Abstract
Orbital disease is encountered in three forms in surgical pathology: as a diagnostic biopsy, as an excision biopsy and in an “exenteration” specimen. In general, the use of biopsy is restricted to tumours or orbital inflammatory processes (pseudotumour) which simulate neoplasia. An orbital exenteration is reserved for inflammatory and neoplastic diseases which involve the tissues extensively, usually when the eye is blind. For the uninitiated, the techniques required for dealing with an exenteration specimen are somewhat specialised and the topic is dealt with separately at the end of the chapter.
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References
Alford EC Jr, Lofton S (1988) Gliomas of the optic nerve or chiasm. Outcome by patients’ age, site and treatment. J Neurosurg 68: 85–98
Antle CM, White VA, Horsman DO, Rootman J (1990) Large cell orbital lymphoma in a patient with acquired immune deficiency syndrome: Case report and review. Ophthalmology 97: 1494–1498
Bickler-Bluth ME, Custer PL, Smith ME (1988) Neurolemmoma as a presenting feature of neurofibromatosis. Arch Ophthalmol 106: 665–667
Bolt HC, Nerad JA (1988) Orbital metastases from prostatic carcinoma. Arch Ophthalmol 106: 1403–1408
Bray WH, Giangiacomo J, Ide CH (1988) Orbital apex syndrome. Sury Ophthalmol 32: 136–140
Brown HH, Kersten RC, Kulwin DR (1991) Lipomatous haematoma of the orbit. Arch Ophthalmol 109: 240–243
Bullen CL, Liesegang TJ, McDonald TH, DeRemee RA (1983) Ocular complications of Wegener’s granulomatosis. Ophthalmology 90: 279–290
Capps DH, Brodsky MC, Rice CD, Mrak RE, Glasier CM, Brown HH (1990) Orbital intramuscular schwannoma. Am J Ophthalmol 110: 535–539
Char DH, Ablin A, Beckstead J (1984) Histiocytic disorders of the orbit. Ann Ophthalmol 16: 867–873
Collison JMT, Miller NR, Green WR (1986) Involvement of orbital tissues by sarcoid. Am J Ophthalmol 102: 302–307
Croxatto JO, Font RL (1982) Hemangiopericytoma of the orbit: a clinicopathologic study of 30 cases. Hum Pathol 13: 210–218
Cutarelli PE, Roessmann UR, Miller RH, Specht CS, Grossniklaus HE (1991) Immunohistochemical properties of human optic nerve glioma. Inv Ophthalmol Vis Sci 32: 2521–2524
Davis JL, Parke DW, Font RL (1985) Granulocytic sarcoma of the orbit. Ophthalmology 92: 1758–1762
de Juan E, Cotton RW, Iliff NT (1983) Allergic periorbital mucocoele in children. Am J Ophthalmol 96: 299–303
Dempster AG, Lee WR, Bahnasawi S, Downie T (1983) Cell necrosis and endocytosis (apoptosis) in an embryonal rhabdomyosarcoma of the orbit. Graefé s Arch Klin Exp Ophthalmol 221: 89–95
De-Smet MD, Rootman J (1987) Orbital manifestations of plasmacytic lymphoproliferations. Ophthalmology 94: 995–1003
Dunlop IS, Billson FA (1988) Visual failure in allergic aspergillus sinusitis. Br J Ophthalmol 72: 127–130
Eijpe AA, Koornneef L, Verbeeten B et al. (1991) Intradiploic epidermoid cysts of the bony orbit. Ophthalmology 98: 1737–1743
Emori M, Hayasaka S, Setogawa T, Miyakuni Y, Fukama A (1991) Recurrent mixed tumor of the right lacrimal gland causes acute contralateral visual loss. Ophthalmologica 202: 138–141
Enzinger FM, Weiss SW (1988) Soft tissue tumours. Mosby, St Louis Fleck BW, Toft AD (1990) Graves’ ophthalmopathy. Br Med J 300: 1352–1353
Fletcher CDM, McKee PH (1990) Pathobiology of soft tissue tumours. Churchill Livingstone, Edinburgh
Font RL, Hidayat AA (1982) Malignant fibrous histiocytoma of the orbit: a clinicopathologic study of 150 cases. Hum Pathol 13: 199–209
Font RL, Jurco S III, Zimmerman LE (1982) Alveolar soft part sarcoma of the orbit. A clinicopathologic analysis of 17 cases and a review of the literature. Hum Pathol 13: 569–579
Freedman SF, Elner VM, Donev I et al. (1988) Intraocular neurilemmoma arising from the posteriorciliary nerve in neurofibromatosis. Pathological findings. Ophthalmology 95: 1559–1564
Gamel JW, Font RL (1982) Adenoid cystic carcinoma of the lacrimal gland. Hum Pathol 13: 219–225
Goldberg RA, Rootman J, Cline RA (1990) Tumours metastatic to the orbit: a changing picture. Sury Ophthalmol 35: 1–24
Grossniklaus HE, Abbuhl MF, McLean IW (1990) Immunohistologic properties of benign and malignant mixed tumor of the lacrimal gland. Am J Ophthalmol 110: 540–549
Harris GJ, Sakol PJ, Bonavolonta G, de Conciliis C (1990) An analysis of thirty cases of orbital lymphangioma: pathophysiologic considerations and management recommendations. Ophthalmology 97: 1583–1592
Hartwick RWJ, Shaw PA, Srigley JR, Hurwitz JJ (1990) In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Can J Ophthalmol 25: 213–217
Hausamen J-E, Stolke D, Trowibzsch E (1988) Diagnostic and therapeutic problems with an unusual congenital cystic hygroma of the orbit. J Craniomaxillofacial Surgery 16: 89–92
Hornblass A, Jakobiec FA, Reifler DM, Mines J (1987) Orbital lymphoid tumours located predominantly within extraocular muscles. Ophthalmology 94: 688–697
Hufnagel TJ, Hickey WF, Cobbs WH, Jakobiec FA, Iwamato T, Eagle RC (1984) Immunohistochemical and ultrastructural studies on the exenterated orbital tissues of a patient with Graves’ disease. Ophthalmology 91: 1411–1419
Iwamoto T, Jakobiec FA (1982) A comparative ultrastructural study of the normal lacrimal gland and its epithelial tumors. Hum Pathol 13: 236–262
Jakobiec FA (ed) (1978) Ocular and adnexal tumours. Aesculapius Publ Co., Birmingham, USA
Jakobiec FA, Lefkowitch J, Knowles DM (1984) B- and T-lymphocytes in ocular disease. Ophthalmology 91: 635–654
Jakobiec FA, Neri A, Knowles DM (1987) Genotypic monoclonality in immunophenotypically polyclonal orbital lymphoid tumours. Ophthalmology 94: 980–984
Jakobiec FA, Rini F, Char D (1989) Primary liposarcoma of the orbit. Problems in the diagnosis and management of five cases. Ophthalmology 96: 180–191
Johnson TE, Bergin DJ, McCord CD (1988) Aneurysmal bone cyst of the orbit. Ophthalmology 95: 86–89
Kelly SP, Lloyd IC, Anderson H, Joyce PW, Pace-balzan A (1991) Solitary extramedullary plasmacytoma of the maxillary antrum and orbit presenting as acute bacterial orbital cellulitis. Br J Ophthalmol 75: 438–439
Kennerdell JS, Maroon JC, Garrity JA, Abla AA (1986) Surgical management of orbital lymphangioma with the carbon dioxide laser. Am J Ophthalmol 102: 308–314
Knowles DM, Jacobiec FA (1982) Ocular adnexal lymphoid neoplasms: clinical, histopathologic, electron microscopic and immunologic characteristics. Hum Pathol 13: 148–162
Knowles DM, Jakobiec FA (1985) Cell marker analysis of extranodal lymphoid infiltrates. To what extent does the determination of mono-or polyclonality resolve the diagnostic dilemma of malignant lymphoma vs pseudo-lymphoma in an extranodal site? Semin Diagn Histopathol 2: 163–168
Knowles DM, Jakobiec FA, McNally L, Burke SJ (1990) Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva and eyelids): a prospective multi-parametric analysis of 108 cases during 1977 to 1987. Hum Pathol 21: 959–973
Lane CM, Wright JE, Garner A (1988) Primary myxoid liposarcoma of the orbit. Br J Ophthalmol 72: 912–917
Lee WR, McGhee CNJ (1989) Pseudotumours in the orbit. In: Anthony PP, MacSween RNM (eds) Recent advances in pathology. Churchill Livingstone, Edinburgh, pp 123–137
Leone CR, Lawton AW, Leone RT (1988) Benign osteoblastoma of the orbit. Ophthalmology 95: 1554–1558
Lerner SF, Morales AG, Croxatto JO (1991) Hydatid cyst of the orbit. Arch Ophthalmol 109: 285
Levine MR, Chu A, Abdul-Karim FW (1991) Brown tumours and secondary hyperparathyroidism. Arch Ophthalmol 109: 847–849
Lindquist TD, Orcutt JC, Gown AM (1988) Monoclonal antibodies to intermediate filament proteins: diagnostic specificity in orbital pathology. Sury Ophthalmol 32: 421–426
Lucas DR, Knox F, Davies S (1982) Apparent monoclonal origin of lymphocytes and plasma cells infiltrating ocular adnexal amyloid deposits: report of two cases. Br J Ophthalmol 66: 600–606
Lyons CJ, McNab AA, Garner A, Wright JE (1989) Orbital peripheral nerve sheath tumours. Br J Ophthalmol 73: 731–738
Mamalis N, Garland PE, Argyle JC, Apple DJ (1985) Congenital orbital teratoma: a review and report of two cases. Sury Ophthalmol 30: 41–46
Mansour AM, Barber JC, Reinecke RD, Wang FM (1989) Ocular choristomas. Sury Ophthalmol 33: 339–358
Margo CE, Levy MH, Beck RW (1989) Bilateral idiopathic inflammation of the optic nerve sheaths. Light and electron microscopic findings. Ophthalmology 96: 200–206
Marquardt MD, Zimmerman LE (1982) Histopathology of meningi-ornas and gliomas of the optic nerve. Hum Pathol 13: 226–235
Mauriello JA, Flanagan JC (1989) Pseudotumour and lymphoid tumour: distinct clinicopathologic entities. Sury Ophthalmol 34: 142–148
McNab AA, Mosely I (1990) Primary orbital liposarcoma: clinical and computed tomographic features. Br J Ophthalmol 74: 437–439
Medeiros LJ, Harris NL (1989) Lymphoid infiltrates of the orbit and conjunctiva. A morphologic and immunophenotypic study of 99 cases. Am J Surg Pathol 13: 459–471
Medeiros LJ, Harmon DC, Linggood RM, Harris NL (1989) Immunohistologic features predict clinical behavior of orbit and conjunctival lymphoid infiltrates. Blood 74: 2121–2129
Meekins BB, Dutton JJ, Proia AD (1988) Primary orbital leiomyosarcoma. A case report and review of the literature. Arch Ophthalmol 106: 82–86
Miettinen M (1987) Melanotic schwannoma coexpression of vimentin and glial fibrillary acidic protein. Ultrastruct Pathol 11: 39–46
Milne HL, Leone CR, Kincaid MC, Brennan MW (1987) Chronic haematic cyst of the orbit. Ophthalmology 94: 271–277
Minehan KJ, Martenson JA, Garrity JA et al. (1991) Local control and complications after radiation therapy for primary orbital lymphoma: a case for low dose treatment. Int J Radiat Oncol Biol Phys 20: 791–796
Orcutt JC, Char DH (1988) Melanoma metastatic to orbit. Ophthalmology 95: 1033–1037
Ormerod DL, Weber AL, Rauch SD, Feldon SE (1987) Ophthalmic manifestations of maxillary sinus mucocoeles. Ophthalmology 94: 1013–1019
Pepose JS, Akata RF, Pflugfelder SC, Voigt W (1990) Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjögreri s syndrome. Ophthalmology 97: 1599–1605
Qingli L, Orcutt JC, Seifter LS (1989) Orbital mucormycosis with retinal and ciliary artery occlusions. Br J Ophthalmol 73: 680–683
Rakes SM, Yeatts RP, Campbell RJ (1985) Ophthalmic manifestations of esthesio-neuroblastoma. Opthalmology 92: 1749–1753
Reifler DM, Leder D, Rexford T (1989) Orbital haemorrhage and eyelid ecchymosis in acute orbital myositis. Am J Ophthalmol 107: 111–113
Riddle PJ, Font RL, Zimmerman LE (1982) Carcinoid tumors of the eye and orbit: a clinicopathologic study of 15 cases with histochemical and electron microscopic studies. Hum Pathol 13: 459–469
Rodger FC (1981) Eye disease in the tropics. Churchill Livingstone, Edinburgh
Rootman J, Daniji KF, Dimmick JE (1989) Malignant rhabdoid tumour of the orbit. Ophthalmology 96: 1650
Rubinfield RS, Gootenberg JE, Chavis RM, Zimmerman LE (1988) Early onset acute orbital involvement in childhood acute lymphoblastic leukaemia. Ophthalmology 95: 1116–1120
Satorre J, Antle CM, O’Sullivan R et al. (1991) Orbital lesions with granulomatous inflammation. Can J Ophthalmol 26: 174–195
Shapiro AM, Tso MOM, Putterman AM, Goldberg MF (1986) A clinicopathologic study of hematic cysts of the orbit. Am J Ophthalmol 102: 237–241
Sherman MD, Van Dalen JT, Conrad K (1990) Bilateral orbital infiltration as the initial sign of a peripheral T cell lymphoma presenting in a leukemic phase. Ann Ophthalmol 22: 93–95
Shields CL, Shields JA, Buchanan HW (1990) Solitary orbital involvement with the juvenile xanthogranuloma. Arch Ophthalmol 108: 1587–1589
Shields JA, Karcioglu ZA, Shields CL, Eagle RC, Wong S (1991) Orbital and eyelid involvement with Erdheim-Chester disease. Arch Ophthalmol 109: 850–854
Smith DL, Kincaid MC, Nicolitz E (1988) Angiolymphoid hyperplasia with eosinophilia ( Kimurâ s disease) of the orbit. Acta Ophthalmol 106: 793–795
Tijl JWM, Koornneef L (1991) Fine needle aspiration biopsy in orbital tumours. Br J Ophthalmol 75: 491–492
Tsuneyoshi M, Daimaru Y, Hashimoto H, Enjoji M (1987) The existence of rhabdoid cells in specified soft tissue sarcomas: histopathological, ultrastructural and immunohistochemical evidence. Virchows Arch(A) 411: 509–514
Tung G, Finger PT, Klein I, Chess Q (1988) Plasmacytoma of the orbit. Arch Ophthalmol 106: 1622
Whitson WE, Orcott JC, Walkenshaw MD (1986) Orbital osteoma in Gardner’s syndrome. Am J Ophthalmol 101: 236–241
Wilkins SR, Hofmann RJ, Byrd WA, Font RL (1987) Heterotopic brain tissue in the orbit. Arch Ophthalmol 105: 390–392
Woodruff G, Thorner P (1988) Primary Ewing’s sarcoma of the orbit presenting with visual loss. Br J Ophthalmol 72: 786–792
Zucker JL, Doyle MF (1991) Mycosis fungoides metastatic to the orbit. Arch Ophthalmol 109: 688–691
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Lee, W.R. (1993). The Orbital Biopsy and the Exenteration Specimen. In: Ophthalmic Histopathology. Springer, London. https://doi.org/10.1007/978-1-4471-3843-3_12
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DOI: https://doi.org/10.1007/978-1-4471-3843-3_12
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