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The Conjunctival Biopsy

  • W. R. Lee

Abstract

Conjunctival tissue is not excised from the eye during the procedure of routine surgical enucleation, so that the tissue is available for study only in autopsy specimens, exenteration specimens or in elective surgical excision of diseased tissue. Biopsy for investigation of systemic disease is a valuable source of material for scientific investigation, but it is underutilised.

Keywords

Bullous Pemphigoid Allergic Conjunctivitis Bulbar Conjunctiva Conjunctival Epithelium Impression Cytology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aaberg TM (1989) The expanding ophthalmic spectrum of Lyme disease. Am J Ophthalmol 107: 77–80PubMedGoogle Scholar
  2. Adams GGW, Dilly PN (1989) Differential staining of ocular goblet cells. Eye 3: 840–841PubMedCrossRefGoogle Scholar
  3. Allaire GS, Hidayat AA, Zimmerman LE, Minardi L (1990) Reticulohistiocytoma of the limbus and cornea. Ophthalmology 97: 1018–1022PubMedGoogle Scholar
  4. Allansmith MR, Korb DR, Greiner JV et al. (1977) Giant papillary conjunctivitis in contact lens wearers. Am J Ophthalmol 83: 697–708PubMedGoogle Scholar
  5. Ashton N, Cook C (1979) Allergic granulomatous nodules of the eyelid and conjunctiva. Am J Ophthalmol 87: 1–28PubMedGoogle Scholar
  6. Borodic GE, Beyer Machule CK, Millin J et al. (1984) Immunoglobulin deposition in localised conjunctival amyloidosis. Am J Ophthalmol 98: 617–622PubMedGoogle Scholar
  7. Casey RJ, Garner A (1981) Epibulbar choristoma and microphthalmia: a report of two cases. Br J Ophthalmol 75: 247–250CrossRefGoogle Scholar
  8. Dugel PU, Gill PS, Frangieh GT, Rao NA (1990) Ocular adnexal Kaposí s sarcoma in acquired immunodeficiency syndrome. Am J Ophthalmol 110: 500–503PubMedGoogle Scholar
  9. Ferry AP, Kaltreider SA, Wyatt DB (1984) Actinic granuloma of the conjunctiva. Arch Ophthalmol 102: 1200–1202PubMedCrossRefGoogle Scholar
  10. Flach AJ, Lavoie PE (1990) Episcleritis, conjunctivitis and keratitis as ocular manifestations of Lyme disease. Ophthalmology 97: 973–975PubMedGoogle Scholar
  11. Folberg R, McLean IW, Zimmerman LE (1985a) Primary acquired melanosis of the conjunctiva. Hum Pathol 16: 129–135PubMedCrossRefGoogle Scholar
  12. Folberg R, McLean IW, Zimmerman LE (1985b) Malignant melanoma of the conjunctiva. Hum Pathol 16: 136–143PubMedCrossRefGoogle Scholar
  13. Folberg R, Jakobiec FA, Bernardino VB, Iwamoto T (1989) Benign melanocytic conjunctival lesions. Clinicopathologic features. Ophthalmology 96: 436–451Google Scholar
  14. Foster CS (1990) Ocular Rosacea: a histologic and immunopathologic study. Ophthalmology 97: 1468–1475PubMedGoogle Scholar
  15. Foster CS, Fong LP, Azar D, Kenyon KR (1988) Episodic conjunctival inflammation after Stevens—Johnson syndrome. Ophthalmology 95: 453–462PubMedGoogle Scholar
  16. Friedlander MH, Okumoto M, Kelley J (1984) Diagnosis of allergic conjunctivitis. Arch Ophthalmol 102: 1198–1199CrossRefGoogle Scholar
  17. Frith PA, Yenning VA, Wojnarowska F (1989) Conjunctival involvement in cicatricial and bullous pemphigoid: a clinical and immunopathological study. Br J Ophthalmol 73: 52–56PubMedCrossRefGoogle Scholar
  18. Hered RW, Spaulding AG, Sanitato JJ, Wander AH (1988) Ophthalmia nodosa caused by tarantula hairs. Ophthalmology 95: 166PubMedGoogle Scholar
  19. Hidayat AA, Riddle PJ (1987) Ligneous conjunctivitis: a clinico-pathologic study of 17 cases. Ophthalmology 94: 949–959PubMedGoogle Scholar
  20. Hoang-Xuan T, Rodriguez A, Zaltas MM, Rice BA, Foster CS (1990) Ocular Rosacea. A histologic and immunopathologic study. Ophthalmology 97: 1468–1475Google Scholar
  21. Holds JB, Mamalis N, Anderson RL (1990) Nodular fasciitis presenting as a rapidly enlarging episcleral mass in a 3-year-old. J Paediatr Ophthalmol Strab 27: 157–159Google Scholar
  22. Holland EJ, Chan C-C, Kuwabara T, Palestine AG, Rowsey JJ, Nussenblatt EB (1989) Immunohistologic findings and ‘results of treatment with cyclosporine in ligneous conjunctivitis. Am J Ophthalmol 107: 160–166PubMedGoogle Scholar
  23. Huntingdon AC, Langloss JM, Hidayat AA (1990) Spindle cell carcinoma of the conjunctiva: an immunohisto-chemical and ultrastructural study of six cases. Ophthalmology 97: 711–717Google Scholar
  24. Jakobiec FA, Brownstein S, Wilkinson RD et al. (1980) Combined surgery and cryotherapy for diffuse malignant melanoma of the conjunctiva. Arch Ophthalmol 98: 1390–1396PubMedCrossRefGoogle Scholar
  25. Jakobiec FA, Sacks E, Lisman RL, Krebs W (1988a) Epibulbar fibroma of the conjunctival substantia propria. Arch Ophthalmol 106: 661–664PubMedCrossRefGoogle Scholar
  26. Jakobiec FA, Rini FJ, Fraunfelder FT, Brownstein S (1988b) Cryotherapy for conjunctival primary acquired melanosis and malignant melanoma. Experience with 62 cases. Ophthalmology 95: 1058–1070PubMedGoogle Scholar
  27. Jakobiec FA, Folberg R, Iwamoto T (1989) Clinico-pathologic characteristics of premalignant and malignant lesions of the conjunctiva. Ophthalmology 96: 147–166PubMedGoogle Scholar
  28. Jaros PA, de Luise VP (1988) Pingueculae and pterygia. Sury Ophthalmol 33: 41–49CrossRefGoogle Scholar
  29. Jeffrey IM, Lucas DR, MacEwan C, Lee WR (1986) Malignant melanoma of the conjunctiva. Histopathology 10: 363–378PubMedCrossRefGoogle Scholar
  30. Karcioglu ZA, Allam B, Insler MS (1988) Ocular involvement in sinus histiocytosis with massive lymphadenopathy. Br J Ophthalmol 72: 793–795PubMedCrossRefGoogle Scholar
  31. Kriegbaum NJ, von Listow M, Oxholm P, Prause JU (1988) Keratoconjunctivitis sicca in patients with primary Sjögrens syndrome. A longitudinal study of ocular parameters. Acta Ophthalmologica 66: 481–484Google Scholar
  32. Lahoud S, Brownstein S, Laflamme MY (1988) Fibrous histiocytoma of the corneoscleral limbus and conjunctiva. Am J Ophthalmol 106: 579–583PubMedCrossRefGoogle Scholar
  33. Lass JH, Jenson AB, Papale JJ, Albert DM (1983) Papilloma virus in human conjunctival papillomas. Am J Ophthalmol 95: 364–368PubMedGoogle Scholar
  34. Lee WR (1981) The conjunctival biopsy. In: Anthony PP, MacSween RNM (eds) Recent Advances in Histopathology 11. Churchill Livingstone, Edinburgh, pp 213–226Google Scholar
  35. Leonard JN, Hobday CM, Hafenden GP et al. (1988) Immunofluorescent studies in ocular cicatricial pemphigoid. Br J Dermatol 118: 209–217PubMedCrossRefGoogle Scholar
  36. Libert J, Tondeur M, van Hoof F (1976) The use of conjunctival biopsy and enzyme analysis in tears for the diagnosis of homozygotes and heterozygotes with Fabry disease. Birth Defects Series 12: 221–239Google Scholar
  37. Lindenmuth KA, Sugar A, Kincaid MC, Nelson CC, Comstock CP (1988) Invasive squamous cell carcinoma of the conjunctiva presenting as necrotising scleritis with scleral perforation and uveal prolapse. Sury Ophthalmol 33: 50–54CrossRefGoogle Scholar
  38. Lucas DR, Dunham AC, Lee WR et al. (1976) Ocular injuries from liquid golf ball centres. Br J Ophthalmol 60: 740–747PubMedCrossRefGoogle Scholar
  39. Lucas DR, Knox F, Davies S (1982) Apparent monoclonal origin of lymphocytes and plasma cells infiltrating ocular adenexal amyloid deposits. Br J Ophthalmol 66: 600–606PubMedCrossRefGoogle Scholar
  40. Mansour AM, Barber JC, Reinecke RD, Wang FM (1989) Ocular choristomas. Sury Ophthalmol 33: 339–358CrossRefGoogle Scholar
  41. McCartney ACE (1989) Limbal allergic granulomatosis. Eye 3: 172–179PubMedCrossRefGoogle Scholar
  42. McDonnell JM, Mayr AJ, Martin WJ (1989) DNA of human papillomavirus type 16 in dysplastic and malignant lesions of the conjunctiva and cornea. N Engl J Med 320: 1442–1446PubMedCrossRefGoogle Scholar
  43. McDonnell JM, Sun Y, Wagner D (1991) HMB-45 immunohistochemical staining of conjunctival melanocytic lesions. Ophthalmology 98: 453–458PubMedGoogle Scholar
  44. Mondino BJ (1990) Cicatricial pemphigoid and erythema multiforme. Ophthalmology 97: 939–952PubMedGoogle Scholar
  45. Odrich MG, Jakobiec FA, Lancaster WD, Kenyon KR et al. (1991) A spectrum of bilateral squamous conjunctival tumours associated with human papilloma virus type 16. Ophthalmology 98: 628–635PubMedGoogle Scholar
  46. Pokorny KS, Hyman BM, Jakobiec FA (1987) Epibulbar choristomas containing lacrimal tissue. Clinical distinction from dermoids and histologic evidence of an origin from the palpebral lobe. Ophthalmology 94: 1249–1257Google Scholar
  47. Reacher MH, Pé er J, Rapoza PA, Whittum-Hudson JA, Taylor HR (1991) T cells and trachoma: their role in cicatricial disease. Ophthalmology 98: 334–341PubMedGoogle Scholar
  48. Resnick SC, Schainker BA, Ortiz JM (1991) Conjunctival synthetic and non-synthetic fiber granulomas. Cornea 10: 59–62PubMedGoogle Scholar
  49. Rice BA, Foster S (1990) Immunopathology of cicatricial pemphigoid affecting the conjunctiva. Ophthalmology 97: 1476–1483PubMedGoogle Scholar
  50. Rodger FC (1981) Eye disease in the tropics. Churchill Livingstone, EdinburghGoogle Scholar
  51. Sacks EH, Jakobiec FA, Wieczorek R et al. (1989) Immunophenotypic analysis of the inflammatory infiltrate in ocular cicatricial pemphigoid. Further evidence for a T cell-mediated disease. Ophthalmology 96: 236–243PubMedGoogle Scholar
  52. Scott KR, Tse DT, Kronish JW (1991) Hemorrhagic lymphangiectasis of the conjunctiva. Arch Ophthalmol 109: 286–287PubMedCrossRefGoogle Scholar
  53. Sheppard JD, Kowalski RP, Meyer MP et al. (1988) Immunodiagnosis of adult chlamydial conjunctivitis. Ophthalmology 95: 434–443PubMedGoogle Scholar
  54. Shields CL, Shields JA, Arbizo V, Augsburger JJ (1986a) Oncocytoma of the caruncle. Am J Ophthalmol 102: 315–319PubMedGoogle Scholar
  55. Shields CL, Shields JA, White D, Augsburger JJ (1986b) Types and frequency of lesions of the caruncle. Am J Ophthalmol 102: 771–778PubMedGoogle Scholar
  56. Spaide RF, Ward DL (1990) Conjunctival biopsy in the diagnosis of sarcoidosis. Br J Ophthalmol 74: 469–471PubMedCrossRefGoogle Scholar
  57. Stopak SS, Dreizen NG, Zimmerman LE, O’Neill JF (1988) Sinus histiocytosis presenting as an epibulbar mass. A clinicopathologic case report. Arch Ophthalmol 106: 1426–1428Google Scholar
  58. Tuft SJ, Kemeny DM, Dart JK, Buckley RJ (1991) Clinical features of atopic keratoconjunctivitis. Ophthalmology 98: 150–158PubMedGoogle Scholar
  59. Wiley L, Springer D, Kowalski RP et al. (1988) Rapid diagnostic test for ocular adenovirus. Ophthalmology 95: 431–433PubMedGoogle Scholar
  60. Winterkorn JMS (1990) Lyme disease: neurologic and ophthalmic manifestations. Sury Ophthalmol 35: 191–204CrossRefGoogle Scholar
  61. Wittpenn JR, Tseng CGS, Sommer A (1986) Detection of early xerophthalmia by impression cytology. Arch Ophthalmol 104: 237–239PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 1993

Authors and Affiliations

  • W. R. Lee
    • 1
  1. 1.Department of PathologyUniversity of GlasgowGlasgowUK

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