletcher CDM (1995) Giant cell angiofibroma. A distinctive orbital tumour in adults. Am J Surg Pathol 19:1286–1293

    Article  Google Scholar 

  • de Juan E, Cotton RW, Iliff NT (1983) Allergic periorbital mucocoele in children. Am J Ophthalmol 96:299–303

    PubMed  Google Scholar 

  • Dempster AG, Lee WR, Bahnasawi S, Downie T (1983) Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. Graefes Arch Clin Exp Ophthalmol 221:89–95

    Article  PubMed  CAS  Google Scholar 

  • De-Smet MD, Rootman J (1987) Orbital manifestations of plasmacytic lymphoproliferations. Ophthalmology 94:995–1003

    PubMed  CAS  Google Scholar 

  • Dorfman DM, To K, Dickersen GR, Rosenberg AE, Pilch BZ (1994) Solitary fibrous tumour of the orbit. Am J Surg Pathol 18:281–287

    Article  PubMed  CAS  Google Scholar 

  • Dunlop IS, Billson FA (1988) Visual failure in allergic aspergillus sinusitis. Br J Ophthalmol 72:127–130

    Article  PubMed  CAS  Google Scholar 

  • Dutton JJ (1992) Optic nerve sheath meningiomas. Sury Ophthalmol 37:167–183

    Article  CAS  Google Scholar 

  • Dutton JJ (1994) Gliomas of the anterior visual pathway. Sury Ophthalmol 38:427–452

    Article  CAS  Google Scholar 

  • Edelstein C, Shields JA, Shields CL, De Potter P et al. (1997) Non-African Burkitt’s lymphoma presenting with oral thrush and an orbital mass in a child. Am J Ophthalmol 124:859–861

    PubMed  CAS  Google Scholar 

  • Eijpe AA, Koorneef L, Verbeeten B, Peeters FLM et al. (1991) Intradiploic epidermoid cysts of the bony orbit. Ophthalmology 98:1737–1743

    PubMed  CAS  Google Scholar 

  • Elner VM, Burnstine MA, Goodman ML, Dortzbach RK (1995) Inverted papillomas that invade the orbit. Arch Ophthalmol 113:1178–1183

    Article  PubMed  CAS  Google Scholar 

  • Emori M, Hayasaka S, Setogawa T, Miyakuni Y, Fukama A (1991) Recurrent mixed tumor of the right lacrimal gland causes acute contralateral visual loss. Ophthalmologica 202:138–141

    Article  PubMed  CAS  Google Scholar 

  • Enzinger FM, Weiss SW (1988) Soft Tissue Tumours. CV Mosby, St Louis

    Google Scholar 

  • Ettl A, Marinkovic M, Koornneef L (1996) Localised hypertrichosis associated with periorbital neurofibroma. Ophthalmology 103:942–948

    PubMed  CAS  Google Scholar 

  • Eviatar JA, Hornblass A, Herschon B, Jakobiec FA (1992) Malignant peripheral nerve sheath tumour of the orbit in a 15 month old child. Nine year survival after local excision. Ophthalmology 99:1595–1599

    PubMed  CAS  Google Scholar 

  • Fay AM, Leib ML, Fountain KS (1998) Multiple myeloma involving the orbit. Ophthal Plast Reconstr Surg 14:67–71

    Article  PubMed  CAS  Google Scholar 

  • Fenton S, Moriarty P, Kennedy S (2001) Solitary fibrous tumour of the orbit. Eye 15:124–126

    Article  PubMed  CAS  Google Scholar 

  • Fleck BW, Toft AD (1990) Graves ophthalmopathy. Br Med J 300: 1352–1353

    Article  CAS  Google Scholar 

  • Fletcher CDM, McKee PH (1990) Pathobiology of Soft Tissue Tumours. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Florine CW, Dwyer M, Holland EJ (1993) Wegener’s granulomatosis presenting with sclerokeratitis diagnosed by antineutrophil cytoplasmic autoantibodies (ANCA). Sury Ophthalmol 37:373–376

    Article  CAS  Google Scholar 

  • Font RL, Hidayat AA (1982) Malignant fibrous histiocytoma of the orbit: a clinicopathologic study of 150 cases. Hum Pathol 13:199–209

    Article  PubMed  CAS  Google Scholar 

  • Font RL, Jurco S III, Zimmerman LE (1982) Alveolar soft part sarcoma of the orbit. A clinicopathologic analysis of 17 cases and a review of the literature. Hum Pathol 13:569–579

    Article  PubMed  CAS  Google Scholar 

  • Freedman SF, Elner VM, Donev I Gunta R, Albert DM (1988) Intraocular neurilemmoma arising from the posterior ciliary nerve in neurofibromatosis. Pathological findings. Ophthalmology 95:1559–1564

    PubMed  CAS  Google Scholar 

  • Gamel JW, Font RL (1982) Adenoid cystic carcinoma of the lacrimal gland. Hum Pathol 13:219–225

    Article  PubMed  CAS  Google Scholar 

  • Glasgow BJ, Foos RY (1993) Ocular Cytopathology. Butterworth Heinemann, Boston

    Google Scholar 

  • Goldberg RA, Rootman J, Cline RA (1990) Tumours metastatic to the orbit: a changing picture. Sury Ophthalmol 35:1–24

    Article  CAS  Google Scholar 

  • Goldberg SH, Sassani JW, Parnes, RE (1992) Traumatic intraconal haematic cyst of the orbit. Arch Ophthalmol 110:378–380

    Article  PubMed  CAS  Google Scholar 

  • Goldstein MH, Soparker CNS, Kersten RC, Orcutt JC, Patrinely JR, Holds J (1998) Conjunctival cysts in the orbit. Ophthalmology 105: 2056–2060

    Article  PubMed  CAS  Google Scholar 

  • Gorevic PD, Rodrigues MM (1994) Ocular amyloidosis. Am J Ophthalmol 117:529–532

    PubMed  CAS  Google Scholar 

  • Green JP, Wojno TH, Wilson MW, Grossniklaus HE (1995) Bone formation in hydroxyapatite orbital implants. Am J Ophthalmol 120: 681–682

    PubMed  CAS  Google Scholar 

  • Gross ND, Wilson DJ, Dailey RA, Beckstead JH, Braziel RM (1998) Nodular sclerosing Hodgkin disease with primary manifestations in the orbit. Ophthal Plast Reconstr Surg 14:169–173

    Article  PubMed  CAS  Google Scholar 

  • Grossniklaus HE, Abbuhl MF, McLean IW (1990) Immunohistologic properties of benign and malignant mixed tumor of the lacrimal gland. Am J Ophthalmol 110:540–549

    PubMed  CAS  Google Scholar 

  • Haik BG, Karcioglu ZA, Gordon RA, Pechous BP (1994) Capillary hemangioma (infantile periocular hemangioma). Surv Ophthalmol 38:399–426

    Article  PubMed  CAS  Google Scholar 

  • Harman LE, Margo CE (1998) Wegener’s granulomatosis. Sury Ophthalmol 42:458–480

    Article  CAS  Google Scholar 

  • Harper L, Savage CO (2000) Pathogenesis of ANCA-associated systemic vasculitis. J Pathol 190:349–359

    Article  PubMed  CAS  Google Scholar 

  • Hartstein ME, Grove AS, Woog JJ, Shore JW, Joseph MP (1998) The multidisciplinary management of psammomatoid ossifying fibroma of the orbit. Ophthalmology 105:591–595

    Article  PubMed  CAS  Google Scholar 

  • Hartwick RWJ, Shaw PA, Srigley JR, Hurwitz JJ (1990) In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Can J Ophthalmol 25:213–217

    PubMed  CAS  Google Scholar 

  • Hatsukawa Y, Furukawa A, Kawamura H, Sugimoto S, Mushiake S, Morimoto K (1997) Rhabdomyoma of the orbit in a child. Am J Ophthalmol 123:142–144

    PubMed  CAS  Google Scholar 

  • Hausamen J-E, Stolke D, Trowibzsch E (1988) Diagnostic and therapeutic problems with an unusual congenital cystic hygroma of the orbit. J Craniomaxillofac Surg 16:89–92

    Article  PubMed  CAS  Google Scholar 

  • Holds JB, Anderson RL, Mamalis N, Kincaid MC, Font RL (1993) Invasive squamous cell carcinoma arising from asymptomatic choristomatous cysts of the orbit. Ophthalmology 100:1244–1252

    PubMed  CAS  Google Scholar 

  • Hornblass A, Jakobiec FA, Reifler DM, Mines J (1987) Orbital lymphoid tumours located predominantly within extraocular muscles. Ophthalmology 94:688–697

    PubMed  CAS  Google Scholar 

  • Howard GR, Nerad JA, Bonavolonta G, Tranfa F (1994) Orbital dermoid cysts located within the lateral rectus muscle. Ophthalmology 101:767–771

    PubMed  CAS  Google Scholar 

  • Hufnagel TJ, Hickey WF, Cobbs WH, Jakobiec FA, Iwamato T, Eagle RC (1984) Immunohistochemical and ultrastructural studies on the exenterated orbital tissues of a patient with Graves disease. Ophthalmology 91:1411–1419

    PubMed  CAS  Google Scholar 

  • Iwamoto T, Jakobiec FA (1982) A comparative ultrastructural study of the normal lacrimal gland and its epithelial tumors. Hum Pathol 13:236–262

    Article  PubMed  CAS  Google Scholar 

  • Jakobiec FA, Rini F, Char D (1989) Primary liposarcoma of the orbit. Problems in the diagnosis and management of five cases. Ophthalmology 96:180–191

    PubMed  CAS  Google Scholar 

  • Jensen OA, Bretlau P (1990) Melanotic schwannoma of the orbit. Immunohistochemical and ultrastructural study of a case and survey of the literature. APMIS 98:713–723

    Article  PubMed  CAS  Google Scholar 

  • Johnson TE, Bergin DJ, McCord CD (1988) Aneurysmal bone cyst of the orbit. Ophthalmology 95:86–89

    PubMed  CAS  Google Scholar 

  • Jordan DR, Addison DJ (1994) Wegener’s granulomatosis. Eyelid and conjunctival manifestations as the presenting feature in two individuals. Ophthalmology 101:602–607

    PubMed  CAS  Google Scholar 

  • Jordan DR, MacDonald H, Noel L, Carpenter B, Brownstein S, Munro S (1995) Alveolar soft-part sarcoma of the orbit. Ophthalmic Surg 26:269–270

    PubMed  CAS  Google Scholar 

  • Jordan DR, Brownstein S, Jolly SS (1996) Abscessed hydroxyapatite orbital implants. A report of two cases. Ophthalmology 103:1784–1787

    PubMed  CAS  Google Scholar 

  • Kalina PH, Lie JT, Campbell RJ, Garrity JA (1992) Diagnostic value and limitations of orbital biopsy in Wegener’s granulomatosis. Ophthalmology 99:120–124

    PubMed  CAS  Google Scholar 

  • Katz SE, Rootman J, Dolman PJ, White VA, Berean KW (1996) Primary ductal adenocarcinoma of the lacrimal gland. Ophthalmology 103:157–162

    PubMed  CAS  Google Scholar 

  • Katz SE, Rootman J, Vangveeravong S, Graeb D (1998) Combined venous lymphatic malformations of the orbit (so called lymphangiomas). Ophthalmology 105:176–184

    Article  PubMed  CAS  Google Scholar 

  • Kazim M, Kennerdell JS, Maroon J, Rothfus W, Marquardt M (1992a) Choristoma of the optic nerve and chasm. Arch Ophthalmol 110: 236–238

    Article  PubMed  CAS  Google Scholar 

  • Kazim M, Kennerdell JS, Rothfus W, Marquardt M (1992b) Orbital lymphangioma. Correlation of magnetic resonance images and intraoperative findings. Ophthalmology 99:1588–1594

    PubMed  CAS  Google Scholar 

  • Kelly SP, Lloyd IC, Anderson H, Joyce PW, Pacebalzan A (1991) Solitary extra-medullary plasmacytoma of the maxillary antrum and orbit presenting as acute bacterial orbital cellulitis. Br J Ophthalmol 75:438–439

    Article  PubMed  CAS  Google Scholar 

  • Kennedy SM, Pitts JF, Lee WR, Gibbons DC (1992) Bilateral Kimura’s disease of the eyelids. Br J Ophthalmol 76:755–757

    Article  PubMed  CAS  Google Scholar 

  • Kennerdell JS, Maroon JC, Garrity JA, Abla AA (1986) Surgical management of orbital lymphangioma with the carbon dioxide laser. Am J Ophthalmol 102:308–314

    PubMed  CAS  Google Scholar 

  • Klapper SR, Lee AG, Patrinely JR, Stewart M, Alford EL (1997) Orbital involvement in allergic fungal sinusitis. Ophthalmology 104:2094–2100

    PubMed  CAS  Google Scholar 

  • Kodsi SR, Shetlar DJ, Campbell RJ, Garrity JA, Bartley GB (1994) A review of 340 orbital tumours in children during a 60-year period. Am J Ophthalmol 117:177–182

    PubMed  CAS  Google Scholar 

  • Kopstein AB, Kristopaitis T, Gujrati TM, Blake KSA, Bouchard CS (1999) Orbital granulomatosis without systemic findings. Ophthal Plast Reconstr Surg 15:467–469

    Article  PubMed  CAS  Google Scholar 

  • Kramer TR, Noecker RJ, Miller JM, Clark LC (1997) Langerhans cell his-tiocytosis with orbital involvement. Am J Ophthalmol 124:814–824

    PubMed  CAS  Google Scholar 

  • Lacey B, Chang W, Rootman J (1999) Nonthyroid causes of extraocular muscle disease. Sury Ophthalmol 44:187–213

    Article  CAS  Google Scholar 

  • Lam DSC, Ng JSK, To KA F, Abdullah V, Liew CT, Tso MOM (1997) Cystic schwannoma of the orbit. Eye 11:798–800

    Article  PubMed  Google Scholar 

  • Lam DS, Li CK, Cheng LL, Teo JGC et al. (1999) Primary orbital Ewing’s sarcoma: report of a case and review of the literature. Eye 13:38–42

    Article  PubMed  Google Scholar 

  • Lane CM, Wright JE, Garner A (1988) Primary myxoid liposarcoma of the orbit. Br J Ophthalmol 72:912–917

    Article  PubMed  CAS  Google Scholar 

  • Lanuza A, Lazaro R, Salvador M, Solanes C, Ramos F, Sorli E (1998) Solitary fibrous tumour of the orbit. Report of a new case. Int Ophthalmol 22:265–268

    Article  PubMed  CAS  Google Scholar 

  • Laucirica M, Font RL (1996) Cytologic evaluation of lymphoproliferative lesions of the orbital adnexa: an analysis of 46 cases. Diagn Cytopathol 15:241–245

    Article  PubMed  CAS  Google Scholar 

  • Lee WR, McGhee CNJ (1989) Pseudotumours in the orbit. In: Anthony PP, MacSween RNM (eds) Recent Advances in Pathology. Churchill Livingstone, Edinburgh, pp 123–137

    Google Scholar 

  • Leidenix MJ, Mamalis N, Olsen RJ, McLeish WM, Anderson RL (1993) Primary T-cell immunoblastic lymphoma of the orbit in a paediatric patient. Ophthalmology 100:998–1002

    PubMed  CAS  Google Scholar 

  • Leone CR, Lawton AW, Leone RT (1988) Benign osteoblastoma of the orbit. Ophthalmology 95:1554–1558

    PubMed  Google Scholar 

  • Lerner SF, Morales AG, Croxatto JO (1991) Hydatid cyst of the orbit. Arch Ophthalmol 109:285

    Article  PubMed  CAS  Google Scholar 

  • Leventer DB, Merriam JC, Defendi R, Behrens MM et al. (1994) Enterogenous cyst of the orbital apex and superior orbital fissure. Ophthalmology 101:1614–1621.

    PubMed  CAS  Google Scholar 

  • Levin LA, Avery R, Shore JW, Woog JJ, Baker AS (1996) The spectrum of orbital aspergillosis: a clinicopathological review. Sury Ophthalmol 41:142–154

    Article  CAS  Google Scholar 

  • Levine MR, Chu A, Abdul-Karim FW (1991) Brown tumours and secondary hyperparathyroidism. Arch Ophthalmol 109:847–849

    Article  PubMed  CAS  Google Scholar 

  • Lindquist TD, Orcutt JC, Gown AM (1988) Monoclonal antibodies to intermediate filament proteins: diagnostic specificity in orbital pathology. Sury Ophthalmol 32:421–426

    Article  CAS  Google Scholar 

  • Llanes F, Sanz Ortega J, Suarez B, Sanz Esponera J (1997) Triton tumor of the parotid area. Case report. Histol Histopathol 12:51–56

    PubMed  CAS  Google Scholar 

  • Lucas DR, Knox F, Davies S (1982) Apparent monoclonal origin of lymphocytes and plasma cells infiltrating ocular adnexal amyloid deposits: report of two cases. Br J Ophthalmol 66:600–606

    Article  PubMed  CAS  Google Scholar 

  • Lucas DR, Campbell RJ, Fletcher CDM, Garrity JA, Nascimento AG, McCartney ACE (1995) Solitary fibrous tumour of the orbit. Int J Surg Pathol. 2:193–198

    Article  Google Scholar 

  • Lyon DB, Tang TT, Kidder TM (1992) Epithelioid hemangioendothelioma of the orbital bones. Ophthalmology 99:1773–1778

    PubMed  CAS  Google Scholar 

  • Lyons CJ, McNab AA, Garner A, Wright JE (1989) Orbital peripheral nerve sheath tumours. Br J Ophthalmol 73: 731–738

    Article  PubMed  CAS  Google Scholar 

  • McElvanny AM, Noble JL, Odonovan DG, Bonshek RE, Banerjee SS (1966) Solitary fibrous tumour: an atypical presentation within the orbit. Eye 10:396–399

    Article  Google Scholar 

  • McNab AA (1998) Orbital osteoma in Gardner’s syndrome. Aust N Z J Ophthalmol 26:169–170

    Article  PubMed  CAS  Google Scholar 

  • McNab AA, Mosely I (1990) Primary orbital liposarcoma: clinical and computed tomographic features. Br J Ophthalmol 74:437–439

    Article  PubMed  CAS  Google Scholar 

  • Malone M (1991) The histiocytosis of childhood. Histopathology 19:105–119

    Article  PubMed  CAS  Google Scholar 

  • Mamalis N, Garland PE, Argyle JC, Apple DJ (1985) Congenital orbital teratoma: a review and report of two cases. Sury Ophthalmol 30:41–46

    Article  CAS  Google Scholar 

  • Mamalis N, Grey AM, Good JS, McLeish WM, Anderson RL (1994) Embryonal rhabdomyosarcoma of the orbit in a 35-year-old man. Ophthalmic Surg 25:332–335

    PubMed  CAS  Google Scholar 

  • Mansour AM, Barber JC, Reinecke RD, Wang FM (1989) Ocular choristomas. Sury Ophthalmol 33:339–358

    Article  CAS  Google Scholar 

  • Mansour AM, Salti H, Uwaydat S, Dakroub R, Bashshour Z (1999) Ethmoid sinus osteoma presenting as epiphora and orbital cellulitis. Surv Ophthalmol 43:413–426

    Article  PubMed  CAS  Google Scholar 

  • Margo CE, Levy MH, Beck RW (1989) Bilateral idiopathic inflammation of the optic nerve sheaths. Light and electron microscopic findings. Ophthalmology 96:200–206

    PubMed  CAS  Google Scholar 

  • Marquardt MD, Zimmerman LE (1982) Histopathology of meningiomas and gliomas of the optic nerve. Hum Pathol 13:226–235

    Article  PubMed  CAS  Google Scholar 

  • Massry GG, Harrison W, Hornblass A (1996) Clinical and computed characteristics of amyloid tumours of the lacrimal gland. Ophthalmology 103:1233–1236

    PubMed  CAS  Google Scholar 

  • Mauriello JA Flanagan JC (1989) Pseudotumour and lymphoid tumour: distinct clinicopathologic entities. Sury Ophthalmol 34:142–148

    Article  Google Scholar 

  • Meekins BB, Dutton JJ, Proia AD (1988) Primary orbital leiomyosarcoma. A case report and review of the literature. Arch Ophthalmol 106:82–86

    Article  PubMed  CAS  Google Scholar 

  • Menon GK, Hollman AS, Dutton GN (2000) Granulomatous orbital myositis. Eye 14:676–678

    Article  PubMed  Google Scholar 

  • Menon J, Brosnahan DM, Jellinek DA (1999) Aneurysmal bone cyst of the orbit: a case report and review of the literature. Eye 13:764–768

    Article  PubMed  Google Scholar 

  • Mentzel T, Calonje E, Fletcher CDM (1994) Leiomyosarcoma with prominent osteoclast-like giant cells. Am J Surg Pathol 18:258–265

    Article  PubMed  CAS  Google Scholar 

  • Mercado GV, Shields CL, Gunduz K, Shields JA, Eagle RC (1999) Giant cell reparative granuloma of the orbit. Am J Ophthalmol 127:485–487

    Article  PubMed  CAS  Google Scholar 

  • Meyer DR, Wobig JL (1992) Bilateral localized orbital neurofibromas. Ophthalmology 99:1313–1317

    PubMed  CAS  Google Scholar 

  • Miettinen M (1987) Melanotic schwannoma coexpression of vimentin and glial fibrillary acidic protein. Ultrastruct Pathol 11:39–46

    Article  PubMed  CAS  Google Scholar 

  • Milne HL, Leone CR, Kincaid MC, Brennan MW (1987) Chronic haematic cyst of the orbit. Ophthalmology 94:271–277

    PubMed  Google Scholar 

  • Minehan KJ, Martenson JA, Garrity JA et al. (1991) Local control and complications after radiation therapy for primary orbital lymphoma: a case for low dose treatment. Int J Radiat Oncol Biol Phys 20:791–796

    Article  PubMed  CAS  Google Scholar 

  • Mombaerts I, Goldschmeding R, Schlingemann RO, Koorneef L (1996a) What is orbital pseudotumour? Surv Ophthalmol 41:66–78

    Article  PubMed  CAS  Google Scholar 

  • Mombaerts I, Schlingemann RO, Goldschmeding R, Koorneef L (1996b) Idiopathic granulomatous orbital inflammation. Ophthalmology 103:2135–2141

    PubMed  CAS  Google Scholar 

  • Murdoch IE, Sullivan TJ, Mosely I, Hawkins PN et al. (1996) Primary localised amyloidosis of the orbit. Br J Ophthalmol 80:1083–1086

    Article  PubMed  CAS  Google Scholar 

  • Newman NJ, Slamovits TL, Friedland S, Wilson B (1995) Neuroophthalmic manifestations of meningocerebral inflammation from the limited form of Wegener’s granulomatosis. Am J Ophthalmol 120:613–621

    PubMed  CAS  Google Scholar 

  • Niffenegger JH, Jakobiec FA, Shore JW, Albert DM (1992) Adult extrarenal rhabdoid tumour of the lacrimal gland. Ophthalmology 99:567–574

    PubMed  CAS  Google Scholar 

  • Obata H, Yamamoto S, Horiuchi H, Machinami R (1995) Histopathologic study of human lacrimal gland. Ophthalmology 102:678–686

    PubMed  CAS  Google Scholar 

  • Orcutt JC, Char DH (1988) Melanoma metastatic to orbit. Ophthalmology 95:1033–1037

    PubMed  CAS  Google Scholar 

  • Ormerod DL, Weber AL, Rauch SD, Feldon SE (1987) Ophthalmic manifestations of maxillary sinus mucocoeles. Ophthalmology 94:1013–1019

    PubMed  CAS  Google Scholar 

  • Ostrowski ML, Font RL, Halpern J, Nicolotz E, Barnes R (1994) Clear cell epithelial myoepithelial carcinoma arising in pleomorphic adenoma of the lacrimal gland. Ophthalmology 101:925–930

    PubMed  CAS  Google Scholar 

  • Pappa A, Jackson P, Stone J, Munro P et al. (1998) An ultrastructural and systemic analysis of glycosaminoglycans in thyroid associated ophthalmopathy. Eye 12:237–244

    Article  PubMed  Google Scholar 

  • Pappa A, Lawson JMM, Calder V, Fells P, Lightman S (2000) T cells and fibroblasts in affected muscles in early and late thyroid associated ophthalmopathy. Br J Ophthalmol 84:517–522

    Article  PubMed  CAS  Google Scholar 

  • Patel AS, Kelman SE, Duncan GW, Rismondo V (1994) Painless diplopia caused by extraocular muscle sarcoid. Arch Ophthalmol 112:879–880

    Article  PubMed  CAS  Google Scholar 

  • Paulino AC, Simon JH, Zhen W, Wen BC (2000) Long-term effects in children treated with radiotherapy for head and neck rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 48:1489–1495

    Article  PubMed  CAS  Google Scholar 

  • Pecorella I, Ciardi A, Amadeo G, Baiocchini A, Marasco A, Di Tondo U (2000) Orbital osteoclastoma of apparent extraskeletal origin in a Pagetic patient: a case report. Hum Pathol 31:1527–1531

    Article  PubMed  CAS  Google Scholar 

  • Pepose JS, Akata RF, Pflugfelder SC, Voigt W (1990) Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjogren’s syndrome. Ophthalmology 97:1599–1605

    PubMed  CAS  Google Scholar 

  • Perry SR, Rootman J, White VA (1997) The clinical and pathological constellation of Wegener granulomatosis of the orbit. Ophthalmology 104:683–694

    PubMed  CAS  Google Scholar 

  • Piacentini M, Mauriello JA, Pokorny K, Mostafavi R, Yepez MC (1998) The role of proliferating cell nuclear antigen (PCNA) in predicting biologic behavior of lymphoid infiltrates of the orbit and ocular adnexa. Ophthal Plast Reconstr Surg 14:164–168

    Article  PubMed  CAS  Google Scholar 

  • Power WJ, Rodrigues A, Neves RA, Lane L, Foster S (1995) Disease relapses inpatients with ocular manifestations of Wegener’s granulomatosis. Ophthalmology 102:154–160

    PubMed  CAS  Google Scholar 

  • Rakes SM, Yeatts RP, Campbell RJ (1985) Ophthalmic manifestations of esthesio-neuroblastoma. Ophthalmology 92:1749–1753

    PubMed  CAS  Google Scholar 

  • Rao JK, Weinberger M, Oddone EZ, Allen NB, Landsman P, Feussner JR (1995) The role of antineutrophil cytoplasmic antibody (c-ANCA) testing in the diagnosis of Wegener granulomatosis. A literature review and meta-analysis. Ann Intern Med 123:925–932

    PubMed  CAS  Google Scholar 

  • Rappaport K, Liesegang TJ, Menke DH, Czervionke LF (1996) Plasmacytoma manifesting as recurrent cellulitis and haematic cyst of the orbit. Am J Ophthalmol 122:595–597

    PubMed  CAS  Google Scholar 

  • Reifler DM, Leder D, Rexford T (1989) Orbital haemorrhage and eyelid ecchymosis in acute orbital myositis. Am J Ophthalmol 107:111–113

    PubMed  CAS  Google Scholar 

  • Reifler DM, Warzynski MJ, Blount WR, Graham DM, Mills KA (1994) Orbital lymphoma associated with acquired immune deficiency syndrome. Sury Ophthalmol 38:371–380

    Article  CAS  Google Scholar 

  • Riddle PJ, Font RL, Zimmerman LE (1982) Carcinoid tumors of the eye and orbit: a clinicopathologic study of 15 cases with histochemical and electron microscopic studies. Hum Pathol 13:459–469

    Article  PubMed  CAS  Google Scholar 

  • Rizzo JF, Lessell S (1994) Choroidal infarction after optic nerve sheath fenestration. Ophthalmology 101:1622–1626

    PubMed  Google Scholar 

  • Roh S, Mawn L, Hedges TR (1997) Juvenile pilocytic astrocytoma masquerading as amblyopia. Am J Ophthalmol 123:692–694

    PubMed  CAS  Google Scholar 

  • Rootman J (1998) Why”orbital pseudotumour” is no longer a useful concept. Br J Ophthalmol 82:339–340

    Article  PubMed  CAS  Google Scholar 

  • Rootman J, Daniji KF, Dimmick JE (1989) Malignant rhabdoid tumour of the orbit. Ophthalmology 96:1650

    PubMed  CAS  Google Scholar 

  • Rootman J, McCarthy M, White V, Harris G, Kennerdell J (1994) Idiopathic sclerosing inflammation of the orbit. A distinct clinicopathologic entity. Ophthalmology 101:570–584

    PubMed  CAS  Google Scholar 

  • Rosen CE, Raikow RB, Burde RM, Kennerdell JS, Mosseri M, Scaline D (1992) Immunohistochemical evidence for IgA1 involvement in Graves ophthalmopathy. Ophthalmology 99:146–152

    PubMed  CAS  Google Scholar 

  • Rubinfeld RS, Gootenberg JE, Chavis RM, Zimmerman LE (1988) Early onset acute orbital involvement in childhood acute lymphoblastic leukaemia. Ophthalmology 95:116–120

    PubMed  CAS  Google Scholar 

  • Sadun F, Hinton DR, Sadun AA (1996) Rapid growth of an optic nerve ganglioglioma in a patient with neurofibromatosis 1. Ophthalmology 103:794–799

    PubMed  CAS  Google Scholar 

  • Sakamoto T, Ishibashi T, Ohnishi Y, Inomata H (1991) Immunohistological and electron microscopical study of nodular fasciitis of the orbit. Br J Ophthalmol 75:636–638

    Article  PubMed  CAS  Google Scholar 

  • Sandgren O (1995) Ocular amyloidosis, with special reference to the hereditary forms with vitreous involvement. Sury Ophthalmol 40:173–196

    Article  CAS  Google Scholar 

  • Sandy CJ, Rose GE, Clark BJ, Plowman PN (2001) Sporadic Burkitt’s lymphoma presenting as solely orbital disease in a 78 year old. Eye 15:113–115

    Article  PubMed  CAS  Google Scholar 

  • Satorre J, Antle CM, O’Sullivan R, White VA et al. (1991) Orbital lesions with granulomatous inflammation. Can J Ophthalmol 26:174–195

    PubMed  CAS  Google Scholar 

  • Scott IU, Tanenbaum M, Rubin D, Lores E (1996) Solitary fibrous tumor of the lacrimal gland fossa. Ophthalmology 103:1613–1618

    PubMed  CAS  Google Scholar 

  • Segal EI, Tang RA, Lee AG, Roberts DL. Campbell GA (2000) Orbital apex lesion as the presenting manifestation of sarcoidosis. J Neuroophthalmol 20:156–158

    Article  PubMed  CAS  Google Scholar 

  • Sekundo W, Roggenkamper P, Tschubel K, Fischer H-P (1996) Hemangiopericytoma of the inner canthus. Am J Ophthalmol 121:445–447

    PubMed  CAS  Google Scholar 

  • Shapiro AM, Tso MOM, Putterman AM, Goldberg MF (1986) A clinicopathologic study of hematic cysts of the orbit. Am J Ophthalmol 102:237–241.

    Article  PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, Buchanan HW (1990) Solitary orbital involvement with the juvenile xanthogranuloma. Arch Ophthalmol 108: 1587–1589

    Article  PubMed  CAS  Google Scholar 

  • Shields JA, Shields CL (1993) Rhabdomyosarcoma of the orbit. Int Ophthalmol Clin 33:203–210

    Article  PubMed  CAS  Google Scholar 

  • Shields JA, Karcioglu ZA, Shields CL, Eagle RC, Wong S (1991) Orbital and eyelid involvement with Erdheim-Chester disease. Arch Ophthalmol 109:850–854

    Article  PubMed  CAS  Google Scholar 

  • Shields JA, Husson M, Shields CL, Krema H, Eagle RC, Singh AD (2001) Orbital malignant fibrous histiocytoma following irradiation for retinoblastoma. Ophthal Plast Reconstr Surg 17:58–61

    Article  PubMed  CAS  Google Scholar 

  • Smith DL, Kincaid MC, Nicolitz E (1988) Angiolymphoid hyperplasia with eosinophilia (Kimura’s disease) of the orbit. Arch Ophthalmol 106:793–795

    Article  PubMed  CAS  Google Scholar 

  • Soukiasian SH, Foster CS, Niles JL, Raizman MB (1992) Diagnostic value of anti-neutrophil cytoplasmic antibodies in scleritis associated with Wegener’s granulomatosis. Ophthalmology 99:125–132

    PubMed  CAS  Google Scholar 

  • Stockl FA, Dolmetsch AM, Saornil MA, Font RL, Burnier MN (1997) Orbital granulocytic sarcoma. Br J Ophthalmol 81:1084–1088

    Article  PubMed  CAS  Google Scholar 

  • Tsai JC, Petrovich MS, Sadun AA (1995) Histopathological and ultrastructural examination of optic nerve sheath decompression. Br J Ophthalmol 79:182–185

    Article  PubMed  CAS  Google Scholar 

  • Tsubota K, Fujita H, Tsuzaka K, Takeuchi T (2000) Mikulicz’s disease and Sjogren’s syndrome. Invest Ophthalmol Vis Sci 41:1666–1673

    PubMed  CAS  Google Scholar 

  • Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M (1987) The existence of rhabdoid cells in specified soft tissue sarcomas: histopathological, ultrastructural and immunohistochemical evidence. Virchows Arch (A) 411:509–514

    Article  CAS  Google Scholar 

  • Tunc M, Sadri E, Char DH (1999) Orbital lymphangiomas: an analysis of 26 patients. Br J Ophthalmol 83:76–80

    Article  PubMed  CAS  Google Scholar 

  • Tung G, Finger PT, Klein I, Chess Q (1988) Plasmacytoma of the orbit. Arch Ophthalmol 106:1622

    Article  PubMed  CAS  Google Scholar 

  • Vangveeravong S, Katz SE, Rootman J, White V (1996) Tumors arising in the palpebral lobe of the lacrimal gland. Ophthalmology 103: 1606–1612

    PubMed  CAS  Google Scholar 

  • Westra WH, Gerald WL, Rosai J (1994) Solitary fibrous tumour: consistent CD34 immunoreactivity and occurrence in the orbit. Am J Surg Pathol 18:992–998

    Article  PubMed  CAS  Google Scholar 

  • White VA, Heathcote JG, Hurvitz JJ, Freeman JL, Rootman J (1994) Epithelioid sarcoma of the orbit. Ophthalmology 101:1680–1687

    PubMed  CAS  Google Scholar 

  • Whitson WE, Orcott JC, Walkenshaw MD (1986) Orbital osteoma in Gardner’s syndrome. Am J Ophthalmol 101:236–241

    PubMed  CAS  Google Scholar 

  • Wilkins SR, Hofmann RJ, Byrd WA, Font RL (1987) Hetertopic brain tissue in the orbit. Arch Ophthalmol 105:390–392

    Article  PubMed  CAS  Google Scholar 

  • Woodruff G, Thorner P, Skarf B (1988) Primary Ewing’s sarcoma of the orbit presenting with visual loss. Br J Ophthalmol 72:786–792

    Article  PubMed  CAS  Google Scholar 

  • Yaghouti F, Nouri M, Mannor GE (1999) Ocular adnexal granulocytic sarcoma as the first sign of acute myelogenous leukaemia relapse. Am J Ophthalmol 127:361–363

    Article  PubMed  CAS  Google Scholar 

  • Yamaguchi A, Mochizuki M, Watanabe T, Yoshimura K et al. (1994) Human T lymphotropic virus type 1 uveitis after Graves disease. Br J Ophthalmol 78:163–166

    Article  PubMed  CAS  Google Scholar 

  • Yohai RA, Bullock JD, Aziz AA, Markert RJ (1994) Survival factors in rhino-orbital-cerebral mucormycosis. Sury Ophthalmol 39:3–22

    Article  CAS  Google Scholar 

  • Zucker JL, Doyle MF (1991) Mycosis fungoides metastatic to the orbit. Arch Ophthalmol 109:688–691

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pathology, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, UK

    William R. Lee (Honorary Senior Research Fellow)

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Lee, W.R. (2002). The Orbit: Biopsy, Excision Biopsy and Exenteration Specimens. In: Ophthalmic Histopathology. Springer, London. https://doi.org/10.1007/978-1-4471-3910-2_12

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