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Fetal and Neonatal Pathology pp 111–147Cite as

Congenital Malformations, Prenatal Diagnosis and Fetal Examination

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Abstract

Congenital malformations are an important cause of perinatal and infant mortality and morbidity. Three per cent of newborns have a single major malformation and 0.7% have multiple major defects. They have fascinated curious individuals for centuries but during the past 50 years infants with major anomalies have become the focus of increasing and diverse professional expertise and consume a large slice of health budgets in developed countries. Their importance as a cause of perinatal mortality has grown as deaths from intrapartum problems have declined and better neonatal care has improved the survival of normally formed low birth weight babies (see Chapter 8). Clinical interest in malformations has been enhanced because sophisticated surgical and anaesthetic management makes correction of some major defects possible. This and the recognition of syndromes, their mode of inheritance and sometimes their aetiology requires detailed information from the pathologist in respect of those babies who die.

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Authors
  1. Jean W. Keeling
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  2. Patricia A. Boyd
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Editors and Affiliations

  1. Department of Paediatric Pathology and Cytogenetics, Royal Hospital for Sick Children, Edinburgh, EH9 1LF, UK

    Jean W. Keeling MBBS, FRCPath, FRCP (Edin) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology)

  2. University of Edinburgh, UK

    Jean W. Keeling MBBS, FRCPath, FRCP (Edin) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology)

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Keeling, J.W., Boyd, P.A. (1993). Congenital Malformations, Prenatal Diagnosis and Fetal Examination. In: Keeling, J.W. (eds) Fetal and Neonatal Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-3802-0_4

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  • DOI: https://doi.org/10.1007/978-1-4471-3802-0_4

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