Advertisement

Chemotherapy for Bronchial Carcinoma

  • Edna Matthews
  • Nicholas Plowman

Abstract

The high incidence and fatality of bronchial carcinoma make it a subject of extreme importance. Regrettably, despite the advances in thoracic surgery and the widespread availability of megavoltage radiotherapy in the last two decades, neither of these modalities has made a significant impression on the survival of the majority of patients. Meanwhile, knowledge and experience in the use of chemotherapy have accumulated and, with the improved clinical results in leukaemia, lymphoma and some other malignancies, there has been an impetus to search for effective drug regimes for bronchogenic cancer. So far, this chemotherapeutic attack has had only limited success, but that success is sufficiently important to justify this full review of the subject.

Keywords

Small Cell Carcinoma Nitrogen Mustard Prophylactic Cranial Radiotherapy Bronchial Carcinoma Megavoltage Radiotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aisner J, Hansen H (1981) Current status of chemotherapy for non-small cell lung cancer. Cancer Treat Rep 65: 979–986PubMedGoogle Scholar
  2. Bersagel D, Jenkin R, Pringle J, White D, Fetterley J, Klassen D, McDermott R (1972) Lung cancer: Clinical trial of radiotherapy alone versus radiotherapy plus cyclophosphamide. Cancer 30: 621–627Google Scholar
  3. British Medical Journal (1971) Study of cytotoxic chemotherapy as an adjuvant to surgery in carcinoma of the bronchus. Br Med J 11: 421–428Google Scholar
  4. Broder LE, Policzer S, Meyerson WH et al. (1982) A phase II clinical trial testing the sequential use of two four drug chemotherapy regimes for bronchogenic adenocarcinoma. The World Conference on Lung Cancer, Tokyo, Japan, 17–20, May 1982, p 184 [Abstr 263]Google Scholar
  5. Cohen MH, Creaven PJ, Fossieck BE, Broder LE, Selawry OS, Johnston AV, Williams CL, Minna JD (1977) Intensive chemotherapy of small cell bronchogenic carcinoma. Cancer Treat Rep 61: 349–354PubMedGoogle Scholar
  6. Cohen MH, Ihde DC, Bunn PA, Fossieck BE, Matthews MS, Chackney SE, Johnston-Early A, Makuch R, Minna JD (1979): Cyclic alternating chemotherapy for small cell bronchogenic carcinoma. Cancer Treat Rep 63: 163–170PubMedGoogle Scholar
  7. Cormier Y, Bergeron D, La Forge J et al. (1982) Benefits of polychemotherapy in advanced non-small cell bronchogenic cancer. Cancer 50: 845–849PubMedCrossRefGoogle Scholar
  8. Dombernowsky P. Hansen HH, Sorenson S, Osterlind K (1979) Sequential versus non-sequential combination chemotherapy using 6 drugs in advanced small cell carcinoma. A comparative trial including 146 patients. Proc Am Soc Clin Oncol 20: 277Google Scholar
  9. Eagan RT, Ingle JN, Frytak S et al. (1977) Platinum based polychemotherapy versus dianhydrogalactitiol in advanced non-small cell lung cancer. Cancer Treat Rep 61: 1399–1445Google Scholar
  10. Evans WK, Feld R. De Boer G et al. (1981) Cyclophosphamide, doxorubicin and cis-platinum in the treatment of non-small cell bronchogenic carcinoma. Cancer Treat Rep 65: 947–954PubMedGoogle Scholar
  11. Farha P, Spitzer G, Valdivieso M et al. (1981) Treatment of small cell bronchial carcinoma (SCBC) with high dose chemotherapy (CT) and autologous bone marrow transplantation (ABMT). Proc Am Soc Clin Oncol [Abstr. C637, p 496]Google Scholar
  12. Fox W, Scadding JG (1973) Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small cell or oat cell carcinoma of bronchus: Ten year follow up. Lancet II: 63–65Google Scholar
  13. Friedman M, Carter S (1980) Results of the Northern California Oncology GroupGoogle Scholar
  14. Gazdar AF, Cohen MH, Ihde DC, Minna JD, Matthews MJ (1979) Bronchial epithelial changes in association with small cell carcinoma of the lung. In: Muggia F, Rozencweig M (eds) Lung cancer, progress in therapeutic research. Raven Press, New York, pp 167–174Google Scholar
  15. Gralla RJ, Casper FS, Kelsen DP et al. (1982) Trials in non-small cell cancer with regimens combining vindesine and cis-platinum. The World Conference on Lung Cancer, Tokyo, Japan, 17–20 May 1982, p 188 [Abstr. 271]Google Scholar
  16. Greco FA, Oldham RK (1979) Current concepts in cancer: small cell lung cancer. N Engl J Med 301: 355–358PubMedCrossRefGoogle Scholar
  17. Green RA, Humphrey E. Close H et al. (1969) Alkylating agents in bronchogenic carcinoma. Am J Med 46: 516–524PubMedCrossRefGoogle Scholar
  18. Hande KR, Oldham RK, Fer MF, Richardson RL, Greco FA (1982) Randomized study of high dose versus low dose methotrexate in the treatment of extensive small cell lung cancer. Am J Med 73: 413–419PubMedCrossRefGoogle Scholar
  19. Hansen HH (1974) Bone metastases in lung cancer. Munksgarrd, CopenhagenGoogle Scholar
  20. Hansen HH (1980) Management of small cell anaplastic carcinoma. Proceedings of the 11„ World Congress on Lung Cancer (Copenhagen 1980 ). Excerpta Medica, Amsterdam Oxford Princeton, pp 113–132Google Scholar
  21. Hansen HH: Management of small cell anaplastic carcinoma 1980–1982. Proceedings of the 111,d World Congress on Lung Cancer (Tokyo 1982 ), pp 31–54Google Scholar
  22. Itri LM, Gralla RJ, Kelsen DP et al. (1983) Cis-platinum, vindesine and bleomycin ( CVB) combination chemotherapy of advanced non-small cell lung cancer. Cancer 51: 1050–1055Google Scholar
  23. Johnson RE, Brereton HD, Kent CH (1978) ‘Total’ therapy for small cell carcinoma of the lung. Ann Thorac Surg 25:509–515Google Scholar
  24. Jones HD, Bleehen NM, Grant RM et al. (1983) Scheduled and unscheduled combination chemotherapy in the treatment of squamous cell lung cancer. ( Cyclophosphamide, adriamycin, vincristine and bleomycin, with and without cis-platinum ). Anti-Cancer Res 3: 235–238Google Scholar
  25. Karnofsky DA, Abelmann WH, Craven LF et al. (1948) The use of nitrogen mustards in the palliative treatment of cancer. Cancer 1: 634–656CrossRefGoogle Scholar
  26. Kelsen DP, Gralla RJ, Stoopler M et al. (1982) Cisplatin, doxorubicin, cyclophosphamide and vindesine combination chemotherapy for non-small cell lung cancer. Cancer Treat Rep 66: 247–251PubMedGoogle Scholar
  27. Knost SA, Greco FA, Hande, KR et al (1981) Cyclophosphamide, doxorubicin and cis-platin in the treatment of advanced non-small cell cancer. Cancer Treat Rep 65: 941–945PubMedGoogle Scholar
  28. Laing AH, Berry RJ, Newman CR, Smith P (1975) Treatment of small cell carcinoma of bronchus. Lancet 1. 129–132PubMedCrossRefGoogle Scholar
  29. Livingston RB, Fee WH, Einhorn LH et al. (1976) Bacon (bloemycin, adriamycin, CCNU, oncovin and nitrogen mustard) in squamous lung cancer. Experience in fifty patients. Cancer 37: 1237–1242PubMedCrossRefGoogle Scholar
  30. Livingston RB, Heilbrun L, Lehane D et al. (1977) Comparative trial of combination chemotherapy in extensive squamous carcinoma of lung: A South West Oncology Group Study. Cancer Treat Rep 61: 1623–1629Google Scholar
  31. Matthews MJ, Rozencweig M, Staquet MJ, Minna JD, Muggia FM (1980) Long term survivors with small cell carcinoma of the lung. Eur J Cancer 16: 527–831PubMedCrossRefGoogle Scholar
  32. Matthews MJ, Mackay B, Likeman J (1983) The pathology of non-small cell carcinoma of lung. Semin Oncol 10: 34–55PubMedGoogle Scholar
  33. Maurer LH, Pajak TF (1981) Prognostic factors in small cell carcinoma of the lung: A cancer and leukaemia group B Study. Cancer Treat Rep 65: 767–774Google Scholar
  34. Maurer LH, Tulloh M, Weiss RB, Blom J, Leone L, Glidewell O, Pajak TF ( 1980 A randomised combined modality trial in small cell carcinoma of the lung: Comparison of combination chemotherapy-radiotherapy versus cyclophosphamide radiotherapy, effects of maintenance chemotherapy and prophylactic whole brain irradiation. Cancer 45: 30–39.Google Scholar
  35. Meyer JA, Comiz RL, Ginsberg SJ, Ikins PM, Burke WA, Parker FB (1979) Selective surgical resection in small cell carcinoma of the lung. J Thorac Cardiovasc Surg 77: 243–248PubMedGoogle Scholar
  36. Mountain CF (1978) Clinical biology of small cell carcinoma: Relationship to surgical therapy. Semin Oncol 5: 272PubMedGoogle Scholar
  37. Plowman PN, Stovin PGI (1980) Chemotherapy induced bronchial epithelial changes. Proceedings of the Ilnd World Congress on Lung Cancer (Copenhagen 1980 ). Excerpta Medica, Amsterdam, Oxford, Princeton p 164Google Scholar
  38. Rissanen PM, Tikka V, Holsti LR (1968). Autopsy findings in lung cancer treated with megavoltage radiotherapy. Acta Radiol Ther Phys Biol 7: 433–442PubMedGoogle Scholar
  39. Roswit B, Patno ME, Rapp R (1968) The survival of patients with inoperable lung cancer: A large scale randomised study of radiation therapy versus placebo. Radiology 90: 688–697Google Scholar
  40. Salazar OM, Creech RH (1980) ‘The state of art’ toward defining the role of radiation therapy in the management of small cell bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 6:1103–1117Google Scholar
  41. Shore DB, Paneth M (1980) Survival after resection of small cell carcinoma of the bronchus. Thorax 35: 819–822PubMedCrossRefGoogle Scholar
  42. Stanley KE (1980) Prognostic factors for survival in patients with inoperable lung cancer. J Natl Cancer Inst 65: 25–32PubMedGoogle Scholar
  43. Trovo MG, Tirelli U, De Paoli A et al. (1982) Combined radiotherapy and chemotherapy with cyclophosphamide, adriamycin, methotrexate, procarbazine (CAMP) in 64 consecutive patients with epidermoid bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 8: 1051–1054PubMedCrossRefGoogle Scholar
  44. Vogl SE, Mehta C (1982) High dose cyclophosphamide in the induction chemotherapy of small cell lung cancer — minor improvements in the rate of remission and in survival. Proceedings of the III° World Congress on Lung Cancer (Tokyo 1982), p 168 [Abstr. 234]Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • Edna Matthews
  • Nicholas Plowman

There are no affiliations available

Personalised recommendations