Elastin and the Lung

  • J. M. Davidson
Part of the Current Topics in Rehabilitation book series (CURRENT REHAB)

Abstract

Elastin, a rubbery, fibrous connective tissue protein, plays several critical roles in the biomechanics of the lung and its associated vasculature. It is the principal component of the elastic fibre, which is a composite of the amorphous elastic protein and one or more microfibrillar components. Elastic fibres provide resiliency to numerous pulmonary structures including the alveolar wall, the bronchiolar interstitium, the medial layers of arterial and venous elements, lymphatics, and the pleura. The unusual hydrophobic properties of the protein, together with the presence of numerous intermolecular crosslinks, in particular desmosine and isodesmosine, produce a highly insoluble, durable network of polypeptide chains that function as a perfect elastomer in an aqueous environment.

Keywords

Aldehyde Proline Glucocorticoid Fibril Acetyl 

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Copyright information

© Springer-Verlag London 1992

Authors and Affiliations

  • J. M. Davidson
    • 1
  1. 1.Research Service, Department of Veterans Affairs Medical Center and Department of PathologyVanderbilt University School of MedicineNashvilleUSA

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