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Osteomyelitis and Staphylococcal Adhesion

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Pathogenesis of Wound and Biomaterial-Associated Infections

Summary

Staphylococcus aureus is the most common pathogen isolated from patients suffering from osteomyelitis. Staphylococcal cells interact with several components of the extracellular matrix, including collagen and fibronectin, both found in bone tissue. We have found that Staphylococcus aureus strains isolated from patients with osteomyelitis or septic arthritis interact specifically with a bone-specific sialoprotein in contrast to strains isolated from patients with endocarditis or other staphylococcal infections. The staphylococcal interaction with bone sialoprotein may thus serve in the localization of those bacteria to bone, specifically. There was no such specificity seen for the interaction between staphylococcal cells and collagen and fibronectin, respectively.

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Authors
  1. Cecilia Rydén
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Editors and Affiliations

  1. Department of Medical Microbiology, University of Lund, POB 117, S-22100, Lund, Sweden

    Torkel Wadström PhD (Professor) & Åsa Ljungh PhD (Assistant Professor) (Professor) &  (Assistant Professor)

  2. Department Medical Microbiology, Sölvegaten 23, S-23362, Lund, Sweden

    Ingvar Eliasson PhD

  3. Burns Institute, Shriners Hospital, Cincinnati, Ohio, USA

    Ian Holder PhD

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© 1990 Springer-Verlag London Limited

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Rydén, C. (1990). Osteomyelitis and Staphylococcal Adhesion. In: Wadström, T., Eliasson, I., Holder, I., Ljungh, Å. (eds) Pathogenesis of Wound and Biomaterial-Associated Infections. Springer, London. https://doi.org/10.1007/978-1-4471-3454-1_8

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  • DOI: https://doi.org/10.1007/978-1-4471-3454-1_8

  • Publisher Name: Springer, London

  • Print ISBN: 978-3-540-19596-2

  • Online ISBN: 978-1-4471-3454-1

  • eBook Packages: Springer Book Archive

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