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The Skeletal System

  • Chapter
Fetal and Neonatal Pathology

Abstract

The different phenotypes of disturbances of skeletal development have for centuries fascinated artists as well as medical men. As an example of achondroplasia, one may admire the painting Don Sebastian de Mora by Velasquez, in the Prado, Madrid. There are, at present, more than 500 disorders known in which the skeleton is involved. These are mostly congenital disorders and are, in part, genetic in nature. The birth prevalence of each disorder is low but, as a whole, they constitute a significant body of disease in childhood. Reliable estimates on their frequency are scarce. The overall frequency among stillbirths and live-borns has been estimated to be 1 per 4000 births and the frequency among perinatal deaths is 1 per 110 deaths (Camera et al. 1982; Orioli et al. 1986).

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Authors
  1. Hans J. van der Harten
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Editors and Affiliations

  1. Department of Paediatric Pathology and Cytogenetics, Royal Hospital for Sick Children, Edinburgh, EH9 1LF, UK

    Jean W. Keeling MBBS, FRCPath, FRCP (Edin) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology)

  2. University of Edinburgh, UK

    Jean W. Keeling MBBS, FRCPath, FRCP (Edin) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology) (Consultant Paediatric Pathologist, Honorary Senior Lecturer in Pathology)

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© 1993 Springer-Verlag London

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van der Harten, H.J. (1993). The Skeletal System. In: Keeling, J.W. (eds) Fetal and Neonatal Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-3802-0_26

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  • DOI: https://doi.org/10.1007/978-1-4471-3802-0_26

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