Skip to main content
SpringerLink
Log in
Book cover

Bronchial Carcinoma pp 23–40Cite as

Hormone Production by Bronchial Tumours

  • Chapter

  • 45 Accesses

Abstract

The production of polypeptide hormones and various ‘tumour-associated’ proteins by neoplasia occurring in non-endocrine tissues such as the lung is classically referred to as ‘inappropriate’ or ‘ectopic’ hormone production. The detection of ectopic hormone synthesis and release and the appreciation of the role this may play in associated endocrine syndromes has led to their extensive study, which has had particular relevance for clinical diagnosis, treatment of the endocrine syndromes, monitoring tumour therapy and the search for tumour markers. More recently they have been used as an important aid to the understanding of the biosynthetic pathways of peptide hormones and their precursors.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aldujaili EAS, Hope J, Estivariz FE, Lowry PJ, Edwards CRW (1981) Circulating human pituitary pro-y-melanotropin enhances the adrenal response to ACTH. Nature 291: 156–159

    Article  CAS  Google Scholar 

  • Amatruda TT, Upton GV (1974) Hyperadrenocorticism and ACTH-releasing factor. Ann NY Acad Sci 230: 168–180

    Article  PubMed  CAS  Google Scholar 

  • Azzopardi JG, Williams ED (1968) Pathology of `non-endocrine’ tumours associated with Cushing’s syndrome. Cancer 22: 274–286

    Article  PubMed  CAS  Google Scholar 

  • Azzopardi JG, Freeman D, Poole G (1970) Endocrine and metabolic disorders in bronchial carcinoma. Br Med J 4: 528–530

    Article  PubMed  CAS  Google Scholar 

  • Bailey RE (1971) Periodic hormogenesis. A new phenomenon. J Clin Endocrinol Metab 32: 317–327

    Article  PubMed  CAS  Google Scholar 

  • Baylin SB, Mendelsohn G (1980) Ectopic (inappropriate) hormone production by tumours: Mechanisms involved and the biological and clinical implications. Endocr Rev 1: 45–77

    Google Scholar 

  • Beck C, Burger HG (1972) Evidence for the presence of immunoreactive growth hormone in cancers of the lung and stomach. Cancer 30: 75–79

    Article  PubMed  CAS  Google Scholar 

  • Beck C, Larkins RG, Martin TJ (1973) Stimulation of growth hormone release from superfused rat pituitary by extracts of hypothalamus and of human lung tumours. J Endocrinol 59: 325–333

    Article  PubMed  CAS  Google Scholar 

  • Becker KL, Snider RH, Silver OL (1978) Calcitonin heterogeneity in lung cancer and medullary thyroid cancer. Acta Endocrinol 89: 89–99

    PubMed  CAS  Google Scholar 

  • Benson RC, Riggs RL, Richard BM, Arnaud CD (1974) Immunoreactive forms of circulating PTH in primary and ectopic hyperparathyroidism. J Clin Invest 54: 175–181

    Article  PubMed  Google Scholar 

  • Berson SA, Yalow RS (1964) Immunoassay of protein hormones. In: Pincus G, Thompson KV, Astwood EB (eds). The hormones, vol iv. Academic Press, New York, London, pp 557–630

    Google Scholar 

  • Bertagna XY, Nicholson WE, Pettengill OS (1978) Ectopic production of high molecular weight calcitonin and corticotropin by human small cell carcinoma cells in tissue culture. Evidence for separate precursors. J Clin Endocrinol Metab 47: 1390–1393

    Google Scholar 

  • Bondy PK (1981) The pattern of ectopic hormone production in lung cancer. Yale J Biol Med 54: 181–185

    PubMed  CAS  Google Scholar 

  • Bondy PK, Gilby ED (1982) Endocrine function in small cell undifferentiated carcinoma of the lung. Cancer 50: 2147–2153

    Article  PubMed  CAS  Google Scholar 

  • Brown WH (1928) A case of pluriglandular syndrome, ‘diabetes of bearded women’. Lancet 11: 1022

    Article  Google Scholar 

  • Connor TB, Thomas WC Jr, Howards JE (1956) Etiology of hypercalcaemia associated with lung carcinoma. J Clin Invest 35: 697 (Abstr)

    Google Scholar 

  • Coombes RCC, Hillyard C, Greenberg PB, Maclntyre I (1974) Plasmaimmunoreactive calcitonin in patients with non-thyroid tumours. Lancet I: 1080

    Google Scholar 

  • Dabek JT (1974) Bronchial carcinoid tumour with acromegaly in two patients. J Clin Endocrinol Metab 38: 329–333

    Article  PubMed  CAS  Google Scholar 

  • Dresner MK, Lebovitz HE (1978) Primary hyperparathyroidism in paraneoplastic hypercalcaemia. Lancet 1: 1004–1006

    Article  Google Scholar 

  • Drury PL, Ratter SJ, Tomlin S, Williams J, Dacie JE, Rees LH, Besser GM (1982) Experience with selective venous sampling in diagnosis of ACTH-dependent Cushing’s syndrome. Br Med J (Clin Res) 284: 9–12

    Article  CAS  Google Scholar 

  • Ennis GC, Cameron DP, Burger HG (1973) On the aetiology of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma: Lack of relationship to elevated growth hormone levels. Aust NZ J Med 3: 157–161

    Google Scholar 

  • Frohman LA, Szabo M, Stachura ME, Berelowitz M (1980) Growth hormone-releasing activity from extrapituitary tumours in patients with acromegaly. J Clin Invest 65: 43–54

    Article  PubMed  CAS  Google Scholar 

  • George JM, Capen CC, Phillips AS (1972) Biosynthesis of vasopressin in vitro and ultrastructure of a bronchogenic carcinoma. J Clin Invest 51: 151–158

    Article  Google Scholar 

  • Gewirtz G, Schneider B, Krieger DT, Yalow RS (1974) `Big ACTH’ conversion to biologically active ACTH by trypsin. J Clin Endocrinol Metab 38:227–230

    Google Scholar 

  • Greenberg PB, Beck C, Martin TJ (1972) Synthesis and release of human growth hormone from lung carcinoma in cell culture. Lancet 1: 350–352

    Article  PubMed  CAS  Google Scholar 

  • Gropp C, Haverman K, Scheuer A (1980) Ectopic hormones in lung cancer patients at diagnosis and during therapy. Cancer 46: 347–354

    Article  PubMed  CAS  Google Scholar 

  • Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB (1982) Growth hormone-releasing factor from a human pancreatic tumour that caused acromegaly. Science 218: 585–587

    Article  PubMed  CAS  Google Scholar 

  • Haefliger JM, Dubied MC, Vallotton MB (1977) Excretion journaliere de l’hormone antidiuretiques lors de carcinome bronchique. Schweiz Med Wochensch 107: 728–732

    Google Scholar 

  • Hale AC, Lytras N, Ratter SJ, Tomlin S, Besser GM, Rees LH (1984) Immunoreactive -y-MSH in human plasma. Cl in Endocrinol

    Google Scholar 

  • Hamilton BPM, Upton GV Amatruda TT (1972) Evidence for the presence of neurophysin in tumours producing the syndrome of inappropriate antidiuresis. J Clin Endocrinol Metab 35: 764–767

    Article  PubMed  CAS  Google Scholar 

  • Hansen M, Hansen HH, Hirsch FR (1980) Hormonal polypeptides and amine metabolites in small cell carcinoma of the lung, with special reference to stage and subtypes. Cancer 45: 1432–1437

    Article  PubMed  CAS  Google Scholar 

  • Heath DA (1976) Hypercalcaemia and malignancy. Ann Clin Biochem 13: 555–560

    PubMed  CAS  Google Scholar 

  • Holdaway 1M, Bloomfield GA, Ratcliffe JG, Hinson KWF, Rees GM, Rees LH (1974) Adrenocorticotrophin levels in normal and neoplastic lung tissue. Taylor S (ed) Endocrinology 1973. Heinemann, London

    Google Scholar 

  • Hope J, Ratter SJ, Estivariz FE, McLoughlin L, Lowry PJ (1981) Development of a radioimmunoassay for an amino-terminal peptide of pro-opiocortin containing the -y-MSH region. Measurement and characterisation in human plasma. Clin Endocrinol 15: 221–227

    Google Scholar 

  • Jeffcoate WJ, Rees LH, Tomlin S, Jones AE, Edwards CRW, Besser GM (1977) Metyrapone in the long-term management of Cushing’s disease. Br Med J 2: 215–217

    Article  PubMed  CAS  Google Scholar 

  • Jeffcoate WJ, Tomlin S, McLoughlin L, Rees LH, Besser GM (1978) Plasma i3-endorphin and adrenocorticotrophin in disease of the pituitary adrenal axis. J Enocrinol 80: 6

    Google Scholar 

  • Krauss S, Macy S, Ichiki AT (1981) A study of immunoreactive calcitonin (CT). Adrenocorticotrophic hormone (ACTH) and carcinoembryonic antigen ( CEA) in lung cancer and other malignancies. Cancer 47: 2485–2492

    Google Scholar 

  • Liddle GW, Nicholson WE, Island DP, Orth DN, Abe K, Lowder SC (1969) Clinical and laboratory studies of ectopic humoral syndromes. Recent Prog Horm Res 25: 283–314

    PubMed  CAS  Google Scholar 

  • Mains RW, Eipper B (1976) Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumour cells. J Biol Chem 251: 4115–4120

    PubMed  CAS  Google Scholar 

  • Mason AMS, Ratcliffe JG, Buckle RM, Stuart Mason A (1972) ACTH secretion by bronchial carcinoid tumours. Clin Endocrinal 1: 3–25

    Article  CAS  Google Scholar 

  • Merrill WW, Bondy PK (1982) Production of biochemical marker substances by bronchogenic carcinomas. Clin Chest Med 3: 307–320

    PubMed  CAS  Google Scholar 

  • Moody TW, Russell EK, O’Donohue TL, Lindon CD, Gazdar AF (1983) Bombesin-like peptides in small cell lung cancer: biochemical characterisation and secretion from a cell line. Life Sci 32: 487–493

    Article  PubMed  CAS  Google Scholar 

  • Morton JJ, Kelly P, Padfield PL (1978) Antidiuretic hormone in bronchogenic carcinoma. Clin Endocrinol 9: 357–370

    Article  CAS  Google Scholar 

  • Nakanishi S, Akira A, Kita T, Nakamura M, Chang ACY, Cohen SN, Noma S (1979) Nucleotide sequence of a cloned cDNA for bovine corticotrophin-13-lipotropin precursor. Nature 278: 423–427

    Article  PubMed  CAS  Google Scholar 

  • North WG, Maurer LH, Valhn H, O’Donnell JF (1980) Human neurophysin as potential tumour markers for small cell carcinoma of the lung. Application of specific radioimmunoassays. J Clin Endocrinol Metab 51: 892–896

    Google Scholar 

  • Odell WD, Wolfsen A, Yoshimoto Y, Weitzman R, Fisher D, Hirose F (1977) Ectopic peptide synthesis: A universal concomitant of neoplasia. Trans Assoc Am Physicians 90: 204

    Google Scholar 

  • Pedersen RC, Brownie AC (1980) Adrenocortical response to corticotrophin is potentiated by part of the amino-terminal region of pro-corticotrophin/endorphin. Proc Natl Acad Sci USA 77: 2239–2243

    Article  PubMed  CAS  Google Scholar 

  • Penman E, Wass JAH, Besser GM, Rees LH (1980) Somatostatin secretion by lung and thymic tumours. Clin Endocrinol 13: 613–620

    Article  CAS  Google Scholar 

  • Pert CB, Schumacher UK (1982) Plasma bombesin concentrations in patients with extensive small cell carcinoma of the lung. Lancet 1: 509

    Article  PubMed  CAS  Google Scholar 

  • Pettengill OS, Faulkner CS, Wurster-Hill DH (1977) Isolation and characterisation of a hormone producing cell line from human small cell anaplastic carcinoma of the lung. J Natl Cancer Inst 58: 511–518

    PubMed  CAS  Google Scholar 

  • Powell D, Singer FR, Murray TM, Mirkin C, Potts JT Jr (1973) Non-parathyroid humoral hypercalcaemia in patients with neoplastic disease. N Engl J Med 289: 176–181

    Article  PubMed  CAS  Google Scholar 

  • Rabson AS, Rosen SW, Tasjran AH (1973) Production of human chorionic gonadotrophin in vitro by a cell line derived from a carcinoma of the lung. J Natl Cancer Inst 50: 669–674

    PubMed  CAS  Google Scholar 

  • Ratcliffe JG, Knight RA, Besser GM, Landon J, Stansfield AG (1972) Tumour and plasma ACTH concentrations in patients with and without the ectopic ACTH syndrome. Clin Endocrinal 1: 27–44

    Article  CAS  Google Scholar 

  • Ratter SJ, Lowry PJ, Besser GM, Rees LH (1980) Chromatographic characterisation of adrenocorticotrophin in human plasma. J Endocrinol 85: 359–369

    Article  PubMed  CAS  Google Scholar 

  • Ratter SJ, Gillies G, hope J, Hale AC, Grossman A, Gaillard R, Cook D, Edwards CRW, Rees LH (1983) Pro-opiocortin related peptides in human pituitary and ectopic ACTH secreting tumours. Clin Endocrinol 18: 211–218

    Article  CAS  Google Scholar 

  • Rees LH, Bloomfield GA, Rees GM (1974) Multiple hormones in a bronchial tumour. J Clin Endocrinol Metab 38: 1090–1097

    Article  PubMed  CAS  Google Scholar 

  • Rees LH, Bloomfield GA, Gilkes JJH, Besser GM (1977) ACTH as a tumour marker. Ann NY Acad Sci 297: 603–620

    Article  PubMed  CAS  Google Scholar 

  • Rivier J. Spiess J, Thorner MO, Vale W (1982) Characterisation of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature 300: 276–278

    Google Scholar 

  • Robertson GL (1978) Cancer and inappropriate antidiuresis. In: Ruddon RW (ed) Biological markers of neoplasia: basic and applied aspects. Elsevier, New York

    Google Scholar 

  • Roos BA, Lindall AW, Baylin SB, O’Neil JA, Frelinger JI, Birnbaum RS, Lambert PW (1980) Plasma immunoreactive calcitonin in lung cancer. J Clin Endocrinol Metab 50: 659–666

    Article  PubMed  CAS  Google Scholar 

  • Schorr I, Hinshaw HT, Cooper MA, Mahafee D, Ney RL (1972) Adenyl cyclase hormone responses of certain human endocrine tumour. J Clin Endocrinol Metab 34: 447–451

    Article  PubMed  CAS  Google Scholar 

  • Schwartz WB, Bennett W, Curelop S, Bartter FC (1957) A syndrome of renal sodium loss and hyponatraemia probably resulting from inappropriate secretion of antiduretic hormone. Am J Med 23: 529–542

    Article  PubMed  CAS  Google Scholar 

  • Seidah NG, Benjannet S, Routhier R, DeSerres G, Rochemont J, Lis M, Chretien M (1980) Purification and characterisation of the N-terminal fragment of pro-opiocomelanocortin from human pituitaries: homology to the bovine sequence. Biochem Biophys Res Commun 95: 1417–1424

    Article  PubMed  CAS  Google Scholar 

  • Silva OL, Broder LE, Doppman JL, Snider RH, Moore CF, Cohen MH, Becker KL (1979) Calcitonin as a marker for bronchogenic cancer. Cancer 44: 680–684

    Article  PubMed  CAS  Google Scholar 

  • Skrabaneck P, McPartlin J, Powell D (1980) Tumour associated hypercalcaemia and `ectopic hyperparathyroidism’. Medicine 59: 262–282

    Google Scholar 

  • Sonksen PH, Ayres AB, Braimbridge M, Corrin DR, Davies GM, Jeremiah SW, Oaten C, Lowy TET, West T (1976) Acromegaly caused by pulmonary carcinoid tumours. Clin Endocrinol 5: 503–513

    Article  CAS  Google Scholar 

  • Sorensen GD, Bloom SR, Ghatei MA, Del Prete SA, Cate CC, Pettengill OS (1982) Bombesin production by human small cell carcinoma of the lung. Regul Pept 4: 59–66

    Article  Google Scholar 

  • Sparagna M, Philips G, Hoffman C, Kucera L (1971) Ectopic growth hormone syndrome with lung cancer. Metabolism 20: 730–736

    Article  Google Scholar 

  • Stewart AF, Horst R, Deftos LJ (1980) Biochemical evaluation of patients with cancer associated hypercalcaemia. Evidence for humoral and non-humoral groups. N Engl J Med 303: 1377–1383

    Google Scholar 

  • Suda T, Demura H, Demura R (1977) Corticotrophin-releasing factor-like activity in ACTH producing tumour. J Clin Endocrinol Metab 44: 440–446

    Article  PubMed  CAS  Google Scholar 

  • Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draynin M, Johanson A, Vale W, Horvath E, Kovacs K (1982) Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumour secreting a growth hormone-releasing factor. J Clin Invest 70: 965–977

    Google Scholar 

  • Track NS, Cutz E (1982) Bombesin-like immunoreactivity in developing human lung. Life Sci 30: 1553–1556

    Article  PubMed  CAS  Google Scholar 

  • Unger RH, Lochner JD, Eisentraut AM (1964) Identification of insulin and glucagon in a bronchogenic metastasis. J Clin Endocrinol Metab 34: 823–831

    Article  Google Scholar 

  • Vale W, Spiess J, Rivier C, Rivier J (1981) Characterisation of.a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotrophin and beta-endorphin. Science 213: 1394–1397

    Article  PubMed  CAS  Google Scholar 

  • Vorherr H (1974) Para-endocrine tumour activity with emphasis on ectopic ADH secretion: Genetic, diagnostic, prognostic and therapeutic aspects. Oncology 29: 382–416

    Article  PubMed  CAS  Google Scholar 

  • Weintraub BD, Rosen SW (1971) Ectopic production of chorionic somatomammotrophin by nontrophoblastic cancers. J Clin Endocrinol Metab 32: 94–101

    Article  PubMed  CAS  Google Scholar 

  • Wharton J, Polak JM, Bloom SR, Ghatei MA, Solcia E, Brown M, Pearse AGE (1978) Bombesin-like immunoreactivity in the lung. Nature 273: 769–770

    Article  PubMed  CAS  Google Scholar 

  • Wood SM, Wood JR, Ghatei MA, Lee YC, O’Shaughnessy D, Bloom SR (1981) Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma. J Clin Endocrinol Metab 53: 1310–1312

    Article  PubMed  CAS  Google Scholar 

  • Yesner R (1978) Spectrum of lung cancer and ectopic hormones. In: Sommers S, Rosen PP (eds) Pathology annual part I. Appleton-Century-Crofts, New York, pp 217–240

    Google Scholar 

Download references

Authors
  1. Sally J. Ratter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lesley H. Rees
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Thoracic Surgeon to the North Middlesex, Royal Northern and Royal Free Hospitals, Bays Hill House, Barnet Lane, Elstree, Hertfordshire, England

    Michael Bates FRCS, FACS

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ratter, S.J., Rees, L.H. (1984). Hormone Production by Bronchial Tumours. In: Bates, M. (eds) Bronchial Carcinoma. Springer, London. https://doi.org/10.1007/978-1-4471-3516-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-3516-6_3

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3518-0

  • Online ISBN: 978-1-4471-3516-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation