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Putative Therapeutic Roles for Zinc

  • Chapter
Zinc in Human Biology

Part of the book series: ILSI Human Nutrition Reviews ((ILSI HUMAN))

Abstract

The trace element, zinc, is both a nutrient and a drug. As a nutrient, its role in correcting zinc deficiency states is incontrovertible. That topic has been reviewed in Chaps. 17 and 18 of this volume. However, a variety of therapeutic roles for zinc, apart from those associated with the reversal of nutritional depletion or recovery from zinc-deficiency-related symptoms, have been suggested. This domain of zinc as a drug will be the focus of the present chapter.

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References

  • Abbasi AA, Prasad AS, Rabbani PR (1979) Experimental zinc deficiency in man. Effect on spermatogenesis. Trans Assoc Am Physicians 92: 292–302

    Google Scholar 

  • Abbasi AA, Prasad AS, Rabbani PR, DuMouchelle E (1980) Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med 96: 544–550

    Google Scholar 

  • Alcala-Santaella R, Castellanos D, Velo JL, Gonzalez-Lara V (1985) Zinc acexamate in treatment of duodenal ulcer. Lancet II: 157

    Google Scholar 

  • Alexiou D, Hatzis T, Koutselinis A (1985) Traitement d’entretien de la maladie de Wilson par le zinc per os. A propos d’un enfant traite pendant 4 ans. Arch Fr Pediatr 42: 447–449

    PubMed  CAS  Google Scholar 

  • Antoniou LD, Shalhoub RJ, Sudhakar T, Smith JC Jr (1977) Reversal of uraemic impotence by zinc. Lancet II: 895–898

    Google Scholar 

  • Barcia PJ (1970) Lack of acceleration of healing with zinc sulfate. Ann Surg 172: 1048–1050

    Article  PubMed  CAS  Google Scholar 

  • Bechetoille A, Ebran JM, Allain P, Mauras Y (1983) Effet therapeutique du sulfate de zinc sur le scotome central des neuropathies optiques alcoolo-tabagiques. J Fr Ophtalmol 6: 237–242

    PubMed  CAS  Google Scholar 

  • Berne B, Venge P, Ohman S (1985) Perifolliculitis capitis abscedens et suffodiens (Hoffman): complete healing associated with oral zinc therapy. Arch Dermatol 121: 1028–1030

    Article  PubMed  CAS  Google Scholar 

  • Bjorndahl L, Kjellberg S, Roomans GM, Kvist U (1986) The human sperm nucleus takes up zinc at ejaculation. Int J Androl 9: 77–80

    Article  PubMed  CAS  Google Scholar 

  • Brewer GJ (1980) Zinc and copper in hematology. In: Karcioglu ZA, Sarper RM (eds) Zinc and copper in medicine. Charles C. Thomas, Springfield, pp 347–375

    Google Scholar 

  • Brewer GJ, Bereza U (1982) Therapy of sickle cell anemia with membrane expander/calmodulin inhibitor classes of drugs. In: Prasad AS (ed) Clinical, biochemical and nutritional aspects of trace elements. Alan R. Liss, New York, pp 211–220

    Google Scholar 

  • Brewer GJ, Krukeberg WC (1979) The anticalcium and erythrocyte membrane effects of zinc, and their potential value in the treatment of sickle cell anemia. In: Rosa J. Beuzard Y, Hercules J (eds) Development of therapeutic agents for sickle cell disease. North Holland Biomedical Press, New York, p 195–204

    Google Scholar 

  • Brewer GJ, Brewer LF, Prasad AS (1977a) Suppression of irreversibly sickled erythrocytes by zinc therapy in sickle cell anemia. J Lab Clin Med 90: 549–554

    PubMed  CAS  Google Scholar 

  • Brewer GJ, Schoomaker EB, Leichtmen DA, Kruckeberg WC, Brewer LF, Meyers N (1977b) The use of pharmacological doses of zinc in the treatment of sickle cell anemia. In: Brewer GJ, Prasad AS (eds) Zinc metabolism; current aspects in health and disease. Alan R. Liss, New York, pp 241–254

    Google Scholar 

  • Brewer GJ, Hill GM, Prasad AS, Cossack ZT, Rabbani R (1983) Oral zinc therapy for Wilson’s disease. Ann Intern Med 99: 314–320

    PubMed  CAS  Google Scholar 

  • Brody I (1977) Treatment of recurrent furunculosis with oral zinc. Lancet II: 1358

    Google Scholar 

  • Burton JL, Goolamali SK (1973) Zinc and sebum excretion. Lancet I: 1448

    Google Scholar 

  • Caldamone AA, Freytag MK, Cockett ATK (1979) Seminal zinc and male infertility. Urology 13: 280–281

    Article  PubMed  CAS  Google Scholar 

  • Carruthers R (1969) Oral zinc sulphate in leg ulcers. Lancet I: 1264

    Google Scholar 

  • Chalmers TC (1981) The clinical trial. Milbank Mem Fund Q 59: 324–339

    Article  CAS  Google Scholar 

  • Clayton RJ (1972) Double-blind trial of oral zinc sulphate in patients with leg ulcers. Br J Clin Pract 26: 368–370

    PubMed  CAS  Google Scholar 

  • Cohen C (1968) Zinc sulphate and bed sores. Br Med J 2: 561

    Article  PubMed  CAS  Google Scholar 

  • Cunliffe WJ, Burke B, Dodman B, Gould DJ (1979) A double-blind trial of a zinc sulfate—citrate complex and tetracycline in the treatment of acne vulgaris. Br J Dermatol 101: 321–325

    Article  PubMed  CAS  Google Scholar 

  • DuVivier A, Munro DD (1975) Alopecia areata autoimmunity and Down’s syndrome. Br Med J 1: 191–192

    Article  CAS  Google Scholar 

  • Ead RD (1981) Oral zinc sulphate in alopecia areata — a double blind trial. Br J Dermatol 104: 483–484

    Article  PubMed  CAS  Google Scholar 

  • Eby GA, Davis DR, Halcomb WW (1984) Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 25: 20–24

    Article  PubMed  CAS  Google Scholar 

  • Emser W (1978a) Zink-Therapie beim Ehlers—Danlos—Syndrom. Mschr Kinderheilk 126: 347–348

    PubMed  CAS  Google Scholar 

  • Emser W (1978b) Fall eines Ehlers—Danlos—Syndrom und seine Behandlung mit Zink. Klin Padiatr 190: 397–402

    PubMed  CAS  Google Scholar 

  • Fair WR, Heston WDW (1977) The relationship of bacterial prostatitis and zinc. In: Brewer GJ, Prasad AS (eds) Zinc metabolism: current aspects in health and disease. Alan R. Liss, New York, pp 129–140

    Google Scholar 

  • Fair WR, Wehrer N (1973) The antibacterial action of canine prostatic fluid and human seminal plasma in an agar diffusion assay system. Invest Urol 10: 262–265

    PubMed  CAS  Google Scholar 

  • Fair WR, Couch J, Wehrer N (1973) The purification and assay of the prostatic antibacterial factor ( PAF ). Biochem Med 8: 329–339

    Google Scholar 

  • Fair WR, Couch J, Wehrer N (1976) The prostatic antibacterial factor: identity and significance. Urology 7: 169–177

    Article  PubMed  CAS  Google Scholar 

  • Fischer PW, Giroux A, L’Abbe MR (1981) The effect of zinc on intestinal copper absorption. Am J Clin Nutr 34: 1670–1675

    PubMed  CAS  Google Scholar 

  • Floersheim G, Lais E (1980) Fehlender Einfluss von oralem Zinksulfat auf die Wundheilung bei Ulcus cruris. Schweiz Med Wochenschr 110: 1138–1145

    PubMed  CAS  Google Scholar 

  • Fraser PM, Doll R, Langman MJS, Misiewicz JJ, Shawdon HH (1972) Clinical trial of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A in the treatment of gastric ulcer. Gut 13: 459–463

    Article  PubMed  CAS  Google Scholar 

  • Frommer D (1975) The healing of gastric ulcers by zinc sulphate. Med J Aust 2: 793–796

    PubMed  CAS  Google Scholar 

  • Goransson K, Liden S, Odsell L (1978) Oral zinc and acne vulgaris. A clinical and methodological study. Acta Derm Venereol (Stockh) 58: 443–448

    Google Scholar 

  • Gordon YJ, Asher Y, Becker Y (1975) Irreversible inhibition of Herpes simplex virus replication in BSC-1 cells by zinc ions. Antimicrob Agents Chemother 8: 377–380

    Article  PubMed  CAS  Google Scholar 

  • Greaves MW, Dawber R (1970) Zinc in psoriasis. Lancet I: 1295

    Google Scholar 

  • Greaves MW, Ive FA (1972a) Double-blind trial of zinc sulphate in the treatment of chronic venous leg ulceration. Br J Dermatol 87: 632–634

    Article  PubMed  CAS  Google Scholar 

  • Greaves MW, Ive FA (19726) Serum-zinc and healing of venous leg ulcers. Lancet I I: 1261

    Google Scholar 

  • Greaves MW, Skillen AW (1970) Effects of long-continued ingestion of zinc sulphate in patients with venous leg ulceration. Lancet II: 889–892

    Google Scholar 

  • Grennan DM, Knudson JML, Dunckley J, Mackinnon MJ, Myers DB, Palmer DG (1980) Serum copper and zinc in rheumatoid arthritis and osteoarthritis. NZ Med J 91: 47–50

    CAS  Google Scholar 

  • Haeger K, Lanner E (1974) Oral zinc sulphate and ischaemic leg ulcers. Vasa 3: 77–81

    PubMed  CAS  Google Scholar 

  • Hallbook T (1984) Zinc and wound healing. In: Zinc in human medicine. TIL Publications, Isleworth, Toronto, pp 51–59

    Google Scholar 

  • Hallbook T, Lanner E (1972) Serum zinc and healing of venous leg ulcers. Lancet II: 780–782

    Google Scholar 

  • Hartoma TR, Nahoul K, Netter A (1977) Zinc, plasma androgen and male sterility. Lancet II: 1125–1126

    Google Scholar 

  • Henkin R, Bradley D (1970) Hypogeusia corrected by Ni“ and Zn”. Life Sci 9: 701–709

    Article  CAS  Google Scholar 

  • Henkin R, Schecter PJ, Friedewald WT, Demets DL, Raff M (1976) A double blind study of the effects of zinc sulfate on taste and smell dysfunction. Am J Med Sci 272: 285–299

    Article  PubMed  CAS  Google Scholar 

  • Hill GM, Brewer GJ, Prasad AS, Hydrik CR, Hartmann DE (1987) Treatment of Wilson’s disease with zinc. I. Oral zinc therapy regimens. Hepatology 7: 522–528

    Google Scholar 

  • Hillstrom L, Pettersson L, Hellbe L, Kjellin A, Leczinsky C-G, Nordwall C (1977) Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris. Br J Dermatol 97: 681–684

    Article  PubMed  CAS  Google Scholar 

  • Hoogenraad T, Koevoet R, de Ruyter Korver E (1979) Oral zinc sulphate as long-term treatment in Wilson’s disease (hepatolenticular degeneration). Eur Neurol 18: 205–211

    Article  PubMed  CAS  Google Scholar 

  • Hoogenraad T, Sindram J (1982) Oral zinc in primary biliary cirrhosis. N Engl J Med 307: 122–123

    Article  PubMed  CAS  Google Scholar 

  • Hoogenraad T, Van den Hamer C, Koevoet R, de Ruyter Korver E (1978) Oral zinc in Wilson’s disease. Lancet II: 1262

    Google Scholar 

  • Hoogenraad T, Van den Hamer C, de Ruyter Korver E (1983) Three years of continuous oral zinc therapy in 4 patients with Wilson’s disease. Acta Neurol Scand 67: 356–364

    Article  PubMed  CAS  Google Scholar 

  • Hoogenraad T, Van den Hamer C, van Hattum J (1984) Effective treatment of Wilson’s disease with oral zinc sulphate: two case reports. Br Med J 289: 273–276

    Article  CAS  Google Scholar 

  • Husain SL (1969) Oral zinc sulphate in leg ulcers. Lancet I: 1069–1071

    Google Scholar 

  • Jablonska S, Wolowa F (1981) Zinc sulphate and alopecia totalis. Br J Dermatol 105: 485–488

    Article  Google Scholar 

  • James O, Macklon A, Watson A (1981) Primary biliary cirrhosis–a revised clinical spectrum. Lancet I: 1278–1281

    Google Scholar 

  • Job C, Menkes CJ, Delbarre F (1980) Zinc sulfate in the treatment of rheumatoid arthritis. Arthritis Rheum 23: 1408–1409

    Article  PubMed  CAS  Google Scholar 

  • Jones R (1979) Genital herpes and zinc. Med J Aust 1: 236

    Google Scholar 

  • Kennedy A, Bessent RG, Reynolds PM (1980) Effect of oral zinc sulfate and penicillamine on zinc metabolism in patients with rheumatoid arthritis. J Rheumatol 7: 639–644

    PubMed  CAS  Google Scholar 

  • Klingberg WG, Prasad AS, Oberleas D (1976) Zinc deficiency following penicillamine therapy. In: Prasad AS (ed) Trace elements in human health and disease, vol 1. Zinc and copper. Academic Press, New York, pp 51–65

    Google Scholar 

  • Kuivaniemi H, Peltonen L, Palotie A, Kaitila I, Kivirikko KI (1982) Abnormal copper metabolism and deficient lysyl oxidase activity in a heritable connective tissue disorder. J Clin Invest 69: 730–733

    Article  PubMed  CAS  Google Scholar 

  • Kvist U, Eliasson R (1980) Influence of seminal plasma on the chromatin stability of ejaculated human spermatozoa. Int J Androl 3: 130–142

    Article  PubMed  CAS  Google Scholar 

  • Kvist U, Bjorndahl L, Kjellberg S, Lindholmer C, Roomans GM (1985) Sperm nuclear zinc: its prostatic origin and its significance for human fertility. Acta Physiol Scand [Suppl 542] 124: 389

    Google Scholar 

  • Lenard HG, Lombeck I (1979) Die Behandlung des Ehlers-Danlos Syndrom mit Zink. Klin Padiatr 191: 578–579

    PubMed  CAS  Google Scholar 

  • Lindelöf B (1984) Zinc and hair. In: Zinc in human medicine. TIL Publications. Isleworth, Toronto, pp 103–123

    Google Scholar 

  • McKusick VA (1972) Heritable disorders of connective tissue, 4th edn. Mosby, St Louis, pp 292–371

    Google Scholar 

  • Mahajan SK, Prasad AS, Briggs WA, McDonald FD (1980) Effect of zinc therapy on sexual dysfunction in hemodialysis patients. Trans Am Soc Artif Intern Organs 26: 139–141

    PubMed  CAS  Google Scholar 

  • Marmar J, Katz S, Praiss DE, DeBenedictis TJ (1975) Semen zinc levels in infertile and postvasectomy patients and patients with prostatitis. Fertil Steril 26: 1057–1063

    PubMed  CAS  Google Scholar 

  • Mathur NK, Bumb RA (1983) Oral zinc in trophic ulcers of leprosy. Int J Lepr 51: 410–411

    CAS  Google Scholar 

  • Mathur NK, Bumb RA, Mangal HN (1983a) Zinc restores hair growth in lepramatous leprosy. Br J Dermatol 107: 240

    Article  Google Scholar 

  • Mathur NK, Bumb RA, Mangal HN (19836) Oral zinc in recurrent erythema nodosum leprosum reaction. Lepr India 55: 547–552

    Google Scholar 

  • Mathur NK, Bumb RA, Mangal HN, Sharma ML (1984) Oral zinc as an adjunct to Dapsone in lepromatous leprosy. Int J Lepr 52: 331–338

    CAS  Google Scholar 

  • Mattingly PC, Mowat A (1982) Zinc sulfate in rheumatoid arthritis. Ann Rheum Dis 41: 456–457

    Article  PubMed  CAS  Google Scholar 

  • Menard MP, McCormick CC, Cousins RJ (1981) Regulation of intestinal metallothionein biosynthesis by dietary zinc. J Nutr 112: 1352–1361

    Google Scholar 

  • Menkes CJ, Job C, Delbarre F (1978) Traitement de la polyarthrite rhumatoide par le sulfate de zinc per os. Nouv Presse Med 7: 760

    PubMed  CAS  Google Scholar 

  • Menkes CJ, Job C, Bruneaux F, Delbarre F (1981) Traitement de la polyarthrite rhumatoide par le sulfate de zinc: resultat d’un essai en double aveugle. Rev Rhum Mal Osteartic 48: 223–227

    CAS  Google Scholar 

  • Merchant HW, Gangarosa LP, Glassman AB et al. (1977) Zinc sulfate supplementation for treatment of recurring oral ulcers. South Med J 70: 559–561

    Article  PubMed  CAS  Google Scholar 

  • Michaelsson G (1984) Zinc in relation to some skin diseases. In: Zinc and human medicine. TIL Publications, Isleworth, Toronto, pp 125–134

    Google Scholar 

  • Michaelsson G, Juhlin L, Vahlquist A (1977a) Effects of oral zinc and vitamin A in acne. Arch Dermatol 113: 31–36

    Article  PubMed  CAS  Google Scholar 

  • Michaelsson G, Juhlin L, Ljunghall K (1977b) A double-blind study of the effect of zinc and oxytetracycline in acne vulgaris. Br J Dermatol 97: 561–566

    Article  PubMed  CAS  Google Scholar 

  • Moore R (1978) Bleeding gastric erosion after oral zinc sulphate. Br Med J 1: 754

    Article  PubMed  CAS  Google Scholar 

  • Munoz N, Wahrendorf J, Bang LS et al. (1985) No effect of riboflavine, retinol, and zinc on prevalence of precancerous lesions of esophagus. Randomized double-blind intervention study in high-risk population of China. Lancet II: 111–114

    Google Scholar 

  • Myers MB, Cherry G (1970) Zinc and the healing of chronic leg ulcers. Am J Surg 120: 77–81

    Article  PubMed  CAS  Google Scholar 

  • Nishiyama S (1976) Hair abnormality in systemic disease. In: Kobori T, Montagna W (eds) Biology and disease of the hair. University of Tokyo Press, Tokyo, pp 329–336

    Google Scholar 

  • Oelshlegel FJ Jr, Brewer GJ, Prasad AS, Knutsen C, Schoomaker EB (1973) Effect of zinc on increasing oxygen affinity of sickle and normal red blood cells. Biochem Biophys Res Commun 53: 560–566

    Article  PubMed  CAS  Google Scholar 

  • Oelshlegel FJ Jr, Brewer GJ, Knutsen C, Prasad AS, Schoomaker EB (1974) Studies on the interaction of zinc with human hemoglobin. Arch Biochem Biophys 163: 742–748

    Article  PubMed  CAS  Google Scholar 

  • Olsson R (1982) Oral zinc treatment in primary biliary cirrhosis. Acta Med Scand 212: 191–192 Orr KB (1976) Healing of gastric ulcers by zinc sulphate. Med J Aust 1: 244

    Google Scholar 

  • Orris L, Shalita AR, Sibulkin D, London SJ, Gans EH (1978) Oral zinc therapy of acne: absorption and clinical effect. Arch Dermatol 114: 1018–1020

    Article  PubMed  CAS  Google Scholar 

  • Patterson WP, Winkelman M, Perry MC (1985) Zinc-induced copper deficiency: megamineral sideroblastic anemia. Ann Intern Med 103: 385–386

    PubMed  CAS  Google Scholar 

  • Pfeiffer CC, Jenney EH (1978) Excess oral zinc in man lowers copper levels. Fed Proc 37: 324

    Google Scholar 

  • Phillips A, Davison M, Greaves MW (1977) Venous leg ulceration: evaluation of zinc treatment, serum zinc and rate of healing. Clin Exp Dermatol 2: 395–399

    Article  PubMed  CAS  Google Scholar 

  • Pories WJ, Henzel JH, Rob CG, Strain WH (1967a) Acceleration of wound healing in man with zinc sulphate given by mouth. Lancet I: 121–124

    Google Scholar 

  • Pories WJ, Henzel JH, Rob CG, Strain WI-I (1967b) Acceleration of healing with zinc sulphate. Ann Surg 165: 432–436

    Article  PubMed  CAS  Google Scholar 

  • Porter KG, McMaster D, Elmes ME, Love AHG (1977) Anaemia and low serum-copper during zinc therapy. Lancet II: 774

    Google Scholar 

  • Prasad AS, Miale A, Farid Z, Schulert A, Sandstead HH (1963) Zinc metabolism in patients with the syndrome of iron deficiency anemia, hypogonadism and dwarfism. J Lab Clin Med 61: 537–549

    PubMed  CAS  Google Scholar 

  • Prasad AS, Schoomaker EB, Ortega J, Brewer GJ, Oberleas D, Oelshlegel FJ Jr (1975) Zinc deficiency in sickle cell disease. Clin Chem 21: 582–587

    PubMed  CAS  Google Scholar 

  • Prasad AS, Ortega J, Brewer GJ, Oberleas D, Schoomaker EB (1976) Trace elements in sickle cell disease. J Am Med Ass 235: 2396–2398

    Article  CAS  Google Scholar 

  • Prasad AS, Abbasi A, Ortega J (1977) Zinc deficiency in man: studies in sickle cell disease. In: Brewer GJ, Prasad AS (eds) Zinc metabolism: current aspects in health and disease. Alan R. Liss, New York, pp 211–236

    Google Scholar 

  • Prasad AS, Brewer GJ, Schoomaker EB, Rabbani P (1978a) Hypocupremia induced by zinc therapy in adults. J Am Med Ass 240: 2166–2168

    Article  CAS  Google Scholar 

  • Prasad AS, Rabbani P, Abbasi A, Bowersox E, Fox MRS (1978b) Experimental zinc deficiency in humans. Ann Intern Med 89: 483–490

    PubMed  CAS  Google Scholar 

  • Ramadori G, Keidl G, Hutteroth T et al. (1985) Orale Zink-Therapie bei Morbus Wilson–eine Alternative zu D-Penicillamin. Z Gastroenterol 23: 25–29

    PubMed  CAS  Google Scholar 

  • Rasker JJ, Kardaun SH (1982) Lack of beneficial effect of zinc sulfate in rheumatoid arthritis. Scand J Rheumatol 11: 168–170

    Article  PubMed  CAS  Google Scholar 

  • Reding P, Duchateau J, Bataille C (1984) Oral zinc supplementation improves hepatic encephalopathy: results of a randomised controlled trial. Lancet II: 493–495

    Google Scholar 

  • Roman W, Oon R, West RF, Reid DP (1967) Zinc sulphate in acute porphyria. Lancet II: 716

    Google Scholar 

  • Roman W, Oon R, West RF, Reid DP (1969) A case of acute intermittent porphyria treated successfully with zinc sulphate and chelation. Med J Aust 1: 633–638

    PubMed  CAS  Google Scholar 

  • Russell RM, Cox ME, Solomons NW (1983) Zinc and the special senses. Ann Intern Med 99: 227–239

    PubMed  CAS  Google Scholar 

  • Schecter PJ, Friedewald WJ, Bronzert DA, Raff MS, Henkin RI (1972) Idiopathic hypogeusia: a description of the syndrome and a single blind study with zinc sulfate. In: Pfeiffer CC (ed) International review of neurobiology. Supplement 1. Academic Press, New York, pp 125–140

    Google Scholar 

  • Schouwink G (1961) De hepato-cerebrale degeneratie (met een onderzoek nar de zinkstowisseling). Thesis, University of Amsterdam Sergeant GR, Galloway RE, Gueri MC ( 1970 ) Oral zinc sulphate in sickle-cell ulcers. Lancet II: 891–893

    Google Scholar 

  • Sherlock S, Scheuer PJ (1973) The presentation and diagnosis of 100 patients with primary biliary cirrhosis. N Engl J Med 289: 674–678

    Article  PubMed  CAS  Google Scholar 

  • Simkin PA (1976) Oral zinc sulphate in rheumatoid arthritis. Lancet II: 539–542

    Google Scholar 

  • Solomons NW (1979) On the assessment of zinc and copper status in man. Am J Clin Nutr 32: 856–871

    PubMed  CAS  Google Scholar 

  • Solomons NW, Cousins RJ (1984) Zinc. In: Solomons NW, Rosenberg IH (eds) Absorption and malabsorption of mineral nutrients. Alan R. Liss, New York, pp 125–197

    Google Scholar 

  • Sonnichsen VN, Reinicke C, Herrman C, Glatzel E (1984) Zinktherapie der Alopecia Arcata. Dermatol Monatsschr 170: 437–442

    PubMed  CAS  Google Scholar 

  • Strain WH, Pories WJ (1966) Zinc levels of hair as tools in zinc metabolism. In: Prasad AS (ed) Zinc metabolism. Charles C. Thomas, Springfield, pp 378–394

    Google Scholar 

  • Swerdel MR, Cousins RJ (1984) Reduction of adjuvant induced arthritis and concomitant increases in ceruloplasmin and metallothionein synthesis in rats by zinc and 13-cis-retinoic acid. Fed Proc 43: 686

    Google Scholar 

  • Tennican PO, Carl GZ, Chvapil M (1979) The diverse effects of topical and systemic administration of zinc on the virulence of herpes simplex genitalis. Life Sci 24: 1877–1883

    Article  PubMed  CAS  Google Scholar 

  • Thurnham DI, Rathakette P, Hambidge KM, Munoz N, Crespi M (1982) Riboflavin, vitamin A and zinc status in Chinese subjects in a high-risk area for oesophageal cancer in China. Hum Nutr Clin Nutr 36c: 337–349

    PubMed  CAS  Google Scholar 

  • Van Caillie-Bertrand M, Degenhart HI, Visser HKA, Sainaasappel M, Bouquet J (1985) Oral zinc sulphate for Wilson’s disease. Arch Dis Child 60: 656–659

    Article  PubMed  Google Scholar 

  • Verma KC, Saini AS, Dhamija SK (1980) Oral zinc sulphate therapy in acne vulgaris: a double-blind trial. Acta Derm Venereol (Stockh) “60: 337–340

    Google Scholar 

  • Voorhees JJ, Chakrabarti SG, Botero F, Miedler L, Harrell BR (1969) Zinc therapy and distribution in psoriasis. Arch Dermatol 100: 669–673

    Article  PubMed  CAS  Google Scholar 

  • Wacker WEC (1976) Role of zinc in wound healing: a critical review. In: Prasad AS (ed) Trace elements in human health and disease, vol 1. Zinc and copper. Academic Press, New York, pp 107–113

    Google Scholar 

  • Walshe J (1984) Treatment of Wilson’s disease with zinc sulphate. Br Med J 289: 558–559

    Article  CAS  Google Scholar 

  • Wang F, Adams BA (1982) Zinc in the treatment of chronic leg ulcers of systemic lupus erythematosus. Singapore Med J 23: 171–173

    PubMed  CAS  Google Scholar 

  • Watkinson M, Aggett PJ, Cole TJ (1985) Zinc and acute tropical ulcers in Gambian children and adolescents. Am J Clin Nutr 41: 43–51

    PubMed  CAS  Google Scholar 

  • Wazewska-Czyzewska M, Wesierska-Gadek J, Legutko L (1978) Immunostimulatory effect of zinc in patients with acute lymphoblastic leukemia. Folia Haematol (Leipz) 105: 727–732

    CAS  Google Scholar 

  • Weimar VM, Puhl SC, Smith WH, tenBroeke JE (1978) Zinc sulphate in acne vulgaris. Arch

    Google Scholar 

  • Dermatol 114: 1776–1778

    Google Scholar 

  • Weissman K, Wadskov S, Sondergaard J (1977) Oral zinc sulphate for acne vulgaris. Acta Derm Venereol 57: 357–360

    Google Scholar 

  • Wolowa F (1982) Behandlung of Alopecia arcata totalis and maligna with Solvezink. Z Hautkr 57: 393–405

    PubMed  CAS  Google Scholar 

  • Wolowa F, Jablonska S (1976) Zinc in the treatment of alopecia arcata. In: Kobori T, Montagna W (eds) Biology and disease of the hair. University of Tokyo Press. Tokyo, pp 305–308

    Google Scholar 

  • Wolowa F, Stachow A (1978) Zinc in the treatment of alopecia arcata. Przegl Dermatol 65: 687–696

    PubMed  CAS  Google Scholar 

  • Wolowa F, Stachow A (1980) Behandlung der Alopecia arcata mit Zinksulfat. Z Hautkr 55: 1125–1134

    PubMed  CAS  Google Scholar 

  • Zimmer C, Luck G, Triebel H (1974) Conformation and reactivity of DNA. IV. Base binding ability of tranairion metal ions to native DNA and effect on helix conformation with special reference to DNA-Zn ( II ). Biopolymers 13: 425–453

    Google Scholar 

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  1. N. W. Solomons
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  2. M. Ruz
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  3. C. Castillo-Duran
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Editors and Affiliations

  1. Rowett Research Institute, AB2 9SB, Bucksburn, Aberdeen, Scotland, UK

    Colin F. Mills MSc, PhD, CChem, FRSC, FRSE (Director of Postgraduate Studies) (Director of Postgraduate Studies)

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Solomons, N.W., Ruz, M., Castillo-Duran, C. (1989). Putative Therapeutic Roles for Zinc. In: Mills, C.F. (eds) Zinc in Human Biology. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-3879-2_19

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  • DOI: https://doi.org/10.1007/978-1-4471-3879-2_19

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3881-5

  • Online ISBN: 978-1-4471-3879-2

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