Abstract
Pulmonary hypertension and right heart failure are major causes of death in patients with COPD.1–3 The effect of pulmonary artery hypertension on right ventricular function is by no means clear. In the past, quantification of right ventricular function has been difficult because of the complex geometry of the right ventricle. Non-invasive radionuclide studies by measuring RVEF have recently indicated preclinical right ventricular dysfunction in patients with COPD. We4 and others5,6, however, convincingly have shown that RVEF appears to be highly dependent on afterload, thus raising the question concerning its use as a parameter of overall right ventricular function.
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References
Mitchel R.S., Webb N.C., Filey G.F.: Chronic obstructive broncho-pulmonary disease III. Factors influencing prognosis. Am. Rev. Resp. Dis. 1964; 89: 878–896
Traver G.A., Cline M.G., Burrow: Predictors of mortality in chronic obstructive pulmonary disease. Am. Rev. Resp. Dis. 1979; 119: 895–902
Higgin M.W., Keller J.W., Becker M: An index of risk for obstructive airway disease. Am. Rev. Resp. Dis. 1982; 125: 144–152
Burghuber O.C., Bergman H., Silberbauer K., Höfer R.: Right ventricular performance in chronic airflow obstruction. Respiration 1984; 45: 124–130
Brent B.N., Berger H.J., Matthay R.A., Mahler D., Rytlik L., Zaret B.L.: Physiologic correlate of right ventricular ejection fraction in chronic obstructive pulmonary disease: a combined radionuclidehemodynamic study. Am. J. Cardiol. 1982; 50: 255–262
Korr K.S., Gandsman E.J., Winkler M.L., Shulman R.S., Bough E.W.: Hemodynamic correlates of right ventricular ejection fraction measured with gated radionuclide angiography. Am. J. Cardiol. 1982; 49: 71–77
Burghuber O.C., Hartter E., Punzengruber C.H., Weissel M., Woloszczuk: Human atrial natriuretic peptide secretion in precapillary pulmonary hypertension. Chest 1988; 93: 31–37
Burghuber O.C., Salzer Muhar U., Bergman H., Götz M.: Right ventricular performance and hemodynamics in adolescent and adult patients with cystic fibrosis. Eur. J. Pediatr. 1988; 148: 187–192
Dehmer G.L., Corbett J., Hillis L.D., Lewis S.E., Parkey R.W., Willerson J.T.: The end syst. P/ V index: a sensitive parameter for the scintigraphic detection of left ventricular in patients with coronary artery disease. Circulation 1980; 62: 4–12
Suga H.:, Sagawa K.: Instantaneous pressure-volume relationship and their ratio in the excised, supported canine left ventricle. Circ. Res. 1974; 35:117–124
Nestaval A., Kidery J., Fridl P., Oppelt A., Jandova R., Widimsky J.: Radionuclide ventriculography of the right ventricle in diseases involving the heart. Prog. Resp. Res. 1985; 20: 117–125
Wong D.F., Natarajan T.K., Summer W., Tibits P.A., Beck T., Koller D.: Right ventricular ejection fraction measured by first pass intravenous krypton 81m: reprodicibility and comparison with Tc 99m. Am. J. Cardiol. 1985; 56: 776–780
Brent B.N., Berger H.J., Matthay R.A., Mahler D., Rytlik L., Zaret B.L.: Physiologic correlates of right ventricular ejection fraction in chronic obstructive pulmonary disease: A combined radionuclide-hemodynamic study. Am. J. Cardiol. 1982; 50: 255–262
Korr K.S., Gandsman E.J., Winkler M.L., Shulman R.S., Bough E.W.: Hemodynamic correlates of right ventricular ejection fraction measured by gated radionuclide angiography. Am. J. Cardiol. 1982; 49: 71–77
Mahler D.A., Brent B.N., Loke J., Zaret B.L., Matthay R.A.: Right ventricular performance and central hemodynamics during upright exercise in patients with chronic obstructive pulmonary disease. Am. Rev. Resp. Dis. 1984; 130: 722–729
Sibbald W.J., Driedger A.A.: Right ventricular function in acute disease state: pathophysiologic considerations. Crit. Care Med. 1983; 11: 339–346
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© 1992 Springer-Verlag London
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Burghuber, O.C. (1992). Right Ventricular Contractility is Preserved and Preload Increased in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Artery Hypertension. In: Ježek, V., Morpurgo, M., Tramarin, R. (eds) Right Ventricular Hypertrophy and Function in Chronic Lung Disease. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3853-2_11
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DOI: https://doi.org/10.1007/978-1-4471-3853-2_11
Publisher Name: Springer, London
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