The Alimentary Tract and Exocrine Pancreas

  • Dick Variend


The gut derives from that part of the secondary yolk sac that becomes enclosed by the head, tail and lateral folds of the embryonic plate at around the 20th day of development. The head and tail folds enclose the fore- and hindgut respectively. The intermediate portion of the intraembryonic yolk sac forms the midgut which connects through a wide communication with the extraembryonic part of the secondary yolk sac (the definitive yolk sac). This communication becomes progressively reduced by better definition of the head, tail and lateral folds of the embryo (Fig. 15.1); by 28 days the communication is via a narrow vitelline duct and the umbilical cord is clearly visible. At about this time the primitive foregut and hindgut come into contact with rostral and caudal invaginations, the stomodeum and proctodeum. The omphalomesenteric duct usually becomes obliterated by the 10th week of embryonic life.


Cystic Fibrosis Exocrine Pancreas Abdominal Wall Defect Duodenal Atresia Intestinal Atresia 
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  1. Aitken J (1963) Exomphalos. Analysis of a 10 year series of 32 cases. Arch Dis Child 38:126–129PubMedCrossRefGoogle Scholar
  2. Amoury RA, Ashcraft KW, Holder TM (1977) Gastroschisis complicated by intestinal atresia. Surgery 82(3):373–381PubMedGoogle Scholar
  3. Andrew A (1971) The origin of intramural ganglia. IV The origin of enteric ganglia: a critical review and discussion of the present state of the problem. JAnat 108(1):169–184Google Scholar
  4. Antonioli DA (1997) Colitis in infants and children. In: Dahms BB, Qualman SJ (eds) Perspectives in pediatric pathology, vol 20. Karger, Basel, pp 77–110Google Scholar
  5. Avery ME, Fletcher BD, Williams RG (1981) The lung and its disorders in the newborn infant, 4th edn. Saunders, PhiladelphiaGoogle Scholar
  6. Ballard ET (1996) Ultrashort segment Hirschsprung’s disease: a case report. Pediatr Pathol & Lab Med 16:319–325Google Scholar
  7. Barr LC, Booth J, Filipe MI, Lawson JON (1985) Clinical evaluation of the histochemical diagnosis of Hirschsprung’s disease. Gut 26:393–399PubMedCrossRefGoogle Scholar
  8. Bax NMA, Pearse RG, Dommering N, Molenaar JC (1980) Perforation of the appendix in the neonatal period. J Pediatr Surg 15(2):200–202PubMedCrossRefGoogle Scholar
  9. Bell MJ, Ternberg JL, Keating JP et al. (1978) Prepyloric gastric antral web: a puzzling epidemic. J Pediatr Surg 13(3):307–313PubMedCrossRefGoogle Scholar
  10. Bell MJ, Keating JP, Ternberg JL, Bower RJ (1981) Perforated stress ulcers in infants. J Pediatr Surg 16(6):998–1002PubMedCrossRefGoogle Scholar
  11. Benacerraf BR, Saltzman DH, Estroff JA, Frigoletto FD (1990) Abnormal karyotype of fetuses with omphalocele: Prediction based on omphalocele contents. Obstet Gynecol 75:317–319PubMedGoogle Scholar
  12. Benson CD, Lloyd JR, Smith JD (1960) Resection and primary anastomosis in the management of stenosis and atresia of the jejunum and ileum. Pediatrics 26:265–272PubMedGoogle Scholar
  13. Bentley JFR, Smith JR (1960) Developmental posterior enteric remnants and spinal malformations. The split notochord syndrome. Arch Dis Child 35:76–86PubMedCrossRefGoogle Scholar
  14. Berdon WE, Baker DH, Wigger HJ et al. (1975) Calcified intraluminal meconium in newborn males with imperforate anus. AJR 125(2):449–455Google Scholar
  15. Bernstein J, Vawter G, Harris GBC, Young V, Hillman LS (1960) The occurrence of intestinal atresia in newborns with meconium ileus. Am JDis Child 99:804–818Google Scholar
  16. Berry CL, Fraser GC (1968) The experimental production of colitis in the rabbit with particular reference to Hirschsprung’s disease. J Pediatr Surg 3:36–42CrossRefGoogle Scholar
  17. Bill AH, Chapman ND (1962) The enterocolitis of Hirschsprung’s disease. Am J Surg 103:70–74CrossRefGoogle Scholar
  18. Bissler JJ, Klein RL (1988) Alimentary tract duplications in children: case and literature review. Clin Pediatr 27:152–157CrossRefGoogle Scholar
  19. Blank E, Chisolm AJ (1973) Congenital microgastria, a case report with a 26 year follow-up. Pediatrics 51(6):1037–1041PubMedGoogle Scholar
  20. Blott M, Greenhough A, Gamsu HR, Nicolaides K, Campbell S (1998) Antenatal factors associated with obstruction of the gastrointestinal tract by meconium. Br Med J 296:250CrossRefGoogle Scholar
  21. Blisard KS, Barton SA (1986) Neonatal haemochromatosis. Hum Pathol 17:376–383PubMedCrossRefGoogle Scholar
  22. Blyth H, Dickson JAS (1969) Apple peel syndrome (congenital intestinal atresia). A family study of seven index patients. J Med Genet 6(3):275–277PubMedCrossRefGoogle Scholar
  23. Boué A, Muller F, Nezelof C et al. (1986) Prenatal diagnosis in 200 pregnancies with a 1-in-4 risk of cystic fibrosis. Hum Genet 74:288–297PubMedCrossRefGoogle Scholar
  24. Brearly S, Armstrong GR, Nairn R et al. (1987) Pseudomembranous colitis: A lethal complication of Hirschsprung’s disease unrelated to antibiotic usage. J Pediatr Surg 22(3):257–259PubMedCrossRefGoogle Scholar
  25. Bremer JL (1944) Diverticula and duplications of the intestinal tract. Arch Pathol 38:132–140Google Scholar
  26. Brink DA, Balsara ZN (1991) Prenatal ultrasound detection of intra-abdominal pulmonary sequestration with postnatal MRI correlation. Pediatr Radiol 21:227PubMedCrossRefGoogle Scholar
  27. Bunton GL, Durbin GM, McIntosh N et al. (1977) Necrotising enterocolitis. Arch Dis Child 52: 772–777PubMedCrossRefGoogle Scholar
  28. Carneiro PMR, Brereton RJ, Drake DP et al. (1992) Enterocolitis in Hirschsprung’s disease. Pediatr Surg Int 7:356–360CrossRefGoogle Scholar
  29. Carter CO, Evans KA (1969) Inheritance of congenital pyloric stenosis. J Med Genet 6:233–239PubMedCrossRefGoogle Scholar
  30. Cantrell JR, Haller JA, Ravitch MM (1958) A syndrome of congenital defects involving the abdominal wall, sternum, diaphragm, pericardium and heart. Surg Gynecol Obstet 107:602PubMedGoogle Scholar
  31. Chang CH, Perrin EV, Bove KE (1983) Pyloric atresia associated with epidermolysis bullosa: special reference to pathogenesis. Pediatr Pathol 1:449–457PubMedCrossRefGoogle Scholar
  32. Chang J, Brueckner M, Rouloukian RJ (1993) Intestinal rotation and fixation abnormalities in heterotaxia: Early detection and management. J Pediatr Surg 28(10):1281–1285PubMedCrossRefGoogle Scholar
  33. Clatworthy HW, Howard WHR, Lloyd J (1956) The meconium plug syndrome. Surgery 39:131–142PubMedGoogle Scholar
  34. Cochran WD, Davis HT, Smith CS (1968) Advantages and complications of umbilical artery catheterisation in the newborn. Pediatrics 42:769–777PubMedGoogle Scholar
  35. Coffin CM, Pappin AL (1997) Polyps and neoplasms of the gastrointestinal tract in childhood and adolescence. In: Dahms BB, Qualman SJ (eds) Perspectives in paediatric pathology, vol 20. Basel: Karger, pp 127–171Google Scholar
  36. Collins DL, Kimura K, Morgan A (1986) Multiple intestinal atresia and amyoplasia congenita in four unrelated infants: A new association. J Pediatr Surg 21(4):331–333PubMedCrossRefGoogle Scholar
  37. Cook RCM, Rickham PP (1969) Neonatal intestinal obstruction due to milk curds. J Pediatr Surg 4(6):599–605PubMedCrossRefGoogle Scholar
  38. Corkery JJ, Dubowitz V, Lister J, Moosa A (1968) Colonic perforation after exchange transfusion. Br Med J II: 345–349Google Scholar
  39. Cotton PB (1980) Congenital anomaly of pancreas divisum as cause of obstructive pain and pancreatitis. Gut 21:105–114PubMedCrossRefGoogle Scholar
  40. Coutinho HB, Carmona de Mota H, Coutinho VB et al. (1998) Absence of lysozyme (muramidase) in the intestinal paneth cells of newborn infants with necrotizing enterocolitis. J Clin Pathol 51:512–514PubMedCrossRefGoogle Scholar
  41. Cruickshank AH (1986) Pathology of the pancreas. Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  42. Cunningham P, Rose JS, Sokol A, Bleicher MA (1980) A case of neonatal intussusception. J Pediatr Surg 15(2):203–204PubMedCrossRefGoogle Scholar
  43. Currie ABM, Hemalatha AH, Doraiswamy NV, Cos SA (1983) Colonic atresia associated with Hirschsprung’s disease. J R Coll Surg Edinb 28:31–34PubMedGoogle Scholar
  44. Déchelotte PJ, Mulliez NM, Bouvier RJ, Vanlieféringhen P, Lémery DJ (1992) Pseudo-meconium ileus due to cytomegalovirus infection: A report of three cases. Pediatr Pathol 12:73–82PubMedCrossRefGoogle Scholar
  45. deLorimier AA, Fonkalsrud EW, Hays DM (1969) Congenital atresia and stenosis of the jejunum and ileum. Surgery 65(5):819–827PubMedGoogle Scholar
  46. Denes J, Honti J, Leb J (1967) Dorsal herniation of the gut: a rare manifestation of the split notochord syndrome. J Pediatr Surg 2(4):359–363PubMedCrossRefGoogle Scholar
  47. deVries P (1980) The pathogenesis of gastroschisis and omphalocele. J Pediatr Surg 15(3):245–251PubMedCrossRefGoogle Scholar
  48. Dickson JAS (1970) Apple peel small bowel: an uncommon variant of duodenal and jejunal atresia. J Pediatr Surg 5(6):595–600PubMedCrossRefGoogle Scholar
  49. Dickson JAS, Variend S (1983): Colonic neuronal dysplasia. Acta Paediatr Scand 72:635–637PubMedCrossRefGoogle Scholar
  50. Dimmick JE, Hardwich DF (1992) Gastrointestinal system and exocrine pancreas. In: Dimmick JE, Klousek DK (eds) Developmental pathology of the embryo and fetus. J B Lippincott Company, Philadelphia, pp 509–544Google Scholar
  51. Dirkes K, Crombleholme TM, Craigo SD et al. (1995) The natural history of meconium peritonitis diagnosed in utero. J Pediatr Surg 30:979–982PubMedCrossRefGoogle Scholar
  52. Dohn K, Povlsen O (1951) Enterocystomas. Report of six cases. Acta Chir Scand 102:21–35PubMedGoogle Scholar
  53. Donnison AB, Shwachman H, Gross RE (1966) A review of 164 children with meconium ileus seen at the Children’s Hospital Medical Center, Boston. Pediatrics 37(5):833–850PubMedGoogle Scholar
  54. Dudgeon DL, Coran AG, Lauppe FA, Hodgman Joan E, Rosenkrantz JG (1973) Surgical management of acute necrotising enterocolitis in infancy. J Pediatr Surg 8:607–614PubMedCrossRefGoogle Scholar
  55. Duncan BW, Adzick NS, Eraklis A (1992) Retroperitoneal alimentary tract duplications detected in utero. J Pediatr Surg 27:1231–33PubMedCrossRefGoogle Scholar
  56. Durham Smith E (1968) Urinary anomalies and complications in imperforate anus and rectum. J Pediatr Surg 3(3):337–349CrossRefGoogle Scholar
  57. Elhalaby EA, Coran AG, Blane CE et al. (1995) Enterocolitis associated with Hirschsprung’s disease: a clinical-radiological characterization based on 168 patients. J Pediatr Surg 30(1):76–83PubMedCrossRefGoogle Scholar
  58. Elliott K, Knight J (1974) Size at birth. Ciba Found Symp 27:202–203Google Scholar
  59. Engel RR, Virnig NL, Hunt CE, Levitt MD (1973) Origin of mural gas in necrotising enterocolitis. Pediatr Res 7:292Google Scholar
  60. Engum SA, Petrites M, Rescorla J et al. (1993) Familial Hirschsprung’s disease: 20 cases in 12 kindreds. J Pediatr Surg 28(10):1286–1290PubMedCrossRefGoogle Scholar
  61. Esterly JR, Baghdassarian OM (1963) Presacral neuroenteric cyst: an unusual malformation resulting from persistence of the neuroenteric canal. Bull Johns Hopkins Hosp 113:202–210PubMedGoogle Scholar
  62. Faix RG, Adam SJT (1994) Neonatal necrotizing enterocolitis: current concepts and controversies. Adv Pediatr Infect Dis 9:1–36PubMedGoogle Scholar
  63. Fallon M, Gordon ARG, Lendrum AC (1954) Mediastinal cysts of foregut origin associated with vertebral abnormalities. Br J Surg 41: 520–533PubMedCrossRefGoogle Scholar
  64. Favara BE, Franciosi RA, Akers DR (1971) Enteric duplications. Thirty seven cases: a vascular theory of pathogenesis. Am JArch Dis Child 122:501–506Google Scholar
  65. Fonkalsrud EW, deLorimier AA, Hays DM (1969) Congenital atresia and stenosis of the duodenum. Pediatrics 43(1):79–83PubMedGoogle Scholar
  66. Forouhar F (1982) Meconium peritonitis. Am J Clin Pathol 78:208–213PubMedGoogle Scholar
  67. Franz ID, L’Heureux P, Engel RR, Hunt CE (1975) Necrotising enterocolitis. J Pediatr 86:259–263CrossRefGoogle Scholar
  68. Fuhr AH, Krogh PHJ (1972) Congenital epulis of the newborn. J Oral Surg 30: 30–35PubMedGoogle Scholar
  69. Fujimoto T, Hata J, Yokoyama S, Mitomi T (1989) A study of the extracellular matrix protein as the migration pathway of neural crest cells in the gut: analysis in human embryos with special reference to the pathogenesis of Hirschsprung’s disease. J Pediatr Surg 24:550–556PubMedCrossRefGoogle Scholar
  70. Garrett JR, Howard ER, Nixon HH (1969) Autonomic nerves in rectum and colon in Hirschsprung’s disease. A Cholinesterase and catecholamine histochemical study. Arch Dis Child 44:406–417PubMedCrossRefGoogle Scholar
  71. Gauderer MWL, Rothstein FC, Izant RJ (1984) Ileal atresia with long-segment Hirschsprung’s disease in a neonate. J Pediatr Surg 19(1):15–17PubMedCrossRefGoogle Scholar
  72. Goldberg HM, Johnson TP (1962) Posterior abdominothoracic enteric duplications. Br J Surg 50:445–449CrossRefGoogle Scholar
  73. Gonzalez-Crussi F (1980) Extragonadal teratomas. Armed Forces Institute of Pathology, Washington DCGoogle Scholar
  74. Goto S, Ikeda K, Toyohara T (1984) Histochemical confirmation of the acetylcholinesterase-activity in rectal suction biosy from neonates with Hirschsprung’s disease. Z Kinderchir 39:246–249PubMedGoogle Scholar
  75. Gough MH (1961) Congenital abnormalities of the anus and rectum. Arch Dis Child 36:146–151PubMedCrossRefGoogle Scholar
  76. Greenwood RD, Rosenthal A, Nadas AS (1974) Cardiovascular malformations associated with omphalocele. J Pediatr 85(6):818–821PubMedCrossRefGoogle Scholar
  77. Grosfeld JL, O’Neill JA, Clatworthy HW (1970) Enteric duplications in infancy and childhood: an 18 year review. Ann Surg 172(1):83–90PubMedGoogle Scholar
  78. Grosfeld JL, Dalsing MC, Hull M, Weber TR (1983) Neonatal apnea, xanthines, and necrotising enterocolitis. J Pediatr Surg 18(1):80–84PubMedCrossRefGoogle Scholar
  79. Hakanson DO, Oh W (1977) Necrotising enterocolitis and hyperviscosity in the newborn infant. J Pediatr 90:458–461PubMedCrossRefGoogle Scholar
  80. Hartwig NG, Vermeij-Keers CHR, deVries HE, Kagie M, Kragt H (1989) Limb body wall malformation complex: an embryologic etiology? Hum Pathol 20(11):1071–1077PubMedCrossRefGoogle Scholar
  81. Hashida Y, Jaffe R, Yunis E J (1983) Pancreatic pathology in trisomy 13: specificity of the morphologic lesion. Pediatr Pathol 1:169–178PubMedCrossRefGoogle Scholar
  82. Heller K, Waag KL, Beyersdorf F (1989) Intestinal duplications — intestinal diverticula — segmental dilatation of the intestine: a common genetic complex. Pediatr Surg Int 4: 249–253CrossRefGoogle Scholar
  83. Hershenson MB, Brouillette RT, Klemka L et al. (1985) Respiratory insufficiency in newborns with abdominal wall defects. J Pediatr Surg 20:348–353PubMedCrossRefGoogle Scholar
  84. Higginbottom MC, Jones KL, Hall BD, Smith DW (1979) The amniotic band disruption complex: timing of amniotic rupture and variable spectra of consequent defects. J Pediatr 95(4):544–549PubMedCrossRefGoogle Scholar
  85. Holder TM, Cloud DT, Lewi SJE, Pilling GP IV (1964) Esophageal atresia and tracheoesophageal fistula. Pediatrics 34:542–549PubMedGoogle Scholar
  86. Holgersen LO (1981) The etiology of spontaneous gastric perforation of the newborn: a re-evaluation. J Pediatr Surg 16(4,1):608–613PubMedCrossRefGoogle Scholar
  87. Holsclaw DS, Eckstein HB, Nixon HH (1965) Meconium ileus. A 20 year review of 109 cases. Am JDis Child 109:101–113Google Scholar
  88. Howard FM, Flynn DM, Bradley JM, Noone P, Swawatkowski M (1977) Outbreak of necrotising enterocolitis caused by Clostridium butyricum: Lancet 11:1099–1102CrossRefGoogle Scholar
  89. Howell WE, Stein H, Romaro AJ (1972) Sublingual dermoid cyst in infant: report of case. J Oral Surg 30:437–441PubMedGoogle Scholar
  90. Hoyme HE, Higginbottom MC, Jones KL (1981) The vascular pathogenesis of gastroschisis: intrauterine interruption of the omphalomesenteric artery. J Pediatr 98(2):228–231PubMedCrossRefGoogle Scholar
  91. Hsueh W, Caplan MS, Tan X, McKendrick W, Gonzalez-Crussi F (1998) Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. Pediatr Develop Pathol 1:2–16CrossRefGoogle Scholar
  92. Huntley CC, Shaffner L, Challa VR, Lyerly AD (1982) Histochemical diagnosis of Hirschsprung disease. Pediatrics 69(6):775–761Google Scholar
  93. Jackson JM (1963) Annular pancreas and duodenal obstruction in the neonate. A review. Arch Surg 87:379–383PubMedCrossRefGoogle Scholar
  94. Jackson RH, Bird AR (1961) Meckel’s diverticulum in childhood. Br Med J 11:1399–1402CrossRefGoogle Scholar
  95. Jaffe R (1991) The pancreas. In: Wigglesworth JS, Singer DB (eds) Fetal and perinatal pathology, vol 2. Blackwell Scientific Publications, Boston, pp 1021–1055Google Scholar
  96. Johnston JH, Penn IA (1966) Exstrophy of the cloaca. Br J Urol 38:302–307PubMedCrossRefGoogle Scholar
  97. Jones PG (1963) Exomphalos (syn. omphalocele). A review of 45 cases. Arch Dis Child 38:180–187PubMedCrossRefGoogle Scholar
  98. Jones KL (1997) Smith’s recognizable patterns of human malformations, 5th edn. Saunders, PhiladelphiaGoogle Scholar
  99. Kiesewetter WB, Smith JE (1958) Malrotation of the midgut in infancy and childhood. AMAArch Surg 77:483–491CrossRefGoogle Scholar
  100. King A, Mueller RF, Heeley AR, Roberton NRC (1986) Diagnosis of cystic fibrosis in premature infants. Pediatr Res 20:536–541PubMedCrossRefGoogle Scholar
  101. King DR, Savrin R, Boles ET (1980) Gastroschisis update. J Pediatr Surg 15(4):553–557PubMedCrossRefGoogle Scholar
  102. Klein MD, Coran JAG, Wesley JR, Drongowski RA (1984) Hirschsprung’s disease in the newborn. J Pediatr Surg 9(4):370–374CrossRefGoogle Scholar
  103. Kleinhaus S, Boley SJ, Sheran M, Sieber WK (1979) Hirschsprung’s disease. A survey of the members of the surgical section of the American Academy of Pediatrics. J Pediatr. Surg 14(5):588–597PubMedCrossRefGoogle Scholar
  104. Kliegman RM (1990) Neonatal necrotising enterocolitis: bridging the basic science with the clinical disease. J Pediatr 117:833–835PubMedCrossRefGoogle Scholar
  105. Konje JC, de Chazal R, MacFadyen U, Taylor DJ (1995) Antenatal diagnosis and management of meconium peritonitis: a case report and review of the literature. Ultrasound Obstet Gynaecol 6:66–69CrossRefGoogle Scholar
  106. Kopel FB (1972) Gastrointestinal manifestations of cystic fibrosis. Curr Clin Concepts 62(3):483–491Google Scholar
  107. Kubota Y, Shimotake T, Yanigihara J, Iwai N (1998) Development of anorectal malformations using etretinate. J Pediatr Surg 33:127–129PubMedCrossRefGoogle Scholar
  108. Lake BD (1981) Metabolic disorders: general considerations. In: Berry CL (ed) Pediatr Path. Springer-Verlag, Berlin, Heidelberg, New York, pp 617–639CrossRefGoogle Scholar
  109. Lemire RJ, Graham CB, Beckwith JB (1971) Skin-covered sacrococcygeal masses in infants and children. J Pediatr 79(6):948–954PubMedCrossRefGoogle Scholar
  110. Lemon SJA, Ridenour R, Orsini EN (1979) Congenital absence of the pancreas and intrauterine growth retardation. Pediatrics 64(2):255–257Google Scholar
  111. Lister J, Rickham PP (1980) Hirschsprung’s disease. In: Rickham PP, Lister J, Irving IM (eds) Neonatal surgery, 2nd edn. Butterworths, London, pp 441–455Google Scholar
  112. Lloyd JR (1969) The etiology of gastrointestinal perforations in the newborn. J Pediatr Surg 4:77–84PubMedCrossRefGoogle Scholar
  113. Lorimer WS, Ellis DG (1966) Meconium peritonitis. Surgery 60(2):470–475PubMedGoogle Scholar
  114. Louw JH (1966) Jejunoileal atresia and stenosis. J Pediatr Surg 1(1):8–23CrossRefGoogle Scholar
  115. McFadden DE, Pantzar JT (1992) Genital System. In: Dimmick JE, Kalousek DK (eds) Developmental pathology of the embryo and fetus. J B Lippincott company, Philadelphia, pp 605–624Google Scholar
  116. McLetchie NGB, Purve SJK, Saunders RLdeCH (1954) The genesis of gastric and certain intestinal diverticula and enterogenous cysts. Surg Gynecol Obstet 99:135–141Google Scholar
  117. Mann L, Feguson-Smith MA, Desai M, Gibson AAM, Raine PAM (1984) Prenatal assessment of anterior abdominal wall defects and their prognosis. Prenat Diagn 4:427–435PubMedCrossRefGoogle Scholar
  118. Marchildon MB, Buck BE, Abdenour G (1982) Necrotising enterocolitis in the unfed infant. J Pediatr Surg 17: 620–623PubMedCrossRefGoogle Scholar
  119. Martin LW, Perrin EV (1967) Neonatal perforation of the appendix in association with Hirschsprung’s disease. Ann Surg 166(5):799–802PubMedCrossRefGoogle Scholar
  120. Martinez-Mora J, Boix-Ochoa J, Tresserra L (1971) Vascular tumours of the parotid region in children. Surg Gynecol Obstet 133:973–977PubMedGoogle Scholar
  121. Martucciello G, Ceccherini I, Lerone M, Jasonni V (2000) Pathogenesis of Hirschsprung’s disease. J Ped Surg 35(7): 1017–1025CrossRefGoogle Scholar
  122. Meier-Ruge W (1974) Hirschsprung’s disease: its aetiology, pathogenesis and differential diagnosis. Curr Top Pathol 59:131–179PubMedCrossRefGoogle Scholar
  123. Merriam JC, Benirschke K (1959) Esophageal erosions in the newborn. Lab Invest 8:39–47PubMedGoogle Scholar
  124. Milla PJ, Smith VV (1993) Intestinal neuronal dysplasia. J Pediatr Gastroenterol Nutrition 17:365–357Google Scholar
  125. Miller ME, Graham JM, Higginbottom MC, Smith DW (1981) Compression-related defects from early amnion rupture: evidence for mechanical teratogenesis. J Pediatr 98(2):292–297PubMedCrossRefGoogle Scholar
  126. Miller JP, Smith SD, Newman B, Sukarochana K (1988) Neonatal abdominal calcification: Is it always meconium peritonitis? J Pediatr Surg 23(6):555–556PubMedCrossRefGoogle Scholar
  127. Mizrahi A, Barlow O, Berdon W, Blanc WA, Silverman WA (1965) Necrotising enterocolitis in premature infants. J Pediatr 66:697–706PubMedCrossRefGoogle Scholar
  128. Moore TC, Schumacker HB (1952) Intussusception of ileum through persistent omphalomesenteric duct. Surgery 31:278–284PubMedGoogle Scholar
  129. Morrell MT, Keynes M (1981) Annular pancreas. In: Keynes WM, Keith RG (eds) The pancreas. Heinemann, London, pp 159–168Google Scholar
  130. Muller F, Aubry MC, Gasser B et al. (1985) Prenatal diagnosis of cystic fibrosis. Prenat Diagn 5:109–117.PubMedCrossRefGoogle Scholar
  131. Nacheff M, Morgan R, Einsenstein EM (1964) The surgical treatment of perforated duodenal ulcer in the newborn. Am J Surg 108:717–723PubMedCrossRefGoogle Scholar
  132. Nakayama DK, Harrison MR, Gross BH et al. (1984) Management of the fetus with an abdominal wall defect. J Pediatr Surg 19:408–413PubMedCrossRefGoogle Scholar
  133. Neal WA, Reynold SJW, Jarvis CW, Williams HJ (1972) Umbilical artery catheterisation: demonstration of arterial thrombosis by aortography. Pediatrics 50:6–13PubMedGoogle Scholar
  134. Neilson IR, Yazbeck S (1990) Ultrashort Hirschsprung’s disease: myth or reality. J Pediatr Surg 25(11):1135–1138PubMedCrossRefGoogle Scholar
  135. Nicolaides KH, Rodeck CH, Fosden CM (1986) Rapid karyotyping in non-lethal fetal malformations. Lancet 1:283–287PubMedCrossRefGoogle Scholar
  136. Nixon HH, Tawes R (1971) Etiology and treatment of small intestinal atresia: analysis of a series of 127 jejunoileal atresias and comparison with 62 duodenal atresias. Surgery 69:41–51PubMedGoogle Scholar
  137. Nyberg DA, Fitzsimmon SJ, Mack LA et al. (1989) Chromosomal abnormalities in fetuses with omphalocele. J Ultrasound Med 8:299–308PubMedGoogle Scholar
  138. Okamoto E, Ueda T (1967) Embryogenesis of intramural ganglia of the gut and its relation to Hirschsprung’s disease. J Pediatr Surg 2(5):437–443CrossRefGoogle Scholar
  139. Olsen MM, Luck SR, Lloyd-Still J, Raffensperger JG (1982) The spectrum of meconium disease in infancy. J Pediatr Surg 17(5):479–481PubMedCrossRefGoogle Scholar
  140. Oppenheimer EH, Esterly JR (1962) Observations in cystic fibrosis of the pancreas. II Neonatal intestinal obstruction. Bull Johns Hopkins Hosp 111:1PubMedGoogle Scholar
  141. Oppenheimer EH, Esterly JR (1975) Pathology of cystic fibrosis. Review of literature and comparison with 146 autopsied cases. In: Rosenberg HS, Bolande RP (eds) Perspectives in pediatric pathology, vol 2. Year Book Medical Publishers, Chicago, pp 241–278Google Scholar
  142. Parikh DH, Tarn PKH, Lloyd DA, van Velzen D, Edgar DH (1992) Quantitative and qualitative analysis of the extracellular matrix protein, laminin, in Hirschsprung’s disease. J Pediatr Surg 27:991–6CrossRefGoogle Scholar
  143. Park RW, Grand RJ (1981) Gastrointestinal manifestations of cystic fibrosis: a review. Gastroenterology 81:1143–61PubMedGoogle Scholar
  144. Parrish RA, Sherman RT, Wilson H (1964) Spontaneous rupture of the gastro-enteric tract in the newborn: a report of 13 cases and description of a characteristic x-ray finding. Ann Surg 159: 244–251PubMedCrossRefGoogle Scholar
  145. Partridge JP, Gough MH (1961) Congenital abnormalities of the anus and rectum. Br J Surg 49:37–49PubMedCrossRefGoogle Scholar
  146. Philippart AI, Reed JO, Geargeson KE (1975) Neonatal small left colon syndrome: intramural not intraluminal obstruction. J Pediatr Surg 10:733–739PubMedCrossRefGoogle Scholar
  147. Pokorny WJ, McGill CW, Harberg FJ (1984) Morgagni hernias during infancy: presentation and associated anomalies. J Pediatr Surg 19(4):394–397PubMedCrossRefGoogle Scholar
  148. Puri P, Lake BD, Gorman F, O’Donnell B, Nixon HH (1983) Megacystis-microcolon-intestinal hypoperistalsis syndrome: a visceral myopathy. J Pediatr Surg 18(1):64–69PubMedCrossRefGoogle Scholar
  149. Qualman SJ, Murray R (1994) Aganglionosis and related disorders. Hum Pathol 25:1141–1149PubMedCrossRefGoogle Scholar
  150. Qualman SJ, Pysher T, Schauer G (1997) Hirschsprung’s disease: differential diagnosis and sequelae. In: Dahms BB, Qualman SJ (eds) Perspectives in pediatric pathology, vol 20. Karger, Basel, Switzerland, pp 111–126Google Scholar
  151. Quan L, Smith DW (1973) The VATER association. J Pediatr 82(1):104–107PubMedCrossRefGoogle Scholar
  152. Reiquam CW, Allen RP, Akers DR (1965) Normal and abnormal small bowel lengths. An analysis of 389 autopsy cases in infants and children. Am JDis Child 109:447–451Google Scholar
  153. Rickham PP (1955) Peritonitis in the neonatal period. Arch Dis Child 30:23–31PubMedCrossRefGoogle Scholar
  154. Rickham PP, Boeckman CR (1965) Neonatal meconium obstruction in the absence of mucovisicidosis. Am J Surg 109:173–177PubMedGoogle Scholar
  155. Robertson FM, Crombleholme TM, Paidas M, Harris, BH (1994) Prenatal diagnosis and management of gastrointestinal anomalies. Semin Perinatol 18:182–195PubMedGoogle Scholar
  156. Rodin AE, Nichols MM, Hsu FL (1973) Necrotising enterocolitis occurring in full-term neonates at birth. Arch Pathol 96:335–338PubMedGoogle Scholar
  157. Rohde RA, Hodgman JE, Cleland RS (1964) Multiple congenital anomalies in the El-trisomy (Group 16–18) syndrome. Pediatrics 33:258–270PubMedGoogle Scholar
  158. Rosenstein B J, Langbaum TS (1980) Incidence of meconium abnormalities in newborn infants with cystic fibrosis. Am JDis Child 134:72–73Google Scholar
  159. Rothschild HB, Storck A, Myers B (1953) Mesenteric occlusion in a newborn infant. J Pediatr 43:569–572PubMedCrossRefGoogle Scholar
  160. Santulli TV, Amoury RA (1967) Congenital anomalies of the gastrointestinal tract. Pediatr Clin North Am 14:21–45PubMedGoogle Scholar
  161. Santulli TV, Blanc WA (1961) Congenital atresia of the intestine: pathogenesis and treatment. Am Surg 151:939–948Google Scholar
  162. Santulli TV, Schullinger JN, Heird WC et al. (1975) Acute necrotising enterocolitis in infancy: a review of 64 cases. Pediatrics 55:376–387PubMedGoogle Scholar
  163. Scharli AF, Meier-Ruge W (1981) Localized and disseminated forms of neuronal intestinal dysplasia mimicking Hirschsprung’s disease. J Pediatr Surg 16(2):164–17PubMedCrossRefGoogle Scholar
  164. Shaw A (1975) The myth of gastroschisis. J Pediatr Surg 10(2):235–241PubMedCrossRefGoogle Scholar
  165. Siebert JR, Beckwith JB (1984) Left ventricular hypoplasia in congenital diaphragmatic hernia. J Pediatr Surg 19(5):567–571PubMedCrossRefGoogle Scholar
  166. Smith B, Clatworthy HW (1961) Meconium peritonitis: prognostic significance. Pediatrics 27:967–970Google Scholar
  167. Smith JR (1960) Accessory enteric formations. Arch Dis Child 35:87–89PubMedCrossRefGoogle Scholar
  168. Smith VV, Milla PJ (1997) Histological phenotypes of enteric smooth muscle disease causing functional intestinal obstruction in childhood. Histopathology 31:112–122PubMedCrossRefGoogle Scholar
  169. Snyder WH, Chaffin L (1954) Embryology and pathology of the intestinal tract: presentation of 40 cases of malrotation. Ann Surg 140:368–379PubMedCrossRefGoogle Scholar
  170. Siplovich L, Davies MRQ, Kaschula ROC, Cywes S (1988) Intestinal obstruction in the newborn with congenital syphilis. J Pediatr Surg 23(9):810–813PubMedCrossRefGoogle Scholar
  171. Spicer RD (1982) Infantile hypertrophic pyloric stenosis: a review. Br J Surg 69:128–135PubMedCrossRefGoogle Scholar
  172. Srikanth MS, Ford EG, Isaacs HJr, Mahour H (1993) Megacystis microcolon intestinal hypoperistalis syndrome: late sequelae and possible pathogenesis. J Pediatr Surg 28:957–959PubMedGoogle Scholar
  173. Stephens FD, Durham Smith E (1986) Classification, identification and assessment of surgical treatment of anorectal anomalies. Pediatr Surg Int 1:200–205CrossRefGoogle Scholar
  174. Stevenson JK, Graham CB, Oliver TK, Goldenberg VE (1969) Neonatal necrotising enterocolitis — a report of twenty-one cases with fourteen survivors. Am J Surg 118:260–272PubMedCrossRefGoogle Scholar
  175. Stewart DR, Colodny AL, Dagget WC (1976) Malrotation of the bowel in infants and children: a 15 year review. Surgery 79(6):716–720PubMedGoogle Scholar
  176. Stocker JT, Heifetz SA (1987) Sirenomelia. A morphological study of 33 cases and review of the literature. Perspect Pediatr Pathol 10:7–50PubMedGoogle Scholar
  177. St-Vil D, Shaw KS, Lallier M, Yazbeck S, Di Lorenzo M (1996) Chromosomal anomalies in newborns with omphalocele. J Pediatr Surg 31(6):831–834PubMedCrossRefGoogle Scholar
  178. Suita S, Okamatsu T, Yamamoto T et al. (2000) Changing profile of abdominal wall defects in Japan: Results of a National Survey. J Ped Surg 35(1):66–72CrossRefGoogle Scholar
  179. Sullivan PB (1996) Hirschsprung’s disease. Arch Dis Childh 74:5–7PubMedCrossRefGoogle Scholar
  180. Tan, HL, Yoong A, Yu CCW (2000) Ectopic pancreatic rests: a rare cause of persistent umbilical discharge. Ped Surg Internat (16):116–117CrossRefGoogle Scholar
  181. Tang TT, Glicklich M, Siegesmund KA, Oechler HWMcCreadie SR (1979) Neonatal cystic choristoma in submandibular salivary gland simulating cystic hygroma. Arch Pathol Lab Med 103: 537–539Google Scholar
  182. Teich S, Schisgall RM, Anderson KD (1986) Ischemic enterocolitis as a complication of Hirschsprung’s disease. J Pediatr Surg 21(2): 143–145PubMedCrossRefGoogle Scholar
  183. Teitelbaum DH, Caniano DA, Qualman SJ (1989) The pathophysiology of Hirschsprung’s-associated enterocolitis: importance of histologic correlates. J Pediatr Surg 24(12):1271–1277PubMedCrossRefGoogle Scholar
  184. Temtamy SA, Miller JD (1974) Extending the scope of the VATER association: definition of the VATER syndrome. J Pediatr 85(3):345–349PubMedCrossRefGoogle Scholar
  185. Thomaidis TS, Arey JB (1963) The intestinal lesions in cystic fibrosis of the pancreas. J Pediatr 63:444–453PubMedCrossRefGoogle Scholar
  186. Thomas DFM, Fernie DS, Bayston R, Spitz L, Nixon HH (1986) Enterocolitis in Hirschsprung’s disease: a controlled study of the etiologic role of Clostridium difficile. J Pediatr Surg 21(1):22–25PubMedCrossRefGoogle Scholar
  187. Thurlbeck WM (1992) Respiratory System. In: Dimmick JE, Kalousek DK (eds) Developmental pathology of the embryo and fetus. J B Lippincott Company, Philadelphia, pp 437–466Google Scholar
  188. Tibboel D, van Nie, CJ, Molenaar JC (1980) The effects of temporary general hypoxia and local ischemia on the development of the intestines: an experimental study. J Pediatr Surg 15(1):57–62PubMedCrossRefGoogle Scholar
  189. Tibboel D, Gaillard JLJ, Molenaar JC (1986) The importance of mesenteric vascular insufficiency in meconium peritonitis. Hum Pathol 17:411–416PubMedCrossRefGoogle Scholar
  190. Touloukian RJ (1973) Gastric ischaemia: the primary factor in neonatal perforation. Clin Paediatr 12:219–225Google Scholar
  191. Toyama WM (1972) Combined congenital defects of the anterior abdominal wall, sternum, diaphragm, pericardium, and heart: a case report and review of the syndrome. Pediatrics 50(5):778–792PubMedGoogle Scholar
  192. van der Putte SCJ (1986) Normal and abnormal development of the anorectum. J Pediatr Surg 21(5):434–440PubMedCrossRefGoogle Scholar
  193. Vanamo K (1996) A 45-year perspective of congenital diaphragmatic hernia. Br J Surg 83:1758–1762PubMedCrossRefGoogle Scholar
  194. Variend S, Howat AJ (1988) Upper oesophageal gastric heterotopia: a prospective necropsy study in children. J Clin Path 41:742–545PubMedCrossRefGoogle Scholar
  195. Vawter GF, Tefft M (1966) Congenital tumours of the parotid gland. Arch Pathol 82:242–245PubMedGoogle Scholar
  196. Veeneklaas GMH (1952) Pathogenesis of intrathoracic gastro-genic cysts. Am JDis Child 83:500–507Google Scholar
  197. Vinograd I, Mogle P, Peleg O, Alpan G, Lernau OZ (1983) Meconium disease in premature infants with very low birth weight. J Pediatr 103:963–966PubMedCrossRefGoogle Scholar
  198. Wallis C (1997) Diagnosing cystic fibrosis: blood, sweat, and tears. Arch Dis Child 76:85–91PubMedCrossRefGoogle Scholar
  199. Waterston DJ, Bonham Carter RE, Aberdeen E (1962) Oesophageal atresia: tracheo-oesophageal fistula. A study of survival in 218 infants. Lancet 1:819–822PubMedCrossRefGoogle Scholar
  200. Weaver DD, Mapstone CL, Yu P (1986) The Vater association. Analysis of 46 patients. Am JDis Child 140:225–229Google Scholar
  201. Weinberg AG (1975) Hirschsprung’s disease — a pathologist’s view. In: Rosenberg HS, Bolande RP (eds) Perspectives in pediatric pathology, vol 2. Year Book Medical Publishers, Chicago, pp 207–239Google Scholar
  202. Weitzman JJ, Vanderhoof RS (1966) Jejunal atresia with agenesis of the dorsal mesentery. Am J Surg 111:443–449PubMedCrossRefGoogle Scholar
  203. White RB (1956) Meconium peritonitis: a surgical emergency. J Pediatr 48:793–796PubMedCrossRefGoogle Scholar
  204. Wiswell TE, Rawlings JS, Wilson JL, Pettett G (1979) Megacystis-microcolon-intestinal hypoperistalsis syndrome. Pediatrics 63(5):805–808PubMedGoogle Scholar
  205. Young DG, Wilkinson AW (1968) Abnormalities associated with neonatal duodenal obstruction. Surgery 63(5):832–836PubMedGoogle Scholar
  206. Yutani C, Sakurai M, Miyaji T, Okuno M (1973) Congenital short intestine. Arch Pathol 96:81–82PubMedGoogle Scholar

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  • Dick Variend

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