Abstract
There has always been an understanding of the importance of proper breathing and eating in health and disease. In the past few decades, the relationships between metabolism and respiratory function, in general, and nutrition and ventilation in particular have been more closely investigated and have acquired growing importance in rehabilitation. Malnutrition, metabolic disorders, electrolyte disturbances and abnormalities of gas exchange can have profound effects on ventilation especially through their effects on the ventilatory muscles. When the diagnosis of a condition which may place the patient at risk of respiratory insufficiency is first made, nutritional and metabolic assessment becomes immediately important.
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References
Aldrich T.K., Arora N.S., Rochester D.F.: The influence of airway obstruction and respiratory muscle strength on maximal voluntary ventilation in lung disease. Am. Rev. Respir. Dis. 1982; 126: 195–99
Aldrich T.K.: The patient at risk of ventilator dependency. Eur. Respir. J. 1989; 7 (Supp.): 645
Aldrich T.K.: The application of muscle endurance training techniques to the respiratory muscles in COPD. Lung 1985; 163: 15–22
Aldrich T.K., Karpel J.P., Ferranti R. et al.: Weaning from mechanical ventilation. Adjunctive use of inspiratory muscle resistive braining. Crit. Care Med. 1989; 17: 2, 143–147
Anderson J.B., Dragsted L., Kann T., Johansen S.H. et al.: Resistive breathing training in severe chronic obstructive pulmonary disease. J. Respir. Dis. 1979; 60: 151–156
Angelillo V.A., Sukhdarson B., Durfee D., Patterson A.J., O’Donohue W.J.: Effects of low and high carbohydrate feedings in ambulatory patients with chronic obstructive pulmonary disease and chronic hypercapnia. Ann. Intern. Med. 1985; 103 (pt 1): 883–885
Apelgen R.N., Rombeau J.T., Twomey P.L., Miller R.A.: Comparison of nutritional indices and outcome in critically ill patients. Crit. Care Med. 1982; 10: 15, 305–307
Arlati S., Rolo J., Micaleh E. et al.: A reservoir nasal cannula improves protection given by oxygen during muscular exercise in COPD. Chest 1988; 93: 1165–1169
Arora N.S., Rochester D.F.: Respiratory muscle strength and maximal voluntary ventilation in undernourished patients. Am. Rev. Respir. Dis. 1982; 126 (1): 5–8
Arora N.S., Rochester D.F.: COPD and human diaphragm muscle dimensions. Chest 1987; 91: 719–724
Arora N.S., Rochester D.F.: Effects of general nutritional and muscular status on the human diaphragm. Am. Rev. Respir. Dis. 1977; 115: 84
Arora N.S., Rochester D.F.: Effects of body weight and muscularity on human diaphragm muscle mass thickness and area. J. Appl. Physiol. 1982; 52 (1): 64–70
Asmundsson T., Kilburn H.: Survival of acute respiratory failure–A study of 239 episodes. Ann. Intern. Med. 1969; 70 (3): 471–485
Aubier M., Marciano D., Lecocquic Y. et al.: Effect of hypophosphatemia on diaphragm contractility in patients with acute respiratory failure. N. Engl. J. Med. 1985; 313: 420–424
Aubier M., Viires N., Piguet J.: Effects of hypocalcemia on diaphragmatic strength generation. J. Appl. Physiol. 1985; 58: 2054–2061
Baier H., Samani P.: Ventilatory drive in normal man during semistarvation. Chest 1984; 85 (52): 222–225
Bassilli H.R., Deitel M.: Effect of nutritional support on weaning patients off mechanical ventilators. J. PEN 1981; 5 (2): 161
Bassilli H.R., Deitel M.: Nutritional support in long term intensive care with special references to ventilator patients, a review. Can. Anaesth Soc. J. 1981; 28 (1): 17
Bellamare F., Bigland Ritchie B.: Central components of diaphragmatic fatigue assessed by phrenic nerve stimulation. J. Appl. Phys. 1987; 62: 1307
Belman M.J., Mittman C.: Ventilatory muscle training improves exercise capacity in chronic obstructive pulmonary disease patients. Am. Rev. Respir. Dis. 1980; 121: 273–81
Beutler B., Cerami A.: Cachectin: more than a tumor necrosis factor. N. Engl. J. Med. 1987; 316: 379
Bergstrom J., Hultman F.: Muscle glycogen synthesis after exercise: an enhancing factor localized to the muscle cell in man. Nature 1966; 210: 309–10
Bistrian B.R., Blackburn G.L., Scrimshaw N.S., Flatt J.P.: Cellular immunity in semistarved states in hospitalized adults. Am. J. Clin. Nutr. 1975; 28: 1148–55
Braun N.M.T., Rochester D.F.: Muscular weakness and respiratory failure. Am. Rev. Respir. Dis. 1979; 119: 123–125
Braun S.R., Keim N.L., Dixon R.M., Clagnaz P., Anderegg A., Shrego E.S.: The prevalence and determinants of nutritional changes in chronic obstructive pulmonary disease. Chest 1984; 86 (4): 558–63
Brown C. Jr., Ferranti R.D., Sparapani M.: Reservoir nasal cannula prevents denaturation in COPD patients during eating. Am. Rev. Respir. Dis. 1988; 137(4) Part 2: 157
Burrows B., Earle R.H.: Care and properties of chronic obstructive lung disease. N. Engl. J. Med. 1969; 280: 397
Casaburi R., Wasserman K., Potessio A. et al.: A new perspective in pulmonary rehabilitation: anaerobic threshold as a discriminant in training. Eur. Respir. J. 1989; 7 (suppl): 618S - 623S
Clowes GHA J., George B.C., Villee C.A. Jr., et al.: Muscle proteolysis induced by a circulating peptide in patients with sepsis or trauma. N. Engl. J. Med. 1983; 308: 545–552
Davis K.J.A., Packer L., Brooks G.A.: Biochemical adaptation of mitochondria, muscle, and whole animal respiration to endurance training. Arch. Biochem. Biophys. 1981; 209: 539–554
Demey H.E., Van Merbeck J.P., Vanderwonde F.F.T., Prove A.M., Martin J.J., Bossaert L.L.: Respiratory insufficiency in acid maltase deficiency. The effect of high protein diet. J. Parenter. Enteral Nutr. 1989; 13: 3, 321–323
Doekel R.C., Zwillic C.W., Scoggings C.H., Kryger M., Weil J.V.: Clinical semi-starvation: depression of hypoxic ventilatory response. N. Engl. J. Med. 1976; 295: 358–61
Dubier M., Trippenbach T., Roussos C.: Respiratory muscle fatigue during cardiogenic shock. J. Appl. Physiol. 1981; 51: 499
Farkas G., Prefant C. et al.: The failing inspiratory muscles under normoxic and hypoxic conditions. Am. Rev. Respir. Dis. 1981; 124: 274–9
Farkas G.A., Roussos C.: Adaptability of the hamster diaphragm to exercise and or emphysema. J. Appl. Physiol. 1982; 53 (5): 1263–72
Felig P.: Starvation. In: DeGrott L.J. (Ed.) Endocrinology. New York, Grune & Stratton, 1979; 3: 1927
Felig P., Havel R.J., Smith L.H. Jr.: Metabolism and Nutrition. New York, McGraw-Hill, 1981; 548–582
Ferranti R.D., Roberto M., Brown C. Jr., Coehlo C.: Oral intake, Oz, dyspnea, dysphagia and other considerations in COPD patients. In: Ferranti R.D. (Ed.) Nutrition and Ventilatory Function - Current Topics in Rehabilition. Verona, Bi & Gi Publishers, London, Springer Verlag, 1992; 181–189
Fiaccadori E., Del Canale S., Guariglia A.: Nutritional and metabolic aspects of COPD in rehabilitation muscles. In: A. Grassino (Ed.) Respiratory Muscles in Chronic Obstructive Pulmonary Disease - Current Topics in Rehabilitation. Verona, Bi & Gi Publishers, London, Springer-Verlag; 1988, 111–123
Gail D.B., Massaro G.D., Massaro D.: Influence of fasting on the lung. J. Appl. Physiol. 1977; 42 (1): 88–92
Garbagni R., Coppo F., Grassini G., Cardillino G.: Effects of lipid loading and fasting on pulmonary function in respiration. 1968; 25: 458–64
Gardiner P.F., Montano G., Simpson D.R. et al.: Effects of glucocorticoids treatment and food restriction on rat limb muscles. Am. J. Physiol. 1980; 238 (Endocrin. Metab. 1): E124 - E130
Gardiner P.F., Hill B., Simpson D.R. et al.: Effect of mild weight-lifting program on the prognosis of glucocorticoid induced atrophy. Pflugers Arch. 1980; 385: 147–153
Gertz I., Hendstierna G., Hellers G., Wahren J.: Muscle metabolism in patients with chronic obstructive lung disease and acute respiratory failure. Clin. Sci. Mol. Med. 1977; 52: 395–403
Gibson G.I., Pride N.B., Davis J.N., Loh L.C.: Pulmonary mechanics in patients with respiratory muscle weakness. Am. Rev. Respir. Dis. 1977; 115 (3): 389–95
Goldberg A.L.: Influence of insulin and contractile activity on muscle and protein balance. Diabetes 1979; 28 (suppl): 18–29
Goldstein S.A., Thomashow B.M., Kretan V., Askanazi J., Kinney J.M., Elwin D.H.: Nitrogen and energy relationships in malnourished patients with emphysema. Am. Rev. Respir. Dis. 1989; 138 (3): 636–44
Goldstein S.A., Askanazi J.: Macronutrients effect on metabolism and ventilation in patients with chronic lung disease. In: Ferranti R.D. (Ed.) Nutrition and Ventilatory Function - Current Topics in Rehabilition. Verona, Bi & Gi Publishers, London, Springer -Verlag, 1992; 167–173
Gross D., Ladd H.W., Riley E.J., MacKlem P.T., Grassino A.: The effect of training on strength and endurance of the diaphragm in quadriplegia. Am. J. Med. 1980; 68: 27–35
Gross I., Rooney S.A., Warshaw J.P.: The inhibition of enzymes related to pulmonary fatty acid and phospholipid synthesis by dietary deprivation in the rat. Biochem. Biophys. Res. Commun. 1975; 64: 69
Hunter A.M.B., Casey M.A., Larsh H.W.: The nutritional status of patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1967; 95: 556–566
Hyes M.P., Farber M.O., Manfredi F.: Acute effects of hypoxia on renal and endocrine function in normal humans. Am. J. Physiol. 1982; 243(3): R 265–270
Iannuzzo C.D., Noble E.G., Hamilton N., Dabroki B.: Effects of streptozotocin diabetes, insulin treatment, and training on the diaphragm. J. Appl. Physiol. 1982; 52 (6): 1471–1475
Ivy J.L., Costill D.L., Maxwell B.D.: Skeletal muscle determinants of maximum aerobic power in man. Eur. J. Appl. Physiol. 1971; 315–25
Jones N.L., Berman L.E., Barkiewicz P.D. et al.: Chronic obstructive respiratory disorders. In: Skinner J. (Ed.) Exercise Testing and Prescription for Special Cases. Philadelphia, Lea & Febiger, 1977; 175–188
Juan G., Calverley P., Talamo C.: Effect of carbon dioxide on diaphragmatic function in human beings. N. Engl. J. Med. 1984; 310: 874–9
Kelsen S.G., Ference M., Kapoor S.: Effects of prolonged undernutrition on structure and function of the diaphragm. J. Appl. Physiol. 1985; 58: 1354–9
Kelsen S.: The effects of undernutrition on the respiratory muscles. Clin. Chest Med. 1986; 7 (4): 100–101
Kinney J.M., Weissman C.: Forms of malnutrition in stressed and unstressed patients. Clin. Chest Med. 1986; 7: 101–110
Kubista V., Kiston J., Pette D.: Thyroid hormone induced changes in the enzyme activity pattern of energy supplying metabolism of fast (white), slow (red) and heart muscle. Eur. J. Biomed. 1971; 18: 553–560
Larca L., Greenbaum D.M.: Effectiveness of intensive nutritional regimens in patients who fail to wean from mechanical ventilation. 1982; 10: 297–300
Lange P., Groth S., Mortensen J. et al.: Diabetes mellitus, plasma glucose and lung function in a cross sectional population study. Eur. Respir. J. 1989; 2: 14
Law D.K., Dudrick S.J., Abdou N.I.: Immunocompetence of patients with protein-caloric malnutrition. Ann Intern. Med. 1973; 79: 545–550
Layzer R.B., Havel R.J., McElroy M.B.: Partial deficiency of carnitine palmityl transferase: physiologic and biochemical consequences. Neurology 1980; 30: 627–33
Lewis M.I., Sieck G.C., Fournier M., Belman M.J.: Effect of nutritional deprivation on diaphragm contractility and muscle fiber size. J. Appl. Physiol. 1988; 60: 596–603
Lewis M.I., Belman M.J.: Nutrition and the respiratory muscles. Clin. Chest Med. 1988; 9 (2): 337–48
Malloy D.W., Dhingra G., Solven F.S.: Hypomagnesemia and respiratory muscle power. Am. Rev. Respir. Dis. 1984; 129: 497–498
Mayer M., Rosen F.: Interaction of glucocorticoids and androgens with skeletal muscle. Metabolism 1977; 26: 937–962
McGavin C.R., Gupta S.P., Lloyd E.L. et al.: Physical rehabilitation for the chronic bronchitic. Results of a controlled trial of exercise in the home. Thorax 1977; 32: 307–311
Mobarhan S.: The role of albumin in nutritional support. J. Am. Coll. Nutr. 1988; 7: 445–52
Niederman M.S., Merrill W.W., Ferranti R.D., Pagano K.M., Palmer L.B., Reynolds H.Y.: Nutritional status and bacterial binding in the lower respiration tract in patients with chronic tracheostomy. Ann. Intern. Med. 1984; 100: 795–800
Nocturnal oxygen therapy trial group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease. Ann. Intern. Med. 1980; 93: 391–398
Openbier D.R.: Nutritional status and lung function in patients with chronic obstructive lung disease. Am. Rev. Respir. Dis. 1981; 124: 376
Ou L.C., Tenney S.M.: Adrenocortical function in rats chronically exposed to high altitude. J. Appl. Physiol. 1979; 47: 1185–1187
Pain V.M., Albertse E.C., Garlick P.J.: Protein metabolism in skeletal muscle diaphragm and heart of diabetic rats. Am. J. Physiol. 1983; 245: E604 - E610
Pardy R.L., Rivington R.N., Despas P.J., Macklem P.T.: The effect of inspiratory muscle training in exercise performance in chronic airflow limitation. Am. Rev. Respir. Dis. 1981; 123: 426–33
Pernow B.B., Havel R.J., Jennings D.B.: The second wind phenomena in McArdle syndrome. Acta Med. Scand. Suppl. 1967; 472: 294–307
Petty T., Finigan M.: Clinical evaluation of prolonged oxygen therapy in chronic airway obstruction. A.M.T. 1968; 45: 242–252
Primlack R.A., Whincup G., Tsanakas J.N., Milner R.D.: Reduced vital capacity in insulin-dependent diabetes. Diabetes 1987; 36: 32–45
Raff H.: Vasopressin, ACTH and corticosteroids during hypercapnia and graded hypoxia in dogs. Am. J. Physiol. 1983; 244: E 453-E458
Reid M.B., Johnson R.L. Jr.: Efficiency, maximal blood flow, and aerobic work capacity of canine diaphragm. J. Appl. Physiol. 1983; 54: 763–72
Renzetti A.D., McClement J.H.: The Veterans Administration cooperative study of pulmonary function: morbidity in relation to respiratory function in chronic pulmonary disease. Am. J. Med. 1966; 41: 115–129
Ries A.L., Archibald C.J.: Endurance and exercise training at maximal targets in patients with COPD. J. Cardiopulmonary Rehab. 1987; 7: 594–601
Roberto M.: Predictors of Outcome in COPD. Yale University, 1989, unpublished
Rochester D.F., Braun N.M.T., Arora N.S.: Respiratory muscle strength in chronic obstructive lung disease. Am. Rev. Respir. Dis. 1979; 119: 151–154
Rochester D.F., Braun N.M.T.: Determinants of maximal inspiratory pressure in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1985; 132: 42–47
Rosenbaum S.H., Askanazi A.L.: Respiratory patterns in profound nutritional depletion (abstract). Anesthesiology 1979; 51: 5366
Roza A.M., Twitt D., Shizgal H.M.: Transferrin, a poor measure of nutritional status. J. Penn. 1984; 8: 523–28
Sahebjami H., Vassallo C.L., Wirman J.A.: Lung mechanics and ultrastructure in prolonged starvation. Am. Rev. Respir. Dis. 1978; 177: 77–83
Sahebjami H., Wirman J.A.: Emphysema-like changes in the lungs of strayed rats. Am. Rev. Respir. Dis. 1981; 124 (5): 619–24
Schols A., Mostert R., Soeters P., Greve L.H., Wouters E.F.: Inventory of nutritional status in patients with COPD. Chest 1989; 96: 247–9
Schols A., Mostert R., Soeters P.: Nutritional status and exercise performance in patients with chronic obstructive lung disease. Thorax 1989; 44: 937–941
ScifferdeckerC., Driscoll D.F., Bistrian R.B.: Management guidelines when drugs and nutrients interact. J. Crit. Illness 1990; 5 (1): 34–41
Sheldon G.F., Petersen S.R.: Malnutrition and cardiopulmonary function. J. Parent. Enteral Nutr. 1980; 4: 376–383
Sirizisma S., Suskind R., Edelman R., Asvapaka C., Olson R.E.: Secretory and serum IgA in children with protein calorie malnutrition. Pediatrics 1975; 55: 166
Sonne L.J., Davis A.J.: Increased exercise performance in patients with severe COPD following inspiratory training. Chest 1982; 81: 436–439
Suspinki G.S., Lelren S.G.: Effect of elastic-induced emphysema on the force generating ability of the diaphragm. J. Clin. Invest. 1982; 70: 978–988
Tiep B.L., Christofer K.L., Spofford B.T. et al.: Pulsed conserving devices. Respir. Care 1985; 30: 833
Tiep B.L., Christofer K.L., Spofford B.T. et al.: Pulsed normal and transtracheal oxygen delivery. Chest 1990; 97: 2
Vanderberg F., Van de Woestine K.P., Gyselen A.: Weight changes in the terminal stages of chronic obstructive lung disease. Am. Rev. Respir. Dis. 1967; 95: 556–660
Vihko V., Salminen A. et al.: Exhaustive exercise, endurance training, and acid hydrolase activity in skeletal muscle. J. Appl. Physiol. 1979; 47: 43–50
Viires N., Sillye G., Gaddes G., Aubier M., Rassidakis A., Roussos C.: Regional blood flow distribution in dog during induced hypotension and low cardiac output. J. Clin. Invest. 1983; 72 (3): 935–67
Vjas M.N., Banister J. W., Morton S. et al.: Response to exercise in patients with chronic airway destruction: effects of breathing 40% oxygen. Am. Rev. Respir. Dis. 1972; 103: 401–412
Whang R., Rydeck P.: Frequency of hypomagnesemia and hypermagnesemia. JAMA 1990; 263 (22): 3063
Wilson D.O., Rogers R.M., Sanders M.H. et al.: Nutritional intervention in undernourished patients with emphysema. Am. Rev. Respir. Dis. 1986; 134: 672–677
Winick M.: Hunger Disease: Studies by the Jewish Physicians in the Warsaw Ghetto. New York, Wiley and Sons, 1979
Woodcock A.A., Gross E.R., Geddes D.M.: Oxygen relieves breathlessness in “Pink Puffers”. Lancet 1981; 907
Fong F., Lowry F.S., Cerami A.: Cachetin/TNF: a macrophage protein that induces cachexia and shock. JPEN 12: 46, Suppl. 72s-75s
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Ferranti, R.D., Malfa, R. (1993). Metabolism and Nutrition in Rehabilitation of the Patient with Respiratory Insufficiency. In: Rampulla, C., Fracchia, C., Ambrosino, N. (eds) Cardiopulmonary Rehabilitation. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3779-5_11
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