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Proteinases and Proteinase Inhibitors in the Pathogenesis of Pulmonary Emphysema in Humans

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Biochemistry of Pulmonary Emphysema

Part of the book series: Current Topics in Rehabilitation ((CURRENT REHAB))

Abstract

Central to our concepts of the pathogenesis of emphysema is the assumption that degradation of lung elastin occurs due to an imbalance between enzymes with the ability to digest this connective tissue and the inhibitors which protect it. This assumption forms the basis of the proteinase/antiproteinase theory of the pathogenesis of emphysema which has dominated the field of emphysema research for more than 25 years.

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  1. Lung Immunobiochemical Research Laboratory, The General Hospital, Birmingham, UK

    R. A. Stockley & D. Burnett

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  1. R. A. Stockley
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  2. D. Burnett
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Editors and Affiliations

  1. Institute of Phthisiology and Respiratory Diseases, IRCCS San Matteo, University of Pavia, Italy

    C. Grassi  & M. Luisetti  & 

  2. Department of Biochemistry, University of Georgia, Athens, GA, USA

    J. Travis

  3. Postgraduate School of Respiratory Diseases, University of Pavia, Italy

    L. Casali

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Stockley, R.A., Burnett, D. (1992). Proteinases and Proteinase Inhibitors in the Pathogenesis of Pulmonary Emphysema in Humans. In: Grassi, C., Travis, J., Casali, L., Luisetti, M. (eds) Biochemistry of Pulmonary Emphysema. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3771-9_5

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