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Zinc in Human Biology pp 259–279Cite as

Severe Zinc Deficiency

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Part of the book series: ILSI Human Nutrition Reviews ((ILSI HUMAN))

Abstract

The realization that acrodermaitis enteropathica (AE) was a zinc-responsive syndrome (Moynahan and Barnes 1973) provided the archetype of severe human zinc deficiency which aided the recognition of sporadic severe zinc deficiency accompanying total parenteral nutrition (TPN) in adults (Kay et al. 1976) and children (Arakawa et al. 1976) and in a variety of other conditions. This chapter outlines the features of severe zinc deficiency and the various conditions in which this has been observed.

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References

  • Aggett PJ, Atherton DJ, Delves HT et al. (1978) Studies in acrodermatitis enteropathica. In: Kirschgessner M (ed) Trace element metabolism in man and animals. Arbeitskreis für Tierernährungsforschung, Weihenstephan, pp 418–422

    Google Scholar 

  • Aggett PJ, Thorn JM, Delves HT, Clayton BE, Harries JT (1979a) Trace element malabsorption in exocrine pancreatic insufficiency. Monogr Paediatr 19: 8–11

    Google Scholar 

  • Aggett PJ, Delves HT, Harries JT, Bangham AD (1979b) The possible role of diodoquin as a zinc ionophore in the treatment of acrodermatitis enteropathica. Biochem Biophys Res Commun 87: 513–517

    Article  PubMed  CAS  Google Scholar 

  • Aggett PJ, Atherton DJ, More J, Davey J, Delves HT, Harries JT (1980) Symptomatic zinc deficiency in a breast fed preterm infant. Arch Dis Child 58: 547–550

    Article  Google Scholar 

  • Aggett PJ, Delves HT, Thorn JM, Atherton DJ, Harries JT, Bangham AD (1981) The therapeutic effect of amphotericin in acrodermatitis enteropathica. Eur J Pediatr 137: 23–25

    Article  PubMed  CAS  Google Scholar 

  • Aggett PJ, Fenwick PK, Kirk H (1982) The effect of amphotericin B on the permeability of lipid bilayers to divalent trace metals. Acta Biochim Biophys 684: 291–294

    Article  CAS  Google Scholar 

  • Ainley CC, Casson J, Carlsson L, Thompson RPH, Slavin BM, Naughton KR (1986) Zinc state in anorexia nervosa. Br Med J 293: 992–993

    Article  CAS  Google Scholar 

  • Ament ME, Broviac J (1973) Acrodermatitis enteropathica: demonstration of small and large intestinal mucosal lesions. Gastroenterology 64: A-9/692

    Google Scholar 

  • Amon RB, Swenson KH, Hanifen JM, Hambidge KM (1976) The glucogonoma syndrome (necrolytic migratory erythema) and zinc. N Engl J Med 295: 962

    PubMed  CAS  Google Scholar 

  • Andersson KE, Bratt L, Denker H, Lanner E (1976) Some aspects of the intestinal absorption of zinc in man. Eur J Clin Pharmacol 9: 423–428

    Article  CAS  Google Scholar 

  • Aquilera-Diaz LF (1971) Un nouveau symptome dans l’acrodermatite enteropathique: la démarche ataxique. Bull Soc Fr Dermatol Syphilgr 78: 259–260

    Google Scholar 

  • Arakawa T, Tamura T, Igarashi Y, Suzuki H, Sandstead HH (1976) Zinc deficiency in two infants during parenteral alimentation. Am J Clin Nutr 29: 197–204

    PubMed  CAS  Google Scholar 

  • Atherton DJ, Muller DPR, Aggett PJ, Harries JT (1979) A defect in zinc uptake by jejunal biopsies in acrodermatitis enteropathica. Clin Sci 56: 505–507

    PubMed  CAS  Google Scholar 

  • Blom I, Jameson S, Crook F, Larsson-stymne B, Wranne L (1980) Zinc deficiency with transitory acrodermatitis enteropathica in a boy of low birthweight. Br J Dermatol 104: 459–464

    Article  Google Scholar 

  • Bohane TD, Cutz E, Hamilton JR, Gall DG (1977) Acrodermatitis enteropathica, zinc, and a paneth cell. Gastroenterology 73: 587–592

    PubMed  CAS  Google Scholar 

  • Bonifazi E, Rigillo N, De Simone B, Meneghini CL (1980) Acquired dermatitis due to zinc deficiency in a premature infant. Acta Derm Venereol 60: 449–451

    PubMed  CAS  Google Scholar 

  • Boosalis MG, Evans GW, McClain CJ (1983) Impaired handling of orally administered zinc in pancreatic insufficiency. Am J Clin Nutr 37: 268–271

    PubMed  CAS  Google Scholar 

  • Brandt T (1936) Dermatitis in children with disturbances of the general condition and the absorption of food elements. Acta Derm Venereol 17: 513–546

    Google Scholar 

  • Braun OH, Heilmann K, Rossner JA, Pauli W, Bergman KE (1977) Acrodermatitis enteropathica, zinc deficiency and ultrastructural findings. Eur J Pediatr 125: 153–161

    Article  PubMed  CAS  Google Scholar 

  • Bronson DM, Barksky R, Barksky S (1983) Acrodermatitis enteropathica: recognition at long last during a pregnancy. J Am Acad Dermatol 9: 140–144

    Article  PubMed  CAS  Google Scholar 

  • Brook AC, Johnston DG, Ward MK, Watson MJ, Cook DB, Kerr DNS (1980) Absence of a therapeutic effect of zinc in the sexual dysfunction of haemodialysis patients. Lancet II: 618–619

    Google Scholar 

  • Brummerstedt E, Bass EA, Flagstead T, Andresen E (1977) Acrodermatitis enteropathica, zinc metabolism: animal model: lethal trait A46 in cattle. Am J Pathol 87: 725–728

    PubMed  CAS  Google Scholar 

  • Bye AM, Goodfellow A, Atherton DJ (1985) Transient zinc deficiency in a full term breast fed infant of normal birthweight. Pediatr Dermatol 2: 308–311

    Article  PubMed  CAS  Google Scholar 

  • Chandra RK (1980) Acrodermatitis enteropathica: zinc levels and cell-mediated immunity. Pediatrics 66: 789–791

    PubMed  CAS  Google Scholar 

  • Danbolt N, Closs K (1942) Acrodermatitis enteropathica. Acta Derm Venereol 23: 127–169

    Google Scholar 

  • Dillaha CJ, Larencz AL, Aavic OR (1953) Acrodermatitis enteropathica: review of the literature and a report of a case successfully treated with diodoquin. J Am Med Ass 152: 509–512

    Article  CAS  Google Scholar 

  • Dinsmore W, Callander ME, McMaster D, Todd SJ, Love AHG (1985) Zinc absorption in alcoholics using zinc-65. Digestion 32: 238–242

    Article  PubMed  CAS  Google Scholar 

  • Dodge JA, Yassa JG (1978) Zinc deficiency syndrome in the British youth with cystic fibrosis. Br Med J 1: 411

    Article  PubMed  CAS  Google Scholar 

  • Dupre A, Bonafe JL, Carriere JP (1979) The hair in acrodermatitis enteropathica–a disease indicator. Acta Derm Venereol 59: 177–178

    PubMed  CAS  Google Scholar 

  • Entwistle BR (1965) Acrodermatitis enteropathica. Aust J Dermatol 8: 13–21

    Google Scholar 

  • Epstein S, Vedder JS (1960) Acrodermatitis enteropathica persisting into adulthood. Arch Dermatol Syph 82: 189–190

    Google Scholar 

  • Ermacora E, Benelli MG (1968) Acrodermatite enteropathica in bambino fenil-chetonurico. Min Derm 41: 523–524

    Google Scholar 

  • Esca SA, Brenner W, Mach K, Gschnait F (1979) Kwashiorkor like zinc deficiency syndrome in anorexia nervosa. Acta Derm Venereol 59: 361–364

    PubMed  CAS  Google Scholar 

  • Feldberg F, Yassur Y, Ben-Sera I, Varsano I, Zelikovitz I (1981) Keratomalacia in acrodermatitis enteropathica. Metab Pediatr Syst Ophthalmol 5: 207–211

    CAS  Google Scholar 

  • Fell GS, Cuthbertson DP, Morrison C et al. (1973) Urinary zinc levels as an indication of muscle catabolism. Lancet I: 280–282

    Google Scholar 

  • Fleming CR, Hodges RE, Hurley LS (1976) A prospective study of serum copper and zinc levels in patients receiving total parenteral nutrition. Am J Clin Nutr 29: 70–77

    PubMed  CAS  Google Scholar 

  • Freeman JB, Stegink LD, May PD, Fry LK, Denbesten L (1975) Excessive urinary zinc losses during parenteral alimentation. J Surg Res 18: 463–469

    Article  PubMed  CAS  Google Scholar 

  • Frier S, Jungreis E (1976) Zinc and acrodermatitis enteropathica. Lancet I: 914–915

    Google Scholar 

  • Fry LK, Stegink LD (1982) Formation of Maillard reaction products in parenteral alimentation solutions. J Nutr 112: 1631–1637

    PubMed  CAS  Google Scholar 

  • Garretts M, Molokhia M (1977) Acrodermatitis enteropathica without hypo-zincaemia. J Pediatr 91: 492–494

    Article  PubMed  CAS  Google Scholar 

  • Gartside JM, Allen BR (1975) Treatment of acrodermatitis enteropathica with zinc sulphate. Br Med J 2: 521–522

    Article  Google Scholar 

  • Gaveau D, Piette F, Cortot A, Dumur V, Vergoend H (1987) Manifestations cutanées du déficit en zinc dans la cirrhose ethylique. Ann Dermatol Venereol 114: 39–53

    PubMed  CAS  Google Scholar 

  • Ginsburg R, Robertson A, Michel B (1976) Acrodermatitis enteropathica; abnormalities of fat metabolism and integumental ultrastructures in infants. Arch Dermatol 112: 653–660

    Article  PubMed  CAS  Google Scholar 

  • Golden BE, Golden MHN (1979) Plasma zinc and the clinical features of malnutrition. Am J Clin Nutr 32: 2490–2494

    PubMed  CAS  Google Scholar 

  • Golden BE, Golden MHN (1981a) Plasma zinc, rate of weight gain, and the energy cost of tissue deposition in children recovering from severe malnutrition in a cow’s milk or soya protein based diet. Am J Clin Nutr 34: 892–899

    PubMed  CAS  Google Scholar 

  • Golden BE, Golden MHN (1981b) Dietary zinc and the output and composition of faeces. In: Howell JMcC, Gawthorne JM, White CL (eds) Trace element metabolism in man and animals–TEMA-4. Australian Academy of Sciences, Canberra, pp 73–76

    Chapter  Google Scholar 

  • Golden BE, Golden MHN (1985) Zinc, sodium and potassium loss in the diarrhoeas of malnutrition and zinc deficiency. In: Mills CF, Bremner I, Chesters JK (eds) Trace elements in man and animals–TEMA-5. CAB International, Farnham Royal, UK, pp 228–231

    Google Scholar 

  • Golden MHN, Golden BE (1981) Effect of zinc supplementation on the dietary intake, rate of weight gain, and energy cost of tissue deposition in children recovering from severe malnutrition. Am J Clin Med 34: 900–908

    CAS  Google Scholar 

  • Golden MHN, Jackson AA, Golden BE (1976) Effect of zinc on thymus of recently malnourished children. Lancet II: 1057–1059

    Google Scholar 

  • Golden MHN, Golden BE, Harland PSEG, Jackson AA (1978) Zinc and immuno-competence in protein-energy malnutrition. Lancet I: 1226–1228

    Google Scholar 

  • Gonzalez JR, Botet MV, Sanchez JL (1982) The histopathology of acrodermatitis enteropathica. Am J Dermatol Pathol 4: 303–311

    Article  CAS  Google Scholar 

  • Graves K, Kestenbaum T, Kalivas J (1980) Hereditary acrodermatitis enteropathica in an adult. Arch Dermatol 116: 562–564

    Article  PubMed  CAS  Google Scholar 

  • Grillet JP, Harms M (1980) Kwashiorkor et déficit en zinc chez une anorexique mentale adulte. Ann Dermatol Venereol 107: 1187–1191

    PubMed  CAS  Google Scholar 

  • Hambidge KM, Neldner KH, Walravens PA et al. (1978) Zinc and acrodermatitis enteropathica. In: Zinc and copper in clinical medicine. Spectrum Publications, Holliswood, New York, pp 81–98

    Google Scholar 

  • Hansen RC, Lennen R, Revsin R (1983) Cystic fibrosis manifesting with acrodermatitis enteropathica-like eruption. Arch Dermatol 119: 51–55

    Article  PubMed  CAS  Google Scholar 

  • Henkin RI, Patten BM, Re PK, Bronzert DA (1975) A syndrome of acute zinc loss: cerebellar dysfunction, mental changes, anorexia, and taste and smell dysfunction. Arch Neurol 32: 745–751

    Article  PubMed  CAS  Google Scholar 

  • Hessov I, Hasselblad C, Fasth C, Hulten N (1983) Zinc depletion after small bowel resections or Crohn’s disease. Hum Nutr Clin Nutr 37C: 353–359

    PubMed  CAS  Google Scholar 

  • Jackson MJ (1977) Zinc and di-iodohydroxyquinoline therapy in acrodermatitis enteropathica. J Clin Pathol 30: 284–287

    Article  PubMed  CAS  Google Scholar 

  • James BE, Hendry PG, MacMahon RA (1979) Total parenteral nutrition of premature infants. II. Requirement for micronutrient elements. Aust Paediatr J 15: 67–71

    Google Scholar 

  • Javett SN (1963) Regrowth of hair during penicillamine treatment of acrodermatitis enteropathica. Lancet I: 504

    Google Scholar 

  • Jones JG, Elmes ME, Aggett PJ, Harries JT (1983) The effect of zinc therapy on lysosomal inclusion bodies in intestinal epithelial cells in acrodermatitis enteropathica. Pediatr Res 17: 354–357

    Article  PubMed  CAS  Google Scholar 

  • Julius R, Schulking M, Sprinkle T, Rennert O (1973) Acrodermatitis enteropathica with immune deficiency. J Pediatr 83: 1007–1011

    Article  PubMed  CAS  Google Scholar 

  • Kay RG, Tasman-Jones C, Pybus J, Whiting R, Black H (1976) A syndrome of acute zinc deficiency during total parenteral alimentation in man. Ann Surg 183: 331–340

    Article  PubMed  CAS  Google Scholar 

  • Keeling PWN, Jones RB, Hilton PJ, Thompson RPH (1980) Reduced leucocyte zinc in liver disease. Gut 21: 561564

    Google Scholar 

  • Keeling PWN, Rus W, Boll A, Hannigan B, Thompson RPH (1981) Direct measurement of hepatointestinal extraction of zinc in cirrhosis and hepatitis. Clin Sci 61: 441–444

    PubMed  CAS  Google Scholar 

  • Keeling PWN, O’Day J, Rus W, Thompson RPH (1982) Zinc deficiency and photo receptor dysfunction in chronic liver disease. Clin Sci 62: 109–111

    PubMed  CAS  Google Scholar 

  • Kelly R, Davidson GP, Rugely R, Townley W, Campbell PE (1976) Reversible intestinal mucosal abnormalities in acrodermatitis enteropathica. Arch Dis Child 51: 219–222

    Article  PubMed  CAS  Google Scholar 

  • Kiilerich S, Dietrichson O, Loud FB et al. (1980) Zinc depletion in alcoholic liver diseases. Scand J Gastroenterol 15: 363–367

    Article  PubMed  CAS  Google Scholar 

  • Klingberg WG, Prasad AS, Oberleas D (1976) Zinc deficiency following penicillamine therapy. In: Prasad AS, Oberleas D (eds) Trace elements in human health and disease, vol 1. Academic Press, New York, pp 51–65

    Google Scholar 

  • Koo SI, Turk DE (1977) Effect of zinc deficiency on the ultrastructure of the pancreatic acinar cell and intestinal epithelium in the rat. J Nutr 107: 896–908

    PubMed  CAS  Google Scholar 

  • Kuramato Y, Igarashi Y, Kato S, Tagami H (1986) Acquired zinc deficiency in two breast fed mature infants. Acta Derm Venereol 56: 359–361

    Google Scholar 

  • Leopold IH (1978) Zinc deficiency and visual impairment? Am J Ophthalmol 85: 871–873

    PubMed  CAS  Google Scholar 

  • Lewis-Jones MS, Evans S, Culshaw MA (1985) Cutaneous manifestations of zinc deficiency during treatment with anticonvulsants. Br Med J 290: 603–604

    Article  CAS  Google Scholar 

  • Lindeman RD, Bottomley RG, Cornelison L, Jacobs LA (1972) Influence of acute tissue injury on zinc metabolism in man. J Lab Clin Med 79: 452–460

    PubMed  CAS  Google Scholar 

  • Lombeck I, von Bassenitz DB, Becker K, Tinschmann P, Kastner H (1974) Ultra-structural findings in acrodermatitis enteropathica. Pediatr Res 8: 82–88

    Article  PubMed  CAS  Google Scholar 

  • Lombeck I, Schnippering HG, Kasperek K et al. (1975) Akrodermatitis enteropathica–Eine Zinkstoffwechselstörung mit Zinkmalabsorption.–Z Kinderheilk 120: 181–189

    Article  CAS  Google Scholar 

  • McClain CJ, Van Thiel DH, Parker S, Badzin LK, Gilbert H (1979) Alterations in zinc, vitamin A, and retinal-binding protein in chronic alcoholics: a possible mechanism for night blindness and hypogonadism. Alcoholism 3: 135–141

    PubMed  CAS  Google Scholar 

  • McClain CJ, Soutar C, Zieve L (1980) Zinc deficiency: a complication of Crohn’s disease. Gastroenterology 78: 272–279

    PubMed  CAS  Google Scholar 

  • McClain CJ, Le-Chu S, Gilbert H, Cameron D (1983) Zinc deficiency induced retinal dysfunction in Crohn’s disease. Dig Dis Sci 28: 85–87

    Article  PubMed  CAS  Google Scholar 

  • Mahajan SK, Prasad AS, Rabbani P, Briggs WA, McDonald RD (1979) Zinc metabolism in uraemia. J Lab Clin Med 94: 693–698

    PubMed  CAS  Google Scholar 

  • Mahajan SK, Prasad AS, Rabbani P, Briggs WA, McDonald FD (1982a) Zinc deficiency: a reversible complication of uremia. Am J Clin Nutr 36: 1177–1183

    PubMed  CAS  Google Scholar 

  • Mahajan SK, Abbasi AA, Prasad AS, Rabbani P, Briggs WA, McDonald FD (1982b) Effect of oral zinc therapy on gonadal function in hemodialysis patients: a double blind study. Ann Intern Med 97: 357–361

    PubMed  CAS  Google Scholar 

  • Mata CS, Felker GV, Ide CH (1975) Eye manifestations in acrodermatitis enteropathica. Arch Ophthalmol 93: 140–142

    Article  Google Scholar 

  • Milla PJ, Moynahan EJ (1972) Acrodermatitis enteropathica with lactose intolerance. Proc R Soc Med 65: 600–601

    PubMed  CAS  Google Scholar 

  • Milla PJ, Aggett PJ, Wolff OH, Harries JT (1979) Studies in primary hypomagnesaemia: evidence for defective carrier mediated small intestinal transport of magnesium. Gut 20: 1028–1033

    Article  PubMed  CAS  Google Scholar 

  • Mills PR, Fell GS, Bessant RG, Nelson OM, Russell RI (1983) A study of zinc metabolism in alcoholic cirrhosis. Clin Sci 64: 527–535

    PubMed  CAS  Google Scholar 

  • Milman N, Hvid-Jacobsen K, Hegnhoj J, Sorenson SS (1983) Zinc absorption in patients with compensated alcoholic cirrhosis. Scand J Gastroenterol 18: 871–875

    Article  PubMed  CAS  Google Scholar 

  • Morishima T, Yagi S, Kuwabara A, Endo M, Takemura T (1980) An acquired form of acrodermatitis enteropathica due to long term lactose free milk alimentation. J Dermatol 7: 121–125

    PubMed  CAS  Google Scholar 

  • Morrison SA, Russell RM, Carney EA, Oaks EV (1978) Zinc deficiency: a case of abnormal dark adaptation in cirrhosis. Am J Clin Nutr 31: 276–281

    PubMed  CAS  Google Scholar 

  • Moynahan EJ (1974) Acrodermatitis enteropathica: a lethal inherited human zinc deficiency disorder. Lancet II: 399–400

    Google Scholar 

  • Moynahan EJ (1976) Zinc deficiency and disturbances of mood and behaviour. Lancet I: 91

    Google Scholar 

  • Moynahan EJ, Barnes PM (1973) Zinc deficiency and a synthetic diet for lactose intolerance. Lancet I: 676–677

    Google Scholar 

  • Moynahan EJ, Johnson FR, McMinn RMH (1963) Acrodermatitis enteropathica: demonstration of possible enzyme defect. Proc R Soc Med 56: 300

    PubMed  CAS  Google Scholar 

  • Murphy JF, Gray OP, Randall JR, Hann S (1985) Zinc deficiency: a problem with preterm breast milk. Early Hum Dev 10: 303–307

    Article  PubMed  CAS  Google Scholar 

  • Neldner KH, Hambidge KM (1975) Zinc therapy of acrodermatitis enteropathica. N Engl J Med 292: 879–882

    Article  PubMed  CAS  Google Scholar 

  • Olholm-Larsen P (1978) Untreated acrodermatitis enteropathica in adults. Dermatologica 156: 155–166

    Article  PubMed  CAS  Google Scholar 

  • Otto HF, Weitz H (1972) Elektronenmikroskopische Untersuchungen an Paneth-Zellen der Ratte unter zinkaner Diät. Beitr Pathol 145: 336–342

    PubMed  CAS  Google Scholar 

  • Pekarek RS, Sandstead HH, Jacob RA, Barcome DF (1979) Abnormal cellular immune responses during acquired zinc deficiency. Am J Clin Nutr 32: 1466–1471

    PubMed  CAS  Google Scholar 

  • Portnoy B, Marsden CW (1961) Acrodermatitis enteropathica without diarrhoea. Arch Dermatol 83: 420–424

    Article  PubMed  CAS  Google Scholar 

  • Racz P, Kovacs B, Varga L, Ujlaki E, Zombai E, Karbuczky S (1978) Bilateral cataract in acrodermatitis enteropathica. J Pediatr Ophthalmol Strabismus 16: 180–182

    Google Scholar 

  • Reding P, Duchateau J, Bataille C (1984) Oral zinc supplementation improves hepatic encephalopathy. Lancet II: 493–495

    Google Scholar 

  • Ridley CM (1982) Zinc deficiency developing in treatment for thalassaemia. J R Soc Med 75: 38–39

    PubMed  CAS  Google Scholar 

  • Roberts LJ, Shadwick CF, Bergstresser PR (1987) Zinc deficiency in two full term breast fed infants. J Am Acad Dermatol 16: 301–304

    Article  PubMed  CAS  Google Scholar 

  • Rodin AE, Goldman AS (1969) Autopsy findings in acrodermatitis enteropathica. Am J Clin Pathol 51: 315–322

    PubMed  CAS  Google Scholar 

  • Sivasubramanian KN, Henkin RI (1978) Behavioural and dermatologie changes and a low serum zinc and copper concentrations in two premature infants after parenteral alimentation. J Pediatr 93: 847–851

    Article  PubMed  CAS  Google Scholar 

  • Smith SZ (1977) Skin changes in short-bowel syndrome. Kwashiorkor-like syndrome. Arch Dermatol 113: 657–659

    Article  PubMed  CAS  Google Scholar 

  • Smythe WR, Alfrey AC, Craswell PW et al. (1982) Trace elements abnormalities in chronic uraemia. Ann Intern Med 96: 302–310

    PubMed  CAS  Google Scholar 

  • Sturniolo GC, Molokhia MM, Shields R, Turnberg LA (1980) Zinc absorption in Crohn’s disease. Gut 33: 387–391

    Article  Google Scholar 

  • Sturtevant FM (1980) Zinc deficiency, acrodermatitis enteropathica, optic atrophy, subacute myelo-optic neuropathy, and 5,7-Dihalo-8-quinolols. Pediatrics 65: 610–613

    PubMed  CAS  Google Scholar 

  • Sullivan JF, Williams RV, Burch RE (1979) The metabolism of zinc and selenium in cirrhotic patients during six weeks of zinc ingestion. Alcoholism 3: 235–239

    PubMed  CAS  Google Scholar 

  • Tompkins RR, Livingood CS (1969) Acrodermatitis enteropathica persisting into adulthood. Arch Dermatol 99: 190–195

    Article  PubMed  CAS  Google Scholar 

  • Valberg LS, Flannagan PR, Jhant CN, Chamberlain MJ (1985) Zinc absorption and leukocyte zinc in alcoholic and non-alcoholic cirrhosis. Dig Dis Sci 30: 329–333

    Article  PubMed  CAS  Google Scholar 

  • van Caillie M, Degenhart H, Luigendijk I, Fernandes J (1978) Zinc content of intravenous solutions. Lancet II: 200–201

    Google Scholar 

  • Verburg DJ, Burd LI, Hoxtell EO, Merrill LK (1974) Acrodermatitis enteropathica and pregnancy. Obstet Gynecol 44: 223–227

    Google Scholar 

  • Warth JA, Prasad AS, Zwas F, Frank RN (1981) Abnormal dark adaptation in sickle cell anaemia. J Lab Clin Med 98: 189–194

    PubMed  CAS  Google Scholar 

  • Weismann K (1977) Lines of Beau: possible markers of zinc deficiency. Acta Derm Venereol 57: 88–89

    PubMed  CAS  Google Scholar 

  • Weismann K, Hagdrup HK (1981) Hair changes due to zinc deficiency in a case of sucrose malabsorption. Acta Derm Venereol 61: 444–447

    PubMed  CAS  Google Scholar 

  • Weismann K, Wadskov S, Nikkelsen HI, Knudsen L, Khristensen KC, Sgorgaard L (1978) Acquired zinc deficiency dermatosis in man. Arch Dermatol 114: 1509–1511

    Article  PubMed  CAS  Google Scholar 

  • Weismann K, Hoe S, Knudsen L, Sorensen SS (1979) 65Zn absorption in patients suffering from acrodermatitis enteropathica and in normal adults assessed by whole-body counting technique. Br J Dermatol 101: 573–579

    Google Scholar 

  • Weismann K, Hoyer H, Christensen E (1980) Acquired zinc deficiency in alcoholic liver cirrhosis: report of two cases. Acta Derm Venereol 60: 447–449

    PubMed  CAS  Google Scholar 

  • Wende GW (1902) Epidermolysis bullosa hereditaria. J Cutan Dis 20: 532–547

    Google Scholar 

  • Wester PO (1980) Urinary zinc excretion during treatment with different diuretics. Acta Med Scand 280: 209–212

    Google Scholar 

  • Weston WL, Clark-Huff J, Humbert JR, Hambidge KM, Neldner KH, Walravens TA (1977) Zinc correction of a defective chemotaxis in acrodermatitis enteropathica. Arch Dermatol 113: 422–425

    Article  PubMed  CAS  Google Scholar 

  • Williams RB, Russell RM, Dutta SK (1979) Alcoholic pancreatitis; patients at high risk of acute zinc deficiency. Am J Med 66: 889

    Article  PubMed  CAS  Google Scholar 

  • Wirsching L (1962) Eye symptoms in acrodermatitis enteropathica. Acta Ophthalmol 40: 567–574

    Google Scholar 

  • Wolman SL, Anderson GH, Marliss EB, Jeejeebhoy KN (1979) Zinc in total parenteral nutrition: requirements and metabolic effects. Gastroenterology 76: 458–467

    PubMed  CAS  Google Scholar 

  • Zimmerman AW, Hambidge KM, Lapow ML, Greenberg RD, Stover ML, Casey CE (1982) Acrodermatitis in breast-fed premature infants: evidence for a defect of mammary zinc secretion. Pediatrics 59: 176–183

    Google Scholar 

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  1. P. J. Aggett
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Editors and Affiliations

  1. Rowett Research Institute, AB2 9SB, Bucksburn, Aberdeen, Scotland, UK

    Colin F. Mills MSc, PhD, CChem, FRSC, FRSE (Director of Postgraduate Studies) (Director of Postgraduate Studies)

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Aggett, P.J. (1989). Severe Zinc Deficiency. In: Mills, C.F. (eds) Zinc in Human Biology. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-3879-2_17

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