Abstract
Hypertensive subjects are at increased risk for coronary heart disease (CHD). Although this may be due to the consequences of an elevated blood pressure per se, it is well known that hypertension frequently is associated with other CHD risk factors that may contribute as well. Kjeldsen et al. observed that blood platelets from subjects with high blood pressure possessed hypersensitivity to adrenaline, and suggested that enhanced platelet activation in essential hypertension was related to raised sympathetic adrenergic tone.1
Supported by the Norwegian Council on Cardiovascular Diseases, the Norwegian Fishermen Sales Organization, and Norsk Hydro.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Kjeldsen S.E., Gjesdal K., Eide I., Aakeson I., Amundsen R., Foss O.P., Leren P.: Increased betathromboglobulin in essential hypertension: interactions between arterial plasma adrenaline, platelet function and blood lipids. Acta Med. Scand. 1983; 213: 369–373
Bonaa K.H., Thelle D.: Association between blood pressure and serum lipids in a population. The Tromso Study. Circulation 1991; 83: 1305–1314.
Bravo E.L.: Metabolic factors and the sympathetic nervous system. Am. J. Hypertens. 1989; 2: 339S - 344S
Reaven G.M., Hoffman B.B.: Hypertension as a disease of carbohydrate and lipoprotein metabolism. Am. J. Med. 1989; 87 (suppl 6A): 2S - 6S
Löscher T.F.: Functional abnormalities of the vascular endothelium in hypertension and atherosclerosis. Scand. J. Clin. Lab. Invest. Suppl. 1990; 50: 28–32
Mann K.G.: Factor VII assays, plasma triglyceride levels, and cardiovascular disease risk. Arteriosclerosis 1989; 9: 783–4
Leaf A., Weber P.C.: Cardiovascular effects of n-3 fatty acids. N. Engl. J. Med. 1988; 318: 549–57
Radack K., Deck C.: The effects of omega-3 polyunsaturated fatty acids on blood pressure: a methodologic analysis of the evidence. J. Am. Coll. Nutr. 1989; 8: 376–85
Norris P.G., Jones C.H.J., Weston M.J.: Effect of dietary supplementation with fish oil on systolic blood pressure in hypertension. Br. Med. J. 1986; 293: 104–5
Knapp H.R., FitzGerald G.A.: The antihypertensive effects of fish oil. A controlled study of poyunsaturated fatty acid supplementation in essential hypertension. N. Engl. J. Med. 1989; 320: 1037–43
Bonaa K.H., Bjerve K.S., Straume B., Gram I.T., Thelle D.: Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromso Study. N. Engl. J. Med. 1990; 322: 795–801
Levinson P.D., Iosiphidis A.H., Saritelli A.L., Herbert P.N., Steiner M.: Effects of n-3 fatty acids in hypertension. Am. J. Hypertens. 1990; 3: 754–60
Radack K., Deck C., Husten G.: The effects of low doses of n-3 fatty acid supplementation on blood pressure in hypertensive subjects. A randomized controlled trial. Arch. Intern. Med. 1991; 151: 1173–80
Meland E., Fugelli P., Latium E., Ronneberg R., Sandvik L.: Effect of fish oil on blood pressure and blood lipids in men with mild to moderate hypertension. Scand. J. Prim. Health Care 1989; 7: 131–5
Dalaker K., Janson T.L., Johnsen B., Skartlien A.H., Prydz H.: A simple method for determination of the factor VII phospholipid complex using Normotest. Thromb. Res. 1987; 47: 87–93
Collins R., Peto R., MacMahon S., Hebert P., Fiebach N.H., Eberlein K.A., Godwin J, Qizilbash N, Taylor JO, Hennekens CH.: Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomized drug trials in their epidemiological context. Lancet 1990; 335: 827–38
Dolecek T.A., Grandits G.: Dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial (MRFIT). In: Simopoulos A.P., Kifer R.R., Martin R.E., Barlow S.M. (Eds): Health effects of omega-3 polyunsaturated fatty acids in seafoods. World Rev. Nutr. Diet. Basel: Karger, 1991; 66: 205–16
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag London
About this paper
Cite this paper
Bønaa, K.H. (1992). n-3 Fatty Acids in Hypertension. In: De Caterina, R., Kristensen, S.D., Schmidt, E.B. (eds) Fish Oil and Vascular Disease. Current Topics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-3890-7_16
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3890-7_16
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3892-1
Online ISBN: 978-1-4471-3890-7
eBook Packages: Springer Book Archive