Summary
Electrical activation of inspiratory muscular activity in response to changing ventilatory demand has been examined by means of implanted electrodes in vagotomized and anaesthetized animals. Findings suggest that the response elicited ultimately depends on the role of the central inspiratory motor control system.
In postulating the applicability of such findings to human subjects, the greater recruitment of extra-diaphragmatic than diaphragmatic inspiratory muscle components observed in anaesthetized animals tallies with the greater contribution of rib cage expansion to tidal volume recorded during CO2 rebreathing in man.
However, the paucity of relevant human data and the possible conditioning of animals responses by anaesthesia mean that acceptance of this hypothesis must as yet be subject to reservations.
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D’Angelo, E. (1988). Patterns of inspiratory muscle activation with changing levels of ventilatory demand. In: Grassino, A., Fracchia, C., Rampulla, C., Zocchi, L. (eds) Respiratory Muscles in Chronic Obstructive Pulmonary Disease. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3850-1_4
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DOI: https://doi.org/10.1007/978-1-4471-3850-1_4
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