Abstract
In early animal experiments, zinc was shown to have a low order of toxicity. At least some of the results arose from the use of diets containing natural ingredients (sources of phytate and fibre) and high levels of essential nutrients capable of interacting with zinc. In humans, zinc toxicity involved infrequent acute poisoning episodes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brown MA, Thom JV, Orth GL, Cova P, Juarez J (1964) Food poisoning involving zinc contamination. Arch Environ Health 8: 657–660
Burke DM, DeMicco FJ, Taper LJ, Ritchey SJ (1981) Copper and zinc utilization in elderly adults. J Gerontol 36: 558–563
Chandra RK (1984) Excess intake of zinc impairs immune responses. J Am Med Ass 252: 1443–1446
Cowan GAB (1947) Unusual case of poisoning by zinc sulphate. Br Med J I: 451–452
FAO/WHO Expert Committee on Food Additives (1982) Evaluation of certain food additives and contaminants. WHO Tech Rep Ser 683: 14–15, 32–33
Festa MD, Anderson HL, Dowdy RP, Ellersieck MR (1985) Effect of zinc intake on copper excretion and retention in men. Am J Clin Nutr 41: 285–292
Fischer PWF, Giroux A, L’Abbe MR (1984) Effect of zinc supplementation on copper status in adult man. Am J Clin Nutr 40: 743–746
Fox MRS, Jacobs RM (1986) Human nutrition and metal ion toxicity. In: Sigel H (ed) Metal ions in biological systems, vol 20, Concepts in metal ion toxicity. Marcel Dekker, New York Basle, pp 201–228
Freeland-Graves JH, Han W-H, Friedman BJ, Shorey RAL (1980) Effect of dietary Zn/Cu ratios on cholesterol and HDL-cholesterol levels in women. Nutr Rep Int 22: 285–293
Gallery EDM, Bloomfield J, Dixon SR (1972) Acute zinc toxicity in haemodialysis. Br Med J 4: 331–333
Hambidge KM, Walravens PA, Neldner KH, Daugherty NA (1978) Zinc, copper and fatty acids in acrodermatitis enteropathica. In: Kirchgessner M (ed) Trace element metabolism in man and animals, Tema-3. Institut für Ernährungsphysiologie Technische Universität München, Freising-Weihenstephan, pp 413–417
Hambidge KM, Casey CE, Krebs NF (1986) Zinc. In: Mertz W (ed) Trace elements in human and animal nutrition, vol 2. Academic Press, New York, pp 1–137
Hooper PL, Visconti L, Garry PJ, Johnson GE (1980) Zinc lowers high-density lipoprotein-cholesterol levels. J Am Med Ass 244: 1960–1961
Klevay LM (1984) The role of copper, zinc, and other chemical elements in ischemic heart disease. In: Rennert OW, Chan W-Y (eds) Metabolism of trace metals in man, vol 1. CRC Press, Boca Raton, pp 130–157
Kumar S (1976) Effect of zinc supplementation on rats during pregnancy. Nutr Rep Int 13: 33–36 Murphy JV (1970) Intoxication following ingestion of elemental zinc. J Am Med Ass 212: 2119–2120
National Research Council (1979) Zinc. University Park Press, Baltimore, pp 249–268
National Research Council (1980a) Mineral tolerance of domestic animals. National Academy of Sciences, Washington, pp 3–7, 553–577
National Research Council (1980b) Recommended dietary allowances. National Academy of Sciences, Washington
Patterson WP, Winkelmann M, Perry MC (1985) Zinc-induced copper deficiency: megamineral sideroblastic anemia. Ann Intern Med 103: 385–386
Petrie JJB, Row PG (1977) Dialysis anaemia caused by subacute zinc toxicity. Lancet I: 1178–1180 Porter KG, McMaster D, Elmes ME, Love AHG ( 1977 ) Anemia and low serum-copper during zinc therapy. Lancet II: 774
Prasad AS, Brewer GJ, Schoomaker EB, Rabbani P (1978) Hypocupremia induced by zinc therapy in adults. J Am Med Ass 240: 2166–2168
Sandstead HH (1982) Copper bioavailability and requirements. Am J Clin Nutr 35: 809–814 Spencer H, Kramer L, Norris C, Osis D (1982) Effect of the calcium intake on the inhibitory action of zinc on calcium absorption. Am J Clin Nutr 35: 816 (abstract)
Spencer H, Kramer L, Norris C, Osis D (1982) Effect of the calcium intake on the inhibitory action of zinc on calcium absorption. Am J Clin Nutr 35: 816 (abstract)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Fox, M.R.S. (1989). Zinc Excess. In: Mills, C.F. (eds) Zinc in Human Biology. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-3879-2_23
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3879-2_23
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3881-5
Online ISBN: 978-1-4471-3879-2
eBook Packages: Springer Book Archive