Summary
Derangements of cell metabolism in course of hypercapnic-hypoxemic Chronic Obstructive Pulmonary Disease (COPD) are not well defined. This seems to be surprising, should one consider that the understanding of the response of body tissues to blood gas alterations is of utmost importance in order to assess the systemic effects of the disease.
The present paper is thus aimed at giving information on cell metabolism derangements in COPD patients with hypercapnia and hypoxemia. In particular, intracellular acid-base, electrolyte and energy metabolism in skeletal muscle will be analyzed.
Moreover, since some of the features of skeletal muscle cell metabolism pressented here can be related to the nutritional status of COPD patients, preliminary data concerning a cross-sectional nutritional study on COPD patients will also be presented.
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References
TUSHAN F.S., BROMBERG P.A. et al: Intracellular pH and electrolyte metabolism in chronic stable stable hypercapnia. Arch. Int. Med. 1970. 125: 967–974.
CAMPBELL R.H.A., BRAND H.L. et al: Body weight and body water in chronic cor pulmonale. Cli. Sci. Mol. Med. 1975. 49: 323–335.
MOLLER P., BERGSTROM J. et al: Energy-rich phosphagens, electrolytes and free aminoacids in leg skeletal muscle of patients with chronic obstructive lung disease. Acta Med. Scand. 1982. 211: 187–193.
FIACCADORI E., DEL CANALE S. et al: Intracellular acid-base and electrolyte metabolism in skeletal muscle of patients with chronic obstructive lung disease and respiratory failure. Clin. Sci., 1986. 71: 6, 703–12.
FIACCADORI E., GUARIGLIA A., et al: Intracellular bicarbonate and pH determination in rat skeletal muscle from acid-labile CO2 measurement from dead-stop end-point potentiometric titrations. Eur. Rev. Med. Pharmacol. Sci., (Rome). 1986. 8: 3–14.
BERGSTROM J., ALVESTRAND A., et al: Muscle intracellular electrolytes in patients with chronic uremia. Kidney Int. 1983. 24 (S16): S153 - S160.
CUNNINGHAM J.N. JR., CARTER N.W. et al: Resting transmembrane potential difference of skeletal muscle in normal subjects and severely ill patients. J. Clin. Invest. 1971. 50: 49–59.
MOLLER P., BERGSTROM J., FURST P. et al: Energy-rich phosphagens, electrolytes and free amino acids in leg skeletal muscle of patients with chronic obstructive lung disease. Acta Med. Scand. 1982. 211: 187–193.
CAMPBELL J.A., HUGHE R.L. et al: Alterations in intercostal muscle morphology and biochemistry in patients with obstructive lung disease. Am. Rev. Resp. Dis. 1980. 122: 679–686.
HUGHES R.L., KATZ H. et al: Fiber size and energy metabolites in five separate muscles from patients with COLD. Respiration 1983. 44: 321–328.
GERTZ I., HEDENSTIERNE G. et al: Muscle metabolism in patients with chronic obstructive lung disease and acute respiratory failure. Clin. Sci. Mol. Med. 1977. 528: 395–403.
DEL CANALE S., SODERLUND K., FIACCADORI E. et al: Abnormal energy metabolism in severe chronic obstructive lung disease. Eur. Rev. Respir. Dis. (Suppl.) 1986. 146, 239–43.
HARRIS R., HULTMAN E., et al: Glycogen, glycolytic intermediate and high energy phosphate in biopsy samples of m. quadriceps femoris of man at rest. Methods and variance of values. Scand. J. Clin. Lab. Invest. 1974. 33: 109–113.
KARLSSON J.T., WILLERSON S.J. et al: Skeletal muscle metabolites in patients with cardiogenic shock or severe congestive heart failure. Scand. J. Clin. Lab. Invest. 1975. 35: 73–79.
BERGSTORM J., BOSTROM H. et al: Preliminary studies of energy-rich phosphagens in muscle from severely ill patients. Crit. Care Med. 1976. 4: 197–204.
RELMAN A.S.: Metabolic consequences of acid-base disorders. Kidney Int. 1972. 1: 347–357.
COHEN R.D., ILES R.A.: Intracellular pH: measurement, control and metabolic interrelationships. CRC Crit. Rev. Clin. Lab. Sci. 1975. 6: 101–142.
HOOD V.L., TANNER R.L.: pH control of lactic and keto acid production: a mechanism of acid-base regulation. Min. Electra Metab. 1983. 9: 317–325.
GRAHAM T.E., WILSON B.A. et al: The effects of hypercapnia on the metabolic response to steady-state exercise. Med. Sci. Sports Exerc. 1982. 14: 286–291.
EHRSAM R.E., HEIGHENHAUSER G.J. F. et al: Effect of respiratory acidosis on metabolism in exercise. J. Appl. Physiol. 1982. 53 (1): 63–69.
MADIAS N.E.; Lactic acidosis. Kidney Int. 1986. 29: 752–774.
FOX I.H.: Metabolic basis for disorders or purine nucleotide degradation. Metabolism. 1981. 30 (6): 616–634.
FURST P., BERGSTROM J. et al: Intermediate energy metabolism for the catabolic state with special regard to muscle tissue. In: Wilkinson A.W., Cuthbertson D. (Eds): Metabolism and the response to injury. London Pitman Medical, p. 94. 1976.
DRIVER G.A., LE BRUN M.: Iatrogenic malnutrition in patients receiving ventilatory support JAMA 244: 1980. 2195–2196.
DRIVER A.G., MC ALEVY M.T. et al: Nutritional assessment of patients with chronic obstructive pulmonary disease and acute respiratory failure. Chest 1982. 82: 568–571.
FRISANCHO A.R.: New standards of weight and body composition by frame size and height for assessment of nutritional status of adults and the elderly. Am. J. Clin. Nutr. 1984. 40: 808–819.
HEYMSFIELD SB, MC MANUS C. et al: Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm muscle area. Am. J. Clin. Nutr. 1982. 36: 680–690.
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Fiaccadori, E., Del Canale, S., Guariglia, A. (1988). Nutritional and metabolic aspects of COPD. In: Grassino, A., Fracchia, C., Rampulla, C., Zocchi, L. (eds) Respiratory Muscles in Chronic Obstructive Pulmonary Disease. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3850-1_11
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DOI: https://doi.org/10.1007/978-1-4471-3850-1_11
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