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Abstract

The perinatal mortality rate (stillbirths from 24 weeks’ gestation and first week neonatal deaths) in the UK is now less than 10 per 1000 total deliveries. The obstetric and paediatric causes of perinatal death for Scotland are shown in Tables 8.1 and 8.2. In the “unexplained < 2500 g” group in Table 8.1 premature labour or preterm rupture of membranes is present in 30% of the cases. In Table 8.2, problems of prematurity are second only to congenital abnormalities as the cause of neonatal death. The latter may be influenced by selective termination but any further decrease in perinatal mortality will rely on our ability to reduce prematurity and its problems. However the proportion of babies delivering preterm (before 37 completed weeks’ gestation) remains constant at around 6% of all deliveries. Preterm babies contribute significantly to the workload of a neonatal unit.

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References

  • Adiotomre PN, Johnstone FD, Laing IA (1997) Effect of absent end diastolic flow velocity in the fetal umbilical artery on subsequent outcome. Arch Dis Child 76:F35-F38

    Article  CAS  Google Scholar 

  • Anderson ABM, Turnbull AC (1982) Effects of oestrogens, progesterones and betamimetics in pregnancy. In: Enkin MW, Chalmers I (eds) Effectiveness and satisfaction in antenatal care. Heinemann, London

    Google Scholar 

  • Baerts W, Fetter WPF, Hop WCJ et al. (1990) Cerebral lesions in preterm infants after tocolytic indomethacin. Dev Med Child Neurol 32:910–918

    Article  PubMed  CAS  Google Scholar 

  • Banker BQ, Larroche J-C (1962) Periventricular leukomalacia in infancy: a form of neonatal hypoxic encephalopathy. Arch Neurol 7:386–410

    Article  PubMed  CAS  Google Scholar 

  • Bauer CR (1992) Necrotizing enterocolitis. In: Sinclair JC, Bracken MB (eds) Effective care of the newborn infant. Oxford University Press, Oxford

    Google Scholar 

  • Bowen FW, Chandra R, Avery GB (1973) Pulmonary interstitial emphysema with gas embolism in hyaline membrane disease. Am J Dis Child 126:117–118

    PubMed  Google Scholar 

  • Brownlee KG, Ng PC, Henderson MJ, Smith M, Green JH, Dear PRF (1992) Catabolic effect of dexamethasone in the preterm baby. Arch Dis Child 67:1–4

    Article  PubMed  CAS  Google Scholar 

  • Cassell GH, Waites KB, Crouse DT et al. (1988) Association of Ureaplasma urealyticum infection of the lower respiratory tract with chronic lung disease and death in very-low-birth-weight infants. Lancet ii:240–245

    Article  Google Scholar 

  • Casson IF, Clarke CA, Howard CV et al. (1997) Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study. Br Med J 315:275–278

    Article  CAS  Google Scholar 

  • Clark DA, Barkemeyer BM, Miller MJS (1993) Perinatal hypoxic-ischaemic risk factors and necrotizing enterocolitis. Pediatr Res 32:207

    Google Scholar 

  • Clark DA, Miller MJS (1990) Intraluminal pathogenesis of necrotizing enterocolitis. J Pediatr 117: S64–S67

    Article  PubMed  CAS  Google Scholar 

  • Clark RH, Gerstmann DR, Null DM, DeLemos RA (1992) Prospective randomized comparison of high frequency oscillatory and conventional ventilation in respiratory distress syndrome. Pediatrics 89:5–12

    PubMed  CAS  Google Scholar 

  • Cliver S, Goldenberg RL, Cutter GR et al. (1992) The relationship among psychosocial profile, maternal size, and smoking in predicting fetal growth retardation. Obstet Gynaecol 80:262–267

    CAS  Google Scholar 

  • Cockburn F (1994) Neonatal brain and dietary lipids. Arch Dis Child 70:F1-F2

    Article  CAS  Google Scholar 

  • Cohen-Overbeek T, Pearce MJ, Campbell S (1985) The antenatal assessment of utero placental and feto placental blood flow using doppler ultrasound. Ultrasound Med Biol 11:329–339

    Article  PubMed  CAS  Google Scholar 

  • Cole SK, Hey EN, Thomson AM (1986) Classifying perinatal death: an obstetric approach. Br J Obstet Gynaecol 93:1204–1212

    Article  PubMed  CAS  Google Scholar 

  • Cooke RW (1991) Factors associated with chronic lung disease in preterm infants. Arch Dis Child 66:776–779

    Article  PubMed  CAS  Google Scholar 

  • Crowley P (1992) Antibiotics for preterm prelabour rupture of membranes. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP (eds) Pregnancy and childbirth module, Cochrane database of systematic reviews: Review No. 04391. Published through Cochrane Updates on Disk, Oxford. Update Software

    Google Scholar 

  • Crowley P, Chalmers I, Keirse MJC (1990) The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. Br J Obstet Gynaecol 97:11–25

    Article  PubMed  CAS  Google Scholar 

  • Crowther CA, Alfirevic Z (1993) Antenatal thyrotropin-releasing hormone (TRH) prior to preterm delivery. In: Enkin MW, Keirse MJNC, Renfrew MJ, Neilson JP (eds) Pregnancy and childbirth module, Cochrane database of systematic reviews: Review No. 2955. Published through Cochrane Updates on Disk, Oxford. Update Software.

    Google Scholar 

  • Crowther CA, Hiller JE, Haslam RR, Robinson JS, Group AS (1995) Australian collaborative trial of antenatal thyrotropin-releasing hormone (ACTOBAT) for prevention of neonatal respiratory disease. Lancet 345:877–882

    Article  Google Scholar 

  • Coalson JJ, Winter V, deLemos RA (1995) Decreased alveolarization in baboon survivors with bronchopulmonary dysplasia. Am J Respir Crit Care Med 152:640–646

    PubMed  CAS  Google Scholar 

  • Cummings JJ, D’Eugenio DB, Gross SJ (1989) A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. N Engl J Med 320: 1505–13510

    Article  PubMed  CAS  Google Scholar 

  • Cunningham S, Fleck BW, Elton RA, Mcintosh N (1995) Transcutaneous oxygen levels in retinopathy of prematurity. Lancet 346:1464–1465

    Article  PubMed  CAS  Google Scholar 

  • de Vries LMS, Eken P, Groenendaal F, Van Haastert IC, Meiners LC (1993) Correlation between the degree of periventricular leukomalacia diagnosed using cranial ultrasound and MRI later in infancy in children with cerebral palsy. Neuropaediatrics 24:263–268

    Article  Google Scholar 

  • Dotsch J, Hohmann M, Kuhl PG (1997) Neonatal morbidity and mortality associated with maternal haemolysis elevated liver enzymes and low platelets. Eur J Pediatr 156:389–391

    Article  PubMed  CAS  Google Scholar 

  • Doyle LW (1995) Outcome to five years of age of children born at 24–26 weeks’ gestational age in Victoria. Med J Aust 163:11–14

    PubMed  CAS  Google Scholar 

  • Erickson AM, de la Monte SM, Moore GW, Hutchins GM (1987) The progression of morphologic changes in bronchopulmonary dysplasia. Am J Pathol 127:474–487

    PubMed  CAS  Google Scholar 

  • Erskine FLA, Ritchie JWK (1985) Umbilical artery blood flow characteristics in normal and growth retarded fetuses. Br J Obstet Gynaecol 92:605–610

    Article  PubMed  CAS  Google Scholar 

  • Eschenbach DA, Nugent RP, Rao AV et al. (1991) A randomized placebo-controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature labour. Am J Obstet Gynecol 164:734–742

    PubMed  CAS  Google Scholar 

  • Fanaroff AA, Wright LL, Stevenson DK et al. (1995) Very low birthweight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol 173:1423–1431

    Article  PubMed  CAS  Google Scholar 

  • Fenton AC, Field DJ, Mason E, Clarke M (1990) Attitudes to viability of preterm infants and their effect on figures for perinatal mortality. Br Med J 300:434–436

    Article  CAS  Google Scholar 

  • Ferrara TB, Hoekstra RE, Couser RJ et al. (1994) Survival and follow-up of infants at 23 to 26 weeks of gestational age: effects of surfactant therapy. J Pediatr 124:119–124

    Article  PubMed  CAS  Google Scholar 

  • Fleck BW, Wright E, Dhillon B, Millar GT, Laing IA (1995) An audit of the 1995 Royal College of Ophthalmologists guidelines for screening for retinopathy of prematurity applied retrospectively in one regional neonatal intensive care unit. Eye 9(suppl.):31–35

    PubMed  Google Scholar 

  • Geary M (1997) The HELLP syndrome. Br J Obstet Gynaecol 104:887–891

    Article  PubMed  CAS  Google Scholar 

  • Glasgow JF, Thomas PS (1977) Rachitic respiratory distress in small preterm infants. Arch Dis Child 52:268–273

    Article  PubMed  CAS  Google Scholar 

  • Greenough A, Roberton NRC (1985) Morbidity and survival in neonates ventilated for the respiratory distress syndrome. Br Med J 290:597–600

    Article  CAS  Google Scholar 

  • Greenough A, Emery EF, Gamsu HR (1992) Dexamethasone and hypertension in preterm infants. Eur J Pediatr 151: 134–135

    Article  PubMed  CAS  Google Scholar 

  • Groneck P, Speer CP (1995) Inflammatory mediators and bronchopulmonary dysplasia. Arch Dis Child 73:F1–F3

    Article  CAS  Google Scholar 

  • Groneck P, Götze-Speer B, Oppermann M, Eiffert H, Speer CP (1994) Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high risk preterm infants. Pediatrics 91:712–718

    Google Scholar 

  • Groneck P, Goetze-Speer B, Speer CP (1996) Inflammatory bronchopulmonary response of preterm infants with microbial colonisation of the airways at birth. Arch Dis Child 74:F51-F55

    Article  CAS  Google Scholar 

  • Halliday HL (1996a) Where are we now with the prenatal steroids and postnatal surfactant. Biol Neonate 69:186–187

    Article  Google Scholar 

  • Halliday HL (1996b) Natural vs synthetic surfactants in neonatal respiratory distress syndrome. Drugs 51:768–774

    Article  Google Scholar 

  • Hammarlund K, Sedin G, Strömberg B (1983) Transepidermal water loss in newborn infants. VIII. Relation to gestational age and post-natal age in appropriate and small for gestational age infants. Acta Paediatr Scand 72:721–728

    Article  PubMed  CAS  Google Scholar 

  • Hauth JC, Goldenberg RL, Andrew W (1995) Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 333:1732–1736

    Article  PubMed  CAS  Google Scholar 

  • Hawdon JM, Ward Piatt MP, Aynsley-Green A (1992) Patterns of metabolic adaptation for preterm and term infants in the first neonatal week. Arch Dis Child 67:357–365

    Article  PubMed  CAS  Google Scholar 

  • Hawthorne G, Robson S, Ryall EA et al. (1997) Prospective population based survey of outcome in pregnancy in diabetic women: results of the Northern Diabetic Pregnancy Audit, 1994. Br Med J 315:279–281

    Article  CAS  Google Scholar 

  • Hey EN, Lloyd DJ, Wigglesworth JS (1986) Classifying perinatal death: fetal and neonatal factors. Br J Obstet Gynaecol 93:1213–1223

    Article  PubMed  CAS  Google Scholar 

  • Hillier SL, Martius M, Krohn M et al. (1988) A case-control study of chorioamniotic infection and histologic chorioam-nionitis and prematurity. N Engl J Med 319:972–978

    Article  PubMed  CAS  Google Scholar 

  • Hoekstra RE, Jackson JC, Myers TF et al. (1991) Improved survival following multiple doses of bovine surfactant in very premature neonates at risk for respiratory distress syndrome. Pediatrics 88:10–18

    PubMed  CAS  Google Scholar 

  • Horsman A, Ryan SW, Congdon PJ, Truscott JG, James JR (1989) Osteopenia in extremely low birthweight infants. Arch Dis Child 64:485–488

    Article  PubMed  CAS  Google Scholar 

  • Hufnagle KG, Khan SN, Penn D et al. (1982) Renal calcification: a complication of long term frusemide therapy in premature infants. Pediatrics 70:360–363

    PubMed  CAS  Google Scholar 

  • Huhta JC, Moise KJ, Fisher DJ et al. (1987) Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography. Circulation 2:406–412

    Article  Google Scholar 

  • Ikegami M, Jobe AH, Newnham J et al. (1997) Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs. Am J Respir Crit Care Med 156:178–184

    PubMed  CAS  Google Scholar 

  • Ikonen RS, Kuusinen EJ, Janas MO, Koivikko MJ, Sorto AE (1988) Possible etiological factors in extensive periventricular leukomalacia of preterm infants. Acta Paediatr Scand 77:489–495

    Article  PubMed  CAS  Google Scholar 

  • Jobe AH, Ikegami M (1998) Mechanisms initiating lung injury in the preterm. Early Hum Dev 53:81–94

    Article  PubMed  CAS  Google Scholar 

  • Johnstone FD, Haddad NG, Hoskins P et al. (1988) Umbilical artery doppler flow velocity waveform; the outcome of pregnancies with absent diastolic flow. Eur J Obstet Gynaecol Reprod Biol 28:171–178

    Article  CAS  Google Scholar 

  • Kanto WP, Wilson R, Breart GL et al. (1987) Perinatal events and necrotizing enterocolitis in premature infants. Am J Dis Child 141:167–169

    PubMed  Google Scholar 

  • Khong TY, De Wolf F, Robertson WB, Brosens I (1986) Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 93:1049–1059

    Article  PubMed  CAS  Google Scholar 

  • Koh THHG, Aynsley-Green A, Tarbit M, Eyre JA (1988) Neural dysfunction during hypoglycemia. Arch Dis Child 63:1353–1358

    Article  PubMed  CAS  Google Scholar 

  • Lamont RF, Taylor-Robinson D, Newman M, Wigglesworth J, Elder MG (1986) Spontaneous early preterm labour associated with abnormal genital bacterial colonization. Br J Obstet Gynaecol 93:804–810

    Article  PubMed  CAS  Google Scholar 

  • Leitich H, Egarter C, Husslein P, Kaider A, Schemper M (1997) A meta-analysis of low dose aspirin for the prevention of intrauterine growth retardation. Br J Obstet Gynaecol 104:450–459

    Article  PubMed  CAS  Google Scholar 

  • Lettieri L, Vintzileos AM, Rodis JF, Albini AM, Salafia CM (1993) Does “idiopathic” preterm labor resulting in preterm birth exist ? Am J Obstet Gynecol 168:1480–1485

    PubMed  CAS  Google Scholar 

  • Levene MI, Dowling S, Graham M, Fogelman K, Galton M, Philips M (1992) Impaired motor function (clumsiness) in five-year-old children: correlation with neonatal ultrasound scan. Arch Dis Child 67:687–690

    Article  PubMed  CAS  Google Scholar 

  • Leveno KJ, Cunningham FG (1992) Beta-adrenergic agents for preterm labour. N Engl J Med 327:349–351

    Article  PubMed  CAS  Google Scholar 

  • Lipscombe AP, Reynolds EOR, Blackwell RJ et al. (1981) Pneumothorax and cerebral haemorrhage in preterm infants. Lancet i:414–417

    Article  Google Scholar 

  • Lucas A, Morley R, Cole TJ (1988) Adverse neurodevelopmental outcome of moderate hypoglycaemia. Br Med J 297: 1304–1308

    Article  CAS  Google Scholar 

  • Lucas A, Brooke OG, Baker BA, Bishop N, Morley R (1989) High alkaline phosphatase activity and growth in preterm neonates. Arch Dis Child 64:902–909

    Article  PubMed  CAS  Google Scholar 

  • Lucas A, Morley R, Cole TJ et al. (1990) Early diet in preterm babies and developmental status at 18 months. Lancet 335:1477–1481

    Article  PubMed  CAS  Google Scholar 

  • Lucey JL, Dangman B (1984) A re-examination of the role of oxygen in retrolental fibroplasia. Pediatrics 73:82–96

    PubMed  CAS  Google Scholar 

  • Lumley J (1993) The epidemiology of preterm birth. Clin Obstet Gynaecol 7(3):477–498

    CAS  Google Scholar 

  • Lyon AJ, McColm J, Middlemist L et al. (1997) Randomised trial of erythromycin on the development of chronic lung disease in preterm infants. Arch Dis Child 78:F10-F14

    Google Scholar 

  • Macfarlane A, Cole S, Johnson A, Botting B (1988) Epidemiology of birth before 28 weeks of gestation. Br Med Bull 44: 861–891

    PubMed  CAS  Google Scholar 

  • Maher JE, Cliver SP, Goldernberg RL et al. (1994) The effect of corticosteroid therapy in the very premature infant. Am J Obst Gynaecol 170:869–873

    CAS  Google Scholar 

  • Major CA, Lewis DF, Harding JA, Port MA, Garite TJ (1994) Tocolysis with indomethacin increases the incidence of necrotizing enterocolitis in the low-birth-weight neonate. Am J Obstet Gynecol 170:102–106

    PubMed  CAS  Google Scholar 

  • Markestad T, Aksnes L, Finne PH, Aarskog D (1984) Plasma concentrations of vitamin D metabolites in premature infants. Pediatr Res 18:269–272

    Article  PubMed  CAS  Google Scholar 

  • McDonald HM, O’Loughlin JA, Polley P et al. (1992) Prenatal microbiological risk factors associated with preterm birth. Br J Obstet Gynaecol 99:190–196

    Article  PubMed  CAS  Google Scholar 

  • McDonald HM, O’Loughlin JA, Vigneswaran R et al. (1997) Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomized, placebo controlled trial. Br J Obstet Gynaecol 104:1391–1397

    Article  PubMed  CAS  Google Scholar 

  • McDonnell M, Serra-Serra V, Gaffnet G, Redman CWG, Hope PL (1994) Neonatal outcome after pregnancy complicated by abnormal velocity waveforms in the umbilical artery. Arch Dis Child 70:F84–F89

    Article  CAS  Google Scholar 

  • McGregor JA (1988) Prevention of preterm births. New initiatives based on microbial-host interactions. Obset Gynecol Survey 43:1–14

    CAS  Google Scholar 

  • Meyer MB (1977) Effects of maternal smoking and altitude on birth weight and gestation. In: Reed DM, Stanley FJ (eds) The epidemiology of prematurity. Urban & Schwarzenberg, Baltimore

    Google Scholar 

  • Milligan DWA, Issler H, Massam M, Reynolds EOR (1984) Treatment of neonatal pulmonary interstitial emphysema by lung puncture. Lancet i: 1010–1011

    Article  Google Scholar 

  • Modi N (1992) Sodium intake in preterm babies. Arch Dis Child 69:87–91

    Article  Google Scholar 

  • Morley CJ (1997) Systematic review of prophylactic vs rescue surfactant. Arch Dis Child 77:F70–F74

    Article  CAS  Google Scholar 

  • Naeye RL (1980) Seasonal variations in coitus and other risk factors, and the outcome of pregnancy. Early Hum Devel 4:61–68

    Article  CAS  Google Scholar 

  • Ng PC (1993) The effectiveness and side effects of dexamethasone in preterm infants with bronchopulmonary dysplasia. Arch Dis Child 68:330–336

    Article  PubMed  CAS  Google Scholar 

  • Northway WH Jr, Rosan RC, Porter DY (1967) Pulmonary disease following respirator therapy of hyaline membrane disease: bronchopulmonary dysplasia. N Engl J Med 276:357–368.

    Article  PubMed  Google Scholar 

  • Oppenheimer SJ, Snodgrass GJAI (1980) Neonatal rickets: Histopathology and quantitative bone changes. Arch Dis Child 55:945–949

    Article  PubMed  CAS  Google Scholar 

  • O’Shea TM, Kothadia JM, Klinepeter KL et al. (1999) Randomized placebo-controlled trial of a 42-day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants: outcome of study participants at 1-year adjusted age. Pediatrics 104:15–21

    Article  PubMed  Google Scholar 

  • Papile LA, Burstein J, Burstein R, Koffler H (1978) Incidence and evolution of subependymal and intraventricular haemorrhage: a study of infants with birthweight <1500g. J Pediatr 92:529–534

    Article  PubMed  CAS  Google Scholar 

  • Pennefather PM, Tin W, Clarke MP, Fritz S, Strong NP (1996) Retinopathy of prematurity in a controlled trial of prophylactic surfactant treatment. Br J Ophthalmol 80:420–424

    Article  PubMed  CAS  Google Scholar 

  • Philips AGS (1994) The changing face of neonatal infection: experience at a regional medical center. Pediatr Infect Dis 13:1098–1102

    Article  Google Scholar 

  • Pike MG, Holstrom G, de Vries LS et al. (1994) Patterns of visual impairment associated with lesions of the preterm infant brain. Dev Med Child Neurol 36:849–862

    Article  PubMed  CAS  Google Scholar 

  • Pinto-Martin JA, Riolo S, Cnaan A et al. (1995) Cranial ultrasound prediction of disabling and nondisabling cerebral palsy at age two in a low birthweight population. Pediatrics 95:249–254

    PubMed  CAS  Google Scholar 

  • Rennie JM, Wheater M, Cole TJ (1996) Antenatal steroid administration is associated with an improved chance of intact survival in preterm infants. Eur J Paediatr 155:576–579

    Article  CAS  Google Scholar 

  • Rennie JM (1997) Neonatal cerebral ultrasound. Cambridge University Press, Cambridge

    Google Scholar 

  • Rojas MA, Gonzalez A, Bancalari E, Claure N, Poole C, Silva-Neto G (1995) Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease J Pediatr 126:605–610

    CAS  Google Scholar 

  • Rushton DI, Preston PR, Durbin GM (1985) Structure and evolution of echodense lesions in the neonatal brain: a combined ultrasound and necropsy study. Arch Dis Child 60: 798–808

    Article  PubMed  CAS  Google Scholar 

  • Scottish Low Birthweight Study Group (1992) The Scottish Low Birthweight Study: I Survival, growth, neuromotor and sensory impairment. Arch Dis Child 67:675–681

    Article  Google Scholar 

  • Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hospkins EM (1988) Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirements in the neonatal period. Pediatrics 82:527–532

    PubMed  CAS  Google Scholar 

  • Shrivastava A, Lyon AJ, Mcintosh N (2000) The effect of dexa-methasone on growth, mineral balance and bone mineralisation in preterm infants with chronic lung disease. Eur J Pediatr 159:380–384

    Article  PubMed  CAS  Google Scholar 

  • Sibai B, Caritis SN, Thorn E et al. (1993) Prevention of preeclampsia with low-dose aspirin in healthy, nulliparous pregnant women. N Engl J Med 329:1213–1218

    Article  PubMed  CAS  Google Scholar 

  • Simon C, Schröder H, Beyer C, Zerbst T (1991) Neonatal sepsis in an intensive care unit and results of treatment. Infection 19:146–148

    Article  PubMed  CAS  Google Scholar 

  • Steichen JJ, Gratton TL, Tsang RC (1980) Osteopenia of prematurity: the cause and possible treatment. J Pediatr 96:528–534

    Article  PubMed  CAS  Google Scholar 

  • Stoll BJ (1994) Epidemiology of necrotizing enterocolitis. Clin Perinatol 21:205–218

    PubMed  CAS  Google Scholar 

  • Takashima J, Tanaka K (1978) Development of cerebral architecture and its relationship to periventricular leukomalacia. Arch Neurol 35:11–16

    Article  PubMed  CAS  Google Scholar 

  • Terry TL (1942) Extreme prematurity and fibroplastic overgrowth of persistent vascular sheath behind each crystalline lens. Am J Ophthalmol 25:203–204

    Google Scholar 

  • Tin W, Wariyar U, Hey E for the Northern Neonatal Network (1997) Changing prognosis for babies of less than 28 weeks’ gestation in the north of England between 1983 and 1994. Br Med J 313:107–111

    Google Scholar 

  • Toce SS, Farrell PM, Leavitt LA, Samules DP, Edwards DK (1984) Clinical and roentgenographic scoring systems for assessing bronchopulmonary dysplasia. Am J Dis Child 138:581–585

    PubMed  CAS  Google Scholar 

  • Trounce JQ, Rutter N, Levene MI (1986) Periventricular leucomalacia and intraventricular haemorrhage in the preterm neonate. Arch Dis Child 61:1196–1202

    Article  PubMed  CAS  Google Scholar 

  • Tschanz SA, Damke BM, Burri PH (1995) Influence of postnatally administered glucocorticoids on rat lung growth. Biol Neonate 68:229–245

    Article  PubMed  CAS  Google Scholar 

  • Tyson J, Guzick D, Rosenfield CR et al. (1990) Prenatal care evaluation and cohort analyses. Pediatrics 85:195–204

    PubMed  CAS  Google Scholar 

  • Uauy RD, Fanaroff AA, Korones SB et al. (1991) Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. J Pediatr 119:185–192

    Google Scholar 

  • Vesikari T, Janas M, Grönroos P et al. (1985) Neonatal septicaemia. Arch Dis Child 60:542–546

    Article  PubMed  CAS  Google Scholar 

  • Watterberg KL, Demers LM, Scott SM, Murphy SM (1996) Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 97:210–215.

    PubMed  CAS  Google Scholar 

  • Watts DH, Krohn KA, Hillier SL, Eschenbach DA (1992) The association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor. Obstet Gynecol 99:2992–2999

    Google Scholar 

  • Wilkinson AR, On behalf of the EPIcure Study Steering Group (1997) The extremely preterm baby — a population based study of outcomes of babies born before 26 weeks gestation in the UK and Ireland. Pediatr Res 42:402

    Google Scholar 

  • Wood NS, Marlow N, Costeloe K, Gibson AT, Wilkinson AR (2000) Neurologic and developmental disability after extremely preterm birth. EPICure Study Group. N Eng J Med 343:378–384

    Article  CAS  Google Scholar 

  • Yeh TF, Lin IJ, Hsieh WS et al. (1997) Early postnatal dexamethasone therapy for the prevention of chronic lung disease in preterm infants with respiratory distress syndrome: a multicentre clinical trial. Pediatrics 100:715–716

    Article  Google Scholar 

  • Yeh TF, Lin YJ, Huang CC et al. (1998) Early dexamethasone therapy in preterm infants: a follow-up study. Pediatrics 101:E7

    Article  PubMed  CAS  Google Scholar 

  • Yoon BH, Kim CJ, Romero R et al. (1998) Experimentally induced intrauterine infection causes fetal brain white lesions in rabbits. Am J Obstet Gynecol 177:797–802

    Article  Google Scholar 

  • Zimmermann P, Eirio V, Koskinen J, Kujansuu E, Ranta T (1997) Doppler assessment of the uterine and uteroplacental circulation in the second trimester in pregnancies at high risk for pre-eclampsia and/or intrauterine growth retardation: comparison and correlation between different Doppler parameters. Ultrasound Obstet Gynaecol 9:330–338

    Article  CAS  Google Scholar 

  • Zuckerman H, Shalev E, Gilad G et al. (1984) Further studies of the inhibition of preterm labor by indomethacin. II. Double blind study. J Perinatol Med 12:25

    Article  CAS  Google Scholar 

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Lyon, A. (2001). Prematurity. In: Keeling, J.W. (eds) Fetal and Neonatal Pathology. Springer, London. https://doi.org/10.1007/978-1-4471-3682-8_8

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