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Headache: Experience with Large Multicenter Trials in the Treatment of Migraine Attacks

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Clinical Trials in Neurology

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Abstract

In this chapter we will discuss experiences with randomised controlled trials (RCTs) in the acute treatment of migraine. With the introduction of the new 5-hydroxytryptamine (5HT)1B/1D receptor agonist sumatriptan [1], the first drug developed specifically for migraine, and recently other triptans, the focus in RCTs in migraine has overwhelmingly been on acute migraine treatment. Only one prophylactic drug, the antiepileptic drug sodium valproate, has been introduced in recent years [2–5]. This chapter is based partly on our personal experience with multicenter RCTs in acute migraine treatment (n = 6) in recent years, partly on what we have perceived as problems in published multicenter RCTs. More systematic reviews on RCTs in migraine therapy are available [5–17].

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Authors
  1. P. Tfelt-Hansen
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  2. K. Seidelin
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Editors and Affiliations

  1. Neuromuscular Unit, West London Neurosciences Centre, 1st Floor Pilot Wing, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK

    Roberto J. Guiloff MD, FRCP (Consultant Neurologist) (Consultant Neurologist)

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© 2001 Springer-Verlag London

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Tfelt-Hansen, P., Seidelin, K. (2001). Headache: Experience with Large Multicenter Trials in the Treatment of Migraine Attacks. In: Guiloff, R.J. (eds) Clinical Trials in Neurology. Springer, London. https://doi.org/10.1007/978-1-4471-3787-0_24

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  • DOI: https://doi.org/10.1007/978-1-4471-3787-0_24

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-856-0

  • Online ISBN: 978-1-4471-3787-0

  • eBook Packages: Springer Book Archive

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