Radiographically Occult Lung Cancer

  • Stewart Clarke


Radiographically occult lung cancer may be defined as that situation in which a patient has sputum positive for cancer cells but a negative chest radiograph (Williams and Cortese 1982). A screening programme for lung cancer was set up in the early 1970s by the U.S. National Cancer Institute involving a collaborative study between Johns Hopkins Hospital, New York Memorial Hospital and the Mayo Clinic. Each centre aimed at enrolling about 10 000 male smokers at risk, 5000 each in the screen and control groups. The majority of the information on radiographically occult lung cancer has been generated therefrom in individual reports (Marsh et al. 1978; Melamed et al. 1981; Williams and Cortese 1982).


Lung Cancer Squamous Cell Cancer Large Cell Carcinoma Bronchial Carcinoma Sputum Cytology 
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  1. Cortese DA, Kinsey JH, Woolner LB, Sanderson DR, Fontana RS (1982) Haemotoporphyrin derivative in the detection and localization of radiographically occult lung cancer. Am Rev Respir Dis 126: 1087–1088PubMedGoogle Scholar
  2. Cortese DA, Sanderson DR (1981) Localization of occult lung cancer. Semin Respir Med 3: 35–36CrossRefGoogle Scholar
  3. Fontana RS, Carr DT, Woolner LB, Miller FK (1965) Value of induced sputum in cytologic diagnosis of lung cancer. JAMA 191: 134–136PubMedCrossRefGoogle Scholar
  4. Geddes DM (1979) The natural history of lung cancer: a review based on rates of tumour growth. Br J Dis Chest 73: 1–17PubMedCrossRefGoogle Scholar
  5. Marsh BR, Frost JK, Erozan YS, Carter D (1978) Diagnosis of early bronchogenic carcinoma. Chest 73: 716–717 [Suppl]Google Scholar
  6. Medical Research Council (1965) Definition-classification of chronic bronchitis for clinical and epidemiological purposes. Lancet I: 775–779Google Scholar
  7. Melamed MR, Flehinger BJ, Muhammad BZ, Heelan RT, Hallerman ET, Martini N (1981) Detection of true pathologic stage 1 lung cancer in a screening programme and the effect on survival. Cancer 47: 1182–1187PubMedCrossRefGoogle Scholar
  8. Muhm JR, Miller WE, Fontana RS, Sanderson DR, Uhlenhopp MA (1983) Lung cancer detected during a screening program using four-month chest radiographs. Radiology 148: 609–615PubMedGoogle Scholar
  9. Oswald NC, Hinson KFW, Canti G, Miller AB (1971) The diagnosis of primary lung cancer with special reference to sputum cytology. Thorax 26: 623–631PubMedCrossRefGoogle Scholar
  10. Stitik FP, Tockman MS (1978) Radiographic screening in the early detection of lung cancer. Radiol Clin North Am 16: 347–366PubMedGoogle Scholar
  11. Williams DE, Cortese DA (1982) The present status of screening and diagnosis of early lung cancer. Semin Respir Med 3: 210–217CrossRefGoogle Scholar
  12. Woolner LB, Fontana RS, Sanderson DR, Miller WE, Muhm JR, Taylor WF, Uhlenhopp MA (1981) Mayo Lung Project: Evaluation of lung cancer screening through December, 1979. Mayo Clin Proc 56: 544–555PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • Stewart Clarke

There are no affiliations available

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