Abstract
It is commonly acknowledged that neutrophil elastase (NE) is responsible for lung elastin degradation that leads to emphysema.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bieth J.G.: Elastases: catalytic and biological properties. In: Mecham R.P.(Ed) Regulation ofmatrix accumulation. New York, Academic Press, 1986; 217–320
Gast A., Dietemann-Molard A., Pelletier A., Pauli G., Bieth J.G.: The antielastase screen of the lower respiratory tract of al-proteinase inhibitor-sufficient patients with emphysema or pneumothorax. Am. Rev. Respir. Dis. 1990; 141: 880–883
Kao R.C., Whener N.G., Skubitz K.M., Gray B.H., Hoidal J.R.: Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J. Clin. Invest. 1988; 82: 1963–1973
Goldschmeding R., van der Schoot C.E., ten Bokkel Huinink D., Hack C.E., van den Ende M.E., Kallenberg C.G.M., von dem Borne A.E.G.Kr.: Wegener’s granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. J. Clin. Invest. 1989; 84: 1557–1587
Senior R.M., Connoly N.L., Cury J.D., Welgus H.G., Campbell E.J.: Elastin degradation by human alveolar macrophages. Am. Rev. Respir. Dis. 1989; 139: 1251–1256
Reilly J.J. Jr, Mason R.W., Chen P., Joseph L.J., Sukhatme V.P., Yee R., Chapmann H.A. Jr.: Synthesis and processing of cathepsin L, and elastase, by human alveolar macrophages. Biochem. J. 1989; 257: 493–498
Bieth J.G.: Human neutrophil elastase. In: Robert L., Hornebeck W. (Eds.) Elastin and elastases. Boca Raton, CRC Press, 1989; vol II, 24–31
Weitz J.I., Crowley K.A., Landman S.L., Lipman B I, Yu J.: Increased neutrophil elastase activity in cigarette smokers. Ann. Intern. Med. 1987; 107: 680–682
Abbound R., Fera T., Ritcher A., Tabona M.Z., Johal S.Z.: Acute effect of smoking on the functional activity of alpha-l-proteinase inhibitor in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 1985; 131: 79–85
Jochum M., Pelletier A., Boudier C., Pauli G., Bieth J.G.: The concentration of leukocyte elastase a,-proteinase inhibitor complex in bronchoalveolar lavage fluids from healthy human individual s. Am. Rev. Respir. Dis. 1985; 132: 913–914
Damiano V.V., Tsang A., Kucich U., Abrams W.R., Rosenbloom J. Kimbel P., Fallahnejad M., Weinbaum G.: Immunolocalization of elastase in human emphysematous lungs. J. Clin. Invest., 1986; 78: 482–493
Takahashi H., Nukiwa T., Yoshimura K., Quick C.D., States D.J., Holmes M.D., Whang-Peng J., Knutsen T., Crystal R.G:: Structure of the human neutrophil elastase gene. J. Biol. Chem. 1988; 263: 14739–14747
Bode W., An-Zhi W., Huber R., Meyer E., Travis J., Neumann S.: X-ray crystal structure of the complex of human leucocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor. EMBO J. 1986; 5: 2453–2458
Ogushi F., Hubbard R.C., Fells G.A., Casolaro M.A., Curiel D.T., Brantly M.L., Crystal R.G.: Evaluation of the S-type of alpha-l-antitrypsin as an in vivo and in vitro inhibitor of neutrophil elastase. Am. Rev. Respir. Dis. 1988; 137: 364–370
Cox D.W., Levison H.: Emphysema of early onset associated with a complete deficiency of alphal-antitrypsin (null homozygotes). Am. Rev. Respir. Dis. 1988; 137: 371–375
Bieth J.G.: Pathophysiological interpretation of kinetic constants of protease inhibitors. Bull. Europ. Physiopath. Respir. 1980; 16 (suppl.): 183–195
Boudier C., Bieth J.G.: Mucus proteinase inhibitor: a fast-acting inhibitor of leucocyte elastase. Biochim. Biophys. Acta. 1989; 995: 36–41
Gast A., Bieth J.G.: Inhibition of human neutrophil elastase by acid soluble inter-a-trypsin inhibitor. Adv. Exp. Med. Biol. 1988; 240: 75–82
Salvesen G., Farley D., Shuman J., Przybyla A., Reilly C., Travis J.: Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinase. Biochemistry 1987; 26: 2289–2293
Holn P.A., Popescu N.C., Hanson R.D., Salvesen G., Ley T.J.: Genomic organization and chromosomal localization of the human cathepsin G gene. J. Biol. Chem. 1989; 264: 13412–13419
Boudier C., Holle C., Bieth J.G.: Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G. J. Biol. Chem. 1981; 256: 10256–10258
Lucey E.C., Stone P.J., Breurer R., Christensen T.G., Calore J.D., Catanese A., Franzblau C., Snider G.L.: Effects of combined human neutrophil cathepsin G and elastase on induction of secretory cell metaplasia and emphysema in hamsters with in vitro observations on elastolysis by these enzymes. Am. Rev. Respir. Dis. 1985; 132: 362–366
Cawston T.E.: Protein inhibitors of metallo-proteinases. In: Barrett A.J., Salvesen G. (Eds.) Proteinases inhibitors. New York, Elsevier, 1986; 589–610
Barrett A.J., Rawlings D., Davies M.E., Machleidt W., Salvesen G., Turk V.: Cysteine proteinase inhibitors of the cystatin superfamily. In: Barrett A.J., Salvesen G. (Eds.) Proteinases inhibitors. New York, Elsevier, 1986; 515–569
Hamdaoui A., Wund-Bisseret F., Bieth J.G.: Fast-solubilization of human lung elastin by Pseudomonas aeruginosa elastase. Am. Rev. Respir. Dis. 1987; 135: 860–863
Hasty K.A., Pourmotabbed T.F., Goldberg G.I., Thompson J.P., Spinella D.G., Stevens R.M., Mainardi C.L.: Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J. Biol. Chem. 1990; 265: 11421–11424
Okada Y., Nakanishi I.: Activation of matrix metalloproteinase 3 (stromelysin) and matrix metalloproteinase 2 (“gelatinase”) by human elastase and cathepsin G. FEBS Lett. 1989; 249: 353–356
Weiss S.J.: Mechanisms of disease. Tissue destruction by neutrophils. N. Engl. J. Med. 1989; 320: 365–376
Sibille Y., Reynolds H.Y.: Macrophages and polymorphonuclear neutrophils in lung defence and injury. Am. Rev: Respir. Dis. 1990; 141: 471–501
Chapman H.A. Jr., Reilly J.J. Jr., Kobzik L.: Role of plasminogen activator in degradation of extracellular matrix protein by live human alveolar macrophages. Am. Rev. Respir. Dis. 1988; 137: 412–419
Desrochers P.E., Weiss S.: Proteolytic inactivation of alpha-l-proteinase inhibitor by a neutrophil metalloproteinase. J. Clin. Invest. 1988; 81: 1646–1650
Vissers M.C.M., George P. M., Bathurt I.C., Brennan O.S., Winterbourn C.C.: Cleavage and inactivation of a1-antitrypsin by metalloproteinases released from neutrophils. J. Clin. Invest. 1988; 82: 706–711
Johnson D.A., Barrett A.J., Mason R.W.: Cathepsin L inactivates a1-proteinase inhibitor by cleavage in the reactive site region. J. Biol. Chem. 1986; 261: 14748–14751
Virca G.D., Lyerly D., Kreger A., Travis J.: Inactivation of al-proteinase inhibitor by Serratia marcescens metalloproteinase. Biochim. Biophys. Acta 1982; 704: 267–271
Morihara K., Tsuzuki H., Harada M., Iwata T.: Purification of human plasma a1-proteinase inhibitor and its inactivation by Pseudomonas elastase. J. Biochem. 1984; 95: 795–804
Potempa J. Watorek W., Travis J.: Inactivation of human at-proteinase inhibitor by Staphylococcus aureus proteinases. J. Biol. Chem. 1986; 261: 14330–14334
Conlan J.W., Williams A., Ashworth L.A.E.: Inactivation of human a,-antitrypsin by a tissue-destructive protease of Legionella pneumophila. J. Gen. Microbiol. 1988; 134: 481–487
Morii M., Travis J.: Amino acid sequence at the reactive site of human a1-antichymotrypsin. J. Biol. Chem. 1983; 258: 12749–12752
Brower M.S., Harpel P.C.: Proteolytic cleavage and inactivation of aZ plasmin inhibitor and Cl inactivator by human polymorphonuclear leukocyte elastase. J. Biol. Chem. 1982;257:9854-
Okada Y., Watanabe S., Nakanishi I, Kishi J.I., Hayakawa T., Watorek W., Travis J., Nagase I.: Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other proteinases. FEBS Lett. 1988; 229: 157–160
Janoff A.: Emphysema: proteinase-antiproteinase imbalance. In Gallin J.I., Goldstein I.M, Snyderman R. (eds): Inflammation: basic principles and clinical correlates. New York, Raven Press, 1988; 803–814
Boudier C., Pelletier A., Pauli G., Bieth J.G.: The functional activity of a,-proteinase inhibitor in bronchoalveolar lavage fluids from healthy human smokers and non-smokers. Clin. Chim. Acta. 1983; 132: 309–315
Stone P.J., Calore J.D.: Functional a,-proteinase inhibitor in the lower respiratory tract of cigarette smokers is not decreased. Science 1983; 221: 1187–1189
Campbell E.J., Endicott S.K., Rios-Mollineda R.A.: Assessment of oxidation of a1-proteinase inhibitor in broncho-alveolar lining fluid by monoclonal immunoassay: comparison of smokers and non-smokers. Am. Rev. Respir. Dis. 1987; 135: A156
Lawrence D.A., Loskutoff D.J.: Inactivation of plasminogen activator inhibitor by oxidants. Biochemistry 1986; 25: 6351–6355
Banda M.J., Rice A.G., Griffin G.L., Senior R.M.: al-proteinase inhibitor is a neutrophil chemoattractant after proteolytic inactivation by macrophage elastase. J. Biol. Chem. 1988; 263: 4481–4484
Banda M.J., Rice A.G., Griffin G.L., Senior R.M.: The inhibitory complex of human a,-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant. J. Exp. Med. 1988; 167: 1608 1615
Lonky S.A., Wohl H.: Stimulation of human leukocyte elastase by platelet factor 4. Physiologic, morphologic and biochemical effects on hamster lungs in vitro. J. Clin. Invest. 1981; 67: 817–826
Frommherz K., Bieth J.G.: Heparin decreases the rate constant for the inhibition of leucocyte elastase by ai-proteinase inhibitor. Eur. Resp. J. 1989;2 suppl. 5: 347S
Hubbard R.G., Sellers S., Czerski D., Stephens L., Crystal R.G.: Biochemical efficacity and safety of monthly augmentation therapy for a1antitrypsin deficiency. JAMA 1988; 260: 1259–1264
Fletcher D.S., Osinga D.G., Hand K.M., Dellea P.S., Ashe B.M., Mumford R.A., Davies P., Hagmann W., Finke P.E., Doherty J.B., Bonney R.J.: A comparison of a1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-Chloromethylketone and specific ß-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster. Am. Rev. Respir. Dis. 1990; 141: 672–677
Niewoehner D.E., Kleinerman J., Rice D.B.: Pathologic changes in the peripheral airways of young cigarette smokers. N. Engl. J. Med. 1974; 291: 755–758
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag London
About this chapter
Cite this chapter
Bieth, J.G. (1992). Lung Proteinases and Emphysema. In: Grassi, C., Travis, J., Casali, L., Luisetti, M. (eds) Biochemistry of Pulmonary Emphysema. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3771-9_4
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3771-9_4
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3773-3
Online ISBN: 978-1-4471-3771-9
eBook Packages: Springer Book Archive