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The Histological Varieties of Bronchial Carcinoma

  • Allen R. Gibbs
  • Roger M. E. Seal

Abstract

It is important to realise that lung cancer is not a homogeneous entity but instead comprises a number of different histopathological groups and subgroups. A knowledge of the histopathology of lung tumours is not just of academic interest but provides a better framework for ascertaining the aetiology of a given tumour, predicting outcome and determining treatment. For example, small cell carcinoma behaves in a very different way from other types of lung cancer; it metastasises very early and is very often surgically inoperable by the time of diagnosis. On the other hand squamous cell carcinoma, if localised to the lung at operative resection, has a relatively good prognosis. The incidence of squamous cell carcinoma and small cell carcinoma is greatly increased in smokers whereas adenocarcinoma does not show as great an increase.

Keywords

Squamous Cell Carcinoma Small Cell Carcinoma Large Cell Carcinoma Histological Variety Papillary Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adamson JS, Senior RM, Merill T (1968) Alveolar cell carcinoma: An electron microscopic study. Am Rev Respir Dis 100: 550–557.Google Scholar
  2. Azzopardi JG (1959) Oat cell carcinoma of the bronchus. J Pathol Bacteriol 78: 513–519PubMedCrossRefGoogle Scholar
  3. Bensch KG, Corrin B, Pariente R, Spencer H (1968) Oat cell carcinoma of the lungs: its origin and relationship to bronchial carcinoid. Cancer 22: 1163–1172PubMedCrossRefGoogle Scholar
  4. Bolen JW, Thorning D (1982) Histogenetic classification of pulmonary carcinomas. Pathol Annu 1: 77–100Google Scholar
  5. Carter D, Eggleston JC (1980) Giant cell carcinoma. In: Tumours of the lower respiratory tract. Second Series Fascicle, AFIP, Washington 17: 155–160Google Scholar
  6. Churg A (1978) The fine structure of large cell undifferentiated carcinoma of the lung. Human Pathol 2: 143–156CrossRefGoogle Scholar
  7. Flanagan CP, Roeckel IE (1964) Giant cell carcinoma of the lung. Anatomical and clinical correlations. Am J Med 36: 214–221PubMedCrossRefGoogle Scholar
  8. Gibbs AR, Seal RME (1982a) Lung carcinomas. In: Gresham GA (ed) Atlas of pulmonary pathology. MTP Press, Lancaster, pp 103–110Google Scholar
  9. Gibbs AR, Seal RME (1982b) Occupational lung disorders II. Silicate pneumoconioses. In: Gresham GA (ed) Atlas of pulmonary pathology. MTP Press, Lancaster, pp 91–95Google Scholar
  10. Goldman KP (1965) Histology of lung cancer in relation to prognosis. Thorax 20: 298–302PubMedCrossRefGoogle Scholar
  11. Greenberg SD, Smith MN,Spjut HJ (1975) Bronchiolo-alveolar carcinoma — cell of origin. Am J Clin Pathol 63: 153–167PubMedGoogle Scholar
  12. Harwood TR, Gracey DR, Yakoo H (1976) Pseudomesotheliomatous carcinoma of the lung. A variant of peripheral lung cancer. Am J Clin Pathol 65: 159–167PubMedGoogle Scholar
  13. Katlic M, Carter D (1979) Prognostic implications of histology, size and location of primary tumours. In: Rozencweig M (ed) Treatment of lung cancer. Raven Press, New York, pp 143–150Google Scholar
  14. Katzenstein A-A, Prioleau PG, Askin FB (1980) The histologic spectrum and significance of clear cell change in lung carcinoma. Cancer 45: 943–947PubMedCrossRefGoogle Scholar
  15. Kodama T, Shimosoto Y, Kameya T (1982) Histology and ultrastructure of bronchogenic and bronchial gland adenocarcinomas (including adenoid cystic and mucoepidermoid carcinomas) in relation to histogenesis. In: Shimosato Y, Melamed MR, Nettesheim P (eds) Morphogenesis of lung cancer, vol I. CRC Press, Boca Raton, vol I, pp 147–166Google Scholar
  16. Kuhn C (1972) Fine structure of bronchiolo-alveolar carcinoma. Cancer 30: 1107–1118PubMedCrossRefGoogle Scholar
  17. Larsson S, Zettergren L (1976) Histological typing of lung cancer. Acta Pathol Microbiol Scand A] 84: 529–537PubMedGoogle Scholar
  18. Lichtiger B, Mackay B, Tessmer CF (1970) Spindle cell variant of squamous carcinoma. A light and electron microscopic study of 13 cases. Cancer 26: 1311–1320PubMedCrossRefGoogle Scholar
  19. McDowell EM, McLaughlin JS, Mereny DK, Kieffer RF, Harris CC, Trump B (1978) The respiratory epithelium V. Histogenesis of lung carcinomas in the human. J Natl Cancer Inst 61: 587–606PubMedGoogle Scholar
  20. Melamed MR, Zaman MB (1982) Pathogenesis of epidermoid carcinoma of lung. In: Shimosato Y, Melamed MR, Nettesheim P (eds) Morphogenesis of lung cancer, vol 1. CRC Press, Boca Raton, pp 37–64Google Scholar
  21. Meyer EC, Liebow AA (1965) Relationship of interstitial pneumonia, honeycoming and atypical epithelial proliferation to cancer of the lung. Cancer 18: 322–351PubMedCrossRefGoogle Scholar
  22. Raeburn C, Spencer H (1953) A study of origin and development of lung cancer. Thorax 8: 1–10PubMedCrossRefGoogle Scholar
  23. Rubinstein I, Baum GL, Kalter Y, Pauzner Y, Lieberman Y, Bubis JJ (1979) The influence of cell type and lymph node metastases on survival of patients with carcinoma of the lung undergoing thoracotomy. Am Rev Respir Dis 119: 253–262PubMedGoogle Scholar
  24. Shimosato Y, Kodama T, Kameya T (1982) Morphogenesis of peripheral type adenocarcinoma of the lung. In: Shimosato Y, Melamed MR, Nettesheim P (eds) Morphogenesis of lung cancer, vol 1. CRC Press, Boca Raton, pp 65–90Google Scholar
  25. Sidhu GS (1982) The ultrastructure of malignant epithelial neoplasms of the lung. Pathol Annu 1: 235–266Google Scholar
  26. Too LC, Delarue NC, Sanders D, Weisbrod G (1978) Bronchiolo-alveolar carcinoma: a correlative clinical and cytologic study. Cancer 42: 2759–2767CrossRefGoogle Scholar
  27. World Health Organisation (1981) Histological typing of lung tumours, 2nd edn. GenevaGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • Allen R. Gibbs
  • Roger M. E. Seal

There are no affiliations available

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