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Pancreas and Islet Transplantation

  • Vassilios E. Papalois
  • Nadey S. Hakim
Chapter
Part of the Springer Specialist Surgery Series book series (SPECIALIST)

Abstract

The syndrome of type I insulin-dependent diabetes mellitus (IDDM) includes not only abnormal glucose metabolism but also specific microvascular complications such as retinopathy, nephropathy and neuropathy. Diabetes mellitus is currently the leading cause of kidney failure and blindness in adults, the number one disease cause of amputations and impotence, and one of the leading chronic diseases of childhood associated with poor quality of life.

Keywords

Superior Mesenteric Artery Graft Survival Splenic Artery Islet Transplantation Prolene Suture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kelly W, Lillehei R, Merkel F. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 1967; 61: 827–35.PubMedGoogle Scholar
  2. 2.
    Najarian J, Sutherland DER, Steffes M. Isolation of human islets of Langerhans for transplantation. Transplant Proc 1975; 7: 611–13.Google Scholar
  3. 3.
    Stratta R. Pancreas transplantation in the 1990s. In: Hakim NS, Stratta R, Dubernard J-M, editors. Proceedings of the Second British Symposium on Pancreas and Islet Transplantation. (ICSS 232 ) London: Royal Society of Medicine, 1998; 103–21.Google Scholar
  4. 4.
    Papalois VE, Romagnoli J, Hakim NS. Use of vascular closure staples in vascular access for dialysis, renal and pancreatic transplantation. International Surgery (in press).Google Scholar
  5. 5.
    Kirsch W, Zhu Y, Gask D, et al. Tissue reconstruction with non-penetrating arcuate-legged clips–potential endoscopie applications. J Reprod Med 1992; 37: 581–6.PubMedGoogle Scholar
  6. 6.
    Dubernand JM, Tajra LC, Dawahra M, et al. Improving morbidity rates of reno-pancreatic transplantation by modification of the technique. In: Hakim NS, Stratta R, Dubernard J-M, editors. Proceedings of the Second British Symposium on Pancreas and Islet Transplantation. (ICSS, 232 ) London: Royal Society of Medicine, 1998; 21–6.Google Scholar
  7. 7.
    Hakim NS, Gruessner A, Papalois BE, et al. Duodenal complications in bladder-drained pancreas transplants. Surgery 1997; 121 (6): 618–24.PubMedCrossRefGoogle Scholar
  8. 8.
    Gruessner A, Sutherland DER. Pancreas transplants results in the United Network for Organ Sharing (UNOS) United States of America (USA) Registry compared with non-USA data in the International Registry. In: Terasaki P, Cecka J, editors. Clinical transplants 1994. Los Angeles: UCLA Tissue Typing Laboratory, 1994; 47–68.Google Scholar
  9. 9.
    Papalois VE, Hakim NS, El-Atrozy T, et al. Evaluation of the arterial flow of the pancreatic graft with duplex-Doppler ultrasonography. Transplant Proc 1998; 30 (2): 255.PubMedCrossRefGoogle Scholar
  10. 10.
    Benedetti E, Gruessner A, Troppmann C, et al. Intra-abdominal fungal infection after pancreatic transplantation: incidence, treatment and outcome. Journal of the American College of Surgeons 1996; 183: 307–16.PubMedGoogle Scholar
  11. 11.
    Hickey D, Bakthavatsalam R, Bannon C, et al. Urological complications of pancreatic transplantation. J Urol 1997; 157: 2042–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Gruessner RWG, Dunn D, Tzardis P, et al. Simultaneous pancreas and kidney transplants versus single kidney transplants and previous kidney transplants in uremic patients and single pancreas transplants in nonuremic diabetic patients: comparison of rejection, morbidity, and long term outcome. Transplant Proc 1990; 22: 622–3.PubMedGoogle Scholar
  13. 13.
    Prieto M, Sutherland DER, Goetz F, et al. Pancreas transplant results according to the technique of duct management: bladder versus enteric drainage. Surgery 1987; 102 (4): 680–91.PubMedGoogle Scholar
  14. 14.
    Phoeg RJ, D’Alessandro AM, Groshek M, et al. Efficacy of human anodal trypsinogen for detection of rejection in clinical pancreas transplantation. Transplant Proc 1994; 26: 531–3.Google Scholar
  15. 15.
    Gruessner A, Sutherland DER. Pancreas transplantation in the United States (US) and non-US as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR). In: Terasaki P, Cecka J, editors. Clinical transplants 1996. Los Angeles: LA Tissue Typing Laboratory, 1996; 47–67.Google Scholar
  16. 16.
    Gruessner RWG. Tacrolimus in pancreas transplantation: a multicenter analysis. Tacrolimus Pancreas Transplant Study Group. Clin Transplant 1997; 11 (4): 299–312.PubMedGoogle Scholar
  17. 17.
    Bartlett ST, Schweitzer EJ, Johnson LB, et al. Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of Tacrolimus immunosuppression with percutaneous biopsy. Ann Surg 1996; 224 (4): 440–9.PubMedCrossRefGoogle Scholar
  18. 18.
    Bandello F, Vigano C, Secchi A, et al. Effect of pancreas transplantation on diabetic retinopathy: a 20 cases report. Diabetologia 1991; 34 (Suppl. 1): 92–4.CrossRefGoogle Scholar
  19. 19.
    Caldara R, Bandello F, Vigano C, et al. Influence of successful pancreatorenal transplantation on diabetic nephropathy. Transplant Proc 1994; 26: 490.PubMedGoogle Scholar
  20. 20.
    Ransay RC, Frederich CG, Sutherland DER, et al. Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus. N Engl J Med 1988; 318: 208–14.CrossRefGoogle Scholar
  21. 21.
    Billus RW, Mauer SM, Sutherland DER, et al. The effect of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes. N Engl J Med 1989; 321: 80–5.CrossRefGoogle Scholar
  22. 22.
    Fioretto P, Mauer SM, Bilou RW, et al. Effects of pancreas transplantation on glomerular structure in insulin-dependent diabetic patients with their own kidneys. Lancet 1993; 342: 1193–6.PubMedCrossRefGoogle Scholar
  23. 23.
    Comi G, Galardi G, Amadio S, et al. Neurophysiological study of the effect of combined kidney and pancreas transplantation on diabetic neuropathy: a 2-year follow-up evaluation. Diabetologia 1991; 34 (Suppl. 1): 103–7.CrossRefGoogle Scholar
  24. 24.
    Solders G, Tyden G, Persson A, et al. Improvement of nerve conduction in diabetic nephropathy. Diabetes 1992; 41: 946–51.PubMedCrossRefGoogle Scholar
  25. 25.
    Navarro X, Kennedy WR, Goetz FGC, et al. Influence of pancreas transplantation on cardiorespiratory reflexes, nerve conduction, and mortality in diabetes mellitus. Diabetes 1990; 39: 802–6.PubMedCrossRefGoogle Scholar
  26. 26.
    Nusser J, Scheuer R, Abendroth D, et al. Effect of pancreatic transplantation and/or renal transplantation on diabetic autonomic neuropathy. Diabetologia 1991; 34 (Suppl. 1): 118–20.CrossRefGoogle Scholar
  27. 27.
    Hathaway DK, Abell T, Cardoso S, et al. Improvement in autonomic and gastric function following pancreas-kidney versus kidney-alone transplantation and the correlation with quality of life. Transplantation 1994; 57: 816–22.PubMedCrossRefGoogle Scholar
  28. 28.
    La Rocca E, Secchi A, Galardi G, et al. Kidney and pancreas transplantation improves hypertension in type I diabetic patients. Abstract book, 7th Congress of the European Society for Organ Transplantation, ESOT `95, Vienna, October 3–7 1995; 362.Google Scholar
  29. 29.
    Pielhlmeier W, Bullinger M, Nusser J, et al. Quality of life in type l (insulin dependent) diabetic patients prior to and after pancreas and kidney transplantation in relation to organ function. Diabetologia 1991; 34 (Suppl. 1): 150–7.CrossRefGoogle Scholar
  30. 30.
    Nakache R, Tyden G, Groth CG. Quality of life in diabetic patients after combined pancreas-kidney or kidney transplantation. Diabetes 1989; 38: 40–2.PubMedGoogle Scholar
  31. 31.
    Zehrer CL, Gross CR. Quality of life of pancreas transplantation recipients. Diabetologia 1991; 34 (Suppl. 1): 145–9.CrossRefGoogle Scholar
  32. 32.
    Zehrer CL, Gross CR. Comparison of quality of life between pancreas/kidney and kidney transplant recipients. 1-year follow-up. Transplant Proc 1994; 26: 508–9.PubMedGoogle Scholar
  33. 33.
    Sutherland DER, Goetz FC, Najarian JS. Living-related donor segmental pancreatectomy for transplantation. Transplant Proc 1980; 12: 19–25.PubMedGoogle Scholar
  34. 34.
    Gruessner RWG, Kendal DM, Drangstveit MB, et al. Simultaneous pancreas-kidney transplantation from live donors. Ann Surg 1997; 226 (4): 471–82.PubMedCrossRefGoogle Scholar
  35. 35.
    Ricordi C, Lacy PE, Scharp DW. Automated islet isolation from human pancreas. Diabetes 1989; 38: 140–2.PubMedGoogle Scholar
  36. 36.
    Hering BJ. Insulin independence following islet transplantation in man -a comparison of different recipient categories. International Islet Transplantation Registry 1996; 6: 5–19.Google Scholar
  37. 37.
    Kaufman DB, Field MJ, Gruber SA, et al. Extended functional survival of murine islet allograft with 15-Deoxyspergualin. Transplant Proc 1992; 24: 1045–7.PubMedGoogle Scholar
  38. 38.
    Wahoff DC, Papalois BE, Najarian JS, et al. Autologous islet transplantation to prevent diabetes after pancreatic resection. Ann Surg 1995; 222 (4): 562–79.PubMedGoogle Scholar
  39. 39.
    Samuelsson BE, Rydberg L, Breimer ME, et al. Natural antibodies and human xenotransplantation. Immunol Rev 1994; 141: 151–68.PubMedCrossRefGoogle Scholar
  40. 40.
    Cairns T, Lee J, Hakim NS, et al. Thomsen Friedenreich and Pk antigens in pig-to-human xenotransplantation. Transplant Proc 1996; 28 (2): 795–6.PubMedGoogle Scholar
  41. 41.
    Papalois VE, Hakim NS, Romagnoli J. et al. Collagenase digestion of the pig pancreas modifies Gala 1–3Gal, Thomsen Friedenreich and Pk antigen expression on adult porcine islets. Transplant Proc 1998; 30 (2): 656.PubMedCrossRefGoogle Scholar
  42. 42.
    Menger MD, Vajkoczy P, Beger C, et al. Orientation of microvascular blood flow in pancreatic islet isografts. J Clin Invest 1994; 93: 2280–5.PubMedCrossRefGoogle Scholar
  43. 43.
    Papalois VE, Hakim NS, Berwanger C, et al. The effect of cryopreservation on Galcsl-3Gal expression on adult porcine pancreatic islets. Transplant Proc 1998; 30 (5); 2474.Google Scholar
  44. 44.
    Colton CK. Engineering challenges in cell encapsulation technology. Trends Biotechnol 1996; 14: 158–62.CrossRefGoogle Scholar
  45. 45.
    Sun Y, Ma X, Zhou D, et al. Normalization of diabetes in spontaneously diabetic cynomolgus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J Clin Invest 1996; 98: 1417–22.PubMedCrossRefGoogle Scholar
  46. 46.
    Shapiro AMJ, Lakey JRT, Ryan EA, Kozbutt GS et al. Islet transplantation in seven patients with Type 1 Diabetes Mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med July 27, 2000; 343: 230–238CrossRefGoogle Scholar
  47. 47.
    Hakim NS. Pancreatic transplantation. Ann R Coll Surg Engl 1998; 80 (5): 313–15.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2001

Authors and Affiliations

  • Vassilios E. Papalois
  • Nadey S. Hakim

There are no affiliations available

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